Feasibility Experiment Research Articles

Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys.

Maternal vaccinations administered prior to conception or during pregnancy enhance the immune protection of newborn infants against many pathogens. A feasibility experiment was conducted to determine if monkeys can be used to model the placental transfer of maternal antibody against SARS-CoV-2. Six adult rhesus monkeys were immunized with adjuvanted recombinant-protein antigens comprised of receptor-binding domain human IgG1-Fc fusion proteins (RBD-Fc) containing protein sequences from the ancestral-Wuhan or Gamma variants. The female monkeys mounted robust and sustained anti-SARS-CoV-2 antibody responses. Blood samples collected from their infants after delivery verified prenatal transfer of high levels of spike-specific IgG, which were positively correlated with maternal IgG titers at term. In addition, an in vitro test of ACE2 neutralization indicated that the infants' IgG demonstrated antigen specificity, reflecting prior maternal immunization with either Wuhan or Gamma-variant antigens. All sera showed stronger ACE2-RBD binding inhibition when variants in the assay more closely resembled the vaccine RBD sequence than with more distantly related variants (i.e., Delta and Omicron). Monkeys are a valuable animal model for evaluating new vaccines that can promote maternal and infant health. Further, the findings highlight the enduring nature and safety of the immune protection elicited by an adjuvanted recombinant RBD-Fc vaccine.

Biochar enhanced anaerobic co-digestion of poultry litter and wheat straw: Performance, microbial analysis, and multiple factors’ interaction

Amendment of anaerobic co-digestion (Co-AD) of poultry litter (PL) and agricultural straw using biochar has rarely been practiced. This study conducted two sequential experiments to evaluate the effect of adding alkaline biochar on improving the batch Co-AD of PL and wheat straw. The feasibility experiment identified the advantages of adding biochar by the improved observed cumulative methane yield (CMYo, mL CH4/g VSsubstrate) of 9.7%; the increased removal rates of the substrate total solids (TSsubstrate) and volatile solids (VSsubstrate) of 15.2% and 14.2%, respectively; the enhanced abundance of both hydrolytic bacteria and methanogens, including hydrogegenotrophic Methanobacterium and, especially, the acetolactic Methanosaeta; and the 37.3% higher abundance of the methanogenic pathways, compared to the control. The interaction experiment showed that biochar dosage (BD) interacted with the initial substrate carbon-to-nitrogen ratio (C/N) and total solids level (TS). The developed mathematical models for CMYo and VSsubstrate removal by response surface methodology were significant, which predicted the optimal conditions being initial substrate C/N ratio 29.93 and TS 6.98%, and BD 9.98% substrate. The optimized CMYo and VSsubstrate removal were 17.7% and 22.1% higher, respectively, than those of the Control. These results support the utilization of biochar in improving the Co-AD of agricultural wastes.

Secured THz communication in photonic microcell networks based on spatial wave mixing of steered beams

Future 6G communication systems are envisioned to expand their carrier frequency to the THz region, where a broad unexplored region of spectrum is available. With this expansion, THz wireless communication has the potential to achieve ultra-high data transmission rates of up to 100Gbit/s. However, as large amounts of data are transmitted in an open wireless environment, there are significant concerns regarding communication security due to the susceptibility to eavesdropping, interception, and jamming. In this work, we proposed a secure approach for THz wireless communication based on spatial wave mixing and flexible beam steering. To achieve this, two frequency-modulated THz waves, which are generated by photonic THz sources and carry encrypted information with true randomness, are mixed at a THz envelope detector with an exclusive-OR logic operation. We analyzed the possible spatial location for the THz detector to ensure a secure microcell network deployment. Our results demonstrate that the size of the decryptable region is directly dependent on the directivity and width of the emitted THz beam. To address this, we have developed an array antenna with integrated uni-traveling-carrier photodiodes (UTC-PDs), which is capable of generating THz waves while also improving the flexibility of beam pointing, allowing for greater control over the location and size of the decodable region. By controlling fiber-optic delay lines, we successfully demonstrated that the directional gain of a 200GHz wave is increased by 8dB through a 1 × 3 UTC-PD-integrated planar bowtie antenna (PBA) array, together with continuous beam steering from -20° to 10°. Additionally, using a 1 × 4 UTC-PD-integrated PBA array to emulate two encryption transmitters and a Femi-level managed barrier diode to detect spatially mixed THz waves, we successfully achieved a feasibility experiment for real-time 200Mbit/s location-based decryption in the 200GHz band. These results indicate that the proposed scheme is feasible for secured THz communication, and would be a powerful candidate to mitigate security risks in 6G microcell networks.

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Although the application of magnetic compression anastomosis is becoming increasingly widespread, the magnets used in earlier studies were mostly in the shape of a whole ring. Hence, a deformable self-assembled magnetic anastomosis ring (DSAMAR) was designed in this study for gastrointestinal anastomosis. Furthermore, its feasibility was studied using a beagle model. The designed DSAMAR comprised 10 trapezoidal magnetic units. Twelve beagles were used as animal models, and DSAMARs were inserted into the stomach and colon through the mouth and anus, respectively, via endoscopy to achieve gastrocolic magnamosis. Surgical time, number of failed deformations, survival rate of the animals, and the time of magnet discharge were documented. A month later, specimens of the anastomosis were obtained and observed with the naked eye as well as microscopically. In the gastrocolic anastomosis of the 12 beagles, the procedure took 65–120 min. Although a deformation failure occurred during the operation in one of the beagles, it was successful after repositioning. The anastomosis was formed after the magnet fell off 12–18 days after the operation. Naked eye and microscopic observations revealed that the anastomotic specimens obtained 1 month later were well-formed, smooth, and flat. DSAMAR is thus feasible for gastrointestinal anastomosis under full endoscopy via the natural orifice.

Health data space nodes for privacy-preserving linkage of medical data to support collaborative secondary analyses.

The potential for secondary use of health data to improve healthcare is currently not fully exploited. Health data is largely kept in isolated data silos and key infrastructure to aggregate these silos into standardized bodies of knowledge is underdeveloped. We describe the development, implementation, and evaluation of a federated infrastructure to facilitate versatile secondary use of health data based on Health Data Space nodes. Our proposed nodes are self-contained units that digest data through an extract-transform-load framework that pseudonymizes and links data with privacy-preserving record linkage and harmonizes into a common data model (OMOP CDM). To support collaborative analyses a multi-level feature store is also implemented. A feasibility experiment was conducted to test the infrastructures potential for machine learning operations and deployment of other apps (e.g., visualization). Nodes can be operated in a network at different levels of sharing according to the level of trust within the network. In a proof-of-concept study, a privacy-preserving registry for heart failure patients has been implemented as a real-world showcase for Health Data Space nodes at the highest trust level, linking multiple data sources including (a) electronical medical records from hospitals, (b) patient data from a telemonitoring system, and (c) data from Austria's national register of deaths. The registry is deployed at the tirol kliniken, a hospital carrier in the Austrian state of Tyrol, and currently includes 5,004 patients, with over 2.9 million measurements, over 574,000 observations, more than 63,000 clinical free text notes, and in total over 5.2 million data points. Data curation and harmonization processes are executed semi-automatically at each individual node according to data sharing policies to ensure data sovereignty, scalability, and privacy. As a feasibility test, a natural language processing model for classification of clinical notes was deployed and tested. The presented Health Data Space node infrastructure has proven to be practicable in a real-world implementation in a live and productive registry for heart failure. The present work was inspired by the European Health Data Space initiative and its spirit to interconnect health data silos for versatile secondary use of health data.

Bottom and Suspended Sediment Backscatter Measurements in a Flume—Towards Quantitative Bed and Water Column Properties

For health and impact studies of water systems, monitoring underwater environments is essential, for which multi-frequency single- and multibeam echosounders are commonly used state-of-the-art technologies. However, the current scarcity of sediment reference datasets of both bottom backscatter angular response and water column scattering hampers empirical data interpretation. Comprehensive reference data derived from measurements in a controlled environment should optimize the use of empirical backscatter data. To prepare for such innovative experiments, we conducted a feasibility experiment in the Delta Flume (Deltares, The Netherlands). Several configurations of sonar data were recorded of the flume floor and suspended sediment plumes. The results revealed that flume reverberation was sufficiently low and that the differential settling of fine-sand plumes in the water column was clearly detected. Following this successful feasibility test, future comprehensive experiments will feature multi-frequency multi-angle measurements on a variety of sediment types, additional scatterers and sediment plumes, resulting in reference datasets for an improved interpretation of underwater backscatter measurements for scientific observation and sustainable management.

A Pilot Study Testing the Novel Use of a Snake Bite Compression Device for Field Hemostasis and Wound Repair in an Animal Model.

A commercially available snake bite device was pilot tested for novel use as a method of hemostasis and wound repair at a noncompressible site in a live swine model. The device is light, is plastic, uses a hook-and-loop strap attachment, and is easily deployed. The device could offer a method for the field repair of an actively bleeding laceration at a noncompressible site in an austere environment. This was an interventional, prospective, controlled study in a large animal model. The study was approved by the Rhode Island Hospital Institutional Review Board (IRB) and the Animal Welfare Committee/Institutional Animal Care and Use Committee and the Lifespan Research Conflict of Interest Committee. Each animal acted as its own control. Blood loss was measured and compared between repairs of standardized incisions with and without the device's application. The lacerations were sutured closed. Two proceduralists alternated tasks of wound repair versus blood collection. Blood loss was measured by using gauze sponges to capture the blood during a 30-second free-bleeding period and during the repair itself. Using a one sample t-test (the expected difference in blood loss between the two incision repair methods = 0 if the null hypothesis were true), we calculated the mean difference in the deltas between the repair methods. The mean delta difference was 3.1 g (SE ± 0.97). The t-test demonstrated that there was a significantly greater blood loss during the standard repair method, t(9) = 3.11, P < 0.01 than during the repair with the device in place (see Fig.2). A statistical power analysis conducted showed that with a sample size of 10 animals, there was sufficient statistical power to detect this significant effect (β = 0.82, α < 0.05, one-tailed). There was statistically significantly less blood loss during the repairs with the device's application. This feasibility experiment demonstrates that a commercially available snakebite device may be useful for hemostasis during laceration repair at anatomic sites not amenable to application of tourniquets or compressive dressings. Strengths of the study include the prospective controlled design, including the use of each animal as its own control; alternating proceduralists to account for any variability in suturing efficiency; and the statistical significance of the results despite the small number of subjects. One weakness is that the time required for each repair was not measured. The device's portability and reusability suggest applicability in austere medical environments. Future studies could include timing the repairs, using a skin stapler or wound adhesive instead of sutures, applying a hemostatic agent before the repair, and sequentially applying the device to wounds longer than the device.

RT-AIDE: A RTOS-Agnostic and Interoperable Development Environment for Real-Time Systems

This article presents RT-AIDE, a real-time operating system (RTOS) Agnostic development environment considering performance evaluation and interoperation with nonreal-time tasks. Most real-time systems adopt RTOSes owing to their multitasking environment and priority-based scheduling. However, selecting for the appropriate RTOS according to application requirements is a complicated process as each RTOS has its own API and semantics. With open-source distributions real-time performance evaluation is also an open problem. RT-AIDE addresses this issue through the portable components to ensure execution across various RTOSes without modifying the source code, which has been proven to reduce development costs and effort as well. We also propose a new metric called real-time performance index to evaluate the behavior of the running application. To validate feasibility, theoretical analysis and practical experiment has been conducted on an actual control system based on Xenomai and RT-Preempt.

Optimal placement criteria of hybrid mounting system for chassis in future mobility based on beam-type continuous smart structures

Recently, research into the development of hybrid and electric vehicles has been vigorously undertaken, indicating a trend toward the replacement of internal combustion engine vehicles. However, while high efficiency and light weight are crucial in the development of vehicles, they increase the excitation force of the engine. In addition, sensor placement in future mobility is very important since it causes malfunctioning of autonomous driving systems when the location and orientation of sensors are changed due to excessive vehicle vibration. To reduce the structure-borne noise and vibration caused by engine excitation, an active engine mounting system must be installed in an optimal location. Thus, in this study, to determine the optimal location for an active engine mounting system applied to a beam structure, a series of simulations with two different methodologies are performed. The overall beam structure with two active mounting systems is modeled based on the lumped parameter model. To determine the optimal position of the active mounting system, it is moved to equal intervals, and the force and phase of the active mounts at each location combination are calculated based on static and dynamic methods. The optimal position is suggested such that the vibration reduction is maximized, while the applied force is minimized. Additionally, a feasibility experiment is conducted to validate the proposed criteria and confirm the simulation results. The results demonstrate that the optimal location of the active engine mounting system with a minimized force requirement and maximized vibration reduction can be identified.

A New 2D Displacement Measurement Method Based on an Eddy Current Sensor and Absolute Encoding

A new method of two-dimensional (2D) plane displacement measurement based on an eddy current sensor is proposed in this paper. A series of grooves with different widths and depths are graved on the linear displacement table to form 2D absolute coding using the idea of pseudorandom coding. The eddy current sensor array is arranged above the groove to identify the coding. An artificial neural network is used to establish a measurement model which is the mapping relationship between the output of the eddy current sensor array and the 2D displacement of the workbench. A feasibility experiment showed that in the range of 20 × 20 mm, the root mean square error of measurement in the X- and Y-directions are 83 and 73 μm, respectively. The new method integrates eddy current sensor and artificial neural network modeling to realize 2D displacement measurement, which provides a new solution for displacement and angle measurement.

Mode shape database-based estimation for machine tool dynamics

The system dynamics of machine tools plays an important role in machine health monitoring and quality assessment of manufacturing products. For former identification methods, the system dynamics are achieved with premises that do not fit with the real cutting conditions, as experimental modal analysis is realized only in idle status, and operational modal analysis limits the excitation form for vibration. Meanwhile, the dynamics variation during the machining is viewed discretely with no proper handles for the changes caused by cutting position movements. In this study, a mode shape database-based TOMA (MSDB-TOMA) estimation method is proposed for the system dynamics of machine tools under variation caused by component movements. The establishment principle of a mode shape database for capturing dynamics variation influenced by movements of cutting positions is proposed, with good fitting performance proved in a finite element model (FEM) of a machine tool. After that, the performance of dynamics estimation with the proposed method is validated using matched mode shapes from the pre-built database. The estimation for system dynamics parameters, e.g., natural frequency, presents a maximum error of within 0.04%, which turns out to be precise when compared with the real value from modal analysis in simulation. The feasibility experiment on FEM for estimating dynamics variation with component movements indicates the possibility of in-process dynamics recognition for real machining using the proposed method.

Research on Unbalanced Vibration Suppression Method for Coupled Cantilever Dual-Rotor System

The cantilever dual-rotor system is a typical structure of the blade output end of the open rotor engine and the coaxial output turboshaft engine. The excessive unbalanced vibration of a coupled cantilever dual-rotor system is one of the main factors limiting the application of the above engine type. In order to accurately describe the vibration coupling effect between the dual-rotor-intermediate bearings, the unbalanced response of the cantilever dual-rotor system is analyzed, and the self-sensitivity coefficient is proposed to guide the selection of measuring points and vibration suppression experiments for the dual-rotor system. On this basis, a new online automatic balance actuator applicable to this dual-rotor system is designed, and a feasibility experiment is carried out. The experimental results indicate that: (1) The self-sensitivity coefficient can be used as the basis for the actual vibration measuring point arrangement and unbalanced vibration suppression strategy of the dual-rotor system, and the proposed step-by-step vibration suppression strategy can reduce the vibration of the dual-rotor system by more than 80%. (2) The designed online automatic balance actuator can reduce the unbalanced vibration by 53% in 3.52 s. The proposed method in this study can provide guidance for the vibration suppression of the dual-rotor system.

Preconceptual Design of Multifunctional Gas-Cooled Cartridge Loop for the Versatile Test Reactor—Part I

An integrated effort by the Versatile Test Reactor (VTR) Gas-Cooled Fast Reactor (GFR) Team to develop an experiment vehicle or extended-length test assembly for the VTR experiments is led by the Idaho National Laboratory and supported by an industrial partner, General Atomics, and university partners, including Texas A&M University, University of Michigan, Oregon State University, University of Houston, and University of Idaho. The overall focus of the effort is to design a helium gas-cooled cartridge loop (GCL) to assist with the testing of fuels, materials, and instrumentation to further support development of advanced reactor systems. This study is divided into two parts. Part I provides the GCL functional requirements and critical irradiation data needs for advancing GFR technologies. Part II includes the measurement techniques developed to measure the thermophysical properties of the different materials in the GCL, as well as the functionality and efficacy of these instrumentation and control systems within the GCL. This paper, Part I, describes the overall preliminary conceptual design of the VTR helium cartridge loop, the design of a fission product venting system, the thermal-hydraulic effects of flow direction, and gamma-heating generation in the cartridge. This paper also describes a three-dimensional computational fluid dynamics study that was carried out to examine the effects of the helium flow direction in the GCL on its thermal-hydraulic characteristics, engineering feasibility, and in-VTR experiment design. Both steady-state operation and a transient scenario (pressurized loss of forced circulation) were analyzed for the upward and downward helium flow options in the test article section in the GCL to provide quantitative data for selection of the helium flow direction. Additional analyses and development, as well as integrated out-of-pile testing, are planned to demonstrate and verify the performance of the GCL prior to insertion into the VTR.

Monitoring Tidal Currents and Macroturbulence in a High-Flow Tidal Channel Using a Kilometer-Scale Acoustic Travel-Time Instrument

A challenge in exploiting tidal energy resources is to determine the most suitable sites for development, and as the industry grows, to monitor the progressive impacts of tidal farms on the flow field and sediment transport regimes. A feasibility experiment was carried out with the fluvial acoustic tomography (FAT) system to assess the combined effects of irregular bathymetry, horizontal and vertical sound-speed gradients, and macroturbulence on the quality of FAT-estimated velocities. The experiment involved reciprocal transmissions at 30-s intervals for four days with two 7-kHz broadband transceivers. To determine the origin and potential interpretive value of the frequent multiple arrivals in the unstratified, highly-turbulent flow conditions, we performed a series of simulations with the Bellhop3D model. We demonstrate that the multiple arrivals mainly arise from out-of-plane sound propagation paths resulting from the effects of the local bathymetry. The maximum mean difference between FAT-estimated currents and the coincident moving-vessel acoustic Doppler current profiler (ADCP) transects is found to be less than 10%. Comparisons are also made between velocity spectra during the full flood and the ebb determined using the FAT velocities and the vertically-averaged velocities from a bottom-mounted ADCP deployed in a later experiment. The spectra exhibit similar shapes in the frequency and wave number overlap regions, indicating that FAT is able to detect macroturbulence. Good agreement is also obtained between the sound-speed estimates based on the travel time and those from <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in situ</i> temperature and salinity data. Overall, the results demonstrate the potential of shallow acoustic tomography for monitoring environmental conditions in high-flow tidal channels.

An explorative digital tool as a pathway to meaning: the case of the inflection point

AbstractThe learning of calculus concepts is considered challenging for students. This claim is actual for calculus in general and for specific concepts in particular. In this paper, we focus on the concept of the inflection point. We argue that one of the roots of this problem is the lack of a useful and productive meaning of the concept—the understanding of the inflection point as the point where the behaviour of a curve (graph of function) changes in relation to the tangent line. With the purpose of helping students to construct this meaning we developed a specific digital tool: a teaching unit based on the interactive diagrams framework. Does this tool help students to achieve this meaning (i.e., to construct and consolidate new knowledge)? To answer this question, we conducted an empirical feasibility experiment (in the form of a case study with two first-year students from the Industrial Engineering College) and analysed the gathered data using the framework of abstraction in context as the theoretical and methodological basis. Our findings show that the designed tool (the interactive digital teaching unit) has potential for helping students to make the above-mentioned meaning for this mathematical concept and can serve as a useful basis to continue the investigation of designing tools that support the meaning-making of advanced mathematical concepts.

In Situ Raman Spectroscopy Monitoring of Material Changes During Proton Irradiation.

Organic molecules are prime targets in the search for life on other planetary bodies in the Solar System. Understanding their preservation potential and detectability after ionic irradiation, with fluences potentially representing those received for several millions to billions of years at Mars or in interplanetary space, is a crucial goal for astrobiology research. In order to be able to perform in situ characterization of such organic molecules under ionic irradiation in the near future, a feasibility experiment was performed with polymer test samples to validate the optical configuration and the irradiation chamber geometry. We present here a Raman in situ investigation of the evolution of a series of polymers during proton irradiation. To achieve this goal, a new type of Raman optical probe was designed, which documented that proton irradiation (with a final fluence of 3.1014 at·cm-2) leads to an increase in the background level of the signal, potentially explained by the scission of the polymeric chains and by atom displacements creating defects in the materials. To improve the setup further, a micro-Raman probe and a temperature-controlled sample holder are under development to provide higher spectral and spatial resolutions (by reducing the depth of field and laser spot size), to permit Raman mapping as well as to avoid any thermal effects.

Intra-row weed density evaluation in rice field using tactile method

• The first attempt to evaluate the density of intra-row weeds in a paddy field based on tactile perception. • A variety of tactile expressions of weed density were obtained. • A novel feature extraction scheme based on the Hilbert-Huang Transform was proposed. • The weed density evaluation model was established based on the feature scheme. Accurate evaluation of weed density is crucial for effective utilization of herbicides, improvement of rice quality, and reduction of herbicide dosages. The application of visual methods is disadvantageous because intra-row weeds are blocked by the canopies of adjacent rice plants. Therefore, an innovative tactile sensing method is proposed. A flexible gasbag filled with special microstructures distributed over its surface was developed. The tactile data of weed density were generated through contact between the microstructures and weeds, and the data were measured using the voltage value of a barometric sensor mounted inside the gasbag. The tactile time series was processed using fractal theory and Hilbert–Huang transform (HHT), and the discriminating features of the weed density were acquired. The discriminating features were input into a neural network to train a weed density classifier to evaluate the weed density. The results of the feasibility experiment demonstrated that the evaluation accuracies for high-density, medium-density, and low-density weeds were 95.4%, 91.8%, and 87.9%, respectively, with an average accuracy of 91.7%. The field validation test demonstrated that the visual-based method had an average classification accuracy of 64.17%, whereas the proposed method had an average accuracy of 77.04%, experimentally demonstrating superior accuracy over the image-based method.

Photonics-Assisted Terahertz-Wave Beam Steering and Its Application in Secured Wireless Communication

Beam forming and beam steering are inevitable technologies for the practical application of high-frequency electromagnetic waves. Specifically, beam control technology using a phased array for terahertz waves above 100 GHz is necessary to realize the future of high-speed wireless communication. By photomixing, which is a promising method for generating terahertz waves, the phase of the generated waves can be tuned in the optical domain, so that the beam from the phased array can be controlled by photonics technologies. Directing the beam of a terahertz wave enables wireless communication to be improved not only via an increase in power efficiency but also in security in the physical layer of the wireless transmission. By utilizing this advantage and using coherent detection at the receiver, a secured wireless communication system is proposed, and the fundamental mechanism is demonstrated in a feasibility experiment.

Rapid cryopreservation of small quantities of human spermatozoa by a self-prepared cryoprotectant without animal component.

Cryopreservation of small quantities of human spermatozoa whilst maintaining adequate post‐thawing motility has been found an essential challenge for male fertility preservation. Therefore, the study used an effective, and convenient rapid‐freezing method to freeze small amounts of human spermatozoa by adding self‐prepared cryoprotectant (SPC) without animal component. In the feasibility experiment, no significant differences in progressive motility, normal sperm morphology, vitality or DNA fragmentation index between the conventional slow freezing and rapid freezing were realised. The present study prospectively analysed the effects of sperm freezing and resuscitation in 175 patients with severe oligozoospermia (sperm concentration <1 × 106/ml). We observed the 120 severe oligozoospermia specimens had a mean recovery rate of 60.19% ± 10.43% and a mean cryosurvival rate of 68.0% ± 9.17%. In addition, 55 cryptozoospermia specimens were analysed. The small‐volume cryopreservation showed advantages. The total sperm recovery, motility recovery and sperm loss rates were 98.48%, 50.17% and 1.52% respectively. In short, the SPC is safe and effective, and can be used to rapidly freeze severe oligozoospermia specimens. That is useful for successful sperm freezing whilst avoiding the risk of azoospermia in the later stages and promoting comprehensive fertility preservation.

Research on the feasibility and machining experiment of the laser-milling combination machining for Kevlar fiber reinforced composite

The Kevlar fiber-reinforced plastic (KFRP) had been received much attention and wide application in the field of weapon armor protection. There were many problems in mechanical processing, such as furry, difficult to chip removal, severe tool wear and so on. Many processing difficulties still remained. In order to avoid these defects of mechanical processing and these drawbacks, the laser-milling combination machining for KFRP was presented in this paper. The feasibility of the machining laser-milling combination machining was analyzed. The results show that the fiber carbonization zone and resin melting zone are observed after KFRP laser processing. In resin melting zone, the fibers are basically intact. The maximum kerf width is no more than 0.5 mm, and the kerf depth is less than 2 mm. The effects of the laser parameters on the kerf width a are relatively small, but that on the kerf depth h, fiber carbonization zone width A and resin melting zone width Am are significant. During milling of the laser-milling processing, the shape of the chip is big blocked and flocculent. If the fibers are incomplete ablation, the burrs are easy to occur. The burrs not only can be effectively avoided, but also the cutting forces and cutting temperature can be greatly reduced. Therefore, the processing quality can be improved and the degree of the processing difficulty can be reduced by using the laser-milling combination machining for KFRP.