Fayoum University Research Articles

Frequency and risk factors of H. pylori infection among dental students: an observational cross-sectional study

Despite Helicobacter pylori infection remains asymptomatic in most people, it is associated with an increased risk of gastric cancer. Considering Egypt had the highest prevalence of H. pylori in healthy asymptomatic population in adults and pediatric age in past studies and currently salivary ELISA could be used for diagnosis of Oral H. pylori infection. Moreover, some researchers speculated that dentists and dental students might be at a higher risk for oral H. pylori infection because they are the most frequently exposed ones to saliva and dental plaque. This study aimed to determine risk factors associated with frequency of H. pylori among a sample of dental students for better management of the disease. 83 participants, with age (21–25 years), attending Faculty of Dentistry, Fayoum University were recruited. A structured questionnaire was used to collect information on sociodemographic parameters and risk factors for H. pylori. Direct inquiry about dyspeptic symptoms were done. Saliva samples were collected and tested for H. pylori antibodies. Overall seroprevalence was 22.9%. Participants in internship were more prone to be positive (p = 0.005). 32.6% of urban residents versus 10.8% of rural were H. pylori positive (p = 0.019). 75.0% of previous history of H. pylori infection versus 14.1% of those with no history were H. pylori positive p < 0.001. 70% of positive H. pylori participants reported positive clinical symptoms that were statistically significant. This study suggests that middle income, previous history of H. pylori and clinical symptoms of dyspepsia are risk factors of oral H. pylori with a decline in its prevalence in Egypt.

Screening of subclinical functional hemoglobin and red blood cell abnormalities among blood donors of Fayoum University Hospital in Egypt: Are RET-He, and IRF useful screening tools?

BackgroundThe effectiveness of red cell transfusion in a given blood unit that relied on both quantity and quality of donated cells undoubtedly affects prognostic outcomes. ObjectiveWe aimed to determine the frequency of subclinical functional hemoglobin and red cell abnormalities in donated blood of Fayoum University Hospital in Egypt. Additionally, to assess the usefulness of reticulocyte mean hemoglobin content (RET-He) and immature reticulocyte fraction (IRF) as screening measures for such abnormalities. Material and methodsThis cross-sectional study enrolled 200 volunteer blood donors who met the national standard criterion of blood donation. Complete blood count with reticulocyte parameters, serum ferritin, sickling test, G6PD assay, Mentzer index, and naked-eye single tube red cell osmotic fragility test were carried out. ResultsFunctional red cell abnormalities represented 44 % of this cohort. Out of them, 4.5 % had iron deficiency, 11 % had a positive sickling test, 19 % had G6PD deficiency, and 9.5 % had suspicious thalassemia. The sensitivity and specificity test for RET-He in selective identification of functional hemoglobin abnormalities in donated blood were 83.3 % and 61.2 %, respectively at a cutoff value of 26.9. Though there was no statistically significant effect of RET-He on the selective detection of G6PD deficiency, IRF had a statistically significant high level with a p-value of 0.04. ConclusionSubclinical functional red cell abnormalities seem to be prevalent among blood donors. Reticulocyte/ erythrocyte indices could be useful screening tools for red cell abnormalities. Further studies are required for assessing the impact of transfusing such abnormalities to neonates and other critical recipients.

A Comparative study of suture fixed versus nonfixed mesh techniques in laparoscopic trans-abdominal preperitoneal repair of noncomplicated adult inguinal hernia

Aim This study aimed at comparing the effect of sutured mesh fixation and non-fixation in cases of laparoscopic trans-abdominal preperitoneal (TAPP) in terms of operative time, hospital stay, and complications particularly recurrence and chronic groin pain (CGP). Patients and methods This prospective randomized comparative study included 40 patients diagnosed with noncomplicated inguinal hernias admitted to the Department of Surgery at Fayoum University Hospital, Egypt from March 2019 to July 2021. Cases were divided into two groups by draw of lots; group A as mesh fixation (n=20) and group B as nonfixation (n=20). Results The results were calculated with χ 2test (P value). Results were found to be not significant in demographic features, in-hospital stay, hernia characteristics, and complications i.e. (intraoperative, postoperative, and long term) and were significant as regards operative time and early postoperative pain in favor of nonfixation group and results were highly significant (P &lt; 0.001). Conclusion TAPP repair without mesh fixation shows advantages over mesh fixation, which include significantly less early postoperative inguinal pain and operative time, with comparable intraoperative, postoperative, and long-term complications (with no increase in hernia recurrence), hospital stay, and mean operative time. Hence, our study favors TAPP without mesh fixation a valuable alternative option.

Comparable detection of nasopharyngeal swabs and induced sputum specimens for viral nucleic acid detection of suspected novel coronavirus (SARS-Cov-2) patients in Fayoum governorate, Egypt

BackgroundThe most commonly utilized samples for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection using real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) are nasopharyngeal swabs (NPS) and oropharyngeal swabs. However, there are some drawbacks. For SARS-CoV-2 detection, induced sputum might be analyzed and may be equivalent to pharyngeal swabs. This study was done to assess the potential superiority of induced sputum over NPS for SARS-CoV-2 detection. Sixty symptomatic COVID-19 patients who attended Fayoum University Hospitals in Fayoum Governorate, Egypt, were included in this cross-sectional descriptive study. Paired NPS and induced sputum samples were collected from each subject on the third and tenth days after symptoms began for RT-qPCR SARS-COV2 diagnosis.ResultsAt day 3, 52 (86.7%) of NPS and 48 (80.00%) of induced sputum specimens had positive RT-qPCR results with a significant statistical difference (P = 0.001). At day 10, 41 induced sputum samples (68.3%) were negative, while 19 (31.7%) were positive. Only three (5.0%) of the 19 positive induced sputum samples tested positive for NPS. NPS samples had a higher viral load than induced sputum samples at day 3 [25 (41.7%) vs. 23 (38.3%)]. At day 10, induced sputum samples had a higher viral load than NPS [9 (15.0%) vs. 6 (10.0%)]. A statistically significant positive correlation between the viral load value of the NPS and the induced sputum sample at day 3 (r = 0.497, p = 0.00) denoting similarity in the results of the two types of samples. By ROC analysis, the highest area under the curve for the overall CT value of the induced sputum was (0.604), with a statistically significant difference (p value = 0.0418).ConclusionIn the early stages of the disease, induced sputum and NPS tests had comparable results, but NPS yielded more false negative results later in the disease course than an induced sputum sample, which yielded higher sample positivity and viral load than NPS. Furthermore, induced sputum collection is a straightforward, non-invasive, and risk-free method. As a result, induced sputum could be useful for COVID-19 confirmation in patients with radiologically or epidemiologically suspected COVID-19 who have a negative NPS or in difficult-to-diagnose COVID-19 patients.

Evaluation of diaphragm in patients with chronic obstructive pulmonary disease using ultrasonography in relation to disease severity in Fayoum University Hospital

Evaluation of diaphragm in patients with chronic obstructive pulmonary disease using ultrasonography in relation to disease severity in Fayoum University Hospital

The Efficacy of Erector Spinae Plane Block Compared With Intrathecal Morphine in Postoperative Analgesia in Patients Undergoing Lumbar Spine Surgery: A Double-blind Prospective Comparative Study

BACKGROUND: Severe postoperative pain is experienced by most patients who undergo spine surgery. Erector spinae plane block (ESPB) is a successful method for postoperative analgesia and has only minor complications. Intrathecal morphine (ITM) demonstrates high efficacy for analgesia up to 24 hours postsurgery. ESPBs and ITM for postoperative analgesia in lumbar spine surgeries have never been compared in prior studies. OBJECTIVES: This study aimed to compare the efficacy of ESPB and ITM in postoperative analgesia after lumbar spine surgeries. STUDY DESIGN: A double-blind prospective comparative study. SETTING: This study was performed at Al Fayoum University Hospital after being confirmed by the local institutional ethical committee (#80) with approval number M520 and retrospectively registered at clinicaltrials.gov number (NCT05123092). METHODS: A prospective randomized double-blinded interventional trial was conducted with 82 patients, 41 in each group. In the ESPB group, a 0.25% bupivacaine injection was used to conduct a bilateral ultrasound-guided ESPB. In the ITM group, an injection of 0.3 mg morphine intrathecally was done. The Visual Analog Scale (VAS) was recorded as the primary outcome. The time to the first analgesic request, intra- and postoperative opioid consumption, hemodynamics, sedation score, and complications were also recorded as secondary outcomes. RESULTS: Postoperative VAS scores were significantly lower in the intrathecal group throughout the postoperative period at all recorded study time points until 48 hours (P &lt; 0.001). Time to the first rescue analgesia and doses of postoperative analgesic required were significant, with a P value of 0.000. Significant differences were found in postoperative oxygen saturation up to 24 hours (P &lt; 0.001) and the sedation score up to 6 hours (P &lt; 0.01). A higher incidence of complications was recorded in the ITM group (P = 0.000). LIMITATIONS: We did not measure patient preoperative VAS scores to ensure that the 2 groups were matched in pain severity. Also, we did not compare patient satisfaction. Another limitation was the inability to determine the degree of pain relief of ESPB since there was no control group in our study. CONCLUSION: We concluded that ITM 0.3 mg provides more potent analgesia up to 48 hours postoperatively than an ESPB, based upon VAS score, analgesic durations, and postoperative analgesic requirements. KEY WORDS: Intrathecal morphine, erector spinae, spine, Visual Analog Scale

Investigation of Transfusion Adverse Events Patterns in Fayoum University Hospitals, Egypt: Hemovigilance Initiative

Background and Objective: Hemovigilance is an adverse reaction surveillance and monitoring system to improve the safety and quality of blood transfusion in terms of corrective and preventive action. Identification of the adverse reactions and their risk factors will assist in taking appropriate steps to reduce their incidence and make blood transfusion safer. The aim of our study was to analyze the nature and incidence of transfusion related adverse events as a tool for implementation of hemovigilance system in Egypt.&#x0D; Study Design and Methods: Our study included all transfusion related adverse reactions from Fayoum University Hospital reported to the Blood Bank over a period of one year from August 2021 to July 2022. All patients receiving transfusion and all blood donors according to The National Blood Transfusion Guidelines were included. All reported reactions were analyzed, categorized and evaluated.&#x0D; Results: 28, 253 blood and blood components units were issued to 13, 544 patients. 273 (0.967%) transfusion related adverse reactions were reported to the blood bank. The most common reaction observed in recipients was allergic reaction 129 (47.25 %) followed by febrile non hemolytic transfusion reaction (FNHTR) 108 (39.56 %).&#x0D; Conclusion: Data related to transfusion related adverse reactions in developing countries are rare in literature. A strict quality assurance measures are required to build a hemovigilance system including, appropriate use of blood, maintain blood cold chain, monitoring, documenting and reporting transfusion reactions so that, the proper hemovigilance system can be attained.

Immunohistochemical Study of The Expression of TACC3 in Colorectal Carcinoma and its Correlation with Other Pathological Prognostic Factors

BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer comprising nearly 10% of all cancer cases worldwide. Many tumor markers have been used to expect the prognosis of CRC. Transforming acidic coiled- coil-containing protein 3 (TACC3) is one of the TACC family proteins. Physiologically, TACC3 is an important protein in the process of cellular division as it plays a key role in the formation of the mitotic spindle. Pathologically, TACC3 expression was studied in CRC, being found to be a poor prognostic factor. AIM: The aim of the study was to study the expression of TACC3 and its relationship with other clinical and histopathological prognostic factors in patients with CRC. METHODS: This is an observational and immunohistochemical study on 45 resection specimens from 45 CRC cases. This study was conducted at the pathology departments of the Faculty of Medicine, Cairo University, and Faculty of Medicine, Fayoum University from July 2019 to February 2020 Tumor tissues were prepared as formalin- fixed and paraffin-embedded specimens. The paraffin blocks were sectioned at the 5 microns thickness. Then, the collected sections were stained with hematoxylin &amp; eosin for histopathological revision and immune-histochemical staining for TACC3 proteins. RESULTS: The mean immunoreactivity score (IRS) for the TACC3 expression in our sample was 70 ± 89.91. TACC3 IRS score was significantly higher in those tumors with N2 stage (IRS = 175 ± 107.1; p = 0.02), and with Stage III tumors (IRS = 136.4 ± 93.5; p = 0.04). The other parameters showed no statistically significant relationship with IRS scores. CONCLUSION: Immunohistochemical expression of TACC3 would be valuable as a prognostic marker in cases of colorectal adenocarcinoma, where the expression was found to show stronger and more widespread expression in cases with higher stages. Furthermore, TACC3 should therefore be considered as a potential candidate for targeted therapy, where its blockade may hinder the tumor’s ability to proliferate and progress.

Extended red blood cell phenotyping among regular donors in Fayoum, Egypt. Red Blood Cell Inventory Plan

Abstract Background Antibodies to clinically significant red cell antigens contribute to hemolytic transfusion reactions and hemolytic disease of fetus and newborn. The aim of the study was to estimate the prevalence of extended red cell antigen phenotypes among regular donors in Fayoum, Egypt, and to create an emergency model database for chronic transfusion patients. Similar data in Egypt is rare to find in the literature. Patients and methods The study was carried out over 1 year from December 2020 until November 2021in Fayoum University Hospital Blood Bank. In all, 1834 healthy known blood donor samples were analyzed for major Rh phenotypes (D, C, c, E, e) and for other clinically significant systems including Kell, Kidd, MNS, and Duffy. Results Phenotypic frequencies of Rh system were D+ (84.4%), e+ (79.6%), and C+ (63.9%). The K antigen frequency was 4.3%, Jka 79.4%, Jkb 62.37%, Fy a 33.2%, Fy b 44.4%, M antigen 88%, N antigen 38.6%, and the S and s antigens 48.2 and 85.3%, respectively. Conclusion Determination of red cell antigen phenotyping in Fayoum, Egypt, plays an important role in setting a routine phenotyping strategy for multiple transfused patients by keeping the donor database for rare phenotypes to prevent hemolytic transfusion reaction.

Fayoum University Students Perception Regarding Reproductive Health

Fayoum University Students Perception Regarding Reproductive Health

Reference values for babies' pulse oximetry recordings, highlighting the impact of cesarean sections and COVID-19 pandemic

Background: With a focus on the consequences of caesarean delivery as a result of mother stress and the first wave of the COVID-19 epidemic as a source of maternal stress, the study sought to identify reference values for pulse oximetry recordings among both healthy full-term neonates and preterm and unhealthy neonates.Methods: A comparative study of 170 neonates admitted to the Fayoum university NICU after being born in the department of obstetrics and gynaecology. Collected pulse oximetry readings at predetermined intervals was done. Patients were classified into group I (before 1st wave of COVID-19 pandemic) and group II (during 1st wave of COVID-19 pandemic).Results: The 5th and 95th percentiles of SpO2 after 1 minute after birth were (65% to 90%), with a mean of 77%, according to the study of 146 full-term healthy newborns. SpO2 readings were (89% to 97.1%) with a mean of 92% after 5 minutes, and finally (90% to 98%) with a mean of 93% after 10 minutes. Statistically significant lower means of SpO2 were found during 1st wave of COVID-19 pandemic after 10 minutes of delivery, and for Apgar score after 1 and 5 minutes of delivery. There was a negative impact of cesarean section delivery on gestational age.Conclusions: This research reveals that after 10 minutes of delivery, a Spo2 recorded range of 90 to 98 for full-term healthy neonates and a mean of 86% for preterm and ill neonates may be appropriate. The first wave of the COVID-19 pandemic had a deleterious impact on neonates' SpO2 recordings and Apgar scores, according to the study. There was a gestational age effect associated with caesarean delivery.

Integrated use of soil humic acid rates under foliar zinc oxide and nanoparticles zinc oxide concentrations on tomato leaf chemical constituents and fruit quality

Two fields experiments were achieved during the Nili season of 2017 and 2018 at Experimental Farm of Faculty of Agriculture, Fayoum University, Fayoum Gornorate to investigate the effect of soil humic acid rates (0, 25, 50 and 75 kg fed-1 ), foliar zinc oxide and nanoparticles zinc oxide concentrations (50 and 100 ppm) on tomato leaf chemical constituents and fruit quality. The interaction between soil humic acid at 75 kg/fad. and foliar spray with zinc oxide at 50 ppm increased the concentrations of chlorophylla, b and total a+b in leaf tissues in the 2nd season. The interaction between soil humic acid at 75 kg/fad. and foliar spray with nanoparticles zinc oxide at 50 ppm increased vitamin c, total soluble solids and lycopen contents in tomato fruits as well as fruit firmness.

Prevalence and risk factor of postoperative adhesions following repeated cesarean section: A prospective cohort study.

To evaluate the prevalence of intraperitoneal adhesions after repeated cesarean delivery and its associated personal and surgical risk factors. This prospective cohort study was conducted at the delivery ward at Fayoum University Hospital from October 2020 to December 2021. Women were recruited according to predetermined inclusion and exclusion criteria. Eligible women were interviewed, and data were obtained for personal history, past surgical and obstetrical history, and data about the current delivery. Nair's scoring system was used to evaluate intraperitoneal adhesions. Postoperative data and complications were reported. Three hundred women were recruited. Moderate to severe adhesions occurred in 186 patients (62%). These patients had a significantly prolonged hospital stay and were delivered by expert surgeons (P< 0.001 and P= 0.008, respectively). The adhesion score correlated positively with patients' age (P< 0.001), parity (P< 0.001), interpregnancy interval (P= 0.033), duration of hospital admission either previously or in the current delivery (P= 0.001 and P< 0.001), time to ambulation (P< 0.001), time to intestinal movement (P< 0.001), operative time (P< 0.001), and surgeons' age and experience (both P= 0.015). Adhesions led to increased maternal morbidity. Multiple contributing factors were significantly related to adhesions with multiple cesarean deliveries.

Proportion and Predictors of Postpartum Depression among Women Attending Fayoum University Hospitals, Egypt

Proportion and Predictors of Postpartum Depression among Women Attending Fayoum University Hospitals, Egypt

EP31.07: Accuracy of fetal structural anomalies detection by ultrasonography at 14–16 weeks of gestation in Fayoum University Hospital: upper Egypt experience

EP31.07: Accuracy of fetal structural anomalies detection by ultrasonography at 14–16 weeks of gestation in Fayoum University Hospital: upper Egypt experience

Clinical grading of pediatric heart failure in Egypt

Background The inability of the heart to satisfy the demands of the target tissues’ metabolism as a result of alterations to the cardiac anatomy or function is known as heart failure (HF). Objective With a focus on the relationship between HF grade and other factors, the study sought to investigate clinical, laboratory, mortality, and severity of HF in children. Patients and methods From April 2022 to September 2022, an analytical cross-sectional study was conducted in the Pediatric Department of the Fayoum University, Faculty of Medicine. A total of 30 children with congestive HF, ranging in age from 3 days to 10 years, made up the study group. The patients’ medical information was gathered from medical records kept in hospital patient files. For grading, the original Ross Classification for pediatric HF was applied. The diagnosis was clinically and echocardiographically verified. Results and conclusion For clinical and therapy evaluation, the severity of HF was determined according to Ross classification. HF cases of classes II, III, and IV were reported in 53.3, 33.3, and 13.3% of the current study population, respectively. A large proportion of the research group patients had anemia (80%), hypoalbuminemia (73.3%), and higher creatinine levels (40%), whereas a lesser proportion had lower sodium and calcium levels. Hypokalemia brought on by diuretics is uncommon in the research group (6.7%). Because anemia correlates well with Ross classification and the quantity of cardiac drugs taken, it has a negative effect on the severity of congestive HF and treatment regimens, with P value less than 0.05. The other side of the coin is that additional adverse effects are brought on by higher drug use. The main causes of death in patients with congestive HF were verified to be severe infections and malnutrition by the high mean of C-reactive protein and low mean of albumin, among nonsurvived cases, with P value less than 0.05.

From SWOT Analysis to Strategic Options: Potential Development of Qaroun Lake in Fayoum Governorate, Egypt

Lake Qaroun is one of the important sources of fish production in Egypt. The lake also considered as important source for minerals. It has a very important economic role. The high levels of pollution in the lake require strategic interventions which might not of significant impact unless deeply investigated. This research aims at determining the most important strategic options for the development of Lake Qaroun using the SWOT Analysis Matrix. Secondary data is used in addition to primary data that obtained through one-on-one interviews using pre-designed structured-questionnaire. Interviews included fishermen, experts and government officials. Results of the SWOT analysis matrix refer to high negative impacts on the development of the lake by both internal and external environment. The implementation of the strategic development of the lake will lead to wasting the resources and capabilities, and reduce the opportunities available at the present time and, thus, the inability of the lake to face the threats it faces at the present time and in the future. It’s essential, before starting the development process, to clarify the most important negative results and provide the necessary instructions and directions. It’s highly recommended to have a powerful integrated entity to be responsible for the management of fisheries in Fayoum Governorate. The entity should include representatives from the following organizations; Fayoum University and other related research institutes, the General Authority for Fish Resources Development, Egyptian Environment Affairs Agency of the Ministry of Environment, water resources police, the cooperative union for water wealth and fishermen's cooperative societies.

Effect of blended learning of the maternity course on academic student's achievements and satisfaction

Background: Blended learning is an advanced model that encompasses the advantages of both traditional teaching in the classroom, Information and Communication Technology supported learning. Blended learning requires rigorous efforts, right attitude, handsome budget and highly motivated teachers and students for its successful implementation. Aim: To assess the nursing students' achievements and satisfaction toward blended learning. Design: A descriptive study design. Setting: Faculty of nursing, Fayoum University. Sample: Convenience sample of 170 nursing student at third level maternity department. Tools: three tools were used to collect study data, structured interviewing questionnaire, Academic achievement form and Student Satisfaction questionnaire. Results: More than half of studied students were female, more than three quarter of them uses smart phones, more than half of students have high achievement score is excellent, majority of students were satisfied with blended learning. There were highly statistically significant between total satisfaction, total achievement and statistically significant between demographic characteristics, achievement and satisfaction. Conclusion: more than half of students with high total achievement score are excellent, about sixty percent were satisfied toward blended learning, and also, there is highly statistically significant between total satisfaction and total achievement. Recommendation: Involve blended learning as alternative plan at the time of crisis.

Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt

BackgroundIn pandemic COVID-19 (coronavirus disease 2019), the prognosis of patients has been determined using clinical data and CT (computed tomography) scans, but it is still unclear whether chest CT characteristics are correlated to COVID-19 severity.AimTo explore the potential association between clinical data and 25-point CT score and investigate their predictive significance in COVID-19-positive patients at Fayoum University Hospital in Egypt.MethodsThis study was conducted on 252 Egyptian COVID-19 patients at Fayoum University Hospital in Egypt. The patients were classified into two groups: a mild group (174 patients) and a severe group (78 patients). The results of clinical laboratory data, and CT scans of severe and mild patients, were collected, analyzed, and compared.ResultsThe severe group show high significance levels of CRP, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, ferritin, lactate dehydrogenase (LDH), neutrophil percent, and heart rate (HR) than the mild group. Lymphopenia, hypoalbuminemia, hypocalcemia, and decreased oxygen saturation (SpO2) were the most observed abnormalities in severe COVID-19 patients. Lymphopenia, low SpO2 and albumin levels, elevated serum LDH, ferritin, urea, and CRP levels were found to be significantly correlated with severity CT score (P<0.0001).ConclusionThe clinical severity of COVID-19 and the CT score are highly correlated. Our findings indicate that the CT scoring system can help to predict COVID-19 disease outcomes and has a strong correlation with clinical laboratory testing.

Incidence and risk factors of urinary tract infection in neonatal sepsis

BackgroundNeonates with sepsis may have concurrent urinary tract infection (UTI), which may be asymptomatic or have nonspecific symptoms. Failure to diagnose UTI, resulting in a delay of appropriate therapy, has been reported to cause renal scarring, hypertension, and kidney failure among infants. This study aimed to determine the contribution of UTI to neonatal sepsis and to assess different risk factors that could be associated with UTI. This cross-sectional study was conducted at the Neonatal Intensive Care Unit (NICU) of Fayoum University Hospital, Fayoum, Egypt, between March 2018 and January 2019. Neonates of both genders from birth to the 28th day of life with clinical features of either early- or late-onset sepsis (during or after the first 3 days of life, respectively) were enrolled in this study. All neonates were subjected to complete history taking from the parents, full clinical examination, and laboratory investigations including complete blood count, C-reactive protein, blood culture, and urine culture.ResultsThe current study included 100 neonates admitted to the NICU with clinical and laboratory features of sepsis. Positive blood culture (proven sepsis) was detected in 60%, and the proportion of positive urine culture (UTI) in the entire study group was 11%. The incidence of UTI was 11.7% in proven sepsis compared to 10% in suspected sepsis, and it was 16.36% in late-onset sepsis (LOS) versus 4.44% in early-onset sepsis (EOS). There was a statistically significant association between poor feeding and feeding intolerance and positive urine culture (UTI). Leukopenia and expert panel criteria score showed high sensitivity (81.80% and 90.90%, respectively) but low specificity for the diagnosis of UTI.ConclusionsGram-negative bacteria have been highly suspected in cases of neonatal sepsis. Poor feeding and feeding intolerance have association with positive urine culture. Finally, urine culture for sepsis was recommended especially in the late type.