With the increasing computing power of computer hardware and the continuous development of Internet technology, it has become possible to sell clothing online. In this context, virtual clothing shops and fitted clothing have also started to appear online and people have a new platform to choose their clothing. In the development of the clothing industry, e-tailoring will become a new trend, and if we look at the clothing industry as a whole, e-tailoring is bound to develop rapidly, as it is now difficult for people to find clothes they are happy with on the shelves. However, many clothing shops on online platforms are now able to provide a more limited service to people, making it difficult for consumers to buy the right clothes for them, and the situation of returns is more serious. So many consumers are still more willing to buy clothes in the physical shop; if we can use the virtual reality environment of three-dimensional clothing design, consumers in the online clothing shop can freely choose their favorite clothing, and then the selected clothing considers the proposed wear in accordance with the size of the consumer production of the human body virtual model to observe the three-dimensional effect so that consumers can choose more suitable clothing. This paper mainly studies the 3D clothing design method in the computer 5G virtual reality environment. In the context of the computer 5G era, this article discusses the characteristics of virtual reality technology in detail and proposes a modeling method for 3D clothing design based on virtual reality. Based on the research status of 3D clothing design at home and abroad, this paper further studies the construction of clothing virtual design and designs and realizes the functions of character virtual modeling, clothing virtual modeling, and accessory virtual modeling. According to the defects of the existing 3D clothing design, a more mature three-dimensional clothing design method based on actual needs is developed. This paper analyzes the 3D clothing design process in detail through demand analysis; constructs the system functional block diagram, system architecture diagram, style customization flowchart, database table, etc.; designs the 3D clothing design module; and designs the main clothing and portraits—part of the modeling. Experimental studies have found that as long as ∣ Z ∣ > 0.042547 is satisfied, the clothing and the human body part can be prevented from crossing when the clothing matches the human body. In this article, in order to prevent large deviations in the garment stitching process, if it is the front piece of the garment, take Z = 0.06 . If it is the back film, take Z = − 0.06 . Virtual reality technology-assisted clothing design has become a new model of computer-aided clothing design, which has successfully promoted the transformation of enterprise employment forms and the improvement of enterprise production efficiency. The percentages of the left neck point, right neck point, left hip point, and right hip point in the human feature points were 15%, 23%, 31%, and 31%, respectively.