Single-phase grounding faults often occur in low-current grounding systems, and the selection of fault lines is an important factor affecting the reliability and safety of the distribution system. Aiming at the problem that the existing line selection criteria may cause misjudgment, this paper makes full use of the changes in the amount of fault information during the occurrence of a fault and proposes a multi-criteria line selection basis that integrates fault information. Since different neutral grounding methods will affect the change of the fault state quantity, the characteristic changes of the fault state quantity under different neutral grounding methods are fully discussed, and different fault quantities are selected as the basis for line selection. In addition, a membership function and a weight coefficient function are respectively set to indicate the possibility and credibility of a single criterion line selection result. The weighted summation of the membership functions corresponding to multiple criteria completes the information integration of multiple criteria, and the formed composite criterion reduces the proportion of misjudgments. The simulation experiment data proves that the proposed method can correctly, effectively, and reliably select faulty lines, greatly reduce the possibility of misjudgment and improve the efficiency and universality of line selection.