In this paper, the problem of fixed-time active fault-tolerant control is studied for systems with sector-bounded nonlinearities, intermittent faults, and input saturation. Since intermittent faults appear and disappear randomly, a fixed-time scheme is considered in the active fault-tolerant control algorithm, composed of detection, isolation, estimation, and the control unit. Utilizing homogeneity-based observers, the fixed-time state estimation is available in the presence of unknown but bounded disturbances, and a fault diagnosis unit is proposed. An input saturation compensator is introduced to analyze the effect of input saturation, and its auxiliary variables are used in the reconfigurable control law. The fault-tolerant controller, which is constructed via the information provided by the fault diagnosis unit and saturation compensator, has two switching modes. As a consequence, intermittent faults are compensated via the designed active fault-tolerant control method and the system reaches practical stability with the entire convergence time bounded in a fixed time. Finally, the example of a heat control system is exploited to demonstrate the effectiveness of the developed active fault-tolerant control scheme.