AbstractThe practical application of traditional data‐driven techniques for process monitoring encounters significant challenges due to the inherent nonlinear and dynamic nature of most industrial processes. Aiming at the problem of nonlinear dynamic process monitoring, a novel fault detection method based on dynamic kernel principal component analysis combined with weighted structural difference (DKPCA‐WSD) is proposed in this paper. Initially, the proposed method leverages a sophisticated nonlinear transformation to project the augmented matrix of the original input data into a high‐dimensional feature space, thereby facilitating the establishment of a DKPCA model. Subsequently, the WSD statistic is computed, utilizing a widely known sliding window technique, to quantify the mean and standard deviation differences across data structures. Ultimately, the WSD statistic is utilized for fault detection, completing the process monitoring task. By integrating the capability of DKPCA to capture nonlinear dynamic characteristics with the effectiveness of the WSD statistic in mitigating the impact of non‐Gaussian data distributions, DKPCA‐WSD significantly enhances the monitoring performance of traditional DKPCA in nonlinear dynamic processes. The proposed method is evaluated through a numerical case exhibiting nonlinear dynamic behaviors and a simulation model of a continuous stirred tank reactor. A comparative analysis with conventional methods, including principal component analysis (PCA), dynamic principal component analysis, KPCA, PCA similarity factor (SPCA), DKPCA, and moving window KPCA (MWKPCA), demonstrates that DKPCA‐WSD outperforms traditional fault detection techniques in nonlinear dynamic processes, offering a substantial improvement in monitoring performance.