An experiment was conducted in the conditions of an industrial complex specializing in the intensive fattening of young cattle, to study the development patterns of respiratory and gastrointestinal pathologies in calves with a history of previous proventriculus dysfunction. The object of the research were calves aged 120 days, which were divided into three groups: control, and two experimental groups - with a difference in using or the absence of phytosorbent. The diet included cereal hay and compound feed (CP 21.5%) according to the norms and regimen of feeding, for animals of this age. It appeared that for calves shortening of the adaptation period to the consumption of a large amount of compound feed had a negative impact on the rumen contractile function and the processes of digestion in it with the formation of a complex of symptoms of frothy tympany and rumen acidosis. After a course of appropriate treatment, the specific symptoms of these pathologies of the rumen disappeared, but the imbalance between the depression of symbiotic and activation of abdominal digestion remained, with the formation of a constant pre-threshold level of local autointoxication. The transfer of animals to the technological diet activated the processes of rumen metabolism and increased biochemical imbalance, which caused the progression of the endogenous intoxication syndrome and vegetative dystonia with a corresponding increase in the risk of developing respiratory and gastrointestinal pathologies. The use of a combined native premix based on the enterosorbent Rigatirin against the background of residual pathological phenomena after proventriculus dysfunctions reduced the level of toxic substances in the rumen, which excluded the generalization of autointoxication with an increase in the functional load on the digestive organs. As a result, the mechanism of pathogenetic integration (predisposition) formation in the body was leveled with a corresponding decrease in the incidence of the lungs, rumen and intestines. As a result, the mechanism of pathogenetic integration (predisposition) formation in the body was leveled, which caused a 6.7-fold decrease in the level of morbidity in animals and a 22.9 % increase in their growth.