The external piping system which connects power devices, valve control devices, actuators, etc. is an essential system on the aero engine. Under the combined effects of high fluid pressure and external vibration, multiaxial fatigue failure is the main factor that seriously affects the safety of the piping system. The objective of this paper is to establish the multiaxial fatigue life model for the typical welded fuel pipe of the piping system by combining fatigue testing, simulation and theoretical analysis which is of great guiding significance for the engineering application of the piping system. Firstly, the fatigue limits of welded fuel pipes under no and 13.5 MPa internal pressure are obtained by rotational bending fatigue tests using the up-and-down method. Three additional stress levels of rotational bending fatigue tests under no internal pressure are supplemented and then the S-N curve is further obtained by the group method. Since the corresponding fracture surface of the specimens locates at the weld toe near the fixed end, peak stress method is adopted to evaluate the fatigue performance of the weld toe on the pipe specimens. In addition, by comparing the fatigue limit with no and 13.5 MPa internal pressured pipes, it is obvious that the equivalent uniaxial stress corrected by Gerber formula is not applicable for the multiaxial fatigue condition which is caused by the combined effect of fluid pressure and displacement load. The local stress concentration factor caused by the weld toe is determined and based on Findley critical plane model, the multiaxial fatigue life model is established which simultaneously takes the local stress concentration effect, mean stress effect and multiaxial stress effect into consideration. The results of rotational bending fatigue tests under 13.5 MPa internal pressure are within the triple error dispersion band and the accuracy of the proposed life model are verified.