Background and Purpose In healthy adults and animals, movement speeds are often chosen to reduce the energy expended; thus, is MS-related slowness of walking and arm reaching linked to increased effort costs? Here, we hypothesized that the costs of walking would be higher in MS due to gait-related impairments such as spasticity, balance deficits, or worsened fitness; whereas the costs of seated reaching would be no different due to its divorce from the sensorimotor covariates associated with elevated walking costs and low cardiorespiratory demand. Methods Participants with MS (pwMS) (n=13) and age- and sex-matched controls (HCs) (n=11) first performed a battery of assessments. On two separate days, metabolic rates were measured via indirect calorimetry while participants walked on a treadmill at five speeds (0.6 up to 1.60m/s) and while performing out-and-back reaching movements with the dominant arm at five speeds (approx. 0.1 up to 0.8m/s). Results Neither age, height, nor weight differed between pwMS and HCs. The only metrics that differed between groups were the time to walk 25 feet (slower for pwMS) and fatigue ratings (higher for pwMS). Net metabolic rate (normalized to body mass) increased with walking speed (p<2e-16) and was ∼20.54% higher for pwMS at any speed than HCs (p=0.0185). However, the net rate (normalized to arm mass) was no different between pwMS and HCs at any speed (p=0.911). Elastic net regression techniques reinforced these findings: selecting MS-status as an important predictor of walking metabolic rate, while excluding this variable for predicting reaching rate, even when controlling for many additional factors. Discussion Individuals with MS who have high mobility and low disability may require more energy expenditure to walk, but not for seated reaching movements. Our results suggest that movement slowness occurring with MS is not altogether a consequence of energy conservation. Instead, other mechanisms such as fitness, perceived effort, or reward sensitivity should be investigated for improving mobility. In healthy adults and animals, movement speeds are often chosen to reduce the energy expended; thus, is MS-related slowness of walking and arm reaching linked to increased effort costs? Here, we hypothesized that the costs of walking would be higher in MS due to gait-related impairments such as spasticity, balance deficits, or worsened fitness; whereas the costs of seated reaching would be no different due to its divorce from the sensorimotor covariates associated with elevated walking costs and low cardiorespiratory demand. Participants with MS (pwMS) (n=13) and age- and sex-matched controls (HCs) (n=11) first performed a battery of assessments. On two separate days, metabolic rates were measured via indirect calorimetry while participants walked on a treadmill at five speeds (0.6 up to 1.60m/s) and while performing out-and-back reaching movements with the dominant arm at five speeds (approx. 0.1 up to 0.8m/s). Neither age, height, nor weight differed between pwMS and HCs. The only metrics that differed between groups were the time to walk 25 feet (slower for pwMS) and fatigue ratings (higher for pwMS). Net metabolic rate (normalized to body mass) increased with walking speed (p<2e-16) and was ∼20.54% higher for pwMS at any speed than HCs (p=0.0185). However, the net rate (normalized to arm mass) was no different between pwMS and HCs at any speed (p=0.911). Elastic net regression techniques reinforced these findings: selecting MS-status as an important predictor of walking metabolic rate, while excluding this variable for predicting reaching rate, even when controlling for many additional factors. Individuals with MS who have high mobility and low disability may require more energy expenditure to walk, but not for seated reaching movements. Our results suggest that movement slowness occurring with MS is not altogether a consequence of energy conservation. Instead, other mechanisms such as fitness, perceived effort, or reward sensitivity should be investigated for improving mobility.