Padel is attracting increased research interest. Although the focus has been on the physical and technical-tactical demands of the game, recently more attention is being paid to its mental demands and, more specifically, the importance of mental fatigue. This literature review provides an overview of mental fatigue in padel. First, we consider the mentally fatiguing nature of padel. Padel players must make complex decisions under high-time pressure, maintain self-confidence, and communicate with their partners in an emotionally charged context. With these cognitive demands, it is not surprising that padel matches and tournaments are mentally fatiguing. Second, we review evidence confirming that mental fatigue is detrimental for padel players’ performance, in agreement with findings observed in other sports. Third, we evaluate strategies to tackle mental fatigue and its effects on padel performance. Until now, the only proven long-term countermeasure is Brain Endurance Training. Finally, we make a series of recommendations for coaches and players to deal with mental fatigue, that focus on the quantification and modulation of mental fatigue among padel players. We strongly recommend i. to include subjective ratings of mental fatigue (i.e., VAS scale) before and after training and competitive matches, ii. to reduce the cognitive load of training before competitions by, for example, use positive feedback or habitual training exercises, and iii. to use Brain Endurance Training during non-competitive moments of the season.