Measures Of Fatigue Research Articles

THE EFFECTS OF TELEREHABILITATION IN RHEUMATIC DISEASES DURING COVID-19 PANDEMIC

Purpose: This study was designed to investigate the effects of telerehabilitation on fatigue, depression, anxiety, disease activity, sleep quality and quality of life in patients with rheumatic diseases. Methods: This study included 28 patients with rheumatic diseases. Patients were divided into two groups as intervention group (IG) (n=16) and control group (CG) (n=12). Both groups kept on their regular medical care and an IG group additionally had exercise program. An exercise program including strengthening, stretching, breathing, posture and relaxation exercises was practiced to the IG via video-conference method while no additional therapy was applied to the CG. Assessments were performed using SurveyMonkey to avoid face to face connection. Anxiety and depression were assessed with Hospital Anxiety and Depression Scale (HADS), fatigue was assessed with Fatigue Severity Scale (FSS), sleep quality was assessed with Pittsburg Sleep Quality Index (PSQI) and quality of life was assessed with Health Assessment Questionnaire (HAQ). Additionally, disease activity was evaluated with disease-specific measurements. Results: Significant differences were found in anxiety (p=0.009), fatigue (p=0.003) and sleep quality (p=0.011) in group-by-time assessments in IG while no significant group-by-time difference were observed in any assessments in CG (p>0.05). No significant differences was observed in delta measurements of fatigue, quality of life, depression, anxiety and sleep quality within groups although patients in IG had better outcomes for all parameters compared to CG (p>0.05). Conclusion: Telerehabilitation was found to be a safe and effective method for patients with rheumatic diseases.

Effects of isolated and combined mental and physical fatigue on motor skill and endurance exercise performance

BackgroundMental fatigue, elicited by cognitive demands, can impair sport and exercise performance. The effects of isolated mental fatigue on performance are well documented but few studies have explored the effects of combined mental and physical fatigue on skilled motor and endurance exercise performance. ObjectiveThis study explored the effects of isolated mental, isolated physical, and combined (mental plus physical) fatigue on skill and exercise task performance. Method164 athletes were randomly assigned to 1 of 4 groups: mental fatigue, physical fatigue, combined fatigue, control (no fatigue). Mental fatigue was induced by a 15-min time-load dual-back cognitive task. Physical fatigue was induced by a 90-s burpee exercise task. Next, all participants completed a throwing skill task and performed burpee exercises to failure. Objective (brief Psychomotor Vigilance Task, PVT-B) and subjective (self-report) measures of mental fatigue and Ratings of Perceived Exertion were obtained throughout. ResultsThe mental fatigue and combined fatigue groups performed the worst on both the throwing and burpee tasks compared with the physical fatigue and control groups. The former reported higher mental fatigue throughout and had worse response accuracy and variation on the end-of-session PVT-B task. The combined fatigue group performed better than the mental fatigue group on the throwing and burpee tasks. ConclusionA demanding cognitive task induced a state of mental fatigue and impaired skill and endurance performance. Mental fatigue alone was more detrimental than combined fatigue to skill and endurance performance, suggesting that the physical activity manipulation reduced the negative effects of mental fatigue on performance.

Rehydration effect of qingshu buye decoction on exercise and high temperature-induced dehydration.

The aim of this study was to conduct a comprehensive evaluation of the rehydration efficacy of QSBYD and elucidate its potential underlying mechanism. 38 participants were randomly assigned to receive either QSBYD or placebo before and after exercise and heat-induced dehydration. Hydration indicators were measured over time. Blood tests assessed cellular anaerobic respiration metabolites, serum inflammatory markers, and coagulation markers. Perceptual measures of thirst, fatigue, and muscular soreness were also taken. QSBYD consumption resulted in lower urine volume (Control vs. QSBYD: 260.83 ± 167.99 ml vs. 187.78 ± 141.34 ml) and smaller decrease in percentage of nude body weight change from baseline (Control vs. QSBYD: -0.52 ± 0.89% vs. -0.07 ± 0.52%). Although no significant differences in urine specific gravity, QSBYD resulted in reduced urine volume at 120 min, suggesting improved fluid retention. Furthermore, QSBYD resulted in lower levels of IL-1β (Control vs. QSBYD: 2.40 ± 0.68 vs. 1.33 ± 0.66 pg/mL), suggesting QSBYD may provide benefits beyond hydration. Further investigation into the underlying mechanisms and long-term effects of QSBYD on hydration is warranted. QSBYD may be an effective alternative to commercial sports drinks in mitigating dehydration effects.

Validation of the Fatigue Impact Scale in Multiple Sclerosis Patients in Serbia.

Fatigue is one of the most frequent complaints of patients with multiple sclerosis (MS). The Fatigue Impact Scale (FIS), one of the 30 available fatigue questionnaires, is commonly applied because it evaluates multidimensional aspects of fatigue. The chief objectives of this study were to validate FIS and evaluate the psychometric properties of MS patients in Serbia. One hundred and twenty-one (121) MS patients and one hundred and twenty-two (122) age-, gender- and education-matched healthy control (HC) subjects completed the FIS and the Beck Depression Inventory. Internal consistency of the FIS subscales was determined using Cronbach's Alpha Coefficient. Test/retest reliability with an intra-class correlation coefficient (ICC) for each FIS subscale was performed. The total FIS score and subscale scores showed statistically significant differences between the MS patients and the HC subjects in both FIS sessions. Cronbach's Alpha was 0.966. All ICCs were statistically significant (p < 0.05). The Serbian version of this instrument may be useful as a clinical measure for fatigue and functionality in patients with MS.

Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration.

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain and spinal cord. Fatigue is a common disabling symptom from MS onset, however the mechanisms by which underlying disease processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments for MS-related fatigue. MRI provides insights into in vivo neuroinflammatory activity and neurodegeneration, although existing evidence for imaging correlates of MS fatigue is mixed. We explore associations between fatigue and MRI measures in the brain and spinal cord to identify neuroinflammatory and regional neurodegenerative substrates of fatigue in early relapsing-remitting MS (RRMS). Recently diagnosed (<6 months), treatment-naive people with RRMS (n = 440) were recruited to a longitudinal multi-centre nationally representative cohort study. Participants underwent 3-Tesla brain MRI at baseline and one year. We calculated global and regional white and grey matter volumes, white matter lesion (WML) load and upper cervical spinal cord cross-sectional area levels C2-3, and assessed new/enlarging WMLs visually. Participants were classed as fatigued or non-fatigued at baseline according to the Fatigue Severity Scale (>/≤36). Disability and depression were assessed with the expanded-disability status scale and Patient Health Questionnaire, respectively. MRI measures were compared between fatigue groups, both cross-sectionally and longitudinally, using regression analyses. Higher disability and depression scores were observed for participants with fatigue, with a higher number of fatigued participants receiving disease-modifying treatments at follow-up. Structural MRI data for brain were available for n = 313 (45% fatigued) and for spinal cord for n = 324 (46% fatigued). Cervical spinal cord cross-sectional area 2-3, white and grey matter volumes decreased, and WML volume increased, over time for both groups (q < 0.05). However, no significant between-group differences in these measures were found either cross-sectionally or longitudinally (q > 0.05). The presence of new/enlarging WMLs (49% in fatigued; 51% in non-fatigued) at follow-up also did not differ between groups (q > 0.05). Our results suggest that fatigue is not driven by neuroinflammation or neurodegeneration measurable by current structural MRI in early RRMS. This novel negative finding in a large multi-centre cohort of people with recently diagnosed RRMS helps to resolve uncertainty in existing literature. Notably, we showed that fatigue is prevalent in patients without brain radiological relapse, who may be considered to have inactive disease. This suggests that symptom detection and treatment should remain a clinical priority regardless of neuroinflammatory disease activity. More sensitive objective biomarkers are needed to elucidate fatigue mechanisms in RRMS, and ultimately facilitate development of effective targeted treatments for this important 'hidden disability'.

Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis

BackgroundCalorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via multiple mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests of daily...

Defining fatigue from the experiences of patients living with chronic fatigue.

Fatigue is a multidimensional, highly individualized symptom experience perceived by people, regardless of health status. It is the most common complaint among those seeking primary care, yet, despite being a frequently reported symptom, it remains poorly understood. This is an exploratory study utilizing a qualitative descriptive approach that aims to explore the description of fatigue from the personal experiences of 16 participants living with chronic fatigue. Themes were generated from transcripts of in-depth interviews that focused on a central question: "how would you describe your fatigue from your own experience?" Analysis of the participants' interview transcripts revealed three themes. The first theme focused on fatigue as a unique personal experience, which included experiential descriptions or measures of fatigue that the participants used to describe their symptoms. The second theme focused on fatigue as an experience beyond self, which highlighted the consequences of fatigue on interpersonal interactions and the performance of social roles, as well as the potential of utilizing social support to cope with the limitations caused by this condition. The last theme was on living with fatigue, which focused on ways participants attempted to discern their condition and manage the consequences of fatigue. Experiences of chronic fatigue have patterns and personal meanings that vary between individuals. Caring for persons experiencing chronic fatigue requires acknowledgment of unique personal experiences and coping strategies. Due to the nature of the method, the results of this study are not generalizable and only reflect the experiences of the participants.

Construct validity of PROMIS pain interference, fatigue, and physical function as patient-reported outcomes in adults with idiopathic inflammatory myopathies: An international study from the OMERACT myositis working group

BackgroundValidated patient-reported outcome measures to assess disease impact in patients with adult idiopathic inflammatory myopathies (IIMs) are needed. The objective of this study was to assess the construct validity of PROMIS Pain Interference, Fatigue, and Physical Function measures in comparison with core disease activity measures. MethodsAdults with IIM, excluding inclusion body myositis, from OMERACT Myositis Working Group (MWG) clinic sites completed PROMIS Short Form v1.0—Pain Interference 6a, PROMIS Short Form v1.0—Fatigue 7a, and PROMIS Short Form v2.0—Physical Function 8b measures. Core disease activity measures including patient and physician global disease activity assessments, manual muscle testing, serum creatine kinase activity, and Health Assessment Questionnaire Disability Index (HAQ-DI) were simultaneously assessed. To evaluate construct validity, a priori hypotheses for the expected correlations between PROMIS measures, age, and core disease measures were determined by >70 % agreement among MWG members and were compared against observed Pearson's correlations. Internal consistency of items and floor or ceiling effects for the PROMIS measures were also assessed. Subgroup analysis according to IIM subtype (dermatomyositis vs. non-dermatomyositis IIM) was performed. Results135 adults with IIM from 5 countries across North America, Europe, Asia, and Australia were included. For construct validity, a priori hypotheses were confirmed for 5 of 6 (83 %) PROMIS Pain Interference, 4 of 5 (80 %) PROMIS Fatigue, and 3 of 4 (75 %) PROMIS Physical Function correlations. Internal consistency was high for each PROMIS measure (Cronbach's alpha >0.9). Ceiling effects were observed only for PROMIS Pain Interference, with low/no pain in 29 % of patients. Subgroup analysis between dermatomyositis (n = 65) and non-dermatomyositis (n = 70) subtypes demonstrated similar correlations between PROMIS measures and disease activity measures. ConclusionsPROMIS Short Form v1.0—Pain Interference 6a, PROMIS Short Form v1.0—Fatigue 7a, and PROMIS Short Form v2.0—Physical Function 8b measures demonstrate strong construct validity when compared to core disease activity measures in IIM, with consistent results across IIM subtypes. These findings support the use of these selected PROMIS measures to assess core domains of interest for measuring life impact in IIMs.

Associations between fatigue impact and physical and neurobehavioural factors: An exploration in people with progressive multiple sclerosis

BackgroundFatigue is common in people with multiple sclerosis (MS). Understanding the relationship between fatigue, physical and neurobehavioural factors is important to inform future research and practice. Few studies explore this explicitly in people with progressive MS (pwPMS). ObjectiveTo explore relationships between self-reported fatigue, physical and neurobehavioural measures in a large, international progressive MS sample of cognitively impaired people recruited to the CogEx trial. MethodsBaseline assessments of fatigue (Modified Fatigue Impact Scale; MFIS), aerobic capacity (VO2peak), time in moderate-vigorous physical activity (MVPA; accelerometery over seven-days), walking performance (6-minute walk test; 6MWT), self-reported walking difficulty (MS Walking Scale; MSWS-12), anxiety and depression (Hospital Anxiety and Depression Scale; HADS and Beck Depression Inventory-II; BDI-II), and disease impact (MS Impact Scale-29, MSIS-29) were assessed. Participants were categorised as fatigued (MFISTotal >=38) or non-fatigued (MFISTotal ≤38). Statistical AnalysisDifferences in individuals categorised as fatigued or non-fatigued were assessed (t-tests, chi square). Pearson's correlation and partial correlations (adjusted for EDSS score, country, sex, and depressive symptoms) determined associations with MFISTotal, MFISPhysical, MFISCognitive and MFISPsychosocial, and the other measures. Multivariable logistic regression evaluated the independent association of fatigue (categorised MFISTotal) with physical and neurobehavioural measures. ResultsThe sample comprised 308 pwPMS (62 % female, 27 % primary progressive, 73 % secondary progressive), mean age 52.5 ± 7.2 yrs, median EDSS score 6.0 (4.5–6.5), mean MFISTotal 44.1 ± 17.1, with 67.2 % categorised as fatigued. Fatigued participants walked shorter distances (6MWT, p = 0.043), had worse MSWS-12 scores (p < 0.001), and lower average % in MVPA (p = 0.026). The magnitude of associations was mostly weak between MFISTotal and physical measures (r = 0.13 to 0.18), apart from the MSWS-12 where it was strong (r = 0.51). The magnitude of correlations were strong between the MFISTotal and neurobehavioural measures of anxiety (r = 0.56), depression (r = 0.59), and measures of disease impact (MSIS-physical r = 0.67; MSIS-mental r = 0.71). This pattern was broadly similar for the MSIF subscales. The multivariable model indicated a five-point increase in MSWS-12 was associated with a 14 % increase in the odds of being fatigued (OR [95 %CI]: 1.14 [1.07–1.22], p < 0.0001) ConclusionManagement of fatigue should consider both physical and neurobehavioural factors, in cognitively impaired persons with progressive MS.

The validity and reliability of quadriceps twitch force as a measure of skeletal muscle fatigue while cycling.

The measurement of skeletal muscle fatigue in response to cycling exercise is commonly done in isometric conditions, potentially limiting its ecological validity, and creating challenges in monitoring the time course of muscle fatigue across an exercise bout. This study aimed to determine if muscle fatigue could be reliably assessed by measuring quadriceps twitch force evoked while pedaling, using instrumented pedals. Nine participants completed three laboratory visits: a step incremental test to determine power output at lactate threshold, and on separate occasions, two constant-intensity bouts at a power output 10% above lactate threshold. Femoral nerve electrical stimulation was applied to elicit quadriceps twitch force both while pedaling (dynamic) and at rest (isometric). The test-retest reliability of the dynamic twitch forces and the agreement between the dynamic and isometric twitch forces were evaluated. Dynamic twitch force was found to have excellent reliability in an unfatigued state (intraclass correlation coefficient (ICC)=0.920 and mean coefficient of variation (CV)=7.5%), and maintained good reliability at task failure (ICC=0.846 and mean CV=11.5%). When comparing dynamic to isometric twitch forces across the task, there was a greater relative decline in the dynamic condition (P=0.001). However, when data were normalized to the 5min timepoint when potentiation between conditions was presumed to be more similar, this difference disappeared (P=0.207). The reliability of this method was shown to be commensurate with the gold standard method utilizing seated isometric dynamometers and offers a new avenue to monitor the kinetics of muscle fatigue during cycling in real time.

Acute performance fatigability following continuous versus intermittent cycling protocols is not proportional to total work done.

Classical training theory postulates that performance fatigability following a training session should be proportional to the total work done (TWD); however, this notion has been questioned. This study investigated indices of performance and perceived fatigability after primary sessions of high-intensity interval training (HIIT) and constant work rate (CWR) cycling, each followed by a cycling time-to-task failure (TTF) bout. On separate days, 16 participants completed an incremental cycling test, and, in a randomized order, (i) a TTF trial at 80% of peak power output (PPO), (ii) an HIIT session, and (iii) a CWR session, both of which were immediately followed by a TTF trial at 80% PPO. Central and peripheral aspects of performance fatigability were measured using interpolated twitch technique, and perceptual measures were assessed prior to and following the HIIT and CWR trials, and again following the TTF trial. Despite TWD being less following HIIT (P=0.029), subsequent TTF trial was an average of 125s shorter following HIIT versus CWR (P<0.001), and this was accompanied by greater impairments in voluntary and electrically evoked forces (P<0.001), as well as exacerbated perceptual measures (P<0.001); however, there were no differences in any fatigue measure following the TTF trial (P≥0.149). There were strong correlations between the decline in TTF and indices of peripheral (r=0.70) and perceived fatigability (r≥0.80) measured at the end of HIIT and CWR. These results underscore the dissociation between TWD and performance fatigability and highlight the importance of peripheral components of fatigability in limiting endurance performance during high-intensity cycling exercise.

Quality of Life Outcomes in Breast Cancer Patients Receiving Chemotherapy With or Without Radiation Therapy

PurposeUnderstanding quality of life (QOL) implications of individual components of breast cancer treatment is important as systemic therapies continue to improve oncologic outcomes. We hypothesized that adjuvant radiation therapy does not significantly impact QOL domains in breast cancer patients undergoing chemotherapy. MethodsData was drawn from three prospective studies in women with localized breast cancer being treated with chemotherapy from March 2014 to December 2019. Patient-reported measures were collected at baseline (pretreatment) and post-treatment using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) measure, which consists of 5 subscales. Changes in mean QOL scores in patients who received radiotherapy were compared to those who did not using a one-sided noninferiority method. Statistical significance was determined below 0.05 to meet noninferiority. ResultsIn a sample of 175 patients, 131 were treated with radiation and 44 had no radiation. The sample consisted mostly of stage I-II breast cancer (78%) with hormone receptor positive (59%) disease, receiving either neoadjuvant (36%) or adjuvant chemotherapy (64%). Mean change in QOL for the group treated with radiation compared to no radiation was noninferior with respect to Physical Well-Being (P = .0027), Social/Family Well-Being (P = .0002), Emotional Well-Being (P = .0203), FACIT-Fatigue Subscale (P = .0072), and the Total FACIT-F score (P = .0005); however, mean change in QOL did not meet noninferiority for Functional Well-Being (P = .0594). ConclusionPatient-reported QOL from baseline to post-treatment, using the Total FACIT-F score, was noninferior in patients treated with versus without radiation therapy. This finding, in addition to individualized QOL subscales, provides important information in the informed decision-making process when discussing the effects of locoregional radiation on QOL in localized breast cancer patients treated with chemotherapy.

Analysis of Risk Factors for Subjective Work Fatigue Levels Among Nurses at RS.Otak DR.Drs. M. Hatta Bukittinggi, West Sumatra, In 2024

Background: Service nursing care that is carried out home nurse Sick for 24 hours a day , very much needed readiness physical , mental and time . This is potential cause work fatigue which has an impact decline alertness and concentration , disturbed taking decisions and occurrences error or accident Work .Purpose : This Study For analyze factors risk level fatigue Work subjective on Nurses at RS.Otak.DR.Drs.M.Hatta Bukittinggi, West Sumatra 2024 .Methods: Study quantitative with design study This cross-sectional on 100 nurses at the Brain Hospital DR. Drs . M. Hatta Bukittinggi, West Sumatra in 2024. The risk factors are the characteristics individual , factor related work and environment Work Lighting . Measurement of work fatigue with a questionnaire SSRT ( Subjective Self Rating Test ) from IFRC; burden mental work with the NASA-TLX ( National Aeronautics Space Administration Task Load Index ) questionnaire ; for role , control and satisfaction work with the COPSOG ( Copenhagen Psychosocial Questionnaire ) III questionnaire ; measurement lighting with lux meterResults: The results showed that 79% of nurses experienced mild levels of work fatigue and moderate levels of work fatigue (21%). Risk factors that had a significant relationship with the level of work fatigue were age (p 0.013; OR 6.82), nutritional status: obese (p 0.020; OR 3.77), sleep duration (p 0.050; OR 3.14).Conclusion: Implementation of fatigue management and fatigue screening periodic expected can lower level of work fatigue .

CORRELATIONS OF SHIFT WORK 2-2-2(2) ROTATION ON SLEEP QUALITY AND FATIGUE OF NURSES IBNU SINA GRESIK GENERAL HOSPITAL

Background: Working as a nurse in a hospital required to work with a shift system. Working with the shift system (morning, afternoon, and night) can affect the circadian rhythm, which has the potential to cause sleep disturbances and fatigue. Purpose: This research aims to analyze the influence of shift work rotation 2-2-2(2) on sleep quality and fatigue in nurses with shift work systems in inpatient rooms at General Hospital Ibnu Sina Gresik. Method: This research was an observational analytics study with a cross-sectional design. The total sample was 80 nurses in an inpatient care unit with a shift work system chosen through purposive sampling techniques. The Subjective Self-Rating Test (SSRT) issued by the Industrial Fatigue Research Committee (IFRC) questionnaire was used for the measurement of fatigue, and the Pittsburgh Sleep Quality Index questionnaire (PSQI) was used for the assessment of sleep quality. Univariate and bivariate analyses were done with a Chi-square statistical test. Result: The study showed that most respondents had good sleep quality (87.5%), and most had low tiredness (71.2%). The Chi-square test results obtained a p-value of 0.224 &gt; 0.05 and a p-value of 0.108 &gt; 0.05, meaning there were no correlations between shift work and sleep quality and fatigue. Conclusion: Shift work had no relationship with sleep quality and fatigue. Appropriate shift work arrangements can contribute to reducing the negative impact of shift work.

Minimal and robust clinically important differences for patient-reported outcome measures of fatigue in chronic stroke survivors after fatigue rehabilitation

Purpose The minimal and robust clinically important difference (MCID and/or RCID) are essential in assessing the clinical significance of multidimensional fatigue inventory-20 and checklist of individual strength-fatigue subscale questionnaires changes scores. This is the first study to determine the MCID and RCID of these questionnaires in chronic stroke survivors. Materials and methods A total of 125 participants in an observational cohort study completed MFI-20 and CIS-fs before and after receiving multidisciplinary rehabilitation (cognitive behavioral therapy, graded exercise and adaptive pacing therapy). Anchor-based MCIDs and RCIDs were calculated using the mean change, the mean difference and the receiver operating characteristics methods. To evaluate the accordance between of distribution-based MCIDs (1 SD, ½ SD, SEM, 1.96 SEM and MDC values) with anchored values, the accuracy, sensitivity, specificity and Youden’s index were calculated. Results The anchored MCIDs were between −5 to −7.33 for MFI-20 and −4.87 to −5.40 for CIS-fs. The anchored RCIDs ranged from −5 to −13.88 and −6 to −9.88 for MFI-20 and CIS-fs, respectively. The values of ½ SD and SEM for CIS-fs were consistent with anchored RCIDs. Conclusions The estimated MCIDs and RCIDs of MFI-20 and CIS-fs can help researchers and clinicians interpret their chronic stroke patient data.

Identifying pre-habilitation targets for the mitigation of long-term side effects of chemotherapy in patients with early breast cancer.

Pre-treatment characteristics of women with early breast cancer that are associated with persistent fatigue or suboptimal health-related quality of life (HRQOL) post-chemotherapy need to be identified as potential targets for pre-habilitation. Ancillary analysis of previously collected data from patients with newly diagnosed Stage I-III breast cancer scheduled to receive chemotherapy. The objective was to identify baseline (pre-chemotherapy) variables associated with meaningful deteriorations in fatigue and other measures of HRQOL from pre-treatment to 6months after chemotherapy completion. Percentages are reported along with unadjusted and adjusted relative risks. In a sample of 249 women post-chemotherapy, 32% reported worsening fatigue (FACIT-F), 35% worsening Physical Well-Being (PWB), 16% worsening Functional Well-Being (FWB), 8% worsening Emotional Well-Being (EWB), and 30% worsening Social Well-Being (SWB). In multivariable (MV) analysis, variables that were significant in univariate analysis - Black race, high BMI, and baseline poorer EWB - remained significant for worsening post-chemotherapy fatigue (FACIT-F). In MV analysis that included race, education, falls, and baseline EWB, Black race and a positive falls history remained significant for worsening PWB. In MV analysis inclusive of race, Short Physical Performance Battery (SPPB) and FWB, lower SPPB and FWB remained significant predictors of worsening FWB. In MV analysis that included baseline Mental Health Index-Anxiety, EWB and SWB, a higher SWB and lower EWB remained significant for worsening SWB. Pre-chemotherapy characteristics in women with early-stage breast cancer that are associated with increased fatigue and reduced HRQOL post-treatment could be used to identify patients who may benefit from pre-habilitation interventions.

NICER: A New and Improved Consumed Endurance and Recovery Metric to Quantify Muscle Fatigue of Mid-Air Interactions

Natural gestures are crucial for mid-air interaction, but predicting and managing muscle fatigue is challenging. Existing torque-based models are limited in their ability to model above-shoulder interactions and to account for fatigue recovery. We introduce a new hybrid model, NICER , which combines a torque-based approach with a new term derived from the empirical measurement of muscle contraction and a recovery factor to account for decreasing fatigue during rest. We evaluated NICER in a mid-air selection task using two interaction methods with different degrees of perceived fatigue. Results show that NICER can accurately model above-shoulder interactions as well as reflect fatigue recovery during rest periods. Moreover, both interaction methods show a stronger correlation with subjective fatigue measurement ( ρ = 0.978/0.976) than a previous model, Cumulative Fatigue ( ρ = 0.966/0.923), confirming that NICER is a powerful analytical tool to predict fatigue across a variety of gesture-based interactive applications.

Probing sustained attention and fatigue across the lifespan.

Trait fatigues reflects tiredness that persists throughout a prolonged period, whereas state fatigue is a short-term reaction to intense or prolonged effort. We investigated the impact of sustained attention (using the SART) on both trait and state fatigue levels in the general population. An online version of the SART was undertaken by 115 participants, stratified across the whole adult lifespan. While pre-task trait fatigue was a strong indicator of the initial state fatigue levels, undergoing the task itself induced an increase in reported subjective state fatigue, and an accompanying reduction in subjective energy rating. Consistent with this finding, greater subjective state fatigue levels were associated with reduced accuracy. In addition, age was the best predictor of inter-participant accuracy (the older the participants, the greater the accuracy), and learning (i.e., task duration reducing reaction times). Moreover, a ceiling effect occurred where participants with higher trait fatigue did not experience greater state fatigue changes relative to those with low trait scores. In summary, we found improved accuracy in older adults, as well as a tight coupling between state fatigue and SART performance decline (in an online environment). The findings warrant further investigation into fatigue as a dynamic, task-dependent state and into SART performance as an objective measure and inducer of fatigue.

Between-day reliability of common muscle fatigue measures during a repeated upper limb fatigue protocol

Neuromuscular fatigue manifestation is of interest in both basic neurophysiological and applied (e.g. sporting, ergonomics) contexts. A unique challenge in fatigue research is that experimental sessions often need to be collected across many days to allow for adequate recovery. The purpose of this study was to examine the between-day reliability of several surface electromyography- and strength-based fatigue measures in response to a repeated fatigue protocol. Twenty participants (10 M, 10 F) performed an isometric elbow flexion fatigue protocol on three different days. The reliability of commonly used amplitude- and frequency-based myoelectric and performance-based indicators of fatigue were assessed using traditional reliability assessment methods. Baseline MVC strength (N) demonstrated excellent between-day reliability (ICCA, 1: 0.96, 95%CI[0.92, 0.98]) with good absolute reliability (SEM: 5.10%, MD95: 14.1%). The absolute reliability of all slope-based fatigue measures was low. However, %MVC Slope (ICC: 0.67, [49, .82]), %MnPF Slope (ICC: 0.75, [.60, .87]), and endurance time (ICC: 0.60, [0.39, 0.77]) had poor/moderate to good relative reliability. Baseline MVC strength was shown to be very repeatable between days. Caution is recommended when using slope-based fatigue measures for cyclic repetitive upper limb tasks, as slope-based measures of muscle fatigue were shown to have low between-session reliability.

Starfish tube feet inspired hydrogel electrode for durable underwater sEMG acquisition

Underwater surface electromyography (UW-sEMG) acquisition with long-term high quality is crucial to underwater activities, including rehabilitation, fatigue measurement, and sports monitoring. However, most UW-sEMG electrodes suffer significant performance decline, especially for hydrogel electrodes, due to the swelling-induced mechanical, electrical, and adhesive degradation. Maintaining high performance underwater over extended periods is challenging. The controlled underwater adhesion-detachment behavior of starfish is inspirative. Here, a starfish tube feet-inspired hydrogel (STFH) electrode is developed for UW-sEMG recording, including a micro-swelling hydrogel pillar, a biomimetic silicone sucker, and an Ag/AgCl disc electrode. By soaking freeze-dried hydrophilic hydrogel in tannic acid (TA) solution, the hydrogel exhibits skin-like modulus of 22.4 kPa, low skin impedance of 18.3 kΩ (10 Hz) and low equilibrium swelling ratio. Unlike traditional strategies for improving anti-swelling properties, this work leverages the interaction between the sucker and the swollen hydrogel to promote conformal contact. Consequently, the sEMG signal exhibits SNR of 26.7 dB and baseline noise of 12.8 μV even after 60 min of underwater working. The STFH electrode also shows anti-noise capability to resist skin vibration and wave oscillation. This STFH electrode enables durable UW-sEMG acquisition, which could further extend from the arm to the wrist to adapt wearing habits.