This research investigates the effect of airflow turbulence intensity on the fatigue life of composite airfoil structures in aerospace engineering. Using advanced Computational Fluid Dynamics (CFD) simulations, this study provides a comprehensive analysis of how varying levels of turbulence intensity—ranging from mild (5%) to severe (30%)—impact the mechanical degradation and fatigue performance of carbon-fiber-reinforced polymers (CFRPs) used in airfoil designs. The research quantifies the relationship between turbulence levels and changes in stress distribution, highlighting critical points of fatigue crack initiation and subsequent propagation. The study includes detailed comparisons of CFD results to experimental data to validate the predictive models and discusses how localized stress fluctuations under high-intensity turbulence accelerate the onset of fatigue failure. We present significant findings that demonstrate a non-linear relationship between turbulence intensity and the reduction in fatigue life, suggesting optimal design modifications for enhanced durability. Furthermore, this paper explores current challenges in merging CFD data with real-world fatigue testing and proposes advanced techniques such as adaptive mesh refinement and hybrid simulation models to improve predictive accuracy and computational efficiency in future research.