In engineering applications, polymer materials are expected to exhibit superior fatigue life and balanced mechanical properties as essential performance criteria. The blending method is an important alternative in improving the performance criteria of ABS polymer in service. Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), and Dynamic Mechanical Analysis (DMA) methods were used for characterization. The effects of the PMMA fraction on the mechanical and fatigue behavior of PMMA/ABS blends were investigated by tensile and fatigue tests. Also, the influence of blend composition, stress amplitudes, stress ratio, holding pressure, and loading frequency on fatigue life is considered. The study improved yield strength, tensile strength, and elongation at break values of blends compared to ABS. In addition, 115 % and 75 % improvements were achieved in fatigue cycles at high and low-stress amplitudes with blends, respectively, for tension/tension loading. Similar improvements were obtained for fully reverse loading at 218 %. Thus, it was determined that the PMMA/ABS blend exhibited superior fatigue life in both tension/tension and fully reverse loading situations. Finally, it has been understood that PMMA/ABS blends can be designed to have mechanical properties and fatigue life behavior that can meet different requirements in conditions for engineering applications.