Through the use of the material test system (MTS), bending fatigue tests are conducted in this work in order to investigate the attenuation law of fatigue performance of asphalt pavement in the end-stage of service. Response surface methodology (RSM) is used to analyze the effects of strain, frequency, and temperature on the asphalt surface layer's initial stiffness, fatigue life, phase angle, and cumulative dissipated energy when there is a 50 % reduction in the initial stiffness. Through multi-factor coupling analysis, the optimal combination is found and verified by the MTS-810 test system. Based on this, the data of the initial stiffness declining to 20 % was used for analysis on the AC-13C asphalt surface mixture of the APT full-size test road in the laboratory. At 15 °C and 10 Hz, the evolution law of the flexural stiffness, the residual stiffness, phase angle, and cumulative dissipated energy of the asphalt mixture was investigated. Analysis of the asphalt mixture's damage evolution under the single stage of loading and various strain levels revealed changes in the fatigue cracking crack. Beam specimens were made from asphalt mixture field test beams of AC-13C (laboratory accelerated pavement test road), AC-20C, and AC-25C (Ji-Qing expressway) to conduct four-point bending fatigue test (4PB). According to the constant strain fatigue prediction equation, and the residual fatigue life of prediction localized model was established. The results show that the influence of frequency and temperature on the initial stiffness and phase angle is more significant than strain, and the influence of strain on number of fatigue is more significant. The flexural stiffness of the asphalt mixture shows an obvious S-curve, and larger the tensile strain at the bottom of the asphalt layer, shorter the time needed to reach the termination condition, that is, the faster the fatigue failure occurs. When the damage termination condition is reached, under the strain level of 200–300 με, 60 % of the number of loading produce about 35–40 % damage, and the remaining 20 % of the number of loading lead to 10–20 % damage.
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