Fat Lesions Research Articles

Nodamura virus, an ether- and chloroform-resistant arbovirus from Japan: physical and biological properties, with ecologic observations.

SummaryNodamura virus, an ether- and chloroformresistant arbovirus, uniformly passed filters with pore sizes of 100 but not 50 mµ, and 55 to 75 mµ virus-like particles were seen in infected mouse brain and heart. It produced limb paralysis, inflammatory and degenerative lesions in centralnervous-system tissues, skeletal muscle and brown fat, and death of suckling mice 5 to 15 days after intracranial, subcutaneous, or intraperitoneal inoculation. Suspensions of mouse limb muscle contained higher concentrations of infectious virus than brain suspensions. Antibody formation without disease occurred after one sc inoculation of a pig and after three or four ip or intramuscular inoculations of adult mice and rabbits; however, neutralizing antibody did not form in baby chicks after one sc inoculation. No overt illness occurred after inoculation of baby chicks (ic or im), weanling mice and rabbits (ic), weanling guinea pigs and Syrian hamsters (ic, ip, and im), or embryonated chicken eggs (chorioallantoic membrane, amniotic sac, or yolk sac). No cytopathologic effects were seen within 9 to 25 days after inoculation of primary cell cultures of Syrian hamster, porcine, calf, rabbit, suckling Swiss albino mouse and cynomolgus-monkey kidney, whole chicken embryo and human amnion, or of continuous cell cultures from human cervical carcinoma (HeLa), human liver and conjunctiva (Chang), C2H mouse subcutaneous tissue (L), rabbit papilloma, and rabbit skin.Infection of swine was common on farms near Tokyo during 1956–57, but only one of 54 herons and egrets, none of 29 rural residents, and none of 13 urban residents near Tokyo showed N antibody in plasma collected during 1956–57.

Acute pancreatitis associated with steroid therapy.

It has been clearly demonstrated that rabbits given high doses of cortisone develop pathologic changes in the pancreatic acini as well as focal fat necrosis and lesions characteristic of focal pancreatitis. 1,2 On the other hand, surprisingly few cases of pancreatitis developing in patients receiving corticotropin (ACTH) or adrenal steroids have been reported. 3-6 The purpose of this paper is to describe 6 patients in whom the clinical and pathological evidence suggested steroid therapy had induced acute pancreatitis. Report of Cases Case 1.— This 42-year-old white man was in good health until March, 1956, when he developed malaise, persistent frontal headache, and daily fever. Extensive bacteriological, serological, and x-ray studies were done. None was revealing. Broad spectrum antibiotics did not alter the fever pattern. A clinical diagnosis of disseminated lupus erythematosis was made, and in April, 40 units of corticotropin and 20 mg. of prednisone per day were begun (Fig.

Participation of brown fat in pathogenesis of experimental poliomyelitis of monkeys.

SummaryFollowing peripheral inoculation, poliomyelitis virus (Type I) proliferates in the brown fat of cortisone-treated monkeys during the preparalytic and paralytic stages of the disease. On subsequent peripheral passage of infected brown fat, the virus can be detected in the brown fat in the absence of cortisone treatment. Characteristic brown fat lesions are incidental to viral proliferation.