Fast Wind Research Articles

Microneedles for Enhanced Bacterial Pathogen Inactivation and Accelerated Wound Healing

AbstractBacterial wound infections are a significant socioeconomic concern in the modern healthcare industry owing to increased morbidity, prolonged hospital stay, and mortality. Bacterial infectious agents that colonize the wound bed develop biofilms, acting as a physical barrier that prevents the effective penetration of topical antimicrobials. Further, bacteria in such infectious wounds express a wide range of virulence factors promoting intercellular transmigration and host cell invasion complicating the treatment regimen. To address this need, a water‐dissolvable poly‐vinyl pyrrolidine (PVP), calcium peroxide (CPO) infused microneedle structure (denoted as PVP/CPO MN) for effective transdermal delivery of antimicrobial payload deep into the tissues is developed. Fluid exudate from the wound bed dissolves the PVP/CPO MN enabling the release of CPO deep into the infected wound bed. A slow catalytic decomposition of CPO results in the sustained release of reactive oxygen species (ROS) deep within the infected wound inhibiting the inter‐ and intracellular pathogens. Here, a systematic study of microneedle fabrication and sterilization after complete packaging is conducted to ensure scalability and safe applicability while maintaining mechanical and antibacterial properties. In vitro, antibacterial efficacy of the microneedles is validated against two common wound pathogens, Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). Moreover, the PVP/CPO MN exhibited significant efficacy in eradicating both extracellular and intracellular bacterial populations within an in vivo porcine wound model. Additionally, the microneedle technology facilitated a faster wound healing, with ≈30% increase compared to control and a 15% improvement over conventional silver dressing.

Comparison of Ion–Proton Differential Speed between Interplanetary Coronal Mass Ejections and Solar Wind near 1 au

The elemental abundance of interplanetary coronal mass ejections (ICMEs) and solar wind near 1 au is often adopted to represent the abundance in the corresponding coronal sources. However, the absolute abundance of heavy ions (relative to hydrogen) near 1 au might be different from the coronal abundance due to the ion–proton differential speed (V ip ). To illustrate the V ip characteristics and explore whether it influences the absolute abundance analysis for ICMEs and solar wind, we perform a statistical study on the V ip for He2+, C5+, O6+, and Fe10+ in both ICMEs and solar wind based on measurements of Advanced Composition Explorer. The results show that the V ip is negligible within ICMEs and slow solar wind (< 400 km s−1), while obvious in the intermediate (400–600 km s−1) and fast wind (> 600 km s−1). Previous studies showed that the V ip in ICMEs keeps negligible during propagation from 0.3 to 5 au, but in solar wind it increases with the decreasing heliocentric distance. Therefore, it might be questionable to infer the absolute abundance of coronal sources through in situ abundance near 1 au for solar wind. Fortunately, the ion–oxygen (O6+) differential speed (V io ) is negligible for He2+, C5+, and Fe10+ within both ICMEs and solar wind, and previous studies suggested that the V io does not vary significantly with the heliocentric distance. This indicates that various heavy ions always flow at the same bulk speed and their relative abundance (relative to oxygen) near 1 au can represent the coronal abundance for both ICMEs and solar wind.

Diminished γδ T Cells during Murine Allergic Skin Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.

Atopic dermatitis results in diminished barrier function and altered production of antimicrobial peptides. Dendritic epidermal T cells (DETCs) play an important role in the wound repair and inflammation process. Our previous work identified an IL-4-dependent loss of DETCs in Stat6VT mice and in the MC903-induced skin inflammation mouse model. However, the mechanisms through which IL-4 mediates the loss of DETCs are unclear. In this study, we show that IL-4Rα germline knockout mice (Il4ra-/-) have increased DETCs, faster wound healing, and increased epidermal differentiation complex gene and fibronectin expression. The absence of IL-4Rα minimized the MC903-induced loss of DETCs, and reciprocal bone marrow chimera experiments in Il4ra-/- and wild-type mice demonstrated structural nonhematopoietic IL-4-responsive cell-mediated DETC homeostasis. Skin keratinocyte-derived IL-15 decreased dramatically in the MC903 model, while injection of IL-15 rescued DETC loss by promoting DETC proliferation and limiting apoptosis. Conditional deletion of IL-4Rα from keratinocytes using Il4rafl/fl K14-Cre mice showed an increase of DETCs, increased IL-15 production, and diminished skin inflammation following wounding. These results suggest that IL-4-dependent effects on DETCs in allergic skin inflammation are mediated by the IL-4Rα receptor of keratinocytes.

On the Heating of the Slow Solar Wind by Imbalanced Alfvén-wave Turbulence from 0.06 to 1 au: Parker Solar Probe and Solar Orbiter Observations

In this work we analyze plasma and magnetic field data provided by the Parker Solar Probe and Solar Orbiter missions to investigate the radial evolution of the heating of Alfvénic slow wind by imbalanced Alfvén-wave (AW) turbulent fluctuations from 0.06 to 1 au. in our analysis we focus on slow solar-wind intervals with highly imbalanced and incompressible turbulence (i.e., magnetic compressibility C B = δ B/B ≤ 0.25, plasma compressibility C n = δ n/n ≤ 0.25, and normalized cross helicity σ c ≥ 0.65). First, we estimate the AW turbulent dissipation rate from the wave energy equation and find that the radial profile trend is similar to the proton heating rate. Second, we find that the scaling of the empirical AW turbulent dissipation rate Q W obtained from the wave energy equation matches the scaling from the phenomenological AW turbulent dissipation rate Q CH09 (with Q CH09 ≃ 1.55Q W ) derived by Chandran & Hollweg based on the model of reflection-driven turbulence. Our results suggest that, as in the fast solar wind, AW turbulence plays a major role in the ion heating that occurs in incompressible slow-wind streams.

Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis.

Flowable resin composites (FRC) are tooth-colored restorative materials that contain a lower filler particle content, and lower viscosity than their bulk counterparts, making them useful for specific clinical applications. Yet, their chemical makeup may impact the cellular population of the tooth pulp. This in-vitro study assessed the cytocompatibility and odontogenic differentiation capacity of dental pulp stem cells (DPSCs) in response to two recent FRC material extracts. Extracts of the FRC Aura easyflow (AEF) and Polofil NHT Flow (PNF) were applied to DPSCs isolated from extracted human teeth. Cell viability of DPSCs was assessed using MTT assay on days 1, 3 and 7. Cell migration was assessed using the wound healing assay. DPSCs' capacity for osteo/odontogenic differentiation was assessed by measuring the degree of mineralization by Alizarin Red S staining, alkaline phosphatase enzyme (ALP) activity, and monitoring the expression of osteoprotegerin (OPG), RUNX Family Transcription Factor 2 (RUNX2), and the odontogenic marker dentin sialophosphoprotein (DSPP) by RT-PCR. Monomer release from the FRC was also assessed by High-performance liquid chromatography analysis (HPLC). DPSCs exposed to PNF extracts showed significantly higher cell viability, faster wound closure, and superior odontogenic differentiation. This was apparent through Alizarin Red staining of calcified nodules, elevated alkaline phosphatase activity, and increased expression of osteo/odontogenic markers. Moreover, HPLC analysis revealed a higher release of TEDGMA, UDMA, and BISGMA from AEF. PNF showed better cytocompatibility and enhancement of odontogenic differentiation than AEF.

Maximization of cytochrome C oxidase enzyme activity by optimizing color conversion from red organic light-emitting diodes

Photobiomodulation (PBM) therapy using red and near-infrared (NIR) light can effectively activate cytochrome C oxidase (CCO) enzyme to promote wound healing in living organisms. To maximize this therapeutic effect, the use of a light source with a spectrum absorbed by the CCO enzyme is necessary. A red/NIR light source optimized for CCO enzyme was obtained by partially color-converting a red organic light-emitting diode with copper indium sulfide/zinc sulfide quantum dots (QDs). To increase color conversion efficiency, the dispersion of QDs was improved by using a fibrous color conversion layer (FCCL). By optimizing the QD content in the FCCL, a red/NIR light source similar to the absorption spectrum of CCO enzyme was obtained with a spectral matching ratio of 81.7 %. When this light source was used in PBM therapy, it was experimentally verified that it showed a much faster wound closure effect compared to general red light, and it was proven that this was due to increased activity of the CCO enzyme. This study is a method of obtaining a red/NIR light source for PBM suitable for a specific enzyme performing a specific function, and is particularly useful due to its excellent form factor of being large, thin, and flexible.

Windblown sand around obstacles - simulation and validation of deposition patterns

Sand dunes are iconic landmarks of deserts, but can also put human infrastructures at risk, for instance by forming near buildings or roads. We present a simulator of sand erosion and deposition to predict how dunes form around and behind obstacles under wind. Inspired by both computer graphics and geo-sciences, our algorithm couples a fast wind flow simulation with physical laws of sand saltation and avalanching, which suffices to reproduce characteristic patterns of sand deposition. In particular, we validate our approach via a qualitative comparison of the erosion and deposition patterns produced by our simulator against real-world patterns measured by prior work under controlled conditions.

Comparison of the effects of platelet-rich plasma and platelet-rich fibrin on the healing process of a rat's mucosal wound

Due to the problems associated with the use of PRP, a platelet concentrates without coagulation factors, called platelet-rich fibrin (PRF), has been developed that, in addition to tissue regeneration and wound healing, contains more white blood cells (WBCs), which are important in the wound healing process. In this study, the effect of these two platelet-rich plasmas on the thickness of the epithelium, the number of blood vessels and fibroblasts, and wound area were measured in two groups of PRP and PRF and at different periods. We divided the rats into three groups: the control group, the group receiving PRP, and the group receiving PRF. The results showed a significant difference in the number of fibroblasts, wound area, thickness of epithelium, and number of vessels in all three groups. Based on the results, the use of PRP and PRF in wounds can accelerate the formation of epithelium, create better and more blood vessels, create a platform for the migration and formation of fibroblast cells, and facilitate faster wound closure. Also, comparing PRP and PRF, it can be concluded that, finally, PRF acts better than PRP in epithelialization.

Origin and Properties of the Near-subsonic Solar Wind Observed by Parker Solar Probe

We identify and examine the solar wind intervals near the sonic critical point (i.e., M S ∼ 1) observed by the Parker Solar Probe. The near-subsonic wind intervals show similar properties: a low density, an extremely low velocity, a low proton temperature, and essentially no magnetic field deflections compared with the surrounding solar wind. The extremely low velocity is the primary contributor to the near crossing of the sonic critical point rather than the sound speed, which is roughly constant in these intervals. Source tracing with a potential-field source-surface model suggests that the near subsonic intervals all connect to the boundaries inside coronal holes. Heliospheric current sheet (HCS) and partial HCS crossings around the near subsonic intervals indicate that the near subsonic wind is a transition layer between the slow and fast winds. The above scenario is consistent with the nature of the near-subsonic wind as a low-Mach-number boundary layer, which facilitates the crossing of the sonic critical point at 15–20 R S . Moreover, we find a dependence of the amplitude of switchbacks on the radial sonic Mach number. Magnetic field deflections essentially disappear near the sonic critical point, which suggests that switchbacks originate from above the sonic critical point.

Temperature Intermittent Structures in the Fast Solar Wind

In the solar wind turbulence, proton temperature fluctuations are highly intermittent, especially at small scales in the inertial range. This phenomenon may contain information about solar wind intermittent heating. However, the physical nature of the temperature intermittency is not yet clear. Based on the measurements from Solar Orbiter between 2020 September and 2022 September, we identify 185 temperature intermittent structures at the scale of 24 s with well-defined minimum variance direction in the fast solar wind and study the nature and kinetic effects of them. According to the variations of proton temperature, the intermittent structures are classified into four types, including temperature bump, step, dip, and chain. When considering the magnetic field configuration together with other plasma properties, we find that, among the bump cases, 46 of them are linear magnetic holes (LMHs) that are mainly related to mirror-mode (MM) instability, and 43 of them are current sheets (CSs) with local temperature enhancement. The step cases are found to be associated with shock-like structures (13 cases) and tangential discontinuities (eight cases) that separate two different parcels of plasma. For the dip cases, 21 of them could be associated with the MM instability, and the rest of the 16 ones may prefer soliton scenario. The 38 chain cases are identified as compressive vortex-like structures and a mixture of LMHs and CSs. These results will help to further understand the intermittent dissipation process in the solar wind turbulence.

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial.

Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence of antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance and wound healing. This study aimed to document the efficacy of a topical silver nanoparticle-based cream on bacteria clearance and wound healing in infected wounds compared to Mupirocin. This open-label parallel randomized clinical trial allocated 86 participants with infected wounds (culture-positive) into Kadermin, silver nanoparticle-based cream arm (n=43) and Mupirocin arm (n=43) and documented the swab culture on day 5 and wound healing at day 28, along with periodic wound status using the Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics and other medications for underlying diseases. The intention-to-treat principle was adopted for data analysis using the chi-square and Student t tests to document the differences between groups according to variable characteristics. All participants completed the follow-up. On day 5, wound bacteria clearance was observed in 86% and 65.1% of the participants in the Kadermin and Mupirocin arms, respectively (p=0.023). At day 28, complete wound healing was observed in 81.4% and 37.2% of the participants in the Kadermin and Mupirocin arms, respectively (p≤0.001). No local or systemic adverse event or local reaction was observed in any of the participants. Kadermin, the silver nanoparticle-based cream, has better efficacy in achieving faster wound bacteria clearance and healing in infected wounds compared to Mupirocin. This may have relevance for its use as an antibiotic-sparing agent in wound management.

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms.

Wound healing is a complex, intricate, and dynamic process that requires effective therapeutic management. The current study evaluates the wound healing potentials of methanolic extract of Cuminum cyminum L. seeds (CCS) in rats. Sprague Dawley (24) rats were distributed into four cages, wounds produced on the back of the neck, and received two daily topical treatments for 14 days: A, rats received normal saline; B, wounded rats treated with intrasite gel; C and D, rats received 0.2mL of 250 and 500mg/kg of CCS, respectively. After that, wound area and closure percentage were evaluated, and wound tissues were dissected for histopathological, immunohistochemical, and biochemical examinations. Acute toxicity trials of methanolic extract of CCS showed the absence of any physiological changes or mortality in rats. CCS application caused a significant reduction in wound size and a statistically elevated percentage of wound contraction than those of vehicle rats. CCS treatment caused significant up-regulation of collagen fiber, fibroblasts, and fewer inflammatory cells (inflammation) in granulation tissues. TGF-β1 (angiogenetic factor) was significantly more expressed in CCS-treated rats in comparison to normal saline-treated rats; therefore, more fibroblasts transformed into myofibroblasts (angiogenesis). CCS-treated rats showed remarkable antioxidant potentials (higher SOD and CAT enzymes) and decreased MDA (lipid peroxidation) levels in their wound tissue homogenates. Hydroxyproline amino acid (collagen) was significantly up-regulated by CCS treatment, which is commonly related to faster wound closure area. The outcomes suggest CCS as a viable new source of pharmaceuticals for wound treatment.

How Does the Structure of Rarefaction Regions Develop?

A rarefaction region (RR) occurs at the trailing edge of the fast solar wind stream. It comes from an area of small longitudinal extent on the solar surface and exhibits a fine and complex structure. In our study, we did a superposed epoch analysis of the proton and α parameters across the RR and observed their gradual evolution. We did not find any clear boundary between the fast and slow solar winds inside the RR because a majority of our observations show that most of the RR plasma corresponds to the fast solar wind; only the α–proton drift velocity decreases from the beginning of the RR. We investigate different ways of its reduction in interplanetary space and show that this feature is likely associated with the mirroring of the multicomponent solar wind. Nevertheless, considering the observed solar wind characteristics and taking into account the mutual relations between the proton and α parameters, we define the composition boundary where the α relative abundance and α–proton temperature ratio change abruptly from the values typical for the fast wind toward slow wind values. This boundary is the most probable candidate for the stream interface. Based on these findings, we speculate that the RR formation starts already near the Sun and formulate two possible scenarios.

Changes in and Recovery of the Turbulence Properties in the Magnetosheath for Different Solar Wind Streams

Solar wind is known to have different properties depending on its origin at the Sun. In addition to the differences in plasma and magnetic field parameters, these streams differ due to the properties of turbulent fluctuations involved in the flow. The present study addresses the changes in the turbulence properties in the magnetosheath—the transition region in front of the magnetosphere. This study is based on statistics from the simultaneous measurements of magnetic field fluctuations in the solar wind and in the magnetosheath. Both the dayside and flank magnetosheath regions are focused on to detect the evolution of the turbulent fluctuations during their flow around the magnetosphere. Turbulent cascade is shown to save its properties for fast solar wind streams. Conditions favorable for the preservation of the turbulence properties at the bow shock may correspond to the increased geoefficiency of large-scale solar wind structures.

Parametric description of intermittent probability distribution functions in solar wind and magnetohydrodynamic turbulence

ABSTRACT In this work, we find empirical evidence that the scale-dependent statistical properties of solar wind and magnetohydrodynamic (MHD) turbulence can be described in terms of a family of parametric probability distribution functions (PDFs) known as Normal Inverse Gaussian (NIG). Understanding these PDFs is one of the most important goals in turbulence theory, as they are inherently connected to the intermittent properties of solar wind turbulence. We investigate the properties of PDFs of Elsasser increments based on a large statistical sample from solar wind observations and high-resolution numerical simulations of MHD turbulence. In order to measure the PDFs and their corresponding properties, three experiments are presented: fast and slow solar wind for experimental data and a simulation of reduced MHD (RMHD) turbulence. Conditional statistics on a 23-yr-long sample of WIND data near 1 au and high-resolution pseudo-spectral simulation of steadily driven RMHD turbulence on a $2048^3$ mesh are used to construct scale-dependent PDFs. The empirical PDFs are fitted to NIG distributions, which depend on four free parameters. Our analysis shows that NIG distributions accurately capture the evolution of the PDFs, with scale-dependent parameters, from large scales characterized by a Gaussian distribution, turning to exponential tails within the inertial range and stretched exponentials at dissipative scales. We also show that empirically-measured NIG parameters exhibit well-defined scaling properties that are similar across the three empirical data sets, which may be indicative of universal behaviour.

Low-cost wind turbine aeroacoustic predictions using actuator lines

Aerodynamic noise is a limitation for further exploitation of wind energy resources. As this type of noise is caused by the interaction of turbulent flow with the airframe, a detailed resolution of the flow is necessary to obtain an accurate prediction of the far-field noise. Computational fluid dynamic (CFD) solvers simulate the flow field but only at a high computational cost, which is much increased when the acoustic field is resolved. Therefore, wind turbine noise predictions using numerical approaches remain a challenge. This paper presents a methodology that couples (relatively fast) wind turbine CFD simulations using actuator lines with a fast turn-around noise prediction method. The flow field is simulated using actuator lines and large eddy simulations. The noise prediction method is based on the Amiet–Schlinker’s theory for rotatory noise sources, considering leading- and trailing-edge noise as unique noise sources. A 2D panel code (XFOIL) calculates the sectional forces and boundary layer quantities. The resulting methodology for the noise prediction method is of high fidelity since the wind turbine geometry is accounted for in both flow and acoustics predictions. Results are compared with field measurements of a full-scale wind turbine for two operational conditions, validating the results of this research.

Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin.

Topical patch delivery of deferoxamine (DFO) has been studied as a treatment for this fibrotic transformation in irradiated tissue. Efficacy of a novel cream formulation of DFO was studied as a RIF therapeutic in unwounded and excisionally wounded irradiated skin. C57BL/6J mice underwent 30 Gy of radiation to the dorsum followed by 4 weeks of recovery. In a first experiment, mice were separated into six conditions: DFO 50 mg cream (D50), DFO 100 mg cream (D100), soluble DFO injections (DI), DFO 1 mg patch (DP), control cream (Vehicle), and irradiated untreated skin (IR). In a second experiment, excisional wounds were created on the irradiated dorsum of mice and then divided into four treatment groups: DFO 100 mg Cream (W-D100), DFO 1 mg patch (W-DP), control cream (W-Vehicle), and irradiated untreated wounds (W-IR). Laser Doppler perfusion scans, biomechanical testing, and histological analysis were performed. In irradiated skin, D100 improved perfusion compared to D50 or DP. Both D100 and DP enhanced dermal characteristics, including thickness, collagen density and 8-isoprostane staining compared to untreated irradiated skin. D100 outperformed DP in CD31 staining, indicating higher vascular density. Extracellular matrix features of D100 and DP resembled normal skin more closely than DI or control. In radiated excisional wounds, D100 facilitated faster wound healing and increased perfusion compared to DP. The 100 mg DFO cream formulation rescued RIF of unwounded irradiated skin and improved excisional wound healing in murine skin relative to patch delivery of DFO.

Parker Solar Probe Observations of Magnetic Reconnection Exhausts in Quiescent Plasmas near the Sun

Parker Solar Probe observations are analyzed for the presence of reconnection exhausts across current sheets (CSs) within R < 0.26 au during encounters 4–11. Exhausts are observed with nearly equal probability at all radial distances with a preference for quiescent Tp < 0.80 MK plasmas typical of a slow-wind regime. High Tp > 0.80 MK plasmas of a fast wind characterized by significant transverse fluctuations rarely support exhausts irrespective of the CS width. Exhaust observations demonstrate the presence of local temperature gradients across several CSs with a higher-Tp plasma on locally closed fields and a lower-Tp plasma on locally open field lines for an interchange-type reconnection. A CS geometry analysis directly supports the property that X-lines bisect the magnetic field rotation θ-angle, whether the fields and plasmas are asymmetric or not, to maximize reconnection rates and available magnetic energy. The CS normal width d cs distributions suggest that a multiscale reconnection process through nested layers of bifurcated CSs may be responsible for observed power-law distributions beyond the median d cs ∼ 1000 km with an exponential d cs distribution present for ion kinetic dissipation scales below this median. Magnetic field shear θ-angles are essentially identical at R < 0.26 and 1 au with medians at θ ∼ 55° near the Sun and θ ∼ 65° at 1 au. In contrast, the tangential flow shear distributions are different near and far from the Sun. A bimodal flow shear angle distribution is present near the Sun with strong shear flow magnitudes. This distribution is modified with radial distance toward a relatively flat distribution of weaker flow shear magnitudes.

Multifunctional fish-skin collagen-based hydrogel sealant with dual-dynamic-bond cross-linked for rapid hemostasis and accelerated wound healing

Collagen (COL) is the most widespread functional protein. Designing and developing dual-dynamic-bond cross-linked COL adhesive hydrogel sealants with multifunctional is highly advantageous for achieving a superior wound closure effect and hemostasis. In this study, we developed hybrid hydrogels consisting of fish-skin COL, oxidized sodium alginate (OSA), borax and polyvinyl alcohol (PVA) to enhance full-thickness wound healing. The hydrogels were furnished with first-rate self-healing capabilities through the dual-dynamic-bond cross-linking of dynamic Schiff base bonds (COL-OSA) and diol boric acid bonds (OSA-borax) with reversible breakage and re-formation. Moreover, the incorporation of PVA stimulated the formation of hydrogen bonds in the system, bolstering the stability of the hydrogel framework. The prepared hydrogel manifests self-healing, injectability, multifunctional adhesiveness and biodegradability. In vivo assessment of the hemostatic capacity of COSP20 hydrogel was superior to gauze both in the mice liver injury model and mice tail amputation model. In addition, a full-thickness skin wound model in mice revealed that the COSP20 hydrogel facilitated faster wound closure by accelerating reepithelialization, COL deposition and angiogenesis. These findings illustrate the potential of hybrid fish-skin COL-based hydrogels to enhance wound healing and promote rapid tissue repair, and provide new possibilities for the effective utilization of marine fishery resources.

Laser hemorrhoidoplasty procedure versus harmonic scalpel hemorrhoidectomy: a comparative study for the treatment of grades III and IV hemorrhoids

Background Hemorrhoids are one of the most commonly presented diagnoses of colorectal diseases. This study aimed to evaluate and compare the outcomes of laser hemorrhoidoplasty (LHP) and harmonic scalpel hemorrhoidectomy (HSH) in the management of grades III and IV hemorrhoids, focusing on some postoperative complications. Patients and methods A randomized, controlled, clinical trial involving 34 patients with grades III and IV hemorrhoids was conducted at the General Surgery Department, Faculty of Medicine, Helwan University, from June 2022 to March 2023. Ethical considerations were adhered to, and patients provided informed consent. The groups underwent either LHP or HSH, and comprehensive patient information was collected, including demographics and preoperative assessments. Postoperative care and follow-up evaluations assessed outcomes such as pain, bleeding, discharge, wound healing, incontinence, recurrence, and stenosis. Results Demographic distribution was similar between the LHP and HSH groups, with comparable operative times. Postoperative bleeding did not significantly differ between groups. HSH was associated with more early discharge, longer wound healing times, and significantly higher postoperative pain levels up to the third week. No significant differences were observed in stenosis, incontinence, or recurrence between the two groups. Conclusion Both HSH and LHP techniques were found to be safe and effective for managing hemorrhoids. LHP demonstrated advantages, including lower postoperative pain levels, reduced seromucous discharge, and faster wound healing compared with HSH. These findings provide valuable insights for clinicians in optimizing patient care during the management of hemorrhoids.