According to GNSS/INSAR measurements, the Konya Basin in Central Anatolia is undergoing rapid subsidence within an uplifting orogenic plateau. Further, geophysical studies reveal thickened crust under the basin and a fast seismic wave speed anomaly in the underlying mantle, in addition to a localised depression in calculated residual topography (down to 280 m) over the Konya Basin, based on gravity-topography considerations. Using scaled laboratory (analogue) experiments we show that the active formation of the Konya Basin may be accounted for by the descent of a mantle lithospheric drip causing local circular-shaped surface subsidence. We interpret that the Konya Basin is developing through a secondary drip pulse that is contemporaneous with broad plateau uplift caused by a larger-scale lithospheric drip since the Miocene. The research reveals that basin evolution and plateau uplift may be linked in a multistage process of lithospheric removal during episodic development of orogenic systems.