Fast biomass pyrolysis is an effective method for bio-oil production and can be performed in fluidised beds, augers, and drop-tube reactors. In this study, the fast pyrolysis of agricultural biomass (oat and corn straw) in a drop-tube reactor was investigated by applying multiparameter analysis involving numerical calculations. The main motivation for this analysis was to determine the operating parameters for fast pyrolysis under which the highest bio-oil production was achieved. In this study, the following operating parameters were involved: pyrolysis temperature (500 – 700 °C), volume flow rate of the carrier gas (3 – 5 l/min), mass flow rate of the feedstock (10 – 30 g/h), and diameter of the particle (250 – 750 µm). The analysis was performed using numerical methods with the Euler-Lagrange multiphase theory in a 2D axisymmetric model. According to the numerical results, selection of a particle size of 500 µm, pyrolysis temperature of 500 °C, and nitrogen flow rate of 3 l/min allows obtaining 51.16% and 52.09% of bio-oil for oat straw and corn straw pyrolysis, respectively. The biomass mass load did not influence the final product yield. The numerical results were successfully confirmed by experimental investigations where experiments supplied 53.2% and 51.3% of bio-oil to oat straw and corn straw, respectively.