Fast Gate Research Articles

Fast super robust nonadiabatic geometric quantum computation

Nonadiabatic geometric quantum computation (NGQC) provides a method for implementing fast and robust quantum gates. To enhance the robustness of NGQC against control errors, many solutions have been proposed by previous researchers. However, these solutions often lead to longer operation times for quantum gates. To simultaneously enhance quantum gate robustness against control errors and reduce operation times to mitigate decoherence effects, we introduce fast super robust NGQC (FSR-NGQC). This approach achieves faster speeds when operating small-angle rotation gates. Through numerical calculations, we have demonstrated the performance of our scheme in a decoherence environment. The results show that our scheme achieves higher fidelity, thus enabling fast and robust geometric quantum computing.

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.

The opening of the Torpedo CLC-0 chloride (Cl-) channel is known to be regulated by two gating mechanisms: fast gating and slow (common) gating. The structural basis underlying the fast-gating mechanism is better understood than that of the slow-gating mechanism, which is still largely a mystery. Our previous study on the intracellular proton (H+i)-induced inhibition of the CLC-0 anionic current led to the conclusion that the inhibition results from the slow-gate closure (also called inactivation). The conclusion was made based on substantial evidence such as a large temperature dependence of the H+i inhibition similar to that of the channel inactivation, a resistance to the H+i inhibition in the inactivation-suppressed C212S mutant, and a similar voltage dependence between the current recovery from the H+i inhibition and the recovery from the channel inactivation. In this work, we further examine the mechanism of the H+i inhibition of wild-type CLC-0 and several mutants. We observe that an anion efflux through the pore of CLC-0 accelerates the recovery from the H+i-induced inhibition, a process corresponding to the slow-gate opening. Furthermore, various inactivation-suppressed mutants exhibit different current recovery kinetics, suggesting the existence of multiple inactivated states (namely, slow-gate closed states). We speculate that protonation of the pore of CLC-0 increases the binding affinity of permeant anions in the pore, thereby generating a pore blockage of ion flow as the first step of inactivation. Subsequent complex protein conformational changes further transition the CLC-0 channel to deeper inactivated states.

Decay-protected superconducting qubit with fast control enabled by integrated on-chip filters

Achieving fast gates and long coherence times for superconducting qubits presents challenges, typically requiring either a stronger coupling of the drive line or an excessively strong microwave signal to the qubit. To address this, we introduce on-chip filters of the qubit drive exhibiting a stopband at the qubit frequency, thus enabling long coherence times and strong coupling at the subharmonic frequency, facilitating fast single-qubit gates, and reduced thermal load. The filters exhibit an extrinsic relaxation time of a few seconds while enabling sub-10-ns gates with subharmonic control. Here we show up to 200-fold improvement in the measured relaxation time at the stopband. Furthermore, we implement subharmonic driving of Rabi oscillations with a π pulse duration of 12 ns. Our demonstration of on-chip filters and efficient subharmonic driving in a two-dimensional quantum processor paves the way for a scalable qubit architecture with reduced thermal load and noise from the control line.

Nav1.2 channel mutations preventing fast inactivation lead to SCN2A encephalopathy

Abstract SCN2A gene-related early-infantile developmental and epileptic encephalopathy (EI-DEE) is a rare and severe disorder that manifests in early infancy. SCN2A mutations affecting the fast inactivation gating mechanism can result in altered voltage dependence and incomplete inactivation of the encoded neuronal Nav1.2 channel and lead to abnormal neuronal excitability. In this study, we evaluated clinical data of seven missense Nav1.2 variants associated with DEE and performed molecular dynamics simulations, patch-clamp electrophysiology, and dynamic clamp real-time neuronal modelling to elucidate the molecular and neuron-scale phenotypic consequences of the mutations. The N1662D mutation almost completely prevented fast inactivation without affecting activation. The comparison of wild-type and N1662D channel structures suggested that the ambifunctional hydrogen bond formation between residues N1662 and Q1494 is essential for fast inactivation. Fast inactivation could also be prevented with engineered Q1494A or Q1494L Nav1.2 channel variants, whereas Q1494E or Q1494 K variants resulted in incomplete inactivation and persistent current. Molecular dynamics simulations revealed a reduced affinity of the hydrophobic IFM-motif to its receptor site with N1662D and Q1494L variants relative to wild-type. These results demonstrate that the interactions between N1662 and Q1494 underpin the stability and the orientation of the inactivation gate and are essential for the development of fast inactivation. Six DEE-associated Nav1.2 variants, with mutations mapped to channel segments known to be implicated in fast inactivation were also evaluated. Remarkably, the L1657P variant also prevented fast inactivation and produced biophysical characteristics that were similar to those of N1662D, whereas the M1501 V, M1501T, F1651C, P1658S, and A1659 V variants resulted in biophysical properties that were consistent with gain-of-function and enhanced action potential firing of hybrid neurons in dynamic action potential clamp experiments. Paradoxically, low densities of N1662D or L1657P currents potentiated action potential firing, whereas increased densities resulted in sustained depolarization. Our results provide novel structural insights into the molecular mechanism of Nav1.2 channel fast inactivation and inform treatment strategies for SCN2A-related EI-DEE. The contribution of non-inactivating Nav1.2 channels to neuronal excitability may constitute a distinct cellular mechanism in the pathogenesis of SCN2A-related DEE.

Hardware-efficient and fast three-qubit gate in superconducting quantum circuits

Hardware-efficient and fast three-qubit gate in superconducting quantum circuits

Updates on Impact Ionisation Triggering of Thyristors

High voltage (HV) generators are used in multiple industrial and scientific facilities. Recent publications have demonstrated that triggering industrial thyristors (relatively slow switching devices) in overvoltage mode, also called impact ionization mode, significantly enhances their dU/dt and dI/dt characteristics. This novel triggering methodology necessitates the application of substantial overvoltage between the thyristor’s anode and cathode, delivered with a swift slew rate exceeding 1 kV/ns. The adoption of compact pulse generators constructed from commercially available off-the-shelf components (COTS) opens up avenues for deploying this technology across various domains, including the implementation of high-speed kicker generators in particle accelerators. In our methodology, we employed commercially available high-voltage SiC MOSFETs along with a custom-designed fast gate driver. This driver was conceptualized based on the recent development of gate boosting techniques, featuring a driving voltage exceeding 600 V. The gate driver for these MOSFETs comprises three key components: a level-shifter with NMOS and PMOS transistors, a compact Marx generator with two avalanche transistors, and a GaN HEMT in a high input and low output impedance configuration. The proposed gate-boosting driver achieves a slew rate exceeding 1 kV/ns for the driving pulse. Furthermore, we demonstrate that with this driver, a 1.7 kV rated SiC MOSFET can produce an output pulse of 1.45 kV and a maximum slew rate of ≈2.5 kV/ns. This gate-boosting driver aims to minimize commutation times, achieves a slew rate of over 1 kV/ns, and handle higher loads, making it ideal for impact ionization triggering of industrial thyristors.

Coherent Control of the Fine-Structure Qubit in a Single Alkaline-Earth Atom.

We report on the first realization of a novel neutral atom qubit encoded in the spin-orbit coupled metastable states ^{3}P_{0} and ^{3}P_{2} of a single ^{88}Sr atom trapped in an optical tweezer. Raman coupling of the qubit states promises rapid single-qubit rotations on par with the fast Rydberg-mediated two-body gates. We demonstrate preparation, readout, and coherent control of the qubit. In addition to driving Rabi oscillations bridging an energy gap of more than 17THz using a pair of phase-locked clock lasers, we also carry out Ramsey spectroscopy to extract the transverse qubit coherence time T_{2}. When the tweezer is tuned into magic trapping conditions, which is achieved in our setup by tuning the tensor polarizability of the ^{3}P_{2} state via an external control magnetic field, we measure T_{2}=1.2 ms. A microscopic quantum mechanical model is used to simulate our experiments including dominant noise sources. We identify the main constraints limiting the observed coherence time and project improvements to our system in the immediate future. Our Letter opens the door for a so-far-unexplored qubit encoding concept for neutral atom-based quantum computing.

Time-optimal multi-qubit gates: Complexity, efficient heuristic and gate-time bounds

Multi-qubit entangling interactions arise naturally in several quantum computing platforms and promise advantages over traditional two-qubit gates. In particular, a fixed multi-qubit Ising-type interaction together with single-qubit X-gates can be used to synthesize global ZZ-gates (GZZ gates). In this work, we first show that the synthesis of such quantum gates that are time-optimal is NP-hard. Second, we provide explicit constructions of special time-optimal multi-qubit gates. They have constant gate times and can be implemented with linearly many X-gate layers. Third, we develop a heuristic algorithm with polynomial runtime for synthesizing fast multi-qubit gates. Fourth, we derive lower and upper bounds on the optimal GZZ gate-time. Based on explicit constructions of GZZ gates and numerical studies, we conjecture that any GZZ gate can be executed in a time O(n) for n qubits. Our heuristic synthesis algorithm leads to GZZ gate-times with a similar scaling, which is optimal in this sense. We expect that our efficient synthesis of fast multi-qubit gates allows for faster and, hence, also more error-robust execution of quantum algorithms.

Silicon spin qubit noise characterization using real-time feedback protocols and wavelet analysis

Recently, several groups have demonstrated two-qubit gate fidelities in semiconductor spin qubit systems above 99%. Achieving this regime of fault-tolerant compatible high fidelities is nontrivial and requires exquisite stability and precise control over the different qubit parameters over an extended period of time. This motivates the search for the efficient calibration of qubit control parameters against different sources of micro- and macroscopic noise and methods for noise analysis. Here, we present several single- and two-qubit parameter feedback protocols, optimized for and implemented in the state-of-the-art fast field-programmable gate array hardware. Furthermore, we present a wavelet-based analysis on feedback data collected over a ∼9 h time frame to gain insight into the different sources of noise in the system. Scalable feedback is an outstanding challenge and the presented implementation and analysis gives insight into the benefits and drawbacks of qubit parameter feedback, as feedback related overhead increases. This work demonstrates a pathway toward robust qubit parameter feedback and systematic noise analysis, crucial for mitigation strategies toward systematic high-fidelity qubit operation compatible with quantum error correction protocols.

Gap Junction Channel Regulation: A Tale of Two Gates-Voltage Sensitivity of the Chemical Gate and Chemical Sensitivity of the Fast Voltage Gate.

Gap junction channels are regulated by gates sensitive to cytosolic acidification and trans-junctional voltage (Vj). We propose that the chemical gate is a calmodulin (CaM) lobe. The fast-Vj gate is made primarily by the connexin's NH2-terminus domain (NT). The chemical gate closes the channel slowly and completely, while the fast-Vj gate closes the channel rapidly but incompletely. The chemical gate closes with increased cytosolic calcium concentration [Ca2+]i and with Vj gradients at Vj's negative side. In contrast, the fast-Vj gate closes at the positive or negative side of Vj depending on the connexin (Cx) type. Cxs with positively charged NT close at Vj's negative side, while those with negatively charged NT close at Vj's positive side. Cytosolic acidification alters in opposite ways the sensitivity of the fast-Vj gate: it increases the Vj sensitivity of negative gaters and decreases that of positive gaters. While the fast-Vj gate closes and opens instantaneously, the chemical gate often shows fluctuations, likely to reflect the shifting of the gate (CaM's N-lobe) in and out of the channel's pore.

Non-intrusive thermometry in water: a novel temporal method using rise time-decay time ratio of ZnO phosphorescence in comparison with RhB PLIF and ZnO spectral imagery

The temporal characteristics of ZnO phosphor emission and the possibility to obtain instantaneous and mean 2D temperature fields in fluids have been analysed in this article. Spectrometer tests have been performed by mixing ZnO micro-particles in liquid (water) to analyse the emission characteristics of the phosphor upon excitation by a 266 nm laser. Using a fast gating camera, it has been shown that 2D phosphor thermometry can be performed through temporal methods using ZnO phosphors, which were thought previously to be unachievable. Additionally, a two-camera temporal method is proposed by exploiting the rise and decay times of the ZnO phosphor emission upon excitation. Sensitivity of the metrology is proposed and compared with commonly used Rhodamine B fluorescence and ZnO spectral methods.

Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon.

The Sec translocon is a highly conserved membrane assembly for polypeptide transport across, or into, lipid bilayers. In bacteria, secretion through the core channel complex-SecYEG in the inner membrane-is powered by the cytosolic ATPase SecA. Here, we use single-molecule fluorescence to interrogate the conformational state of SecYEG throughout the ATP hydrolysis cycle of SecA. We show that the SecYEG channel fluctuations between open and closed states are much faster (~20-fold during translocation) than ATP turnover, and that the nucleotide status of SecA modulates the rates of opening and closure. The SecY variant PrlA4, which exhibits faster transport but unaffected ATPase rates, increases the dwell time in the open state, facilitating pre-protein diffusion through the pore and thereby enhancing translocation efficiency. Thus, rapid SecYEG channel dynamics are allosterically coupled to SecA via modulation of the energy landscape, and play an integral part in protein transport. Loose coupling of ATP-turnover by SecA to the dynamic properties of SecYEG is compatible with a Brownian-rachet mechanism of translocation, rather than strict nucleotide-dependent interconversion between different static states of a power stroke.

Fast nuclear-spin gates and electrons-nuclei entanglement of neutral atoms in weak magnetic fields

Fast nuclear-spin gates and electrons-nuclei entanglement of neutral atoms in weak magnetic fields

High-performance repetition cat code using fast noisy operations

Bosonic cat qubits stabilized by two-photon driven dissipation benefit from exponential suppression of bit-flip errors and an extensive set of gates preserving this protection. These properties make them promising building blocks of a hardware-efficient and fault-tolerant quantum processor. In this paper, we propose a performance optimization of the repetition cat code architecture using fast but noisy CNOT gates for stabilizer measurements. This optimization leads to high thresholds for the physical figure of merit, given as the ratio between intrinsic single-photon loss rate of the bosonic mode and the engineered two-photon loss rate, as well as an improved scaling below threshold of the required overhead, to reach an expected level of logical error rate. Relying on the specific error models for cat qubit operations, this optimization exploits fast parity measurements, using accelerated low-fidelity CNOT gates, combined with fast ancilla parity-check qubits. The significant enhancement in the performance is explained by: 1- the highly asymmetric error model of cat qubit CNOT gates with a major component on control (ancilla) qubits, and 2- the robustness of the repetition cat code error correction performance in presence of the leakage induced by fast operations. In order to demonstrate these performances, we develop a method to sample the repetition code under circuit-level noise that also takes into account cat qubit state leakage.

High-fidelity Rydberg controlled-Z gates with optimized pulses

High-fidelity controlled-Z (CZ ) gates are essential and mandatory to build a large-scale quantum computer. In neutral atoms, the strong dipole–dipole interactions between their Rydberg states make them one of the pioneering platforms to implement CZ gates. Here we numerically investigate the optimized pulses to generate a high-fidelity Rydberg C Z gate in a three-level ladder-type atomic system. By tuning the temporal shapes of Gaussian or segmented pulses, the populations on the intermediate excited states are shown to be suppressed within the symmetric gate operation protocol, which leads to a C Z gate with a high Bell fidelity up to . These optimized pulses are robust to thermal fluctuations and the excitation field variations. Our results promise a high-fidelity and fast gate operation under amenable and controllable experimental parameters, which goes beyond the adiabatic operation regime under a finite blockade strength.

Field programmable gate array‐based energy‐efficient and fast epileptic seizure detection using support vector machine and quadratic discriminant analysis classifier

AbstractEpilepsy is a serious neurological disorder that results in seizures. It can be diagnosed by analyzing the brain's electrical activity using an electroencephalogram (EEG). However, the detection of seizures from massive EEG datasets is a challenging task. To address this challenge, researchers have developed several machine‐learning classifiers and feature extraction techniques for detecting seizures. This paper proposes an energy‐efficient and fast field programmable gate array (FPGA) architecture for detecting epileptic seizures using minimal computational resources. The seizure detection system uses the one Hjorth parameter (mobility) and another statistical parameter (nonlinear energy) as features and employs two efficient classifiers, quadratic discriminant analysis and linear support vector machine (LSVM), for classifying signals into seizure and nonseizure categories. The feature extractor block is connected individually to each of these classifiers. Subsequently, the performance of these two proposed models is evaluated in terms of accuracy, sensitivity, power consumption, resource utilization, and other metrics. The results demonstrate that the SVM classifier‐based model achieved the highest accuracy (99.4%) and sensitivity (98.8%) while consuming minimal dynamic power (0.057 mW) and utilizing the minimum FPGA resources. Thus, the proposed hardware system offers a reliable and energy‐efficient solution for detecting seizures in clinical and real‐time applications.

Distinct ClC-6 and ClC-7 Cl- sensitivities provide insight into ClC-7's role in lysosomal Cl- homeostasis.

ClC-6 and ClC-7 are closely related, intracellular Cl- /H+ antiporters belonging to the CLC family of channels and transporters. They localize to acidic late endosomes and lysosomes and probably function in ionic homeostasis of these contiguous compartments. ClC-7 transport function requires association with the accessory protein Ostm1, whereas ClC-6 transport does not. To elucidate their roles in endo-lysosomes, we measured Cl- - and pH-dependences of over-expressed wild-type ClC-6 and ClC-7, as well as disease-associated mutants, using high-resolution recording protocols. Lowering extracellular Cl- (corresponding to luminal Cl- in endo-lysosomes) reduced ClC-6 currents, whereas it increased transport activity of ClC-7/Ostm1. Low extracellular Cl- activated ClC-7/Ostm 1 under acidic extracellular conditions, as well as under conditions of low intracellular chloride. Activation is conserved in ClC-7Y713C , a variant displaying disrupted PI(3,5)P2 inhibition. Detailed biophysical analysis of disease-associated ClC-6 and ClC-7 gain-of-function (GoF) variants, ClC-6Y553C and ClC-7Y713C , and the ClC-7Y577C and ClC-6Y781C correlates, identified additional functional nuances distinguishing ClC-6 and ClC-7. ClC-7Y577C recapitulated GoF produced by ClC-6Y553C . ClC-6Y781C displayed transport activation qualitatively similar to ClC-7Y713C , although current density did not differ from that of wild-type ClC-6. Finally, rClC-7R760Q , homologous to hClC-7R762Q , an osteopetrosis variant with fast gating kinetics, appeared indifferent to extracellular Cl- , identifying altered Cl- sensitivity as a plausible mechanism underlying disease. Collectively, the present studies underscore the distinct roles of ClC-6 and ClC-7 within the context of their respective localization to late endosomes and lysosomes. In particular, we suggest the atypical inhibition of ClC-7 by luminal Cl- serves to limit excessive intraluminal Cl- accumulation. KEY POINTS: ClC-6 and ClC-7 are late endosomal and lysosomal 2 Cl- /1 H+ exchangers, respectively. When targeted to the plasma membrane, both activate slowly at positive voltages. ClC-6 activity is decreased in low extracellular (i.e. luminal) chloride, whereas ClC-7 is activated by low luminal chloride, even at acidic pH. The functional gain-of-function phenotypes of the ClC-6 and ClC-7 disease mutations ClC-6Y553C and ClC-7Y715C are maintained when introduced in their respective homologues, ClC-7Y577C and ClC-6Y781C , with all mutations retaining chloride dependence of the respective wild type (WT). An osteopetrosis mutation of ClC-7 displaying fast gating kinetics (R762Q) was less sensitive to extracellular chloride compared to WT. The opposing substrate dependences of ClC-6 and ClC-7 Cl- / H+ exchangers point to non-overlapping physiological functions, leading us to propose that inhibition of ClC-7 by luminal chloride and protons serves to prevent osmotic stress imposed by hyper-accumulation of chloride.

Wire Length-Matching Aware Placement Method for Rapid Single Flux Quantum Logic Circuits

This paper proposes a fast automatic gate placement method for gate-level-pipelined Rapid Single Flux Quantum (RSFQ) circuits that are designed to have a high throughput. In such circuits, the gates in a pipeline stage are placed in a column and wires are routed in the area between adjacent columns. In wire routing, wire length-matching is performed. The proposed method performs gate placement for a given netlist to minimize the sum of the maximum distance between connected gates in each pair of adjacent columns. It leads to short wire extensions in wire length matching for increasing the operation frequency and small circuit area. The proposed method consists of a recursive procedure including two placements, selecting a pivot column, and determining the gate placement in the pivot column. The netlist is divided into two netlists with the pivot column. The recursive procedure performs gate placements for the two divided netlist. It is repeated until the location of every gate is determined. We implemented a placement tool by the proposed method and performed the gate placement for three circuits including several hundreds of gates. The proposed placement was 14 to 40 times faster than a placement based on simulated annealing where the sum of the maximum distance between connected gates is approximately the same.

Design of Scalable Superconducting Quantum Circuits Using Flip-Chip Assembly

We present design results of scalable superconducting quantum circuits using the flip-chip assembly. In order to achieve the longest relaxation time ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$T_{1}$</tex-math></inline-formula> ) of a qubit possible, gap between two chips in flip-chip assembly is determined to be 12 μm where low surface dielectric loss from two-level system (TLS) defects can be achieved while maintaining large readout coupling strength between two chips in the flip-chip assembly. Superconducting transmon qubit design is then optimized to have a target anharmonicity of 200 MHz and to have the longer <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$T_{1}$</tex-math></inline-formula> in consideration of surface energy participation ratios of TLS defects within the compact footprint. To achieve strong coupling strength but low qubit to qubit crosstalk (ZZ) for fast and high fidelity multi-qubit gates, direct coupler and compact multi-path coupler designs for coupling qubits are compared by numerically solving Hamiltonian of the coupled two qubits. Monte-Carlo simulation results on the yield rate of the extended circuits indicate that low manufacturing errors are required.

Fast Saturating Gate for Learning Long Time Scales with Recurrent Neural Networks

Fast Saturating Gate for Learning Long Time Scales with Recurrent Neural Networks