Event Abstract Back to Event NHE1 and membrane remodeling: What role for cancer cell death/survival regulation? Dominique Lagadic-Gossmann1* 1 UMR Inserm 1085 / IRSET / University of Rennes 1, France The ubiquitous Na+/H+ exchanger 1 (NHE1) is known to play a central role in a wide variety of cell functions, from pH and volume regulation to control of cell metabolism, migration and proliferation/cell death balance. This transporter, which is preferentially located in lipid rafts in plasma membrane, has been shown to regulate biophysical characteristics of plasma membrane as well as to be sensitive to membrane remodelling. In this paper, we will see how such modulations can play an important role in the activation of the Fas-dependent apoptosis induced by cisplatin (Rebillard et al., Cancer Res, 2007), and in the intrinsic apoptosis elicited by an important environmental carcinogen, i.e. benzo[a]pyrene (Tekpli et al., Toxicol Appl Pharmacol, 2010). Such interactions between NHE1 and membrane remodeling might open new ways for modulating cell growth, especially in the context of anticancer therapy. Acknowledgements Supported by Ligue Contre le Cancer, Région Bretagne, Rennes Métropole, Conseil Général 35, Union Européenne (FEDER) (MembraTox project; contract number 32508, 350 keuros), Egide (Aurora) Keywords: NHE1, lipid raft, Apoptosis, benzo[a]pyrene, membrane remodelling Conference: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer, Garching, Germany, 10 Oct - 12 Oct, 2013. Presentation Type: Abstract Topic: 7. pH and stroma-tumor interactions, metastasis Citation: Lagadic-Gossmann D (2014). NHE1 and membrane remodeling: What role for cancer cell death/survival regulation?. Front. Pharmacol. Conference Abstract: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer. doi: 10.3389/conf.fphar.2014.61.00026 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Jan 2014; Published Online: 07 Feb 2014. * Correspondence: Dr. Dominique Lagadic-Gossmann, UMR Inserm 1085 / IRSET / University of Rennes 1, RENNES cédex, 35043, France, dominique.lagadic@univ-rennes1.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dominique Lagadic-Gossmann Google Dominique Lagadic-Gossmann Google Scholar Dominique Lagadic-Gossmann PubMed Dominique Lagadic-Gossmann Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.