Simple SummarySmall animals such as goats, sheep and chickens are an important source of income for rural livelihoods, especially for women farmers in Africa, because they are able to control the resources that come from the sale of these animals. However, one of the biggest problems they face is livestock diseases, even when vaccines are available. In Kenya, Contagious Caprine Pleuropneumonia (CCPP) is a highly infectious disease of goats with a mortality rate of more than 70%. A vaccine for CCPP is available but difficult to access by women in the rural areas. This study examines the gaps and barriers that prevent women smallholder farmers from effectively accessing and adopting CCPP vaccination for their animals in the Machakos district of Kenya. Our results indicate that key constraints to vaccine access and adoption for rural smallholder women farmers are lack of a cold chain for vaccine maintenance, inadequate and late delivery of veterinary services, lack of information and training, and limited financial capacity to purchase the vaccine. If more resources, information, and training is made available to women smallholder farmers through government or the private sector, there would be improved livestock productivity, better livelihoods, and increased opportunities and agency for women.Most rural women smallholder farmers in Kenya generate income from the sale of small ruminant animals. However, diseases such as Contagious Caprine Pleuropneumonia (CCPP) prevent them from optimizing earnings. A crucial aspect for the control of CCPP is vaccination. In Kenya, CCPP vaccines are distributed through a government delivery mechanism. This study examines gaps and barriers that prevent women smallholder farmers from accessing CCPP vaccines. Qualitative data collection tools used were focus groups discussions, focus meals, jar voices and key informant interviews. Using outcome mapping (OM) methodology, critical partners and stakeholders in the CCPP vaccine value chain (CCPP-VVC) were identified to be the manufacturers, importers, distributors, agrovets, public and private veterinarians, local leaders, and farmers. Respondents highlighted the barriers to be limited access to vaccines due to cold chain problems, inadequate and late delivery of services, lack of information and training on vaccines, and financial constraints. Identified opportunities that can support women’s engagement in the CCPP-VVC are the Kenya Governments two-third gender rule, which requires that not more than two thirds of the members of elective or appointive bodies shall be of the same gender, and positive community perception of female veterinarians. We conclude that more resources and training should be made available to women farmers, and that gender perspectives on policy development related to livestock production and disease prevention are urgently needed to improve livestock productivity and increase agency for women.