In Nigeria, despite the enormous contribution of MSMEs to the development of the agricultural sector is plagued by severe funding constraints. This study investigates the effect of enterprise management on the performance of Micro, Small, and Medium Scale poultry farming in North Central Nigeria. Other specific objectives are: Examine the extent to which strategic orientation affects the growth of poultry farmers in North Central Nigeria, Investigate how resource orientation influences the profitability of poultry farming in North Central Nigeria, Evaluatethe degree to which management structure improve the performance of poultry farming in North Central Nigeria, Examine the extent to which growth orientation influence the performance of poultry farming in North Central Nigeria, Examine the extent to which entrepreneurial culture influence the performance of poultry farming in North Central Nigeria, Investigate the effect of Reward philosophy on profitability of poultry farming in Nigeria. The study utilized mixed methods research design based on a population of five hundred and six (506) registered livestock farmers across North Central comprising of Kogi, Benue, Plateau, Niger, Kwara, Nasarawa and Abuja from which a multi-stage sample of two hundred and twenty-three (223) sample arrived using Taro Yamane’s size calculation formula. The data collected through a well-structured questionnaire was analyzed using both simple percentage and regression analysis at, 0.05 alpha level of significance. The study found that there is a significant and positive relationship between strategic orientation, management structure, entrepreneurial culture and business growth, profitability and business sustainability of poultry farming. It was also found that assets strategic orientation has a significant positive effect on business growth. In addition, the study found that management structure has a positive significant effect on profitability. Finally, it was established that government subsidies is a common denominator used in promoting business sustainability for young graduate poultry farmers. The study submitted that enterprise management play a significant role in promoting economic the growth of poultry farming operating in the agricultural sector. Among others, the study recommended that financial and technical support should be provided for small-scale business enterprises across sectors especially those into poultry farming. Also, the government should provide conducive macroeconomics that will raise the creation of decent jobs through the Agricultural sector.