In this paper, the software FLUENT is used as simulation tool, and the two-dimensional time-domain Computational Fluid Dynamics (CFD) approach is employed to compute the sound reflection coefficient of circular duct without and with gas flow. In the absence of mean flow, the pressure far-field boundary condition could be used as non-reflecting boundary condition in Fluent, and good agreement between the CFD prediction and experiment measurement available in the literature is observed. For the case with gas flow, the general non-reflecting boundary condition is available only with the density-based solver (high-speed compressible flow or Strong coupling flow) in FLUENT, and it is difficult to acquire the convergent solution for the calculation that the density-based solver is used to compute the reflection coefficient of circular pipe. Therefore, the non-reflecting boundary condition is not applied in the model. The computational results from time-domain CFD approach basically agree with experimental resul...