Reinforced concrete frame-bent structures are one of the structural forms commonly used in industrial factory buildings. In order to study the seismic behaviour of frame-bent structures located near fault areas, eight pulse-like, eight non-pulse near-fault motions and eight far-fault ground motions have been selected in this paper. The finite element model of a reinforced concrete frame-bent structure was established to study seismic responses to near-fault and far-field ground motions. Numerical analysis results indicate that the maximum base shear of the structure under the action of near-fault ground motion was 5.10 times that of far-fault and 1.47 times that of non-pulsed near-fault ground motion; the maximum story drift angle under pulse-like near-fault ground motion was 3.8 times that of non-pulse and 19.7 times that of far-fault ground motion. Therefore, engineering designers should pay more attention to the seismic performance of frame-bent structures under the action of near-fault ground vibration.