Fang Research Articles

Combined postoperative adjuvant transarterial chemoembolization and portal vein chemotherapy to treat patients with hepatocellular carcinoma and portal vein tumor thrombosis: a meta-analysis

Objective To systematically review the clinical effectiveness of combined postoperative adjuvant transcatheter arterial chemoembolization (TACE) with portal vein chemotherapy (PVC) versus TACE alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). Methods Databases including PubMed, Embase, Cochrane Library, Medline, Web of Science, CNKI, China Biology Medicine, Wan Fang and VIP were searched from Jan 1st 2000 to Jun 30th 2019 for eligible studies on clinical effectiveness of combined postoperative adjuvant TACE with PVC versus TACE alone in patients with HCC and PVTT. The primary endpoints were overall survival (OS) and disease-free survival (DFS). The secondary endpoint was adverse events. These endpoints were evaluated by odds ratio (OR) and 95% confidence interval (CI) using Review Manager 5.3 software. Results Nine studies with 642 patients were enrolled in this meta-analysis. There were 323 patients in the TACE group and 319 patients in the TACE plus PVC group. The pooled OR for the 1-, 2-, and 3-year OS were all significantly better in the TACE plus PVC group than the TACE group (1-year OS, OR=2.20, 95% CI: 1.53-3.17; 2-year OS, OR=2.44, 95% CI: 1.69-3.53; 3-year OS, OR=2.30, 95% CI: 1.52-3.46) (all P 0.05). Conclusion Postoperative adjuvant TACE combined with PVC for patients with HCC and PVTT was safe and effective, and was significantly better than TACE alone in long-term prognosis. Large-scale, multi-center, prospective studies are needed to support the conclusion. Key words: Carcinoma, hepatocellular; Portal vein tumor thrombosis; Transarterial chemoembolization; Portal vein chemotherapy; Meta-analysis

Interfacial Tension Measurement for Alkaline-Polymer Flooding Application for Oil from Fang Oilfield, Thailand

With the high demand of oil and gas consumption, oil is required for more production. Fang oilfield is one of the main oilfields in Thailand. An enhanced oil recovery method especially alkaline-polymer flooding is an essential technique to improve oil production. It involves an injection of alkaline to lower the interfacial tension (IFT) between oil and water and polymer for improving the mobility ratio to produce more oil. In Fang oilfield, a light oil recovery is improved by using the solution to reduce IFT of oil and water. In this study, sodium hydroxide (NaOH) and hydrolysed polyacrylamide (HPAM) are used as alkali and polymer to lower the IFT with different conditions. The aim of this work is to measure the IFT and to assess the effects of pressure, temperature, concentration and salinity on IFT reduction for oil from Fang oilfield. The results present that the concentration of the chemical plays a key role for IFT reduction accounting for 99.49 %. IFT decreases with an increase in temperature up to 49.30 %. The effect of pressure is insignificant for IFT reduction. Salinity can increase IFT for 94.74 % at the low alkali concentration while HPAM could be more benefit in other aspects such as the mobility control process. The outcome of this work can be used as a fundamental data to enhance more oil recovery with the new technique for Fang oilfield.

Risk factors related to contralateral hip fracture following hip fracture in elderly patients: a meta analysis and review

Objective To evaluate the factors related to contralateral hip fracture in the elderly patients with hip fracture by meta analysis. Methods Pubmed, Cochrane, CBMdisc, CNKI Chinese Journal Full Text Database and Wan Fang Database were searched for publications at home and abroad from January 2005 to April 2018 on factors related to contralateral hip fracture after hip fractures in the elderly. The publication quality was strictly evaluated before the data were extracted concerning gender and age(>65 years) of the patients, concomitant osteoporosis (Singh sign ≥4), primary fracture type, concomitant Parkinson disease, concomitant stroke, concomitant senile dementia, concomitant cataract, concomitant rheumatoid arthritis, concomitant diabetes, type of internal fixation for primary fracture and therapeutic compliance. Revman5.0 was used to perform the statistical analysis and the OR value and 95% CI were calculated fore each index. Results A total of 17 studies were included involving 1,504 patients with contralateral hip fracture among 13,717 elderly patients with hip fracture. The factors related to the refracture of the contralateral hip were the age of the patients (OR=-3.55, 95% CI:-5.60~-1.50, P<0.001), osteoporosis (OR=2.38, 95% CI: 1.36~4.17, P=0.002), Parkinson disease (OR=4.54, 95% CI: 2.74~7.53, P<0.001), stroke (OR=0.33, 95% CI: 0.18~0.59, P<0.001), senile dementia (OR=0.43, 95% CI: 0.29~0.62, P<0.001), cataract (OR=0.37, 95% CI: 0.22~0.63, P< 0.001), rheumatoid arthritis (OR=0.32, 95% CI: 0.21~0.50, P<0.001), diabetes (OR=0.65, 95% CI: 0.47~0.91, P=0.01), type of internal fixation for primary fracture (OR=0.51, 95% CI: 0.30~0.85, P=0.01), and therapeutic compliance (OR=0.36, 95% CI: 0.21~0.64, P<0.001). However, the refracture of the contralateral hip was not related to gender (OR=1.07, 95% CI: 0.45~2.56, P=0.88), smoking (OR=0.86, 95% CI: 0.40~1.86, P=0.70), fracture type (OR=0.97, 95% CI: 0.60~1.57, P=0.90), or hypertension (OR=0.70, 95% CI: 0.41~1.21, P=0.20). Conclusions In elderly patients with hip fracture, the risks for contralateral hip fracture may be advanced age, concomitant osteoporosis, Parkinson disease, stroke, senile dementia, cataract, rheumatoid arthritis and diabetes, type of internal fixation for primary fracture, and poor therapeutic compliance. However, no sufficient evidence has suggested that gender, smoking, type of hip fracture or concomitant hypertension might be associated with the contralateral hip fracture. Key words: Elderly; Hip fracture; Meta-analysis; Contralateral hip fracture; Related factors

The necessity of presetting ureteral stents before ureteroscopic lithotripsy: a Meta-analysis

Objective To systematically evaluate the necessity of presetting double-J stent before flexible ureteroscope lithotripsy. Methods Computer retrieved clinical studies on the effect of preoperative presetting double-J-catheter on flexible ureteroscope lithotripsy in PubMed, Cochrane Library, Embase, Scopus, Wan fang, CNKI and VIP databases were reviewed. The retrieval time was from the database construction to November 2018. All of the possible combinations of the following terms were used for the search: flexible ureteroscopic, preoperative, double J stent, and calculus. Two researchers independently conducted literature screening, quality evaluation and data extraction, and completed Meta analysis by using statistical software RevMan5.3. Results Thirty-two case-control trials and 14 randomized controlled trials were screened, with a total of 17 480 patients, including 6 211 patients in the experimental group and 11 269 patients in the control group. The results of meta-analysis showed that the experimental group was superior to the control group in term of the overall postoperative stone clearance rate (OR=1.69, 95%CI 1.37-2.08, P<0.05). In terms of postoperative kidney stone removal rate, the experimental group was superior to the control group (OR=1.67, 95%CI 1.41-1.99, P<0.05). In terms of the removal rate of ureteral calculi after surgery, there was no significant difference between the two groups (OR=1.71, 95%CI 0.91-3.20, P=0.10). The success rate of flexible ureteroscope access sheath implantation was higher in the experimental group (OR=5.77, 95%CI 3.32-10.31, P<0.05). The rate of passive usage balloon dilation in the control group was higher(OR=0.23, 95%CI 0.15-0.35, P<0.05). For the incidence of intraoperative complications, the experimental group was lower (OR=0.56, 95%CI 0.38-0.84, P=0.004). For the incidence of postoperative complications, the experimental group was also lower(OR=0.64, 95%CI 0.45-0.90, P=0.01). The operation time of the control group was longer(MD=-4.95, 95%CI -8.90--1.01, P=0.01). Conclusions Presetting double-J-catheter can improve the stone removal rate after flexible ureteroscope lithotripsy for the treatment of kidney stone, improve the success rate of flexible ureteroscope access sheath implantation, reduce the utilization rate of ureteral balloon dilator, reduce the incidence of intraoperative and postoperative complications, and shorten the operation time. Key words: Urinary calculus; Flexible ureteroscopic; Double J stent; Meta-analysis

Effects of abdominal massage on gastrointestinal tolerance in critically ill patients fed by nasogastric tube: a systematic review and Meta-analysis

Objective To evaluate the effect of abdominal massage on gastrointestinal tolerance in critically patients with nasogastric tube feeding. Methods The Chinese Biomedical Literature Database, China National Knowledge Infrastructure, The Wang fang database, Chinese Science and Technology Periodical Database, Cochrane Libraty, PubMed, Embase, CENTRAL were searched. Two researchers conducted quality evaluation and data extraction on studies that met the inclusion criteria. Data were analyzed with RevMan5.3 software. Results Eight randomized controlled trials were included, including 628 patients. The results of Meta-analysis showed that abdominal massage could reduce the gastric residual volume of critically ill patients (WMD=-45.45, 95%CI -56.62--34.28, P<0.01), and reduce the incidence of gastric retention (OR=0.13, 95%CI 0.06 -0.29, P<0.01), incidence of abdominal distension (OR=0.23, 95% CI 0.13-0.43, P<0.01), incidence of vomiting (OR=0.14, 95% CI 0.06-0.36, P<0.01). Conclusions For critically ill patients with nasogastric tube feeding, abdominal massage can reduce the gastric residual volume and reduce the incidence of gastric retention, distension and vomiting. Key words: Abdomen; Massage; Critical care; Enteral nutrition; Meta-analysis

The effects of hyperbaric oxygen on the hemodynamics and intracranial pressure of patients with severe brain injury: A systematic review of randomized and controlled trials

Objective To systematically evaluate the effects of hyperbaric oxygen on the hemodynamics and intracranial pressure of patients with severe craniocerebral injury (STBI). Methods Reports of randomized and controlled trials applying hyperbaric oxygen in the treatment of STBI were retrieved from the Pubmed, Cochrane Library, Embase, CBM, CNKI, VIP and Wan Fang databases. Each report found was evaluated by two researchers independently applying pre-defined inclusion and exclusion criteria. The data were extracted and combined and a meta-analysis was performed. Results Eight trials involving 725 patients were included in the meta-analysis. They combined to demonstrate that intracranial pressure, oxygen uptake and scores on the Glasgow coma scale improved significantly more in the hyperbaric oxygen group than in the control group after between 3 and 10 days of treatment. Conclusion Hyperbaric oxygen therapy is effective in treating severe craniocerebral injury and it is worthy of clinical application. Key words: Hyperbaric oxygen; Craniocerebral injury; Brain trauma, intracranial pressure; Meta-analysis

Comparative analysis of clinical effects according to syndrome differentiation of Qili Qiangxin Capsules on ischemic heart failure: Meta-analysis

Databases including CNKI,Wan Fang,CBM,VIP,PubMed and Cochrane Library were searched to collect qualified researches,and the quality of articles was evaluated according to scales. Meta-analysis including subgroup analysis was performed by using Rev Man 5. 3 software and Meta-regression test was performed by using Stata 12. 0 software. All of these methods were used to systematically evaluate the safety and clinical efficacy of Qili Qiangxin Capsules in treatment of ischemic heart failure under two circumstances( with or without syndrome differentiation). A total of 22 randomized controlled trials( RCTs) involving 1 942 patients were included,with generally low quality. RESULTS: of Meta-analysis showed that as compared with the routine Western treatment alone,additional use of Qili Qiangxin Capsules could improve the clinical efficacy( RR = 1. 21,95%CI[1. 16,1. 27],P<0. 000 01) in treatment of ischemic heart failure,with its combined effect of syndrome differentiation group greater than that of non-syndrome differentiation group( P= 0. 03,I~2= 78. 9%),Meta-regression( sig = 0. 9,P = 0. 057); left ventricular ejection fraction( WMD = 7. 28,95% CI[5. 18,9. 38],P<0. 000 01),with combined effect of syndrome differentiation group greater than that of non-syndrome differentiation group( P= 0. 01,I2= 83. 2%),Meta-regression( I~2= 81. 09%,R2= 29. 08%,sig = 0. 47,P = 0. 029); 6-minute walk test( WMD = 33. 20,95%CI[24. 70,41. 70 ],P < 0. 000 01); left ventricular end diastolic diameter( WMD =-4. 61,95% CI[-5. 38,-3. 84 ],P <0. 000 01); left ventricular end diastolic volume( WMD =-34. 43,95%CI[-38. 81,-30. 05],P< 0. 000 01); and left ventricular end systolic volume( WMD =-9. 60,95% CI[-13. 16,-6. 05],P < 0. 000 01). Adverse effects were reported in 11 patients taking Qili Qiangxin Capsules and in 20 patients with routine treatment group,tolerable in both groups. None of the patients had obvious abnormality in liver and kidney function. Qili Qiangxin Capsules were effective and safe in the treatment of ischemic heart failure,which can further improve clinical efficacy as compared with routine treatment alone. Qili Qiangxin Capsules with syndrome differentiation showed more significant effects than those without syndrome differentiation,indicating better efficacy of clinical syndrome differentiation. However,these conclusions still need to be verified with more high-quality and large-sample literature.

Application of a gaussian model to simulate contaminants dispersion in industrial accidents

The increase of the industrial production and the development of new processes led to the necessity of better regulations of activities concerning potential risks for human health and environment. Accomplishing such purposes requires studies on both the chemistry of the involved phenomenon and the dispersion mechanism in the surrounding environment. While the chemistry of reaction can be determined at small scale via laboratory experiments and models, the dispersion in the environment is an extremely complex phenomenon to model, because it is strongly affected by the atmospheric conditions. Several models with the purpose of simulating pollutants dispersion were developed (Gariazzo et al., 2012; Alemayehu et al., 2015; Fang et al., 2018); among those, Gaussian models found many applications in safety engineering, due to both their effectiveness and relatively low computational costs. The US-EPA recommends the use of the Gaussian model AERMOD for the simulation of dispersions within 50 km from the emission source. It is important to underline that most of these models were developed with the aim to simulate the dispersion of continuous emissions such as those from industrial chimneys. Such systems can be assumed to work under steady-state conditions, since they are supposed to work for a long time. Nonetheless, industrial accidents, which can have a severe impact on people and environment, generally occur at a relatively small time scale, thus their dispersion has not yet reached the steady state conditions.In this work, we developed a modified non-steady-state Eulerian Gaussian model able to simulate the dispersion of contaminants produced by an industrial accident, which is hypothesized to be a point source. The model requires as input data time-dependent meteorological conditions and topographic information of the site, concerning: the source, physical properties of the pollutant, emission height and release temperature. The proposed model was applied to the 2,3,7,8-Tetrachlorodibenzodioxin (TCCD) dispersion after the Seveso accident (1976) near the source (radius of about 4 km). Results highlighted a good agreement with available literature experimental data.

The relationship between cholecystolithiasis or cholecystectomy and the risk of colorectal cancer: a Meta-analysis

Objective To analyze the correlations between cholecystolithiasis or cholecystectomy and the risk of colorectal cancer, and make a brief summary combining with the present study. Methods Qualified studies about the correlations between cholecystolithiasis or cholecystectomy and the risk of colorectal cancer published in English and Chinese before April 2018 were retrieved from PubMed, Cochrane Library, China National Knowledge Infrastructure(CNKI), Wan Fang Data, and VIP. Case-control and cohort studies were selected according to the inclusion and exclusion criteria and assessed by the Newcastle-Ottowa Scale, then we chose the high-quality literature to extract the data and analyze those data by RevMan 5.3 software. Publication bias was analyzed by Stata 12.1 software. Results A total of 28 articles were finally included in the systematic review, including 23 case-control studies and 5 cohort studies. The results showed that there is a significant relationship between cholecystolithiasis and the risk of colorectal cancer(OR=1.70, 95%CI: 1.39~2.08, P 0.05). Conclusion There is a positive association between cholecystolithiasis and colorectal cancer, but cholecystectomy itself may be not the risk of rectal cancer. Key words: Cholecystolithiasis; Cholecystectomy; Colorectal cancer; Meta-analysis

Effects of ripple cross angles and turbulence models on wet curtain resistance

To study the influence of ripple cross angles on the resistance of wet curtains, wet curtains with different ripple cross angles (45°/45°, 45°/15°) were tested on agricultural ventilation equipment performance testing benches, and the static pressure drop under different wind speeds (1-3 m/s) was determined. Four turbulence models (κ-e, RNG κ-e, κ-ω, SST κ-ω) were adopted for numerical simulations of the two types of wet curtain, and the simulations’ results were compared with those of experiments. The average errors found are 41.1%, 48.7%, 27.1%, and 27.8%, respectively, and the κ-ω model is found to be the most suitable one for the calculation of wet curtain resistance among the four turbulence models. By using the κ-ω turbulence model, the static pressure drop performances of wet curtains with ripple cross angles 45°/35° and 45°/25° were calculated. Resistance increases with wind speed and ripple cross angles, and a large ripple cross angle has a higher resistance growth rate with increasing wind speed. Keywords: wet curtain, ripple cross angle, resistance, turbulence model, ventilation, cooling and humidifying system DOI: 10.25165/j.ijabe.20191204.3446 Citation: Ding T, Fang L M, Shi Z X, Li B M, ZhaoY. Effects of ripple cross angles and turbulence models on wet curtain resistance. Int J Agric & Biol Eng, 2019; 12(4): 43–46.

Meta-analysis of rhES combined with TACE versus TACE alone for hepatocellular carcinoma: short-term therapeutic efficacy and subgroup analysis

Objective To evaluate the short-term efficacy of recombinant human endostatin (rhES) combined with transcatheter arterial chemoembolization (TACE) versus TACE alone for intermediate and advanced primary hepatic carcinoma. Methods The relevant controlled trials about rhES plus TACE versus TACE alone in the treatment of intermediate and advanced primary hepatic carcinoma were retrieved from the databases of PubMed, Elsevier, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wan Fang Database. The retrieval time limited was from the database construction to January 2018, and the Meta-analysis was performed by using RevMan5.3 software. Results 18 controlled trials were included in this Meta-analysis. There were 948 cases, of which 522 cases in rhES plus TACE group and 426 cases in TACE alone group. According to the usage of rhES, the trials were further divided into intrahepatic arterial embolization group, intrahepatic arterial pump group, and intravenous infusion group. rhES plus TACE had an overall advantage over TACE alone in terms of objective response rate (ORR), and the difference was statistically significant (RR=1.59, 95%CI: 1.41~1.79, P<0.05). And the ORR of rhES plus TACE in intrahepatic arterial embolization group, intrahepatic arterial pump group, intravenous infusion group was better than that of TACE alone (Intrahepatic arterial embolization group RR=1.63, 95%CI: 1.36~1.95; Intrahepatic arterial pump group RR=1.49, 95%CI: 1.24~1.79; Intravenous infusion group RR=1.69, 95%CI: 1.22~2.34), and the difference was statistically significant (P<0.05). The subgroups analysis of anthracycline and platinum also showed that ORR in rhES plus TACE patients was better than that in TACE patients alone. Conclusion The short-term efficacy of rhES plus TACE in the treatment of intermediate and advanced primary hepatic carcinoma was better than that of TACE alone, and the same results were obtained by subgroup analysis. Key words: Liver neoplasms; Chemoembolization, therapeutic; Meta-analysis; Recombinant human endostatin

A Meta-analysis of laparoscopic lithotomy and transurethral ureteroscope lithotripsy in the treatment of upper ureteral obstructive stones

Objective To systematically compare the differences of clinical efficacy in the treatment of obstructive upper ureteral stones by laparoscopic lithotomy and transurethral ureteroscope lithotripsy. Methods The search strategy and the inclusion and exclusion criteria were made by two independent reviewers. We searched online PubMed, EMBASE, Cochrane Clinical Controlled Trials Database, China National Knowledge Infrastructure(CNKI), Wang fang and VIP citation database from the inception to September 2017 for randomized controlled trials(RCT)studies, which assessing the efficacy of laparoscopic ureterolithotomy (LU) and transurethral ureteroscope lithotripsy (URSL) for obstructive upper ureteral calculus. RevMan 5.3 software was used to perform a clinical meta-analysis of relevant literature data. Results Nine randomized controlled trials (RCTs) were included, a total of 994 cases of related patients, including LU group of 501 cases, URSL group of 493 cases. The results showed that URSL contained a shorter time of surgery[WMD=31.34 min, 95%CI(16.83, 45.85), P<0.01] and length of hospital stay[WMD=1.88 d, 95%CI(0.93, 2.82), P<0.01] compared with LU group. However, LU group had a lower postoperative complications[OR=0.47%, 95%CI(0.32, 0.70), P<0.01] and higher stone clearance rates[OR=6.63%, 95%CI(3.91, 11.25), P<0.01]than URSL group. Conclusions Although URSL requires less operative time and hospital stay than LU for the treatment of obstructive upper ureteral stones, the postoperative complication and stone clearance rate performance are poor in URSL. Key words: Ureteral Calculi; Laparoscopy; Ureteroscopy

Meta analysis of the effect of continuing nursing intervention on high risk patients with diabetic foot

Objective To evaluate the effect of continuous care on patients with high risk of diabetic foot in China. Methods A random control of continuing care for patients with diabetes foot at high risk before June 2018 was published in the full text of the Chinese VP full text database (VIP), the full text database (CNKI), the Chinese biomedical literature database (CBM), Wan Fang, PubMed, Science Library. The test (randomized clinical trial), by 2 researchers, according to the inclusion and exclusion criteria, the literature quality was evaluated and extracted by the document quality standard of Cochrane cooperation network, and the different subgroups were divided according to the difference of the determination time of each outcome index, and the RevMan5.3 software was used to match the data. The required literature is analyzed by Meta. Results A total of 13 randomized clinical trials were included in the Mate analysis, including 1 450 subjects, 721 in the intervention group and 729 in the control group. The results showed that continuous nursing could effectively reduce the value of fasting blood glucose (combined effect MD=-1.34, 95%CI -1.44--1.24, P < 0.01), and effectively reduce the value of glycosylated hemoglobin (combined effect MD=-0.75, 95%CI -1.24- -0.27, P=0.002), and reduce the diabetic foot in patients with diabetic foot risk(combined effect RR=0.31, 95%CI 0.24-0.40, P<0.01). Continuous care could improve patients′ self-management ability and self-foot nursing ability. Conclusions Continuous care can reduce the fasting blood glucose, glycosylated hemoglobin and the incidence of diabetic foot in high-risk patients with diabetic foot, improve their self-management ability and self-foot nursing ability, which is of great significance to prevent and reduce the occurrence and development of diabetic foot. Key words: Continuous care; Diabetic foot; Intervention study; Meta analysis

Fang Tang. Explicitation in consecutive interpreting

Fang Tang. <i>Explicitation in consecutive interpreting</i>

Amber Fang: Hunted by Arthur Slade

Amber Fang: Hunted by Arthur Slade

Mirror therapy improves the upper limb function of hemiparetic stroke survivors: A meta-analysis

Objective To evaluate systematically the efficacy of mirror therapy for improving the upper limb function, daily life and pain of stroke survivors. Methods The PubMed, EBSCO, Web of Science, Ovid, Cochrane Library, Open Gray, China Biological Medicine, China National Knowledge Infrastructure, GoogleScholar, VIP and Wan Fang Data databases were searched for reports of randomized and controlled trials (RCTs) of mirror therapy for improving the upper limb function of stroke survivors. Only papers published before December 2015 were surveyed. The relevant references of the primary studies were also searched. The literature screening, data extraction and assessments were conducted by two reviewers independently. The meta-analysis was performed using version 5.2 of the RevMan software. Results A total of 22 RCTs involving 823 patients were discovered, some not dealing with mirror therapy. Comparing the studies with and without visual feedback, there were significant differences in upper limb motor function as measured by the Fugl-Meyer, ARAT and Brunnstrom instruments. The average Barthel indexes and visual analogue scale were also significantly different. Conclusion Mirror therapy can improve upper limb function and ability in the activities of daily living, and also relieve pain among stroke survivors to some degree, though its long-term efficacy is still unclear. Large-sample, multi-center, high-quality RCTs are required to verify these conclusions. Key words: Mirror therapy; Stroke; Upper limb function; Meta-analyses

Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology

Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology

Meta-analysis of effectiveness of laminectomy decompression compared with vertebral lamina decompression combined with lumbar fusion in Degree I spondylolisthesis and spinal canal stenosis

Objective To analyze the effectiveness of laminectomy decompression compared with vertebral lamina decompression combined with lumbar fusion in Degree I spondylolisthesis and spinal canal stenosis. Methods PubMed, Science Direct Online, Springer, CNKI, Wan Fang and VIP were retrieved to collect relevant randomized controlled trials(RCT). According to inclusion and exclusion criteria, two researchers screened literatures, extracted data and evaluated quality.RevMan5.0 software was used for Meta analysis.A total of 11 RCT were included, with a total of 1684 patients.Meta analysis showed that compared with the simple laminectomy group, the VAS score of lumbar pain in the lumbar fusion group at 1 years after operation decreased (MD and 95%CI: -1.20(-1.57- -0.83), P<0.05), and the VAS score of the 1 year postoperative leg pain in the lumbar fusion group decreased(MD and 95%CI: -0.88(-1.32- -0.44), P<0.05), the excellent rate of lumbar fusion group at 2 years after operation was higher(OR and 95%CI: 1.65(1.13-2.41), P<0.05). There was no significant difference in postoperative complications and lumbar spondylolisthesis at 1 years after operation. Conclusion In long term, compared with decompression alone, vertebral lamina decompression combined with lumbar fusion has more ideal effectiveness in the treatment. Key words: Laminectomy decompression; Vertebral lamina decompression combined with lumbar fusion; DegreeⅠspondylolisthesis; Meta analysis

Peripheral inflammatory markers in the patients with mild cognitive impairment: a meta-analysis

Objective To evaluate the association of peripheral blood inflammatory cytokines with mild cognitive impairment (MCI). Methods Databases including Pubmed, Cochrane library, Ovid, Web of science, CNKI, CBM, VIP and Wan Fang were retrieved to collect case-control studies related to the concentration of inflammatory cytokines in peripheral blood of MCI. After extracting data and appraising the quality of the included studies, meta-analysis were conducted using RevMan 5.3 and CMA 3.0. Results The levels of CRP, TNF-α, IL-1, MCP-1 and M-CSF and other 9 kinds of inflammatory factors in 33 studies were included in the analysis. A total of 8 742 subjects were enrolled, including 2 398 patients and 6 344 controls. The Meta-analysis showed that the levels of CRP (SMD=0.87, 95%CI (0.48, 1.26), P<0.0001), TNF-α(SMD=1.16, 95%CI (0.32, 2.00), P=0.007), IL-1β (SMD=0.96, 95%CI (0.17, 1.76), P=0.02), IL-6 (SMD=1.07, 95%CI (0.53, 1.61), P<0.0001), IL-8 (SMD=1.65, 95%CI (0.36, 2.93), P=0.01) in peripheral blood of patients with MCI were significantly higher than that of normal control group; however, there was no statistical difference between the two groups in the levels of IL-10, IL-12, MCP-1 and M-CSF. Conclusion The patients with MCI has a higher levels of CRP, TNF-α, IL-1β, IL-6 and IL-8 in peripheral blood, which suggesting that these inflammatory factors may be related to the occurrence and development of AD. Key words: Mild cognitive impairment; Inflammatory cytokines; Meta-analysis

The prevalence of fatigue in maintenance hemodialysis in China: a Meta-analysis

Objective To evaluate the prevalence and distribution characteristics of fatigue in maintaining hemodialysis in China. Methods Literature search was conducted to collect cross-sectional studies on the prevalence of fatigue in maintenance hemodialysis in PubMed,The Cochrane Library,Embase, Web of Science,China National Knowledge Internet,China Biology Medicine and Wan Fang Data.The studies were selected according to the exclusion and inclusive criteria and the qualities of studies were evaluated. Meta-analysis was performed with software of Stata 14.0. Results A total of 19 studies,including a total size of 3 171 and 2 253 patients of fatigue,were eligible for inclusion in the review.The prevalence of fatigue by analyzing the effect size was 72.1%(95% CI 63.6%-80.6%),the prevalence of mild to moderate fatigue by analyzing the effect size was 15.8%(95% CI 7.0%-24.7%), 43.6%(95% CI 40.1%-47.1%) and the prevalence of severe fatigue was 19.8%(95% CI 12.0%-27.6%).Subgroup analyses indicated that the fatigue rate of female maintenance hemodialysis was higher than male,the prevalence level estimated by the Piper Fatigue revised scale was higher than other tools(80.8%),the prevalence level estimated by the Vitality Subscale of the SF-36 (SF-36 VS), Short-Form Health Survey was lower than other tools(46.8%).The fatigue rate in the central and western areas were higher than that of the eastern region.The harder the economic was,the higher the prevalence of fatigue was.The prevalence of fatigue in the population dialysis aged 6 to 10 years was lower than that in dialysis age≤5 and dialysis age>10 years.Sensitivity analysis showed that the pooled effect size had good stability and reliability. Conclusion S The prevalence of fatigue in maintenance hemodialysis in China is high,which suggest that we should pay more attention to this situation.There are differences in the prevalence of fatigue in maintenance hemodialysis patients on different scales, areas, sex, dialysis years, and economic. Key words: Maintenance hemodialysis; Fatigue; Prevalence; Meta- analysis