Shallow rock and soil have a heat transfer temperature difference with the external environment, which can affect the external temperature through natural ventilation. In order to study and research the ventilation and energy saving of underground buildings based on this point, this study uses natural ventilation, field measurement, and DeST numerical simulation method to test the actual natural supply air rate of Zhengzhou metro station and the temperature, humidity, and CO2 concentration in the station. After further simulation analysis, the energy-saving design method and operation mode that make full use of natural ventilation are proposed in the end, and the energy-saving advantages that natural ventilation can bring are further explored. The results show that during the ventilation season, increasing the natural ventilation in March, April, and November can improve the thermal environment in the station and reduce the opening time of draught fan, saving the energy consumption of the fan operation, while in the months when the outdoor temperature is lower, such as in January, February, and in December, maintaining the existing natural ventilation is able to meet the station temperature requirements. It can be seen that the design of this study is reasonable and has achieved the expected effect. It can use the effect of natural ventilation on the metro station to achieve energy saving.