Role Of Family Research Articles

The multifaceted therapeutical role of low-density lipoprotein receptor family in high-grade glioma.

The diverse roles of the low-density lipoprotein receptor family (LDLR) have been associated with many processes critical to maintaining central nervous system (CNS) health and contributing to neurological diseases or cancer. In this review, we provide a comprehensive understanding of the LDLR's involvement in common brain tumors, specifically high-grade gliomas, emphasizing the receptors' critical role in the pathophysiology and progression of these tumors due to LDLR's high expression. We delve into LDLR's role in regulating cellular uptake and transport through the brain barrier. Additionally, we highlight LDLR's role in activating several signaling pathways related to tumor proliferation, migration, and invasion, engaging readers with an in-depth understanding of the molecular mechanisms at play. By synthesizing current research findings, this review underscores the significance of LDLR during tumorigenesis and explores its potential as a therapeutic target for high-grade gliomas. The collective insights presented here contribute to a deeper appreciation of LDLR's multifaceted roles and implications for physiological and pathological states, opening new avenues for tumor treatment.

Influence of moral reasoning and environmental concern on sustainable food consumption behaviors: A gender comparison among university students

Currently, South American countries face social and environmental challenges that can be addressed through the transformation of food purchasing and preparation patterns. This study aims to enhance comprehension regarding personal factors influencing sustainable food consumption, by examining the impact of moral reasoning and environmental concern on this behavior. The responses of 233 Chilean university students to an online self-report survey were analyzed using Partial Least Squares Structural Equation Modeling. The results have shown that moral reasoning and environmental concern positively impact sustainable food consumption behaviors, such as opting for food with minimal packaging, conserving energy during cooking, and repurposing food waste. Additionally, significant gender differences in these effects were observed. These novel findings provide further evidence supporting the necessity of bolstering moral education and environmental consciousness to foster the adoption of sustainable food consumption practices among university students in developing South American nations. Furthermore, the results underscore the importance of considering gender distinctions in education, particularly in light of entrenched family and societal roles.

From supply to demand: the role of families in the construction of new territorial alliances under the educational government of Cambiemos in the Province of Buenos Aires (2015-2019)

From supply to demand: the role of families in the construction of new territorial alliances under the educational government of Cambiemos in the Province of Buenos Aires (2015-2019)

The Vital Role of the CAMTA Gene Family in Phoebe bournei in Response to Drought, Heat, and Light Stress.

The calmodulin-binding transcriptional activator (CAMTA) is a small, conserved gene family in plants that plays a crucial role in regulating growth, development, and responses to various abiotic stress. Given the significance of the CAMTA gene family, various studies have been dedicated to uncovering its functional characteristics. In this study, genome-wide identification and bioinformatics analysis were conducted to explore CAMTAs in Phoebe bournei. A total of 17 CAMTA genes, each containing at least one domain from CG-1, TIG, ANK, or IQ, were identified in the P. bournei genome. The diversity of PbCAMTAs could be varied depending on their subcellular localization. An analysis of protein motifs, domains, and gene structure revealed that members within the same subgroup exhibited similar organization, supporting the results of the phylogenetic analysis. Gene duplications occurred among members of the PbCAMTA gene family. According to the cis-regulatory element prediction and protein-protein interaction network analysis, eight genes were subjected to qRT-PCR under drought, heat, and light stresses. The expression profiles indicated that PbCAMTAs, particularly PbCAMTA2, PbCAMTA12, and PbCAMTA16, were induced by abiotic stress. This study provides profound insights into the functions of CAMTAs in P. bournei.

Roles of the NR2F Family in the Development, Disease, and Cancer of the Lung.

The NR2F family, including NR2F1, NR2F2, and NR2F6, belongs to the nuclear receptor superfamily. NR2F family members function as transcription factors and play essential roles in the development of multiple organs or tissues in mammals, including the central nervous system, veins and arteries, kidneys, uterus, and vasculature. In the central nervous system, NR2F1/2 coordinate with each other to regulate the development of specific brain subregions or cell types. In addition, NR2F family members are associated with various cancers, such as prostate cancer, breast cancer, and esophageal cancer. Nonetheless, the roles of the NR2F family in the development and diseases of the lung have not been systematically summarized. In this review, we mainly focus on the lung, including recent findings regarding the roles of the NR2F family in development, physiological function, and cancer.

The Impact of Paternal Closeness and Familial Incarceration on the Self-Esteem of Black Adolescents

Background:Racially minoritized individuals make up the majority of the incarcerated population. The incarceration of a family member has lasting effects on family dynamics, particularly impacting the lives of adolescents. There is a need to understand how these experiences affect adolescent self-esteem and the role of family boundaries.Objective:To examine the impact of familial incarceration on adolescent self-reported self-esteem and the moderating role of boundaries between adolescents and their fathers, using structural family therapy as a guiding framework.Methods:The study utilized data from the 2016 wave of the National Longitudinal Survey of Youth-Children and Young Adults (NLSY-CYA), with a sample size of 341 adolescents. Simple linear and hierarchical regressions were conducted to assess the relationships between familial incarceration, perceived parental closeness, and adolescent self-esteem.Findings:Regression analysis revealed that having an incarcerated family member and lower perceived parental closeness were significantly associated with reduced self-esteem in adolescents. Additionally, closeness to fathers did not act as a protective factor in mitigating the negative impact of familial incarceration on adolescent self-esteem.Conclusions:The findings indicate that while familial incarceration and perceived parental closeness negatively impact adolescent self-esteem, closeness to fathers does not serve as a buffer. These results suggest that practitioners should explore alternative protective factors to support adolescents' self-esteem following familial incarceration.

Genome-Wide Identification of MsICE Gene Family in Medicago sativa and Expression Analysis of the Response to Abiotic Stress

To predict the role of the MsICE gene family in the response to abiotic stress, in this study, bioinformatics analysis and real-time fluorescence quantitative PCR were performed. Alfalfa (Medicago sativa) is one of the most economically valuable crops globally. Inducer of CBF expression (ICE), which is part of the basic helix–loop–helix (bHLH) transcription factor (TF) family, acts as a key regulator of cold tolerance. Despite this, there is little information available about ICE genes in alfalfa. Therefore, we studied the function of ICE TFs in alfalfa. We identified 11 MsICE genes from the alfalfa genome and classified them into two groups. Analysis of the protein motif and gene structure revealed relatively high conservation among subgroups of the tightly clustered MsICE genes. Through synteny analysis, we detected duplication events in the MsICE gene family, suggesting that the ICE gene family was formed through fragment duplications. All the MsICE proteins were located in the nucleus according to subcellular localization predictions. The promoter cis-regulatory elements of MsICE genes are largely involved in light (Box 4), hormone (ABRE), and stress (MYB) responses. The MsICE01/MsICE07/MsICE09/MsICE10/MsICE11 genes contained MYB- and MYC-binding motifs, indicating an association with abiotic stress. The specific expression patterns of MsICE genes in leaves were revealed by examining their expression patterns in different tissues. These findings suggest that these genes may sense external environmental changes through leaves. Abiotic stress can cause striking upregulation of MsICE07 (PCA score: −4.03) and MsICE10 (PCA score: −4.05) expression. In this study, candidate genes associated with cold stress were identified, and subsequent molecular biological analyses allowed elucidation of the biological functions of these genes in alfalfa. This research provides a theoretical foundation for enhancing alfalfa yield and quality under cold conditions.

Staff perspectives on fall prevention activities in long-term care facilities for older residents: "Brief but often" staff education is key.

Falls are a serious health problem in long-term care facilities (LTCFs), affecting more than 50% of residents. A key role of LTCF staff is to assess fall risks and implement fall prevention activities. Understanding the barriers and facilitators is key to successful implementation. This descriptive qualitative study involving four LTCF facilities (varied provider types and sizes) in southwest Ireland. We recruited a convenience sample of 17 LTCF staff, who participated in semi-structured online 1:1 interviews (n = 7) or small group interviews (n = 10). The data were analysed using Braun and Clarke's reflective thematic analysis. The participants included two directors of nursing, three therapists, one ward manager, one general practitioner, five nurses and five healthcare assistants. Six main themes were identified, reflecting factors that influenced fall prevention: a need for sufficient staff and appropriate skill mix; fall policy, documentation and leadership; equipment and safe environments; person-centred care; staff knowledge, skills and awareness in falls prevention; and staff communication and collaborative working. A wide range of approaches that supported LTCF staff to overcome barriers were identified, including audits and feedback, falls champions, fall prevention leaders, daily communication (e.g., safety pauses) and staff collaboration. Formal multidisciplinary meetings and identification systems to highlight residents at high risk of falling were not considered helpful. Staff suggested that education should be briefer, ongoing and practice-based ("brief but often") to promote ownership and responsibility. LTCF staff identified several approaches to prevent falls in LTCFs as part of usual care, rather than lengthy, formal meetings and training. The potential role of families in fall prevention was under-appreciated and should be investigated further.

Role of Family for Under-aged Working Children

This study aims to explain the role of the family in child labor that occurs at the Balong Cangkring intersection in Mojokerto, seeing the phenomenon of child labor as a public concern for the weakening of human resources in the future era for the next generation. It is necessary to re-reflect the awareness of the role of parents that this child labor system becomes a capitalist system as the growth of family economic capital. This research method uses a qualitative case study analysis approach, the data collection methods used are interviews, observation and documentation. The results of the study show that child labor as buskers, car glass cleaners, hawkers that occur at the Balong Cangring intersection is influenced by an environment far from civilization, human resources and education which are difficult for children to access due to the weakening role of parents. The lack of the role of parents towards children and the pattern of sustenance that is not optimal so that child labor still occurs in Mojokerto. Human capitalism against child labor in Balong Cangkring is carried out by parents to earn money by employing underage children at school age.

Exploring the Roles of the Swi2/Snf2 Gene Family in Maize Abiotic Stress Responses.

The maize Snf2 gene family plays a crucial role in chromatin remodeling and response to environmental stresses. In this study, we identified and analyzed 35 members of the maize Snf2 gene family (ZmCHR1 to ZmCHR35) using the Ensembl Plants database. Each protein contained conserved SNF2-N and Helicase-C domains. Phylogenetic analysis revealed six groups among the Snf2 proteins, with an uneven distribution across subfamilies. Physicochemical analysis indicated that the Snf2 proteins are hydrophilic, with varied amino acid lengths, isoelectric points, and molecular weights, and are predominantly localized in the nucleus. Chromosomal mapping showed that these genes are distributed across all ten maize chromosomes. Gene structure analysis revealed diverse exon-intron arrangements, while motif analysis identified 20 conserved motifs. Collinearity analysis highlighted gene duplication events, suggesting purifying selection. Cis-regulatory element analysis suggested involvement in abiotic and biotic stress responses. Expression analysis indicated tissue-specific expression patterns and differential expression under various stress conditions. Specifically, qRT-PCR validation under drought stress showed that certain Snf2 genes were upregulated at 12 h and downregulated at 24 h, revealing potential roles in drought tolerance. These findings provide a foundation for further exploration of the functional roles of the maize Snf2 gene family in development and stress responses.

Genome-Wide Analysis of the Nramp Gene Family in Kenaf (Hibiscus cannabinus): Identification, Expression Analysis, and Response to Cadmium Stress.

Kenaf (Hibiscus cannabinu) is a grass bast fiber crop that has the ability to tolerate and accumulate heavy metals, and it has been considered as a potential heavy metal accumulator and remediation plant. Nramp is a natural resistance-related macrophage, which plays an important role in the transport of divalent metal ions, plant growth and development, and abiotic stress. In this study, the Nramp gene family of kenaf was analyzed at the whole genome level. A total of 15 HcNramp genes were identified. They are distributed unevenly on chromosomes. Phylogenetic analysis classified 15 HcNramp proteins into 3 different subfamilies. All proteins share specific motif 4 and motif 6, and the genes belonging to the same subfamily are similar in structure and motif. The promoters are rich in hormone response, meristem expression, and environmental stress response elements. Under different treatments, the expression levels of HcNramp genes vary in different tissues, and most of them are expressed in roots first. These findings can provide a basis for understanding the potential role of the Nramp gene family in kenaf in response to cadmium (Cd) stress, and are of great significance for screening related Cd tolerance genes in kenaf.

Examining the Role of Family, Media, Peers in Young Caucasian Men’s Understandings of Body Dissatisfaction: A Thematic Analysis Using the Tripartite Influential Model and Social Comparison Theory

This study explores the factors contributing to body dissatisfaction among young Caucasian men. It focuses on family, peers, and media influences, addressing a gap in the literature that rarely integrates men’s experiences. The research draws on the Tripartite Influence Model and Social Comparison Theory, using thematic analysis to examine semi-structured interviews with eight participants aged 20–21. The research considers participants’ sexual orientation and country of origin when analysing the data. The findings show that family, peers, and the media positively and negatively shape body dissatisfaction among participants. Positive familial support can enhance body image, while negative comments from family members and peers exacerbate dissatisfaction. Social media was found to often reinforce unattainable body standards. The research contributes to the limited literature on men’s body dissatisfaction by expanding the application of the Tripartite Influence Model and Social Comparison Theory to this population. The study underscores the need for greater societal awareness and a more inclusive approach to body image research that considers diverse ethnic backgrounds and sexual orientations. We argue that more attention needs to be paid to men’s body dissatisfaction, as men are often excluded from these discussions. This study provides valuable insights into the dynamics of male body image, offering a foundation for future research and societal discourse on this often-overlooked issue.

Alternative Justice Using Religious Principles in Solving Domestic Violence of Muslim Family in Thailand

The purpose of this research was to find the level of Muslim domestic violence and the pattern of alternative justice corresponding to religious principles to solve the problem of Muslim domestic violence in southern border areas in Thailand. This was qualitative research using in-depth interviews with 52 samples, including victims, close persons, the provincial Islamic council, and Thai-Muslim family role models. The research showed that the level of Muslim domestic violence in studied communities was divided into 3 levels: 1) extreme violence, namely physical abuse 2) conflict, namely a quarrel with non-physical abuse, and 3) the way the family encountered both internal and external problems that might lead to quarrel and domestic violence. For the pattern of alternative justice corresponding to religious principles, reconciliation approaches should be used by focusing on the justice processes of all sectors along with the community. Furthermore, the recommendation of this research was to promote knowledge and skills of family life and educate good values according to Islamic principles.

THE RELATIONSHIP BETWEEN THE ROLE OF FAMILY AND THE READINESS OF FEMALE STUDENTS IN FACING MENARCHE

The current trend of decreasing menarche age has caused many high-grade elementary school students to experience menarche. Currently, the age of menarche tends to get younger with an average age between 9-12 years old, which causes children to need family roles to prepare themselves to face menarche. This research aimed to determine the relationship of family role with female students’ readiness in facing menarche at Kartika XVII-3 Sungai Raya Elementary School. This research was conducted from February 28 to March 2, 2024. This research was quantitative research, with a cross-sectional approach. The sample collection technique used a questionnaire. With a sample number of 39 using the total sampling method. Data analysis using the Spearman Rank test. The age range of respondents was 9-13 years, with the highest number aged 11 years as much as 46.2%. In the criteria for parental employment, 69.2% of respondents were IRT. As many as 74.4% of children get information sources from families. Family roles 61.5% of respondents have family roles that are not good. There are 69.2% of respondents are not prepared for menarche. The results of the Spearman Rank test found that the p-value < α (0.000 ≤ 0.005) and there was a relationship between the role of family and the readiness of female students in facing menarche at Kartika XVII-3 Sungai Raya Elementary School. The information obtained by the child from the family will further affect a child's readiness to face the first menstruation. Information about menstruation is not conveyed properly and correctly, it will affect the child's readiness to face menstruation. Future researchers are expected to be able to develop more deeply the relationship between family roles and the readiness of schoolgirls to face menarche and can develop other variables that affect the unpreparedness to face menarche so that they can be used for further research.

Discovery of myosin light chain kinase gene variant in a patient with tetralogy of Fallot suffering aortic dissection: implications for pathogenesis and the role of family and population screening

Discovery of myosin light chain kinase gene variant in a patient with tetralogy of Fallot suffering aortic dissection: implications for pathogenesis and the role of family and population screening

Political Critiques and Power Dynamics within Pakistani Society: A Critical Discourse Analysis (CDA) of Pakistani Drama "Ishq Murshid"

This research paper proposes examining postmodern political power in the Pakistani Urdu television drama “Ishq Murshid” (2023), employing Critical Discourse Analysis (CDA) as its theoretical framework that is utilized to examine how the drama reflects, reinforces, and critiques political matters and power dynamics within Pakistani society. The study's main objective is to analyze how the selected drama portrays political power, ideology, and resistance and examine the implications of political narratives and political realities in Pakistani discourse. This study is based on the qualitative method and systematically identifies and interprets political discourse within the political narrative, exploring the themes of authority, power, corruption, and social injustices represented in all the episodes of “Ishq Murshid.”. This study uses the tools and techniques for analysis including thematic coding, discourse markers identification, and critical contextualization of dialogues and narrative structures. The study aims to contribute to understanding the media's role in shaping and reflecting political discourse in South Asia, mainly through the lens of popular Urdu drama. The findings of the study of “Ishq-e-Murshid” critique Pakistan's political and social structures, highlighting corruption, moral resistance, and power dynamics. It critiques stereotypes, societal mistrust, and the role of family and legacy.

Influence of marital status on persuasion strategies in advertising regarding intention to purchase

This study has three chief objectives. Firstly, it aims to identify individual susceptibility to Cialdini’s persuasion strategies among consumers with different marital status. Secondly, it focuses on determining the susceptibility of each family member to persuasive strategies. Finally, the study examines the purchasing funnel among consumers with different marital status and different family roles. Two measurement scales are applied: the STPS questionnaire to establish susceptibility to persuasion strategies and the purchase funnel hierarchy model. The results of the first analysis of variance (ANOVA) show that divorced/separated users are susceptible to the principle of liking and authority, and married users – to commitment/consistency and social proof. The second variance analysis found the susceptibility of the children in the family: the first child was affected by liking, the second child – by scarcity, and the third – by commitment/consistency. Analysis of covariance (ANCOVA) of a family member with age differences as the covariate shows that consumers of advertising exhibit a strong sensitivity to the principle of unity, which affects widowed husbands or wives. In the second covariance analysis, a strong sensitivity to product preferences was observed for single husbands over 25 and for young adults under 25 for divorced/separated people. These scientific findings may be valuable to various specialists in social psychology, consumer behavior, and those interested in the dynamics of family purchases.

Activating mutations remodel the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia.

Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A-gene rearrangements (KMT2A-r). However, how these mutations cooperate with the KMT2A-r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3, we show that FLT3 ITD , FLT3 N676K , and NRAS G12D remodeled the chromatin accessibility landscape and associated transcriptional networks. Although the activating mutations shared a common core of chromatin changes, each mutation exhibits unique profiles with most opened peaks associating with enhancers in intronic or intergenic regions. Specifically, FLT3 N676K and NRAS G12D rewired similar chromatin and transcriptional networks, distinct from those mediated by FLT3 ITD . Motif analysis uncovered a role for the AP-1 family of transcription factors in KMT2A::MLLT3 leukemia with FLT3 N676K and NRAS G12D , whereas Runx1 and Stat5a/Stat5b were active in the presence of FLT3 ITD . Furthermore, transcriptional programs linked to immune cell regulation were activated in KMT2A-r AML expressing NRAS G12D or FLT3 N676K , and the expression of NKG2D-ligands on KMT2A-r cells rendered them sensitive to CAR T cell-mediated killing. Human KMT2A-r AML cells could be pharmacologically sensitized to NKG2D-CAR T cells by treatment with the histone deacetylase inhibitor LBH589 (panobinostat) which caused upregulation of NKG2D-ligand levels. Co-treatment with LBH589 and NKG2D-CAR T cells enabled robust AML cell killing, and the strongest effect was observed for cells expressing NRAS G12D . Finally, the results were validated and extended to acute leukemia in infancy. Combined, activating mutations induced mutation-specific changes in the epigenetic landscape, leading to changes in transcriptional programs orchestrated by specific transcription factor networks.

Interleukin-1 family cytokines and soluble receptors in hidradenitis suppurativa.

Hidradenitis suppurativa (HS) is a chronic skin disease, characterized by clinical inflammation of the hair follicle with the recurrence of abscesses, nodules, and tunnels. Recently, several studies suggested a role of IL-1 family (IL-1F) cytokines in eliciting and sustaining the disease. The aim of this work is to perform a comprehensive analysis of IL-1F cytokines, soluble inhibitors and receptors in a cohort of HS patients not treated with biological agents. Sixteen patients affected by HS and 16 healthy controls were recruited; clinical data were collected and disease severity evaluated by means of the International HS Severity Score System (IHS4). Serum levels of IL-1F cytokines, inhibitors and receptors were measured using a Multiplex Assays. IL-18 and free IL-18 levels were significantly higher in patients vs controls. Among soluble inhibitors, IL-1Ra, IL-1R2 and ST2/IL-1R4 were significantly increased. IL-18, free IL-18 and IL-33 levels are strongly correlated with IHS4. Also the inhibitors IL-1Ra and IL-18BP show a correlation with IHS4. The data obtained in this study confirm the involvement of IL-1F cytokines in mediating the disease and determining its severity and suggest a possible role for IL-18 as novel serum biomarker of active disease.

Abstract 49: Activator protein 1 (AP-1) Complex in Antigen Presenting Cells contributes to Salt-Sensitive Blood Pressure in Humans

Salt-sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular morbidity and mortality. The exact mechanism by which salt intake increases blood pressure is complex and not fully understood. We previously found that sodium entry into antigen-presenting cells (APCs) via the epithelial sodium channel (ENaC) activates proinflammatory cytokines to activate T cells and modulate salt-sensitive hypertension. The activator protein 1 (AP-1) transcriptional factors (FOS/JUN) have been implicated in activating the pro-inflammatory pathway, but its role in SSBP is unknown. We hypothesized that high salt activates the AP-1 signaling pathway and inflammation in APCs and contributes to SSBP. Our bulk RNA-sequencing data in human monocytes, demonstrated that high salt increases the expression of the AP-1 gene family, FOS (2,378.1 ± 480.7 vs 6,494.0 ± 945.5, p= 0.0009), and JUN (7,313.9 ± 984.9 vs11,370.0 ± 1,286.3, p= 0.0015) compared to normal salt-treated monocytes. In additional experiments, we enrolled patients with hypertension and phenotype them for SSBP using an established inpatient protocol of salt-loading/depletion and performed single-cell transcriptomic analyses on peripheral blood mononuclear cells (PBMCs). We observed expression of the e FOS (r= 0.5041, p= 0.0464) and JUN (r= 0.7083, p= 0.0021) genes changes in concert with blood pressure in salt-sensitive (SS) but not in salt-resistant (SR) patients. To confirm whether genes expression translates to protein expression, we cultured total splenocytes from salt-sensitive SV/129 mice for 24 hours in either normal (150 mM) or high salt media (190 mM) and performed flow cytometry. Compared to normal salt, high salt-induced a significant increase in the expression of FOS-JUN genes in monocytes of the spleen. We also adoptively transferred PBMCs from salt-sensitive (SS) and salt-resistant (SR) hypertensive individuals into immunodeficient NSG mice, treated with the high salt diet for three weeks and performed flow cytometry on immune cells of the kidney, aorta, and spleen. We found that immune cells from SS people demonstrated a higher propensity to infiltrate mouse tissues with increased expression of FOS-JUN genes than immune cells from SR people. These preliminary findings disclose the role of the AP-1 gene family in salt-sensitive hypertension and may provide a potential therapeutic target for the treatment and diagnosis of SSBP.