selected from a stratified multistage clustered area probability sample of households within the 39 municipalities of Sao Paulo, Brazil. Analyses used weighted simple and multiple logistic regression models with childhood neglect, physical abuse, sexual abuse, and family violence as exposures and heart disease and hypertension as outcomes, adjusted for socio-demographic variables and early onset of major depressive disorder. Results: In models adjusted for socio-demographic factors and early onset of depression, physical abuse (OR = 1.64, 95% CI: 1.30–2.07) and family violence (OR = 1.37, 95% CI: 1.10–1.71) were associated with hypertension. Physical abuse was a significant risk factor for heart disease (OR = 1.74, 95% CI: 1.06–2.85) when controlling for socio-demographic variables, but this association lost significance when controlling for early onset of depression. When additionally controlling for other childhood adversities simultaneously, physical abuse remained associated with adult hypertension (OR = 1.68, 95% CI: 1.28–2.20; OR = 1.59, 95% CI: 1.22–2.07 with and without adjusting for depression, respectively). Physical abuse lost significance when also adjusting for the other childhood adversities simultaneously. Conclusions: Results suggest a positive association between childhood physical abuse and hypertension in adulthood, even when adjusting for other childhood adversities, onset of depression and socio-demographic risk factors. Efforts to curb child physical abuse could potentially reduce subsequent hypertension, and morbidity and mortality due to cardiovascular disease.
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