Background: Laribacter hongkongensis is increasingly being reported worldwide since its discovery as a potential pathogen two decades ago in Hong Kong. An organism of fresh-water environments, L. hongkongensis is a motile facultative anaerobic gram-negative bacilli under the family Neisseriaceae. Case description: Here, we describe a case of L. hongkongensis in a 54-year old male with stage IV Hodgkin's Lymphoma, complicated with neutropenic sepsis. Upon an elective admission for his second cycle of chemotherapy, the patient presented with a high-degree pyrexia and a history of intermittent diarrhea, followed by severe neutropenia and thrombocytopenia. A pure growth of non-lactose fermenters, identified as L. hongkongensis via mass spectrometry (MALDI-ToF) and 16S rDNA sequencing, was isolated from blood culture. Discussion: Further phenotypic antibiotic sensitivity testing and interpretation of MIC breakpoints was commenced in accordance to the performance standards by CLSI for non-Enterobacteriaceae. Molecular detection of associated antibiotic resistance genes disclosed the amplification of a quinolone resistance gene (qnrS). The patient achieved prompt clinical improvement with Piperacillin-Tazobactam, which was started empirically by the primary team, as evidenced by the clearance of this organism from repeated blood cultures along with resolution of fever and normalization of blood counts. Conclusion: Because of its overlapping phenotypic characteristics with many other non-Enterobacteriaceae, L. hongkongensis may be easily overlooked if conventional bench methods were to be used alone. This highlights the need for further improvements of selective media as well as the employment of mass spectrometry and molecular methods as effective diagnostic aids in the pursuit of isolating this potentially emerging pathogen.