According to official sources, the amounts of children-to-parent violence (CPV) in most advanced countries have been on an increasing trend for more than a decade, which generates great social concern. This phenomenon has also aroused enormous interest among researchers, who have identified risk and protective factors related to adolescent CPV in numerous studies. The aim of the present study was to analyse the relationship between offensive family communication and CPV in adolescence, and the moderating role that two psychosocial adjustment factors may be playing: a positive attitude towards the transgression of rules and psychological distress. A total of 7787 adolescents between 11 and 16 years of age (M = 13.37, SD = 1.34) from secondary schools in the state of Nuevo León (Mexico) participated in the study (51.5% boys, 48.5% girls). Structural equation modelling was performed using structural equation modelling software (EQS). The results showed that offensive family communication has a direct and significant relationship with CPV. It was also observed that there is an indirect relationship between both variables, through the relationships of psychological distress and a positive attitude towards the transgression of rules. The multigroup analysis performed showed gender differences in some of these relationships. Finally, the results and their implications in the field of family intervention are discussed.