Family History Of Vitiligo Research Articles

Vitiligo as a Reaction to Topical Treatment with Diphencyprone

During the topical treatment of 45 patients, who had extensive forms of alopecia areata, with the allergen diphencyprone, 3 of them (6.7%) developed vitiligo. Two were females and 1 male aged 53, 19 and 28 years respectively. None of these patients had a personal or family history of vitiligo. Vitiligo appeared 3-5 months after the onset of treatment and was localized only to the areas of topical application in the younger woman and the man. In the older woman, vitiligo extended to several areas apart from those where the medicament was applied. After the end of diphencyprone treatment, vitiligo had a spontaneous significant improvement only in the man. Mitochondrial autoantibodies were found in the older woman only. To our knowledge, vitiligo due to diphencyprone has not been previously reported.

Disappearance of a Nevocellular Nevus With Depigmentation

Incomplete depigmentation of a congenital nevocellular nevus has been reported previously.^1,2We report herein the complete resolution of a fairly large nevus with depigmentation, followed by partial repigmentation. <h3>Report of a Case</h3> A 2-year-old boy was first seen in August 1979 with a history of a nevus of the extensor surface of the right arm present since birth. He had no family history of vitiligo, halo nevi, congenital nevi, or malignant melanoma. On examination, the lesion was a 5.5 × 1.8-cm, raised, brown, scaly, nonhairy nevus (Fig 1). Surgical removal of the lesion was planned for about three years later. Seven months after the initial examination, however, the nevus was smaller, measuring 4.7 × 1.7 cm with a faint marginal depigmentation (Fig 2). There had been no pruritus and there was no erythema present at that time. Marked, progressive depigmentation of the lesion was noted when the patient's age