Family History Of Osteoarthritis Research Articles

An evaluation of knee osteoarthritis pain in the general community-Asir region, Saudi Arabia.

Knee osteoarthritis (KOA) is one of the most common conditions resulting in disability, particularly in the elderly population. Osteoarthritis (OA) is the most common articular disease and the leading cause of chronic disability in the developed world. This study was carried out to evaluate knee pain in the Asir region of Saudi Arabia. An analytical cross-sectional survey design was adopted in the Asir region from April 2023 to August 2023 to assess the knee pain of the adult population using an anonymous online questionnaire. Of 1234, 332 were men (26.90) and 902 were women (73.09). WOMAC index score category 55.34% (n = 683) of the subjects had a low risk (score <60), 28.68% (n = 354) had a moderate risk (score 60-80), and 15.96% (n = 197) had a high risk (score ≥81) for KOA. According to clinical criteria, 79.33% (n = 979) of the study subjects had OA. Age group, gender 2.17 (1. 67-2.82) [OR 2.17; 95% CI 1.67-2.82), family history of OA [OR 0.47; 95% CI 0.37-0.62], diabetes [OR 2.78; 95% CI 2.17-3.56], hypertension [OR 0.35; 95% CI 0.26-0.45] were significantly associated with the percentage of the WOMAC index score using the Chi-square test analysis (P<0.05). Therefore, the WOMAC index showed higher diagnostic precision with a statistically significant association [OR 9.31 CI 6.90-12.81] with a P< 0.0001. KOA is more common in older, obese people who have reached the age of 50 in the Asir region, and it is more prevalent in women. Alarms the need for appropriate awareness programs for better disease prevention and health outcomes for the benefit of the community through general public health programs.

Prevalence of Symptomatic Knee Osteoarthritis in Saudi Arabia and Associated Modifiable and Non-Modifiable Risk Factors: A Population-Based Cross-Sectional Study

This study aimed to determine the prevalence of knee osteoarthritis (OA) in Saudi Arabia and the association between knee OA and modifiable and non-modifiable risk factors. A self-reported, population-based, cross-sectional survey between January 2021 and October 2021 was conducted. A large, population-representative sample (n = 2254) of adult subjects aged 18 years and over from all regions of Saudi Arabia was collected electronically using convenience sampling. The American College of Rheumatology (ACR) clinical criteria were used to diagnose OA of the knee. The knee injury and osteoarthritis outcome score (KOOS) was used to investigate the severity of knee OA. This study focused on modifiable risk factors (body mass index, education, employment status, marital status, smoking status, type of work, previous history of knee injury, and physical activity level) and non-modifiable risk factors (age, gender, family history of OA, and presence of flatfoot). The overall prevalence of knee OA was 18.9% (n = 425), and women suffered more compared to their male counterparts (20.3% vs. 13.1%, p = 0.001). The logistic regression analysis model showed age (OR: 1.06 [95% CI: 1.05-1.07]; p < 0.01), sex (OR: 2.14 [95% CI: 1.48-3.11]; p < 0.01), previous injury (OR: 3.95 [95% CI: 2.81-5.56]; p < 0.01), and obesity (OR: 1.07 [95% CI: 1.04-1.09]; p < 0.01) to be associated with knee OA. A high prevalence of knee OA underlines the need for health promotion and prevention programmes that focus on modifiable risk factors to decrease the burden of the problem and the cost of treatment in Saudi Arabia.

Association of DVWA rs11718863 Gene Polymorphism with Knee Osteoarthritis in Iraqi Patients

Background: Osteoarthritis (OA) is a complex degenerative articular disease that has an ambiguous pathogeny because variant risk factors participate in the process of cartilage deterioration. Genetic factors may have a role in the onset and progression of OA. Objective: To investigate potential association between severity of knee OA (KOA) and Double von Willebrand factor A domains DVWA rs11718863 gene polymorphism. Methods: One hundred and twenty Iraqi patients diagnosed with KOA, aged (45 years and above) and sixty healthy people (control) at the same age range, with no family history of OA were evaluated at Al-Imamein Al-Kadhimein Medical City (Rheumatology Department). The degree of severity of KOA was assessed by clinical and radiographic assessment. DVWA rs11718863 genotyping was performed using DNA sequencing (Sanger’s method). Results: Two different genotypes wild homozygote (TT) genotype and heterozygote (AT) appeared by genotyping of DVWArs:11718863. Highly significant difference (p&lt;0.001) was found in distribution of the two genotypes in the three study groupsl the genotype (TT) was more frequent in control group (95.0%). Also, high significant difference (p&lt;0.001) was noted in the two alleles (A, T) frequencies between control group and KOA patients group giving odd ratio 6.437 with 95% confidence intervals of (1.93-21.42). Conclusion: Iraqi subjects carrying AT genotype of DVWA rs11718863 gene are mostly susceptible for developing of KOA and the allele A of Tyr169Asn polymorphism are more frequent in those patients indicating that allele A may be a risk factor of onset of this disease. Age and body mass index are considered risk factors of onset and progression of KOA. Keywords: Double von Willebrand factor A domains (DVWA), single nucleotide polymorphism (SNP), body mass index, Knee osteoarthritis, KOA Citation: Hasan NN, Alwasiti EA, Ahmed MH. Association of DVWA rs11718863 gene polymorphism with knee osteoarthritis in Iraqi patients. Iraqi JMS. 2022; 20(2): 207-216. doi: 10.22578/IJMS.20.2.7

An Assessment of Risk Factors Associated with Osteoarthritis: A Study in a Tertiary Care Hospital of Bangladesh

Introduction: Osteoarthritis (OA) is a common musculoskeletal disorder which occur in different patterns. It is the most common form of arthritis, affecting millions of people worldwide year after year. It occurs when the protective cartilage that cushions the ends of your bones wears down over time. OA can damage any joint that affects joints in one’s hands, knees, hips and spine. As there had been very few studies in Bangladesh we have not enough data regarding the risk factors of osteoarthritis. Objective: The aim of this prospective observational study was to evaluate the risk factors associated with osteoarthritis (OA). Methodology: This was a retrospective study which was conducted at the Department of Orthopedics Surgery in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from January 2018 to December 2018. Data were collected by a pre-designed questioner and analyzed by computer program, SPSS Version 20. Incomplete data-sheets were rejected before analysis and finally total study population was fixed to 146 with Osteoarthritis (OA). Result: Risk factor, family history was associated with 29 (19.86%) patients. It was the highest engagement and it was followed by Diabetes Mellitus: 27 (18.49%), history of injury: 14 (9.59%), Hypertension: 12 (8.22%) and previously operated: 7 (4.79%). In This study the comparison of sample data regarding risk factors have been displayed. Here against ACR, LEFS, K and L and VAS score P values were 0.876, 0.893, 0.067 and 0.436 respectively. So there was not any significant correlation. Conclusion: In this study ‘family history of osteoarthritis’ and ‘Diabetes Mellitus (DM)’ were two most frequent risk factors which was associated with osteoarthritis. But we did not find any significant correlation regarding any risk factor. More studies regarding OA are necessary to get the clear concepts about this issue.

Vitamin D receptor gene variants contribute to hip and knee osteoarthritis susceptibility

Vitamin D receptor (VDR) gene polymorphisms could play a significant role in the susceptibility and pathogenesis of osteoarthritis (OA), the most common degenerative joint disorder in humans. The current study involved 94 OA patients and 100 healthy, asymptomatic controls. VDR variants FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) and EcoRV (rs4516035) were genotyped using TaqMan-based real-time PCR. Adjusted odds ratio (OR) analysis showed that VDR TaqI and FokI polymorphisms are significantly associated with susceptibility to OA (OR=1.986, P=0.001 and OR=1.561, P=0.017, respectively). Joint-specific analysis showed that the VDR TaqI polymorphism was associated with risk of hip OA (OR=1.930, P=0.005) and knee OA (OR=1.916, P=0.028), while the VDR FokI polymorphism was associated with higher risk of knee OA (OR=2.117, P=0.012). VDR TaqI and FokI polymorphisms are associated with the occurrence of persistent pain (P=0.005 and P=0.027, respectively), while ApaI was associated with a family history of OA (p=0.004). The VDR FokI and TaqI genetic variants significantly contribute to osteoarthritis susceptibility, the occurrence of persistent pain, and potentially to joint-specific OA risk.

Age-Related Macular Degeneration in Primary Osteoarthritis Egyptian Patients.

IntroductionBoth primary osteoarthritis (OA) and age-related macular degeneration (AMD) cause disability in old people. This study aimed to detect the relation between primary osteoarthritis and age-related macular degeneration in a sample of geriatric Egyptian population.MethodsThis cross-sectional study included 222 primary OA patients. Medical history, musculoskeletal examination, body mass index (BMI) calculation, and ophthalmological examination, radiographs of anteroposterior view and weight-bearing position for both hips and both knees and posteroanterior view for hands, Kellgren and Lawrence grading score for radiological severity of OA, optical coherence tomography (OCT), and fundus fluorescence angiography FFA for evaluation of the macula were done. AMD was classified into early, intermediate, and late. The collected data were analyzed using SPSS version 25.0.ResultsForty-six OA patients had AMD [19 cases had early, 15 cases had intermediate and 12 cases with late (7 neovascular (NV) and 5 geographic atrophy (GA))]. There was a significant correlation between AMD stages and OA grading score. There were significant differences between OA patient with AMD and those without AMD regarding age, disease duration, disease severity, family history of OA, daily mild exercise and calcium, and vitamin D intake. Multivariable analysis revealed that older age, more severe OA, low exercise and less calcium and vitamin D intake were considered independent risk factors for AMD development in primary OA.ConclusionPrimary OA patients are more liable to AMD due to common risk factors and related pathogenesis. Ophthalmological follow up of those patients is recommended.

Prevalence, Risk Factors and Primary Prevention of Osteoarthritis in Asia: A Scoping Review

Introduction: Osteoarthritis (OA) is estimated to be the eleventh leading cause of disability worldwide. In Asian countries, OA is much less well-known than in the caucasian population and strongly associated with aging. Therefore, this article focuses comprehensively on the prevalence, risk factors and primary prevention for OA identified in Asian countries.&#x0D; &#x0D; Methods: This scoping review used the methodological framework by Arksey and O'Malley (2005). Pertaining to this topic, a comprehensive search on academic journals published from 2008 to 2018 (English) was conducted.&#x0D; &#x0D; Results: A total of 30 studies were selected in this review from 221,510 studies screened from electronic databases. The overall prevalence of OA is in a range of 20.5% to 68.0%. Most of the Asian populations reported to have knee OA in a range of 13.1% to 71.1% in various Asian countries. Risk factors that have been associated with OA are advanced age, being the female and obesity. Osteoporosis, higher body mass density, low level of education, family history of OA, smoking and environmental factors appeared as significant risk factors for OA. A strategic method of primary prevention for OA through lifestyle modification is reducing obesity and treating concomitant cardiovascular disease.&#x0D; Conclusion: Determining OA prevalence and risk factors will provide important information for planning future cost-effective preventive strategies.

Occupation-related physical activities in osteoarthritis of the knee in female

The aim of this study was to determine the role of occupation-related physical activities in the osteoarthritis of the knee. The study was conducted on 87 female patients from September 2016 to August 2017. The same number of healthy females of the same age group were included as a control. Data was collected using a structured interviewer-administered questionnaire, enquiring about demographic data and details of risk factors. There were statistically significant (p&lt;0.05) changes in the occupation-related physical activities like sustained knee bending, climbing stairs (&gt;10 flights/day), kneeling (&gt;30 min/day), squatting (&gt;30 min/day), in patients when compared to the control group. However, there were no significant changes in other occupation-related physical activities. Obese (BMI ≥30 kg/m2) patients were found 29.9% in the patient and 17.2% in the control group. Patients with a positive family history of osteoarthritis of the knee were 13.8% in the case group and 3.4% in the control group. The difference was statistically significant (p&lt;0.05) between the two groups. In conclusion, occupation-related physical activities like sustained knee bending, climbing stairs, kneeling and squatting had a significant association with osteoarthritis of the knee in the female.

Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study.

To determine risk factors for 3 knee osteoarthritis (KOA) outcomes, knee pain (KP), radiographic KOA (RKOA), and total knee replacement (TKR) in professional footballers. This was a cross-sectional study involving a postal questionnaire, followed by radiographic assessment in a subcohort of responders. Four thousand seven hundred seventy-five questionnaires were sent to retired professional footballers, who had played in the English football league, and 1207 responded. Of these, 470 underwent knee radiographs. Potential factors include age, body mass index (BMI), knee alignment, a history of football-related knee injury, and training hours (during career) were collected through the questionnaire. Knee osteoarthritis outcomes were current KP (pain for most days of the previous month), TKR (self-reported), and RKOA (observed through radiographs). Football-related injury was the strongest risk factor for KP [adjusted odds ratio (aOR), 4.22; 95% confidence interval (CI), 3.26-5.48], RKOA [aOR, 2.88; 95% CI, 1.81-4.59], and TKR [aOR, 4.83; 95% CI, 2.87-8.13]. Footballers had a 7% increased risk of RKOA for every 1000 hours trained. Although age and gout were associated with all 3 KOA outcomes, BMI, nodal osteoarthritis (OA), a family history of OA, knee malalignment, and 2D:4D ratio were associated with one or another of these 3 KOA outcomes. This study is the first to examine KOA risk factors in retired professional footballers. The study has identified several risk factors, both specific (eg, knee injury and training dose) and nonspecific (eg, age and gout) to footballers. This may be used to develop prevention strategies to reduce the risk of KOA in professional footballers after retirement.

Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29\u201359\xa0year olds in Denmark: a cross-sectional analysis

BackgroundThis study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29–59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain.MethodsParticipants completed the “Early Detection and Prevention” pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described.ResultsTwo thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29–39 year old men. A higher BMI was associated with persistent knee/hip pain in 40–59 year old women, and 50–59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain.ConclusionsKnee/hip pain within the last month was frequent among individuals aged 29–59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis.Trial registrationClinicalTrials.gov (NCT02797392). Registered April 29,2016.

The prevalence of osteoarthritic symptoms of the hands amongst female massage therapists

Background: Numerous occupations increase one's risk of developing osteoarthritis. Massage therapists rely heavily on their hands and cumulative hand strain injuries that occur whilst performing a massage may lead to the development of osteoarthritic symptoms. Females are at greater risk of developing osteoarthritis. Furthermore age weight, genetic predisposition; working years, working hours as well as body mass index all increase the risk of developing osteoarthritis.Objective: This study sought to investigate the prevalence of osteoarthritic symptoms of the hands amongst female massage therapists, as well as to establish both an average age of symptomatic onset and whether their daily work productivity was influenced.Materials and methods: Since the massage industry is predominantly practiced by females, female massage therapists, irrespective of age and registered with a South African Regulating Body were included. Participants were required to complete a self-administered questionnaire which evaluated age, self-reported symptomatic presence of and family history of osteoarthritis, and body mass index. Participants also completed the AUSCAN™ Hand Osteoarthritis Index LK3.1 (Australian/Canadian Hand Osteoarthritis Index) which assesses pain, disability and joint stiffness of the hands. The sample was divided into two groups based on the presence or absence of self-reported symptoms. All gathered data was analysed by the University of Johannesburg's statistics department (Statkon) by use of IBMSPSS Statistics software version 21.Results: The mean age of symptomatic presentation was 43 years. The AUSCAN™ Index found that more than half of the total sample reported osteoarthritic symptoms in their hands. Participants in the non-symptomatic group also indicated a positive response to symptoms on the AUSCAN™ Index although they did not self-report a symptomatic onset age.Conclusion: In this sample, massage therapists experienced osteoarthritic symptoms that cause pain and stiffness in their hands. It also seemed evident that the symptoms experienced were also responsible for placing strain on their ability to perform daily tasks. This study serves as a basis for further dialogue, research and professional awareness.

Vitamin C Intakeand Risk Factors for Knee Osteoarthritis

Background : Knee osteoarthritis (OA) is a degenerative disease of the knee joints characterized by progressive softening and disintegration of articular cartilage. In OA, which is influenced by several risk factors, free radicals are increased by local ischemia in the cartilage. As an exogenous antioxidant, vitamin C also plays an important role in collagen and glycosaminoglycan synthesis. This study was carried out to identify vitamin C intake as well as risk factors in knee OA. Methods : The study population was determined by non-probability sampling with convenient approach to knee OA patients at the Rheumatology Outpatient Clinic of Dr. Hasan Sadikin General Hospital in October–November 2013. Data were obtained through questionnaire interview about risk factors, severity index of OA and vitamin C intake profile. Data presentation was conducted by descriptive method. Results : There were 47 patients diagnosed with knee OA in the Rheumatology Outpatient Clinic. The result showed that 7 patients (14.9%) had low vitamin C intake for the last 3 months. There were 30 patients with family history of OA (63.8%). Thirty two patients (68.1%) were passive smokers, 44 patients (93.6%) had history of repeated use of knee joints and majority of respondents had obesity. Conclusions : Most of the subjects have sufficient vitamin C intake and more than half have risk factors that may contribute to the incidence of knee OA. DOI: 10.15850/amj.v4n2.1067

The prevalence of osteoarthritic symptoms of the hands amongst female massage therapists

BackgroundNumerous occupations increase one's risk of developing osteoarthritis. Massage therapists rely heavily on their hands and cumulative hand strain injuries that occur whilst performing a massage may lead to the development of osteoarthritic symptoms. Females are at greater risk of developing osteoarthritis. Furthermore age weight, genetic predisposition; working years, working hours as well as body mass index all increase the risk of developing osteoarthritis. ObjectiveThis study sought to investigate the prevalence of osteoarthritic symptoms of the hands amongst female massage therapists, as well as to establish both an average age of symptomatic onset and whether their daily work productivity was influenced. Materials and methodsSince the massage industry is predominantly practiced by females, female massage therapists, irrespective of age and registered with a South African Regulating Body were included. Participants were required to complete a self-administered questionnaire which evaluated age, self-reported symptomatic presence of and family history of osteoarthritis, and body mass index. Participants also completed the AUSCAN™ Hand Osteoarthritis Index LK3.1 (Australian/Canadian Hand Osteoarthritis Index) which assesses pain, disability and joint stiffness of the hands. The sample was divided into two groups based on the presence or absence of self-reported symptoms. All gathered data was analysed by the University of Johannesburg's statistics department (Statkon) by use of IBM SPSS Statistics software version 21. ResultsThe mean age of symptomatic presentation was 43 years. The AUSCAN™ Index found that more than half of the total sample reported osteoarthritic symptoms in their hands. Participants in the non-symptomatic group also indicated a positive response to symptoms on the AUSCAN™ Index although they did not self-report a symptomatic onset age. ConclusionIn this sample, massage therapists experienced osteoarthritic symptoms that cause pain and stiffness in their hands. It also seemed evident that the symptoms experienced were also responsible for placing strain on their ability to perform daily tasks. This study serves as a basis for further dialogue, research and professional awareness.

Factors predicting progression of hip osteoarthritis: a systematic review

Purpose: The goal was to systematically review the literature on factors predictive for progression in patients with hip osteoarthritis (OA). Methods: A systematic search was done in Embase, Medline (OvidSP), Web-of-science, Cochrane library, PubMed publisher and Google scholar from origin until August 8th 2016. Reference lists of relevant articles were screened. Studies were included if they met the following criteria: 1. Studies had a cohort or case control design, 2. they studied the association between factors (patient variables, disease characteristics or chemical/imaging markers) and progression (measured clinically, radiologically or receiving total hip replacement, THR), 3. patients had reported complaints like pain, disability or stiffness of the hip, suspected or confirmed (radiological or clinical) to originate from hip OA, 4. follow-up was at least 1 year, 5. hip OA caused by specific conditions was excluded. Risk of bias was assessed independently by two reviewers using the QUIPS tool. If clinical heterogeneity was considered low, study results were pooled per factor. If pooling was considered not appropriate a best evidence synthesis was conducted. The best evidence synthesis was conducted as follows: associations were categorized as positive, negative or no association. The ranking of levels of evidence was formulated as 1. Strong evidence: consistent finding (≥ 75% of the studies showing the same association) in multiple studies with a low risk of bias in all domains of the QUIPS tool, 2. Moderate evidence: consistent findings (≥75% of the studies showing the same association) in multiple studies with a moderate of high risk of bias in one or more domains of the QUIPS tool, 3. Limited evidence: one study with a low risk of bias in all domains of the QUIPS tool or 2 studies with moderate of high risk of bias in one or more domains of the QUIPS tool, 4. Conflicting evidence: <75% of the studies showing the same association, 5. No evidence: No studies found. Results: We included 56 different articles, describing 147 different factors. Three studies were assessed as low risk of bias in all domains of the QUIPS tool. Seventy-nine factors were reported once (one study). The clinical heterogeneity of the studies describing the other 68 factors (reported more than once) was considered too large to conduct a meta-analysis. Therefore we conducted a best evidence synthesis, separately for each factor regarding clinical progression (C), radiological progression (R) or progression to THR (T). No strong evidence was found for any prognostic factor. Moderate evidence was found for more or faster progression in patients having comorbidity (C), a family history of OA (R), more pain at baseline (T), a lower global assessment reported by the patient at baseline (T), certain modes created by statistical shape modelling (T) and a higher K-L grade at baseline (T). Moderate evidence for no association with progression was found for female gender (T+C), longer duration of symptoms at baseline (T), BMI (R), Diabetes Mellitus (R), Forestier’s disease (R), NTX-I (R), higher age at baseline (C), employment (C), social support (C), living alone (C), concurrent knee pain (C), depression (C), quality of life at a baseline (C), use of pain medication (C), range of motion of internal and external hip rotation (C). Conclusions: No strong evidence was found for prognostic factors of the progress of hip OA. Moderate evidence for an association or for no association with progression was found for several factors, while conclusions for most factors were inconclusive.

Identification of a serum protein biomarker panel for the diagnosis of knee osteoarthritis

s / Osteoarthritis and Cartilage 24 (2016) S8eS62 S23 knee criteria and included features related to osteophytes, cartilage damage, bone marrow lesions, subchondral cysts and labral lesions. Logistic regression analysis was used to evaluate the association of FAI with moderate cartilage damage ( 2), moderate BML ( 2) and MRI-OA. Analyses were adjusted for age, sex, body mass index and family history of OA and, in secondary analyses, also for physical activity. Results: Subjects in the MRI study (n 1⁄4 182) had mean age 43.5 years, mean BMI 26.8, mean WOMAC pain 14.4 and 65.4% were female. FAI was present in 48.9% and hip pain in 51.7%. Cartilage score 2, BML 2 and MRI-OA were present in 11.0%, 9.9% and 8.9%, respectively. FAI was not significantly associated with cartilage damage 2 (OR 2.0, 95% CI 0.7e5.5) and this relationship remained non-significant after adjustment for physical activity (OR 1.8, 95% CI 0.6e5.2). There was a statistically significant association of FAI with BML 2 (OR 4.7, 95% CI 1.4e16.0) and with MRI-OA (OR 3.4, 95% CI 1.1e12.3). Additional adjusting for physical activity did not change the findings for BML (OR 4.2, 95% CI 1.4e14.7) and MRI-OA (OR 2.9, 95% CI 0.9e10.6), although the latter was only of borderline statistical significance. Conclusions: In this population-based cross-sectional study of young adults, the risk of moderate BML and MRI-defined OA was significantly increased in subjects with radiographic FAI compared to those without radiographic FAI. No association was found for FAI with moderate cartilage damage. These findings suggest that FAI is linked to early osteoarthritic changes onMRI in young adults. Whether BML is a precursor to future cartilage damage and radiographic OA requires longitudinal evaluation of this cohort. 27 IDENTIFICATION OF A SERUM PROTEIN BIOMARKER PANEL FOR THE DIAGNOSIS OF KNEE OSTEOARTHRITIS L. Lourido y, B. Ayoglu z, J. Fern andez-Tajes x, F. Henjes z, J.M. Schwenk z, C. Ruiz-Romero y, P. Nilsson z, F.J. Blanco y. yRheumatology Div., ProteoRed/ISCIII Proteomics Group, INIBIC e Hospital Universitario de A Coru~ na, Spain; zAffinity Proteomics, SciLifeLab, Sch. of Biotechnology, KTH-Royal Institute of Technology, Stockholm, Sweden; xWellcome Trust Ctr. For Human Genetics, McCarthy's Group, University of Oxford, Oxford, United Kingdom Purpose: Osteoarthritis (OA) is the most common rheumatic disease. Despite the active research in the OA biomarker field, no single protein is sufficiently reliable for its use in OA diagnosis. This is mainly due to the lack of validation studies in large populations, making the findings questionable to be considered as robust biomarkers for the OA joint turnover. In this study we addressed a large-scale study with the aim of search for proteins that could serve as potential indicators of knee OA. Methods: Antibody suspension bead arrays were applied to profile serum samples from patients with knee OA (n 1⁄4 288) with different Kellgren-Lawrence (K/L) scores and compare to patients with rheumatoid arthritis (RA, n 1⁄4 288), psoriatic arthritis (PsA, n 1⁄4 288) and healthy control (n 1⁄4 96) subjects with non-radiographic knee osteoarthritis. The serum protein content was labelled and protein profiles obtained using 174 antibodies from the Human Protein Atlas targeting 78 different proteins. A focused bead array was then built to further profile 46 selected protein targets as a replication of the first findings and also to validate these results in an independent cohort of serum samples composed by patients with OA (n 1⁄4 196), RA (n 1⁄4 192), PsA (n1⁄4 192) and healthy control individuals (n1⁄4 92). The panel of proteins proposed and analysed for this study was selected based on previous internal protein profiling studies in the context of rheumatic diseases. For the statistical analysis, a lineal regression analysis adjusting by sex, age and body mass index (BMI) was applied to observe differences in protein profiles between compared groups and these were denoted statistically significant if they concordantly revealed p.values 2-fold increase in the risk of incident ROA, while sarcopenia alone had no increased risk, compared with those who were non-obese non-sarcopenic (Table 1). This association of obesity persisted after adjustment for body weight. Similar results were

Is rugby playing load predictive of lower limb osteoarthritis in former international rugby players?

Purpose: Rugby union (rugby) is a full contact collision sport with global participation of over 7.23 million men, women and children across 120 countries. Osteoarthritis (OA) is a leading cause of pain and chronic disability globally, more commonly diagnosed in older populations. There is a known association between injury and the development of OA; however the relationship between sport, exercise and injury remains ill-defined. As participation in rugby continues to rise and sport, exercise and physical activity are promoted, it is important to understand whether there is an association between sporting exposure and joint loading attributable to sports participation, and any subsequent development of negative musculoskeletal outcomes of the lower limb. The aim of this study was to describe the prevalence of OA within a cohort or former elite International rugby players, and examine which potentially modifiable rugby-related and injury-related risk factors are most predictive of OA-related outcomes. Methods: A cross-sectional questionnaire was sent to former English International rugby players. Both postal and online recruitment strategies were used. Players received an initial overview describing the study’s aims and objectives before its launch, a formal approach to participate following its launch, and reminder communications. Former players reported their playing history, injury history, family history of OA, current pain, sentiments on their rugby career and the sport, and an abbreviated medical history. GP-diagnosed wear and tear, degeneration or OA and joint replacement were reported per person and by joint. Rugby-specific risk factors of total playing duration, duration at International level and total number of matches were tested for association with the primary outcome of any OA (physician diagnosed or joint replacement) at any joint; and the secondary outcome of site-specific OA at the knee or hip. Injury-specific risk factors of any rugby injury, and any joint-specific rugby injury were assessed for association with any OA and lower limb joint-specific OA. Univariable logistic regression was used to assess the association of each predictor with the primary and secondary outcomes. Results: 138 participants responded to this questionnaire. Participant demographics (mean (SD)) are: Age, 62 (15.5); Height 1.8 (0.1) m; Weight, 94.8 (16.2) kg; BMI, 28.9 (3.5) kg/m2. The prevalence of any GP-diagnosed OA was 61.5% and any joint replacement was 27.0%. GP-diagnosed OA at the hip was reported by 19.6% of respondents, with 16.9% reporting hip replacement. GP-diagnosed OA at the knee was reported by 38.5% of players, with 12.2% reporting knee replacement. The majority of players reflected positively on their playing career, with 90.5% of players stating that they would do the same again. Most players would recommend the sport to their relatives (74.3%) and 90.5% of players felt that rugby had enriched their lives. The mean (SD) playing load values are: total years rugby, 32.7 (4.5); number of seasons at International level, 3.8 (2.6); number of matches, 437.7 (185.5). The vast majority of players reported having had a severe injury, defined as 4 weeks or more of reduced participation in exercise, training or sport (86.7%). Severe injury of the knee was more prevalent (38.5%) than for the hip (20.3%). In this unadjusted univariable logistic regression of rugby-related predictors, no association was found between rugby playing load and OA outcomes at any or specific joints (Table 1 - * denotes significance). Rugby-related injury was found to be associated with GP-diagnosed OA, and associations were found between joint-specific rugby injury and OA of the hip (GP-diagnosed and joint replacement) and knee (GP-diagnosed). Conclusions: This study has described the prevalence of OA-outcomes in this population, and demonstrates a higher prevalence of hip and knee OA than many other population-based studies which range from 5.4 to 14.3 for symptomatic radiographic OA of the knee and 0.7–5.5 for symptomatic radiographic OA of the hip. The association of rugby injury (any, knee and hip) with OA reaffirms data previously published, suggesting an increased risk of the development of OA following joint injury. This study has shown that rugby playing load is not predictive of negative OA-outcomes in later life, at the knee and hip. The strong association of rugby injury with OA-outcomes at the knee and hip reinforces that injury is the most significant modifiable-risk factor of these predictors.Table 1The association between rugby and injury-specific risk factors and OA-outcomesPredictorAny GP OAAny TJRGP: HipTJR: HipGP: KneeTJR: KneeInjuryOR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)Any1.93 (.71–5.22)0.73 (.25–2.11)2.25 (.49–10.40)1.09 (.29–4.08)1.84 (.62–5.49)0.64 (.17–2.50)Any rugby injury2.57 (1.11–5.94)*0.73 (.30–1.79)0.87 (.32–2.39)0.69 (.25–1.93)2.14 (.85–4.43)0.56 (.18–1.72)Joint-specific rugby injury––4.88 (1.99–11.92)*6.75 (2.65–17.24)*7.15 (3.04–16.78)*1.73 (.58–5.15)RugbyTotal years of play0.96 (.88–1.03)0.97 (.89–1.06)0.97 (.87–1.07)0.97 (.87–1.08)0.97 (.91–1.07)1.03 (.92–1.15)Years at highest level1.03 (.90–1.17)0.99 (.86–1.14)0.99 (.85–1.16)0.95 (.80–1.13)1.01 (.90–1.16)0.96 (.79–1.16)Number of games0.99 (.99–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00) Open table in a new tab

Osteoarthritis of knee and factors associated with it in middle aged women in a rural area of central Kerala, India

Background: Osteoarthritis is the fourth leading cause of years lived with disability around the world. Prevalence of osteoarthritis is more in females compared to males. Objective of the study is to find out the prevalence of osteoarthritis of knee in middle aged women and factors associated with it. Methods: A cross -sectional study was conducted in ward 16 of Ettumanoor panchayat. A total of 375 women above 40 years were included in the study. The data was collected at their residences using a semi structured interview schedule which include demographic details and various factors associated with osteoarthritis. Weight, height, waist circumference were measured and knee joint examination was done. Data analyzed by SPSS version 19.0.The factors that were found to have a statistical significant relationship with osteoarthritis were analyzed using logistic regression. Results: The prevalence of knee osteoarthritis in the study sample was 41.6% (95% CI- 41.6±1.25%). Among them 66.2% have bilateral osteoarthritis of knee joint. The factors that had a significant association with osteoarthritis were increasing age (p value of 0.001(OR=2.47(1.61-3.79), attained menopause or not (p value of 0.001(OR=3.15(1.96-5.06), underwent hysterectomy or not (p value of 0.038) (OR=2(1.02-4.04), family history of osteoarthritis (p value of 0.035 (OR=1.61(1.04-2.61), BMI>30 ( p value of 0.027(OR=1.86 (1.03-3.33), and history of trauma to the knee joint (p value of 0.042 (OR=1.51(0.88-2.59). Conclusions: The prevalence of knee osteoarthritis in the study was 41.6% and the factors associated with knee osteoarthritis as per the study were increasing age, attainment of menopause, hysterectomy, family history of osteoarthritis, BMI>30 and history of trauma to the knee joint.

Risk and risk perception of knee osteoarthritis in the US: a population-based study

We sought to investigate risk perception among an online cohort of younger US adults compared with calculated risk estimates. We recruited a population-based cohort 25-44 years of age with no history of knee osteoarthritis (OA) using Amazon's Mechanical Turk, an online marketplace used extensively for behavioral research. After collecting demographic and risk factor information, we asked participants to estimate their 10-year and lifetime risk of knee OA. We compared perceived risk with risk derived from the OA risk calculator (OA Risk C), an online tool built on the basis of the validated OA Policy Model. 375 people completed the study. 21% reported having 3+ risk factors for OA, 25% reported two risk factors, and 32% reported one risk factor. Using the OA Risk C, we calculated a mean lifetime OA risk of 25% and 10-year risk of 4% for this sample. Participants overestimated their lifetime and 10-year OA risk at 48% and 26%, respectively. We found that obesity, female sex, family history of OA, history of knee injury, and occupational exposure were all significantly associated with greater perceived lifetime risk of OA. Risk factors are prevalent in this relatively young cohort. Participants consistently overestimated their lifetime risk and showed even greater overestimation of their 10-year risk, suggesting a lack of knowledge about the timing of OA onset. These data offer insights for awareness and risk interventions among younger persons at risk for knee OA.

Clinical Profile, Level of Affection and Therapeutic Management of Patients With Osteoarthritis in Primary Care: The Spanish Multicenter Study EVALÚA

ObjectiveTo determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis. MethodsObservational study (health centres from 14 autonomous regions, n=363 primary care physicians), involving patients with clinical and/or radiological criteria from the American College of Rheumatology, consecutively selected (n=1258). Sociodemographic variables, clinical and radiological findings, comorbidity and therapeutic management were analysed. ResultsMean age was 68.0±9.5 years old; 77.8% were women and 47.6% obese. Distribution by location was 84.3% knee, 23.4% hip, and 14.7% hands.All patients reported pain. The most frequent radiographic Kellgren-Lawrence grade was stage III for knee and hip (42.9% and 51.9%, respectively), and III (37.2%) and II (34.5%) for hip.Time since onset of osteoarthritis symptoms was 9.4±7.5 years, with a mean age at onset of around 60 years and a family history of osteoarthritis in 66.0%.The most frequent comorbidities were hypertension (55.1%), depression/anxiety (24.7%) and gastroduodenal diseases (22.9%).A total of 97.6% of the patients received pharmacological treatment, with oral analgesics (paracetamol) (70.5%) and oral NSAIDs (67.9%) being the most frequent drugs.Bilateral osteoarthritis was present in 76.9% of the patients with knee osteoarthritis, 59.3% in hip and 94.7% in hands. Female gender and time since onset were associated with bilateral knee and hip osteoarthritis. ConclusionsThe profile of the osteoarthritis patient is female, >65 years old, overweight/obese, with a comorbidity, frequent symptoms and moderate radiologic involvement. Most of the patients had bilateral osteoarthritis, associated with female gender and time since onset of disease. Paracetamol was the most common pharmacological treatment.

Perfil clínico, grado de afectación y manejo terapéutico de pacientes con artrosis en atención primaria: estudio multicéntrico nacional EVALÚA

ObjectiveTo determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis. Material and methodObservational study (health centers from 14 autonomous regions, n=363 primary care physicians), involving patients with clinical and/or radiological criteria for osteoarthritis from the American College of Rheumatology, consecutively selected (n=1,258). Sociodemographic variables, clinical and radiological findings, comorbidity and therapeutic management were analyzed. ResultsMean age was 68.0±9.5 years old; 77.8% were women and 47.6% obese. Distribution by location was: 84.3% knee, 23.4% hip, 14.7% hands.All patients reported pain. The most frequent radiographic Kellgren-Lawrence grade was stage 3 for knee and hip (42.9% and 51.9%, respectively), and 3 (37.2%) and 2 (34.5%) for hip.Time since onset of osteoarthritis symptoms was 9.4±7.5 years, with a mean age at onset of around 60 years old and a family history of osteoarthritis in 66.0%.The most frequent comorbidities were: hypertension (55.1%), depression/anxiety (24.7%) and gastroduodenal diseases (22.9%).A total of 97.6% of the patients received pharmacological treatment, with oral analgesics (paracetamol) (70.5%) and oral NSAIDs (67.9%) being the most frequent drugs.Bilateral osteoarthritis was present in 76.9% of patients with knee osteoarthritis, 59.3% in hip and 94.7% in hands. Female gender and time since onset were associated with bilateral knee and hip osteoarthritis. ConclusionsThe profile of the osteoarthritis patient is female, >65 years old, overweight/obese, with comorbidity, frequent symptoms and moderate radiologic involvement. Most of patients had bilateral osteoarthritis, associated with female gender and time since onset of disease. Paracetamol was the most common pharmacological treatment.