Family Health History Research Articles

Promoting health information and healthy behaviors: Results from a qualitative study

Abstract Background and aim Healthy living behaviors can prevent many chronic diseases. This study aimed to explore qualitative perceptions and behaviors about healthy lifestyles in a district’s residents. Methods This qualitative research was conducted through in-depth interviews with 24 participants aged 28 to 63 in Türkiye. Results Of the 24 participants, six were men. The themes were daily routines; health information-seeking behavior, beliefs, motivation for healthy living, dietary habits, daily movement, psychological relaxation, unhealthy behaviors, facilitators, and barriers. Individuals’ daily routines were shaped by caregiving duties or work. Health information was preferred from professionals, TV, family health history, and the Internet. Male participants lacked the need to seek health information. Also, some participants believed that diseases are unavoidable and incurable. People with growing children or a family member with a serious illness like cancer often report practicing healthy behaviors. Participants have different healthy eating patterns, including organic eating, home cooking, regular meals, more fruits and vegetables, increased water intake, avoiding late-night eating, and steering clear of packaged foods, salt, and sugar. Many participants walked regularly for physical and mental health; they also expressed avoiding negative people and engaging in hobbies and social activities to maintain psychological well-being. Smoking participants had attempted to quit smoking. Some participants said that adding salt to their food before tasting. Factors cited as hindering healthy behaviors included lack of time, financial constraints, and cultural reasons. Conclusions Despite awareness of healthy living, many participants struggle to implement it due to lack of motivation, busy work schedules, social and physical environments, and economic factors. Multisectoral collaboration to create environments that support healthy behaviors can improve public health.

Family history and cancer risk study (FOREST): A clinical trial assessing electronic patient-directed family history input for identifying patients at risk of hereditary cancer

BackgroundHereditary cancer syndromes cause a high lifetime risk of early, aggressive cancers. Early recognition of individuals at risk can allow risk-reducing interventions that improve morbidity and mortality. Family health history applications that gather data directly from patients could alleviate barriers to risk assessment in the clinical appointment, such as lack of provider knowledge of genetics guidelines and limited time in the clinical appointment. New approaches allow linking these applications to patient health portals and their electronic health records (EHRs), offering an end-to-end solution for patient-input family history information and risk result clinical decision support for their provider. MethodsWe describe the design of the first large-scale evaluation of an EHR-integrable, patient-facing family history software platform based on the Substitutable Medical Applications and Reusable Technologies on Fast Healthcare Interoperability Resources (SMART on FHIR) standard. In our study, we leverage an established implementation science framework to evaluate the success of our model to facilitate scalable, systematic risk assessment for hereditary cancers in diverse clinical environments in a large pragmatic study at two sites. We will also evaluate the success of the approach to improve the efficiency of downstream genetic counseling resulting from pre-counseling pedigree generation. ConclusionsOur research study will provide evidence regarding a new care delivery model that is scalable and sustainable for a variety of medical centers and clinics. Trial registrationThis study was registered on ClinicalTrials.gov under NCT05079334 on 15 October 2021.

Usability, Engagement, and Report Usefulness of Chatbot-Based Family Health History Data Collection: Mixed Methods Analysis.

Family health history (FHx) is an important predictor of a person's genetic risk but is not collected by many adults in the United States. This study aims to test and compare the usability, engagement, and report usefulness of 2 web-based methods to collect FHx. This mixed methods study compared FHx data collection using a flow-based chatbot (KIT; the curious interactive test) and a form-based method. KIT's design was optimized to reduce user burden. We recruited and randomized individuals from 2 crowdsourced platforms to 1 of the 2 FHx methods. All participants were asked to complete a questionnaire to assess the method's usability, the usefulness of a report summarizing their experience, user-desired chatbot enhancements, and general user experience. Engagement was studied using log data collected by the methods. We used qualitative findings from analyzing free-text comments to supplement the primary quantitative results. Participants randomized to KIT reported higher usability than those randomized to the form, with a mean System Usability Scale score of 80.2 versus 61.9 (P<.001), respectively. The engagement analysis reflected design differences in the onboarding process. KIT users spent less time entering FHx information and reported more conditions than form users (mean 5.90 vs 7.97 min; P=.04; and mean 7.8 vs 10.1 conditions; P=.04). Both KIT and form users somewhat agreed that the report was useful (Likert scale ratings of 4.08 and 4.29, respectively). Among desired enhancements, personalization was the highest-rated feature (188/205, 91.7% rated medium- to high-priority). Qualitative analyses revealed positive and negative characteristics of both KIT and the form-based method. Among respondents randomized to KIT, most indicated it was easy to use and navigate and that they could respond to and understand user prompts. Negative comments addressed KIT's personality, conversational pace, and ability to manage errors. For KIT and form respondents, qualitative results revealed common themes, including a desire for more information about conditions and a mutual appreciation for the multiple-choice button response format. Respondents also said they wanted to report health information beyond KIT's prompts (eg, personal health history) and for KIT to provide more personalized responses. We showed that KIT provided a usable way to collect FHx. We also identified design considerations to improve chatbot-based FHx data collection: First, the final report summarizing the FHx collection experience should be enhanced to provide more value for patients. Second, the onboarding chatbot prompt may impact data quality and should be carefully considered. Finally, we highlighted several areas that could be improved by moving from a flow-based chatbot to a large language model implementation strategy.

3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings.

The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis-generation, we produced an open-source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980-2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are cataloged in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity.

Women’s preferences for genetic screening in routine care: A qualitative study

ObjectiveExamine decision-making regarding when women would prefer to receive reproductive carrier and cancer predisposition screening and from what clinician. Methods20 women completed in-depth interviews via Zoom exploring their views on the provision of reproductive carrier and cancer predisposition screening. Our analysis identified themes related to what informs women’s preferences for when they would like to receive a genetic screening offer and by which clinician. ResultsParticipants’ responses to questions about when they would be interested in receiving genetic screening were best understood through the lens of the Extended Parallel Process Model. Specifically, personal utility of the information, a woman’s family health history and cost were key factors in decision-making. Women considered their clinician’s knowledge and their trust in and relationship with the clinician when deciding from whom they would prefer to receive an offer of genetic screening. ConclusionOB/GYN clinic patients may accept an offer of genetic screening from a knowledgeable and trusted clinician for carrier and cancer predisposition screening preconceptionally or prenatally. Practice implicationsIntegrating genetic reproductive and cancer predisposition screening into the care provided to reproductive age OB/GYN patients may be acceptable to this population.

Development of a computer-based tool to obtain a family health history in Vietnam.

Background: Family health history (FHH) is central to human genomic profiling construction; however, there is no protocol for documenting FHH in a pedigree format in Vietnam.Aim: A "Gia Su Suc Khoe" (GSSK) tool was developed to create a user-friendly interface for collecting FHH and offering diseases' risk assessment.Results: A tool was described (https://giasusuckhoe.vn/) with good feedback from genetic counselors and family-medicine doctors. Among 20 surveys, 100% of respondents noted that the report accurately reflected their FHH and were satisfied with the tool's display. About 74% of familial conditions were covered. Overall, all constructive feedback has been adapted into the updated version.Conclusion: Gia Su Suc Khoe has the potential to significantly improve healthcare delivery and outcomes in Vietnam.

Qualitative Analysis of Pregnant Women with Preeclampsia at Muhammadiyah Ahmad Dahlan Hospital, Kediri

Background: Together with bleeding and infection included in the deadly triad, gestational hyper­tension affects 5-10% of pregnancies worldwide. Pre-eclampsia itself causes more than 70,000 maternal deaths and 500,000 fetal deaths. This study aimed to find significant predisposing factors that cause preeclampsia. Subjects and Method: Qualitative study with a phenomenological approach conducted at Muhammadiyah Ahmad Dahlan Hospital. The informants in this study were 15 pregnant women with preeclampsia. The focus of this research is to explore the predisposing factors for preeclampsia in pregnant women There are 4 research focuses related to pregnant women with preeclampsia, namely: (1) demographic data of pregnant women; (2) obstetric history; (3) nutrition; and (4) family health history. Data collection was carried out using interview techniques. The data collection were collected by interview techniques. Results: Pregnant women with preeclampsia were mostly housewives or low socio-economic, old and too young, obese, had families with a history of hypertension, were pregnant with different husbands. All of this can be detected using the preeclampsia screening sheet. Conclusion: Preeclampsia screening is performed periodically, to identify and diagnose the condition early, to allow for more careful monitoring and effective disease management.

3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: an open-source catalogue of findings.

The relatively few conditions and family members investigated in autism family health history limits etiologic understanding. For more comprehensive understanding and hypothesis-generation we produced an open-source catalogue of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980-2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6,462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are catalogued in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/views/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and non-genetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity.

Examining knowledge of cancer-related family history in an urban underserved patient population.

e22550 Background: An accurate assessment of family history of cancer is essential in assigning cancer risk, and in decision making regarding the timing and method of cancer screening. However, obtaining a complete and accurate cancer-related family history, including first- and second-degree relatives, is often challenging in underserved communities. Familial dynamics such as single parent households, kinship care, and estrangement may act as barriers to an individual’s knowledge of their family health history. Presently, Electronic Medical Record systems constrain users to a binary documentation of cancer history as either ‘yes’ or ‘no’. However, patients may be unaware or uncertain of their family’s cancer history. These unknowns are not captured, resulting in poor understanding of patient knowledge regarding their family history of cancer. Objective: To assess knowledge of cancer-related family history for first- and second-degree relatives among an urban underserved patient population. Funding source: The American Cancer Society. Methods: University of Illinois Health patients aged 45-75 years without a history of colorectal cancer, who received an order for colorectal cancer screening through fecal immunochemical testing or screening colonoscopy were eligible to participate. A total of 88 respondents completed a 23-item telephone survey assessing knowledge of their family cancer health history using a 5-point Likert scale. Surveys were administered in both English and Spanish languages. Results: Of the 88 survey participants, 50 (57%) were female, 54 (61%) were of black or African American race, and 31 (36%) were of Hispanic or Latino ethnicity. On a single-item question assessing overall knowledge of their cancer-related family history, 35 (39.7%) responded they know it well or very well, versus 13 (14.8%) with little or no knowledge. On knowledge of maternal cancer related history, 8 participants (9.1%) reported little or no knowledge of their mother’s cancer history, and 29 participants (33%) reported little or no knowledge of their maternal relatives’ cancer history. On knowledge of their father’s cancer history, 35 (39.8%) reported little or no knowledge of their father’s cancer history, and 48 participants (54.5%) reported little or no knowledge of their paternal relatives’ cancer history. Conclusions: This original research study addresses the current gap in understanding patient knowledge regarding familial cancer health history. Survey results demonstrate a striking discrepancy between respondent reported overall knowledge of cancer-related family history, and knowledge of their maternal and paternal cancer histories. Moreover, respondents reported increased knowledge of their mother’s versus father’s cancer history p &lt; 0.0001. Improved recognition of unknown family history in first- and second-degree family members may improve cancer-risk assessment.

PERANCANGAN SISTEM REKOMENDASI POLA HIDUP SEHAT BAGI PERESIKO ASAM URAT

Gout is caused by several things, one of which is the consumption of foods high in purine, choosing the right food menu for all foods consumed is an obligation... apart from this, there are various other factors that can increase the risk of this disease, namely increasing age and male gender, family health history, obesity, consumption of certain medications, certain medical conditions, unhealthy lifestyles and injuries due to surgery. The low priority given by health services to non-communicable diseases and inadequate public knowledge. Gout is a public health problem in Indonesia and is still not fully addressed. Knowledge and assistance regarding the right food to consume is a solution in overcoming this problem. For this reason, the authors in this study developed an expert system as a reference for gout risk to improve healthy lifestyle patterns. This system was developed with 2 benefits, namely getting recommendations and monitoring uric acid levels. As a result of the tests carried out, it is known that from a health practitioner's point of view, the system developed is suitable for use to accompany prevention and monitoring activities for gout sufferers and the information regarding the patient's dietary history presented by the system can be used as evaluation material during control. Users strongly agree with the system created due to lack of knowledge and lack of control in consuming foods that cause gout.

The Intergenerational Transfer of Mental Disorders: A Population-Based Multigenerational Linkage Study: Le transfert intergénérationnel des troubles mentaux : une étude sur les liens multigénérationnels basée sur la population.

The aetiology of mental disorders involves genetic and environmental factors, both reflected in family health history. We examined the intergenerational transmission of multiple mental disorders from parents and grandparents using population-based, objectively measured family histories. This population-based retrospective cohort study used administrative healthcare databases in Manitoba, Canada and included adults living in Manitoba from 1977 to 2020 with linkages to at least one parent and one grandparent. Index date was when individuals turned 18 or 1 April 1977, whichever occurred later. Mental disorder diagnoses (mood and anxiety, substance use and psychotic disorders) were identified in individuals, parents and grandparents from hospitalization and outpatient records. Cox proportional hazards regression models included sociodemographic characteristics, individual's comorbidity and mental disorder history in a grandparent, mother and father. Of 109,359 individuals with no mental disorder prior to index date, 47.1% were female, 36.3% had a mental disorder during follow-up, and 90.9% had a parent or grandparent with a history of a mental disorder prior to the index date. Both paternal and maternal history of a mental disorder increased the risk of the disorder in individuals. Psychotic disorders had the strongest association with parental history and were mostly influenced by paternal (hazards ratio [HR] 3.73, 95% confidence interval [CI] 2.99 to 4.64) compared to maternal history (HR 2.23, 95% CI, 1.89 to 2.64). Grandparent history was independently associated with the risk of all mental disorders but had the strongest influence on substance use disorders (HR 1.42, 95% CI, 1.34 to 1.50). Parental history of mental disorders was associated with an increased risk of all mental disorders. Grandparent history of mental disorders was associated with a small risk increase of the disorders above and beyond parental history influence. This three-generation study further highlights the need for family-based interventional programs in families affected by mental disorders. The Intergenerational Transfer of Mental Illnesses.

Abstract PO4-09-08: Perceptions and Experiences of Black Women on Family History Sharing and Genetic Testing for Hereditary Breast and Ovarian Cancer

Abstract Black women experience significant disparities in morbidity and mortality related to hereditary breast and ovarian cancer (HBOC). Early identification of women with HBOC is essential for proactive screening and timely diagnosis. However, evidence suggests that Black women receive genetic testing for HBOC at lower rates than their White counterparts. We conducted in-depth qualitative interviews with 107 Black women with a personal or family history of breast or ovarian cancer, to understand their perceptions of their familial risk of HBOC and interest in genetic testing. In phase 1 of this study, participants were recruited from the networks of patient support organizations and historically Black sororities representing mostly highly educated and well insured patients. In phase 2, participants were recruited from a family medicine safety net clinic in Jacksonville, FL for socioeconomic diversity. Participants in both cohorts frequently expressed a lack of awareness about their family cancer history and identified many barriers to family disclosure of a cancer diagnosis. These include a culture of silence around medical issues and a belief that personal difficulties should be kept to oneself. Practical and cultural barriers to family history sharing were magnified among those with lower socioeconomic status. Many participants in both cohorts indicated a strong desire to understand their own risk of HBOC. They also expressed interested in genetic testing to proactively mitigate risk to themselves and future generations. Understanding of the potential relevance of HBOC testing to one’s personal health and post-test actionability was variable across both groups, although perceptions of genetic testing were generally favorable. These findings suggest that culturally tailored educational materials and alternative clinical modalities to collect family health history may be beneficial to improve timely identification of Black women who meet NCCN Guidelines for HBOC testing. Specifically, greater attention should be given to addressing barriers that led to underestimation of HBOC risk among patients experiencing disparities driven by adverse social determinants of health. Citation Format: Kirsten Riggan, Jane Yap, Ewan Cobran, Michele Halyard, Sarah James, Marion Kelly, Daphne Phillips, Megan Allyse. Perceptions and Experiences of Black Women on Family History Sharing and Genetic Testing for Hereditary Breast and Ovarian Cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-09-08.

Mixed-Methods Evaluation of the Implementation of a Hereditary Cancer Risk Screening Questionnaire in a Safety Net Hospital [ID 2683409

INTRODUCTION: Patients belonging to medically underserved groups who meet testing criteria for hereditary cancer syndromes are less likely to be referred for genetic services and to complete testing. In our safety net hospital women’s health clinics, we introduced a novel National Comprehensive Cancer Network (NCCN)-based screening questionnaire as part of a community health worker (CHW)-supported hereditary cancer risk assessment and testing program. METHODS: We quantified program effect and conducted semistructured interviews with nurses and providers (n=12). We used rapid qualitative analysis to assess familiarity with screening questionnaire and barriers to its utilization. Institutional review board approval was obtained. RESULTS: Since January 2020, 2,282 patients were screened: 169 via provider referral and 2,113 via questionnaire. 312 met NCCN criteria for testing, with 30 ultimately testing positive. Nurses were familiar with the screening questionnaire and assumed an active role in facilitating completion. They reported minimal familiarity with the process after questionnaire completion. Providers reported minimal familiarity with the screening questionnaire but did assess family history and refer for genetic services. Barriers to successful utilization of the questionnaire included time constraints, patient literacy, language barriers, and gaps in patients' knowledge of their family history. CONCLUSION: Implementation of a targeted questionnaire may increase access to testing for hereditary cancer syndromes. We identified the following opportunities for implementation improvement: staff education, increased clinic efficiency, and CHW support with collection of accurate histories from patients with limited literacy/knowledge of their family's health history. Replication of a CHW-supported questionnaire-based screening program could reduce disparities in access to genetic services for patients in safety net settings.

User experience of a family health history chatbot: A quantitative analysis.

Family health history (FHx) is an important tool in assessing one's risk towards specific health conditions. However, user experience of FHx collection tools is rarely studied. ItRunsInMyFamily.com (ItRuns) was developed to assess FHx and hereditary cancer risk. This study reports a quantitative user experience analysis of ItRuns. We conducted a public health campaign in November 2019 to promote FHx collection using ItRuns. We used software telemetry to quantify abandonment and time spent on ItRuns to identify user behaviors and potential areas of improvement. Of 11,065 users who started the ItRuns assessment, 4305 (38.91%) reached the final step to receive recommendations about hereditary cancer risk. Highest abandonment rates were during Introduction (32.82%), Invite Friends (29.03%), and Family Cancer History (12.03%) subflows. Median time to complete the assessment was 636s. Users spent the highest median time on Proband Cancer History (124.00s) and Family Cancer History (119.00s) subflows. Search list questions took the longest to complete (median 19.50s), followed by free text email input (15.00s). Knowledge of objective user behaviors at a large scale and factors impacting optimal user experience will help enhance the ItRuns workflow and improve future FHx collection.

The Health History of First-Degree Relatives' Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia.

Genetic testing is key in modern healthcare, particularly for monogenic disorders such as familial hypercholesterolemia. This Tohoku Medical Megabank Project study explored the impact of first-degree relatives' dyslipidemia history on individual responses to familial hypercholesterolemia genomic results. Involving 214 participants and using Japan's 3.5KJPN genome reference panel, the study assessed preferences and intentions regarding familial hypercholesterolemia genetic testing results. The data revealed a significant inclination among participants with a family history of dyslipidemia to share their genetic test results, with more than 80% of participants intending to share positive results with their partners and children and 98.1% acknowledging the usefulness of positive results for personal health management. The study underscores the importance of family health history in genetic-testing perceptions, highlighting the need for family-centered approaches in genetic counseling and healthcare. Notable study limitations include the regional scope and reliance on questionnaire data. The study results emphasize the association between family health history and genetic-testing attitudes and decisions.

Efficacy of Community Health Worker-Delivered Family Health History-Based Breast Cancer Education and Services Among Chinese Americans.

Family health history (FHH) is an evidence-based genomics tool used in cancer prevention and education. Chinese Americans, the largest Asian American group, face unique barriers in FHH collection and communication. This study aimed to evaluate the efficacy of culturally and linguistically appropriate community health worker (CHW)-delivered FHH-based breast cancer (BC) education and services to Chinese Americans. A total of 1129 Chinese Americans received FHH-based BC education and service delivered by our trained Chinese American CHWs. Participants responded to evaluation surveys before, immediately after, and 3months after the education and service. Participating Chinese Americans showed significant increases in rates of collecting FHH of BC, discussing FHH of BC with family members, informing their primary care physicians of their FHH of BC, and discussing their FHH of BC with their primary care physicians at 3months post-education and service compared to the baseline data (all Ps < 0.01). Attitudes, intention, and self-efficacy related to FHH of BC communication and collection and FHH of BC knowledge were improved both immediately after and 3months after the delivery of the education and services (all Ps < 0.01). Within 3months, ~ 14.3% of participants who had a high risk of BC based on FHH reported visiting geneticists for genetic evaluation. Our Chinese American CHW-delivered FHH-based BC education and services showed initial success in increasing knowledge, collection and communication of BC-related FHH, and genetic service utilization among Chinese American participants. This study can serve as a starting point for conducting more robust studies, such as randomized controlled trials, in the future.

Determinants of body weight changes during Ramadan fasting in India amid COVID-19: A cross-sectional study.

Ramadan intermittent fasting (RIF) presents unique challenges and opportunities for public health and clinical practice, especially in populations with a high prevalence of non-communicable diseases. This study aims to investigate the impact of RIF on weight change among Indian Muslims and explore the associated demographic, dietary, and behavioral factors. A cross-sectional survey was conducted with a sample of Indian Muslim adults who observed RIF. Participants were asked to report their demographic information, family and personal health history, and dietary and lifestyle behaviors before and during Ramadan month. The primary outcome was body weight change, with secondary outcomes including changes in dietary patterns, physical activity, and other health-related lifestyle behaviors. The study found that during Ramadan, nearly half of the participants (48.5%) self-reported a retained initial weight, while a significant fraction (30.9%) self-reported a modest weight reduction between 0.5 to 2.5 kg at the end of Ramadan. Additionally, self-reported eating practices demonstrated moderately altered by about half (48.4%) of the study participants, with 32.2% reporting minor changes and 8.2% indicating substantial changes. An urban residence was associated with a higher likelihood of weight gain, where urban residents showed 3 times the odds of increased weight compared to rural inhabitants. Employment status emerged as a significant determinant for weight fluctuation, influencing both weight gain and loss. During Ramadan, there was a significant rise in snacking frequency, increasing from 21.7% to 32.6% in comparison with pre-Ramadan. The consumption of large quantities of food more frequently grew from 14.9% to 36%, and the incidence of eating despite not being hungry went up from 17.4% to 33.2%. The study demonstrates that RIF is associated with variable changes in body weight among adult Indian Muslims, influenced by urbanization, employment status, and dietary changes. The findings suggest that clinicians should provide tailored advice about body weight regulation during Ramadan and consider integrating community-based health initiatives within religious settings to improve health outcomes.

Intense Negative Thoughts in Seniors Can Cause the Rupture of Blood Vessels in Fragile Areas

Background Seniors living alone are more vulnerable and often exert great effort to perform daily activities. Aim Highlight the impact of intense negative thoughts on the blood vessels of seniors. Material &amp; Method The author conducted a qualitative study in 2023 within the community, exploring the significance of mental health among older adults and its impact on bodily function. Findings In the autumn of 2023, a 93-year-old patient experienced stress for four consecutive days, as she was unable to carry out certain seasonal activities. She was also anxious that people did not respond promptly to her request to collect her products. On the morning of the fifth day, she noticed a red spot on her right eye’s sclera. Patient’s health history: cholecystectomy, 1970. Patient’s family health history: parents, brothers: arterial hypertension.

The Effect of Individual Characteristics, Physical Activity, and Consumption of Sweetened Foods and Drinks on the Incidence of Type 2 Diabetes Mellitus in Adults Aged 30–60 Years in Medan

&lt;p&gt;&lt;em&gt;The Sustainable Development Goals (SDGs) aim to reduce morbidity and mortality from non-communicable diseases, including diabetes mellitus, by 2030. Around 8.5 percent of adults worldwide are living with of type 2 diabetes mellitus, and up to 1.5 million people die from it. The prevalence of diabetes mellitus in Indonesia was 2 percent in 2018, and in North Sumatera was 249.519 cases with the highest number of cases in Medan City. This increase in diabetes mellitus prevalence is associated with several risk factors. This study aims to analyze the effect of individual characteristics, physical activity, and consumption of sweetened foods and drinks on the incidence of type 2 diabetes mellitus in 30–60 years age group in Medan. This type of research was observational analytic used a case control design. This study was conducted in 6 community health centers with the highest number of diabetes cases divided into 3 sub-districts with the highest number of type 2 diabetes mellitus cases. This study was conducted from February to October 2023. The sampling technique uses purposive sampling. The population in this study were people 30-60 years age group in Medan with sample size of 66 cases and 66 controls. Logistic regression was used for data analysis. The results showed that there was an effect between age (p=0.002), physical activity (p=0.034), consumption of sweetened foods and drinks (p=&amp;lt;0.001), and family history (p=&amp;lt;0.001) on the incidence of type 2 diabetes mellitus. The community is expected to do regular physical activity of at least 150 minutes per week, limit sugar intake every day, and conduct regular health checks if they know the family health history that contributes to the development of type 2 diabetes mellitus.&lt;/em&gt;&lt;/p&gt;&lt;strong&gt;&lt;em&gt;Keywords: Diabetes, Drinks, Foods , Physical Activity, Sweetened&lt;/em&gt;&lt;/strong&gt;

Abstract A079: Implementation of the FOREST cancer risk study at an HBCU: The family history and cancer risk study at Meharry Medical College

Abstract PURPOSE: Family Health History (FHH) is a key factor in assessing cancer risk, yet health providers often do not have adequate time or resources to collect FHH systematically. African Americans and other medically underserved populations suffer significantly higher cancer incidence and mortality. These populations would benefit if their cancer risk were better defined. The Family History and Cancer Risk Study (FOREST) aims to implement a patient-facing web-based FHH cancer risk assessment platform called MeTree in a clinic with a high percentage of underserved patients at Meharry Medical College (MMC) and a cohort at Vanderbilt University Medical Center. METHODS: Partnering with the MMC Community Engagement Core (CEC), we conducted two virtual studios with 12 Nashville minority community members. Topics of concern were medical data privacy, potential benefits, and proper informed consent. CEC recommendations informed our pre-implementation planning. Recruitment methods consisted of a staffed table outside of and, later, presence inside the MMC Family &amp; Community Med. Clinic waiting room. Patients could also request assistance to navigate MeTree with the study research coordinator (in person or virtually). RESULTS: Since October 2022, 76 potential participants have been invited to FOREST from MMC. 26 patients were interested, 18 were eligible, 16 patients consented, and 12 patients completed the MeTree FHH. Of note, 6 patients utilized in-person assistance from the research study coordinator. Overall, 2 of the 12 patients who completed MeTree were determined to be at high-risk for cancer. CONCLUSION: We observed a 30% enrollment rate and 43% completion rate. Also, 6 of 26 patients requested and received assistance. In-person recruitment had the highest volume of potential enrollments (16 interested), yet lower completion rates (5/16 = 31%) compared to the pamphlet QR code (5 interested with 3/5 completing = 60%). We realize that these numbers are not large enough to show statistical significance at this early stage, and we plan to implement FOREST in a higher volume clinic (Internal Medicine at Nashville General Hospital) to determine if this trend scales. Citation Format: Clasherrol Edwards, Dana R. Marshall, Leah Alexander, Justin D. Andujar, S.T. Bland, Jillian Duke, Sarah Jones, Jeffrey Leegon, Kate F. Mittendorf, Lori A. Orlando, Georgia L. Wiesner, Siddharth Pratap. Implementation of the FOREST cancer risk study at an HBCU: The family history and cancer risk study at Meharry Medical College [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A079.