Allergic Family History Research Articles

The significance of allergic family history and cord blood-immunoglobulin E as a predictor of the development of allergic diseases in later life

Rationale The family history (FHx) of allergic disease(AD) and cord blood immunoglobulin E have been known to be most valuable predictors of the development of AD. The purpose of this study is to evaluate total eosinophil count (TEC) and eosinophil cationic protein (ECP) in maternal, baby, and cord blood as well as the above two predictors could be a significant predictor for subsequent AD later in life. Methods Fifty pregnant women and their newborns with FHx and fifty other those without FHx were investigated. IgE, TEC, and ECP level in those blood were measured. We have conducted clinical follow-up study for AD in twenty three babies for 8 year. Results 1) Cord blood IgE of AD group was 0.45-3.09IU/ml and higher than that of non-AD group (0.06-1.20IU/ml)(p=0.07). 2) The differences of ECP and TEC in those blood between AD and non-AD group were not significant. Between positive and negative FHx group, there were no significant differences of IgE, ECP level, and TEC in those blood. 3) There was no significant correlation among cord, neonatal, and maternal blood IgE 4) In the group with positive FHx and high cord blood IgE, 67% of the cases showed AD until 8 year-old age. However, in the group with negative FHx and low cord blood IgE, only 22% of the cases showed AD for 8 years. Conclusions Cord blood IgE and family history are the most important factors to predict AD later in life but TECs and ECP levels in those blood were not significant for the prediction of it.

Prevalence and Risk Factors of Allergic Rhinitis and Cedar Pollinosis among Japanese Men

Background. Although recent reports show a worldwide increase in allergic diseases during the past 10– years, few epidemiological studies on secular trend and the age-specific prevalence of allergic rhinitis have been carried out in Japan. We conducted a study to clarify the age-specific prevalence of allergic rhinitis and cedar pollinosis to provide baseline data for a prospective study and to investigate the association of rhinitis with both environmental and personal factors among 2,307 Japanese men.Methods. Allergic rhinitis was determined from self-reported allergic rhinitis or from the seasonal symptoms of the nose. Seasonal rhinitis was defined as symptoms evoked in the subjects from February to May. Cedar pollinosis was defined as the presence of cedar-specific IgE positivity among subjects with seasonal rhinitis.Results. The prevalences of allergic rhinitis, seasonal rhinitis, and cedar pollinosis were 35.5, 28.8, and 11.0%, respectively. Age was a negative risk factor for all allergic conditions. Allergic family history and residence along a main street were strong risk factors for all allergic rhinitis.Conclusions. The current prevalence of each rhinitis was higher than previously reported. The risk factors were similar for each allergic rhinitis except for a past history of atopy.

Prevalence of atopy in students from Málaga, Spain.

Epidemiologic studies are necessary to determine the prevalence of allergic diseases. This varies widely depending on allergen preparations and patients studied. To investigate the prevalence of atopic disease, skin test reactivity, total and specific IgE to common allergens, and other variables in a sample of students from Málaga, southern Spain. Three hundred sixty-five students (age 17.9 +/- 1.18) were interviewed by an allergist. Skin prick tests were performed with Dermatophagoides pteronyssinus, Artemisia vulgaris, Plantago lanceolata, Chenopodium album, Olea europaea, Phleum pratense, Parietaria judaica, Cynodon dactylon, Alternaria tenuis, and cat dander. Total and specific IgE to D. pteronyssinus, Olea, and Parietaria were determined. Of all subjects studied, 19.9% suffered from rhinoconjunctivitis, 4.1% rhinoconjunctivitis plus asthma, 3.1% asthma alone, and 0.8% atopic dermatitis; 46.4% had a positive skin test to at least one allergen (28.2% to D. pteronyssinus, 20.4% to Olea, 13.8% to Phleum); and 43% had total IgE > 100 kU/L and 44.7% a family history of atopy. Allergic symptoms were strongly associated with skin test positivities and family allergic history. Patients with asthma or skin prick test positive had higher total IgE values than others (P < .01). There was a significant correlation between specific IgE values and wheal size in skin test. Our findings confirm the high prevalence of atopic diseases, and the close relationship of skin tests reactivity (or presence of specific IgE) to allergens with symptoms of asthma and rhinitis. The presence of a family history of allergic diseases influences the development of positive skin tests and atopic illness. Dermatophagoides pteronyssinus and pollen of Olea europaea were found to be the most common allergens.

Increased levels of serum IgE in children of mothers with systemic lupus erythematosus.

Various allergic diseases have been described in patients with systemic lupus erythematosus (SLE). In the present study, we evaluated the prevalence of allergic disease and serum IgE levels in 36 children of 26 mothers with SLE. None of the subjects had any rheumatic symptoms. There was at least one type of allergic disease in 28 (78%) of the 36 children of mothers with SLE, as compared with 30% in Japanese control children (P < 0.01). The prevalence of atopic dermatitis and bronchial asthma was higher in children of mothers with SLE (64% and 28%) than in controls (19% and 9%) (P < 0.01, respectively). Fourteen of the 36 subjects (39%) had higher levels of serum IgE than those of normal range for age-matched healthy Japanese children with no atopic family disease in the immediate family history, and these children had atopic disease. Among the 14 children with high serum-IgE levels, seven had neither immediate nor remote family history of atopic disease, while the others had an immediate family history of atopic disease. We think that genetic factors may influence the presence of allergic disease in children of mothers with SLE, and that the increased serum IgE levels in children of SLE mothers with no allergic family history may be a part of subclinical immunologic abnormalities related to SLE.

Acerola juice—The richest known source of Vitamin C: A clinical study in infants

Summary Acerola juice is the richest known source of vitamin C, having from fifty to one hundred times the ascorbic acid content of orange juice. Thirty infants ranging in age from 3 to 7 weeks were given acerola juice as the only significant source of ascorbic acid in their diet. All infants showed average or better growth and development for their age and weight. Ascorbic acid levels in the blood plasma of all infants were above average after the acerola juice was introduced into the diet. No reactions occurred from ingestion or from skin and intradermal tests with acerola juice. Acerola juice can be blended with apple juice which is naturally low in vitamin C, and used to satisfy the ascorbic acid requirements in infant feeding. It is particularly valuable in infants who are allergic to orange juice or where the family allergic history deems it advisable to delay giving orange juice until one year of age.

Use of soybean milk as an aid in prophylaxis of allergic disease in children

T HE purpose of this study was to determine whether the incidence of atopic dermatitis (eczema) and other major allergies, as well as their allergic sequelae in potentially allergic infants might be influenced by completely withholding cow’s milk from their diets from birth until the age of six to nine months. By a potentially allergic infant is meant an infant who has one or more allergic parents or siblings. A previous publication1 has discussed the underlying reasoning for, and demonstrated the feasibility of, raising infants in this manner. Ninety-one infants comprised the experimental group. They were all either offsprings or siblings of one or more individuals with one or more major allergies, that is, asthma, pollinosis (rose or hay fever), atopic dermatitis (eczema), or perennial allergic rhinitis (P.:1.R.). Cow’s milk was deliberately withheld from each infant from birth. Each was fed a commercially available soybean formula.” Table I indicates the age at which these infants were changed from soybean milk to cow’s milk. Table 11 shows the length of the follow-up of this group which was continued until the t,irne of this writing. The histories of sixty-five siblings of those in the experimental group were also reviewed. In addition, a second control group was chosen as follows : From reviewing the histories of 4,710 allergic individuals in 1,215 families, 175 children with approsimatelp the same allergic family history were selected. Those in the sibling group, as well as those in the nonre!ated control group, were considered as suffering from a major allergy only if their allergic symptoms occurred !J!-/ or before the age Of onset of their counterparts in the experimental group. For each group the following data were sought: (1) the total incidence of major allergic diseases, (2) the incidence of at,opic dermatitis. (3) the incidence of other allergies to cow’s milk (colic, diarrhea, etc.), and (4) the allergic sequelae of atopic dermatitis and other allergies due to cow’s milk. Table III summarizes the comparative data obtained from the three groups of infants studied. Major allergy occurred in 14 per cent of the experimental group, in 64 per cent of the siblin g controls, and in 52 per cent of the unrelated control group. The chances that these findings are due merely to coincidence is less than one in one hundred (Chi square equals sixteen). The differences in

REPORT OF A CASE OF STATUS ASTHMATICUS WITH AUTOPSY

Case Reports1 July 1937REPORT OF A CASE OF STATUS ASTHMATICUS WITH AUTOPSYJOSEPH R. WISEMAN, M.D., F.A.C.P.JOSEPH R. WISEMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-1-212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCASE REPORTMrs. E. H., a housewife, aged 40, entered the University Hospital, October 16, 1935, complaining of severe asthma.Her mother, aged 77, has arteriosclerosis. Her father died at 50 of heart trouble. One brother is living and well; no sibs have died. She has four living children, one of whom has diabetes for which insulin is taken; one child died at four of nephrosis. No allergic family history could be obtained. The patient lived in Syracuse, New York all of her life except for two trips to Florida in 1925 and 1927. In childhood she had measles, mumps,...Bibliography1. COHENRUDOLPH MBJA: The use and abuse of drugs in asthma, Jr. Am. Med. Assoc., 1932, xcviii, 1864. CrossrefGoogle Scholar2. JACKSON DE: The pharmacology of bronchial asthma, Jr. Lab. and Clin. Med., 1915, i, 126. Google Scholar3. FEINBERG SM: Allergy in general practice, 1934, Lea and Febiger, Philadelphia, p. 126. Google Scholar4. SOLLMANN T: A manual of pharmacology, 1932, W. B. Saunders Co., Philadelphia, p. 296. Google Scholar5. BARACH AL: Use of helium in the treatment of asthma and obstructive lesions in the larynx and trachea, ANN. INT. MED., 1935, ix, 739. Google Scholar6. BARACH AL: The therapeutic use of helium, Jr. Am. Med. Assoc., 1936, cvii, 1273. CrossrefGoogle Scholar7. MAYTUMPRICKMANBOOTHBY CKLEW: Use of helium and oxygen in the treatment of severe intractable asthma, Proc. Staff Meet. Mayo Clin., 1935, x, 785. Google Scholar8. HUEBERKOESSLER HLKK: The pathology of bronchial asthma, Arch. Int. Med., 1922, xxx, 689. CrossrefGoogle Scholar9. COCAWALZERTHOMMEN AFMAA: Asthma and hay fever, 1931, C. C. Thomas, Springfield, Ill., p. 136 to 170. Google Scholar10. MICHAELROWE PPAH: The pathology of two fatal cases of bronchial asthma, Jr. Allergy, 1935, vi, 150. CrossrefGoogle Scholar11. ALEXANDER HL: Discussion of paper by Michael and Rowe, Jr. Allergy, 1935, vi, 169. Google Scholar12. KOUNTZALEXANDER WBHL: Death from bronchial asthma, Arch. Path., 1928, v, 1003. Google Scholar13. BUBERTWARNER HMJG: Fatal asthma, Jr. Am. Med. Assoc., 1935, civ, 1469. CrossrefGoogle Scholar14. WRIGHT CB: Death from bronchial asthma, Jr. Am. Med. Assoc., 1930, xciv, 1218. CrossrefGoogle Scholar15. HARKAVY J: Observations of fatal bronchial asthma, Jr. Allergy, 1930, i, 1434. Google Scholar16. MURPHYCASE JAEA: Sudden death from bronchial asthma, Jr. Allergy, 1930, i, 434. CrossrefGoogle Scholar17. COOKE RA: Infective asthma, indication of its allergic nature, Am. Jr. Med. Sci., 1932, clxxxiii, 309. CrossrefGoogle Scholar18. KOEFF AK: Ploetzlicher Tod bei Asthma Bronchiale; Thesis, Leipzig, 1930. (Cites 26 cases from the literature.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syracuse, New York*Received for publication November 5, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDeaths from asthmaPulmonary pathology with special emphasis on bronchial asthmaRecent developments in asthma and hay fever 1 July 1937Volume 11, Issue 1Page: 212-221KeywordsAsthmaAutopsyChildrenHeartInsulinMeaslesMumps ePublished: 1 December 2008 Issue Published: 1 July 1937 PDF downloadLoading ...