You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Kidney & Bladder II1 Apr 2015MP20-20 CYSTECTOMY FOR REFRACTORY HEMORRHAGIC CYSTITIS: CONTEMPORARY ETIOLOGY, PRESENTATION AND OUTCOMES Brian Linder, Robert Tarrell, and Stephen Boorjian Brian LinderBrian Linder More articles by this author , Robert TarrellRobert Tarrell More articles by this author , and Stephen BoorjianStephen Boorjian More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.992AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the clinical presentation, management and outcomes for patients undergoing cystectomy for refractory hemorrhagic cystitis. METHODS We identified 21 patients with refractory hematuria treated with cystectomy at our institution between 2000–2012. Prior to cystectomy, all patients had failed clot evacuation, bladder fulguration, and bladder irrigation. Additionally, 45% had received prior intravesical therapy (Amicar, Alum, or Formalin), hyperbaric oxygen therapy (25%), nephrostomy tube placement for attempted urinary diversion (15%), and/or selective bladder angioembolization (5%). Survival was estimated using the Kaplan Meier method and compared with the log-rank test. RESULTS Median patient age at surgery was 77 years (IQR 72,80), while 81% (17/21) were male. The most common etiology for hemorrhagic cystitis was prior radiation therapy for prostate cancer (17; 81%). Median time from receipt of radiation to cystectomy in these patients was 91 months (IQR 73,125). Median American Society of Anesthesiologists Score at cystectomy was 3, while the median pre-operative hemoglobin was 10.2 g/dL. Median length of stay following cystectomy was 10 days (IQR 7, 19). Severe (Clavien Grade III-V) complications were noted in 42% of patients (8/19) and the 90-day mortality rate in this cohort was 16% (3/19). With a median postoperative follow-up of 13 months (IQR 4, 21) the 1 and 3-year overall survival for those undergoing cystectomy for hemorrhagic cystitis was 84% and 52%, respectively. Interestingly, when compared to a matched cohort of patients with pT0 bladder cancer at cystectomy (1:1), no statistically significant difference in overall survival was found between the cohorts (p=0.38). CONCLUSIONS Cystectomy for hemorrhagic cystitis is associated with a high risk of perioperative complications and mortality, consistent with the baseline clinical status of this patient cohort, and as such should remain a last resort to control bleeding after failure of conservative measures. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e231 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brian Linder More articles by this author Robert Tarrell More articles by this author Stephen Boorjian More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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