Mission-critical applications demand robust and reliable database management. This paper examines key strategies for Database Administrators (DBAs) managing these applications in the cloud. We discuss critical aspects such as performance optimization through sharding, replication, and read replicas. We also explore strategies for ensuring high availability and disaster recovery, including leveraging cloud-native services like autoscaling and failover mechanisms. Furthermore, we delve into critical security considerations, including data encryption, access control, and threat detection. Finally, we analyze best practices for optimizing cloud database costs while maintaining performance and reliability. This Paper explores as cloud-based infrastructures continue to change, a deep understanding of the differences between SQL databases, such as MySQL, SQL Server, RedShift, PostgreSQL, and Oracle, and NoSQL solutions, such as MongoDB, Cassandra, and DynamoDB, a prerequisite to design to manage systems
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