Four experiments employing old rats and two experiments using young rats as serum donors showed that starvation of these animals altered the ability of their sera to support growth of Trypanosoma lewisi in mice. The reduction of trypanosome growth was greatest (167-fold) with sera from old animals starved for 12–14 days. Reduction was sixford with sera from old animals starved for 7–9 days and with sera from young animals starved for 5 days.
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