Child Factors Research Articles

Clinical Characteristics and Risk Factors in Children with Acute Leukemia Complicated with Multiple Drug Resistant Bacterial Septicemia

To investigate the clinical characteristics and risk factors of acute leukemia complicated with multi-drug resistant bacterial septicemia in children. The clinical data of children with acute leukemia complicated with septicemia admitted to the Affiliated Hospital of Guangdong Medical University from January 2013 to May 2021 were retrospectively analyzed. Their flora composition and drug resistance were also analyzed. The children were divided into multi-drug resistant bacteria (MDRB) group and non-multi-drug resistant bacteria (non-MDRB) group according to the drug sensitivity results, and the differences in clinical data between the two group were compared. A total of 108 children had drug sensitivity results, 47 cases in the MDRB group, including 26 strians of Gram-positive bacteria (G+), the most common multi-drug resistant G+ bacteria were coagulase-negative staphylococci (CoNS) and Staphylococcus aureus, and the most common multi-drug resistant Gram-negative bacteria G- bacteria were Escherichia coli and Klebsiella pneumoniae subspecies pneumoniae. Compared with non-MDRB group, children in MDRB group had higher C-reactive protein (CRP) level and mortality rate (P <0.001, P =0.009), lower initial empirical anti-infection efficiency (P <0.001), and were more likely to have septic shock (P =0.003). Logistic analysis showed that the risk factors of acute leukemia complicated with MDRB septicemia in children were previous MDRB infection (OR =6.763, 95% CI: 1.141-40.092, P =0.035), duration of agranulocytosis before infection≥7 days (OR =3.071, 95% CI: 1.139-8.282, P =0.027), and previous use of antimicrobial drugs within 90 days before infection (OR =7.675, 95% CI: 1.581-37.261, P =0.011). The clinical features of acute leukemia complicated with MDRB septicemia in children include a heavy inflammatory response, significantly elevated CRP, susceptibility to secondary septic shock, low efficiency of initial empirical anti-infective therapy, and high mortality rate. Previous MDRB infection, duration of agranulocytosis before infection≥7 days, and previous use of antimicrobial drugs within 90 days before infection are risk factors of acute leukemia complicated with MDRB septicemia in children.

Frequency of Peripheral Intravenous Infiltration and Determination of Risk Factors in Children: A Cohort Study

Objective: Intravenous therapy is one of the most commonly used routes for drug administration. The aim of this study was to determine the frequency of peripheral intravenous infiltration and risk factors in children. Methods: This cross-sectional and cohort study was conducted in a university hospital in pediatric patients. An information form and the Infiltration Rating Scale were used. Data were obtained from patients, their parents, and patient records. Infiltration data was obtained by researchers through direct observation. Significance was assumed as p&amp;lt;0.05 at 95% confidence interval. Results: A total of 176 pediatric patients made up the study cohort. Most of the peripheral venous catheters were inserted by nurses and into upper extremities. The incidence of infiltration was 57.9%, and most of the infiltrates were first-degree. The development of infiltration was significantly associated with the medical specialty being attended (p=0.001) and the number of catheter insertion attempts (p=0.013). Conclusion: The specific medical specialty and the number of catheter insertion attempts were shown to play a significant role in the development of infiltration.

Prevalence of Resilience, Risk, and Protective Factors in Children and Youth in Foster Care: A Systematic and Meta-Analytic Review

ABSTRACT: Youth in foster care often experience abuse, disrupted attachment, social ostracization, and challenges in developing belonging and social interest. Some fostered youths are resilient, but the prevalence and impact factors of resilience are unknown. This meta-analysis includes studies ( k = 89; N = 121,869) with participants aged 0–19 years from demographically diverse regions worldwide. The prevalence rate (event rate, i.e., the proportion of the sample assessed as resilient; ER) for aggregated resilience (behavioral and psychological resilience combined) was 0.61 ( k = 89; 95% CI 0.56–0.66; p &lt; .001). Male sex and race were significant risk factors. Those aged 7–11 years had the lowest resilience ERs (combined = 0.58 vs. 0.63), suggesting developmental impacts and mistaken lifestyles (i.e., mistakes in the chosen way to approach tasks and problems; Adler, 1931) reinforced in school. Interventions must accommodate different sexes, ages, and races and should incorporate Adlerian principles (e.g., encouragement, understanding mistaken beliefs, social embeddedness, motivations). Developmental and trauma-informed policies are needed.

Do early life factors explain the educational differences in early labour market exit? A register-based cohort study

BackgroundSocioeconomic inequalities in labour market participation are well established. However, we do not fully know what causes these inequalities. The present study aims to examine to what extent factors in childhood and late adolescence can explain educational differences in early labour market exit among older workers.MethodsAll men born in 1951–1953 who underwent conscription examination for the Swedish military in 1969–1973 (n = 145 551) were followed from 50 to 64 years of age regarding early labour market exit (disability pension, long-term sickness absence, long-term unemployment and early old-age retirement with and without income). Early life factors, such as cognitive ability, stress resilience, and parental socioeconomic position, were included. Cox proportional-hazards regressions were used to estimate the association between the level of education and each early labour market exit pathway, including adjustment for early life factors.ResultsThe lowest educated men had a higher risk of exit through disability pension (HR: 2.72), long-term sickness absence (HR: 2.29), long-term unemployment (HR: 1.45), and early old-age retirement with (HR: 1.29) and without income (HR: 1.55) compared to the highest educated men. Factors from early life explained a large part of the educational differences in disability pension, long-term sickness absence and long-term unemployment but not for early old-age retirement. Important explanatory factors were cognitive ability and stress resilience, whilst cardiorespiratory fitness had negligible impact.ConclusionsThe association between education and early exit due to disability pension, long-term sickness absence and long-term unemployment was to a large part explained by factors from early life. However, this was not seen for early old-age retirement. These results indicate the importance of taking a life-course perspective when examining labour market participation in later working life.

Effect of the Nutritional Intervention Program on Body Weight and Selected Cardiometabolic Factors in Children and Adolescents with Excess Body Weight and Dyslipidemia: Study Protocol and Baseline Data.

Excess body weight and associated dyslipidemia in children and adolescents are the main risk factors for cardiovascular diseases in young adults. There is a reasonable need to develop an effective lifestyle modification program that includes various dietary therapies. A low-glycemic index (GI) diet may be recommended in the treatment of obesity. Its use is also recognized as reasonable in cardiovascular diseases, including dyslipidemia. The aim of the presented nutritional intervention program was to evaluate the effectiveness of an energy-balanced diet based on the principal recommendation on Cardiovascular Health Integrated Lifestyle Diet-2 (CHILD-2) and low-GI products (LGI diet) in children and adolescents with excess body weight and dyslipidemia. The study involved 64 children and adolescents (44 boys and 20 girls) aged 8-16 with overweight or obesity and dyslipidemia. For 8 weeks, the participants followed a dietary treatment using two types of diets: one based on products with a low GI, and one standard therapy diet. During this time, they participated in three visits with a dietitian, during which the assessment of their current and habitual food intake was made, and anthropometric measurements and blood pressure were taken. Patients were under the care of a pediatrician who qualified them for the study and ordered lipid profile tests. This article presents the design, protocol of the nutritional intervention program, and baseline data. The collected results will be used to develop practical nutritional recommendations for children and adolescents with excess body weight and dyslipidemia.

The Prevalence of Hypertension and its Related Factors in Children Aged 7 to 12 Years in Larestan (South Fars Province, Iran)

Background: Childhood hypertension can have serious consequences for children, especially during their adulthood. This study aimed to determine the prevalence of hypertension and its related factors in children aged 7 to 12 years in Larestan (Iran).&#x0D; Methods: In this cross-sectional study, 1110 students from 7 to 12 years old in Larestan were enrolled in the study using cluster sampling. In order to collect educational data, 10 girls' primary schools and 10 boys' primary schools were randomly selected from all the girls' and boys' primary schools. Then, considering that each school has different number of students, 55 students of each school were randomly selected. Students' blood pressure was measured as standard. Their personal information was also recorded in a checklist. A checklist containing demographic information, factors and variables that affect the prevalence of hypertension in children aged 7 to 12 years was used. To collect information, a checklist was used that included demographic information such as age, gender, and place of residence. Also, in order to identify factors and variables effective in the prevalence of high blood pressure (HBP), tools such as sphygmomanometer and other risk factors including obesity, type of diet, physical activities, and body mass index (BMI) were used.&#x0D; Results: The mean age of girls was 9.11 ± 1.53 and boys were 9.19 ± 1.52, which did not differ significantly from the statistical point of view. The prevalence of pre hypertension was 6.03% (95% CI: 4.71-7.60) and the prevalence of hypertension was 4.14% (95% CI: 3.05-5.49). Systolic and diastolic blood pressure has direct relation with height and weight of children. Diastolic blood pressure also had a higher prevalence in girls (P &lt; 0.001).&#x0D; Conclusion: Overweight and obesity as a moderate aggressive factor were significantly associated with blood pressure. Also, the prevalence of HBP in children was significant, and it is necessary to pay attention to it in childhood. Moreover, hypertension cases should be identified and treatment should start faster for the affected person to prevent the adverse consequences in the future.

Perioperative Anesthesia-Related Complications and Risk Factors in Children: A Cross-Sectional Observation Study in Rwanda.

Despite an increasing awareness of the unmet burden of surgical conditions, information on perioperative complications in children remains limited especially in low-income countries such as Rwanda. The objective of this study was to estimate the prevalence of perioperative anesthesia-related adverse events and to explore potential risk factors associated with them among pediatric surgical patients in public referral hospitals in Rwanda. Data were collected for all patients under 5 years of age undergoing surgery in 3 public referral hospitals in Rwanda from June to December 2015. Patient and family history, type of surgery, comorbidities, anesthesia technique, intraoperative adverse events and postoperative events in the postanesthesia care unit (PACU) were recorded. The incidence of perioperative adverse events was assessed and associated risk factors analyzed with univariate logistic regression. Of 354 patients enrolled in this study 11 children had a cardiac arrest. Six (1.7%) suffered an intraoperative cardiac arrest, 2 of whom (0.6%) died intraoperatively. In the PACU, 6 (1.8%) suffered a postoperative cardiac arrest, 5 of whom (1.5%) died in the PACU. One child had both an intraoperative cardiac arrest and then a cardiac arrest in PACU but survived. Eighty-nine children (25.1%) had an intraoperative adverse event, whereas 67 (20.6%) had an adverse event in PACU. A review of the cases where cardiac arrest or death occurred indicated that there were significant lapses in the expected standard of care. Age <1 week was associated with cardiac arrest or death. The rate of perioperative complications, including death, for children undergoing surgery in tertiary care hospitals in Rwanda was high. Quality improvement measures are needed to decrease this rate among surgical pediatric patients in this low resource setting.

Childhood predictors of successful self-reported delinquents

ABSTRACT The main aim of this research is to investigate the childhood predictors of successful self-reported delinquents, defined as those who were not convicted. In the Cambridge Study in Delinquent Development (CSDD), 411 London males have been followed up from age 8 to age 61. Self-reported offending was measured for the whole sample for ages 10–14, 15–18, 27–32, and 42–47, for five crimes: burglary, theft of a vehicle, theft from a vehicle, shoplifting, and vandalism. The prevalence of self-reported offending was 64% at ages 10–18 and 11% at ages 27–47, compared with the prevalence of convictions of 23% and 8% respectively. Successful self-reported delinquents were defined as those who offended between ages 10 and 18 but were not convicted up to age 26; 126 successful delinquents were compared with 120 convicted delinquents. Sixteen childhood factors, including attainment, self-control, socioeconomic, parental, family and behavioural factors, predicted successful self-reported delinquents. The most important independent predictors were committing less serious and fewer offences as well as high school attainment, unconvicted parents, low risk-taking, and unseparated families.

The mediators for the link between autism and real-world executive functions in adolescence and young adulthood.

Childhood factors that predict real-world executive function in autism spectrum disorder during the transition into adulthood are largely unknown. This study aimed to identify the predictors for the behavioral and cognitive aspects of real-world executive function in late adolescent and young adult autistic populations. We followed up 289 autistic youth (mean age 11.6 years) and 203 non-autistic controls (10.7 years) to their ages of 16.9 and 15.8, respectively. The Behavior Rating Inventory of Executive Function scale was used to measure the real-world executive function at late adolescence and young adulthood at follow-up. Potential predictors such as autistic symptoms, inattention or hyperactivity symptoms, peer relationship, emotional symptoms, and parenting styles were assessed in childhood at first enrollment. The results showed that childhood inattention, withdrawn behaviors, social communication difficulties, and child-reported emotion and inattention/hyperactivity may predict real-world lower executive function in late adolescence and young adults with autism. When separating executive function into behavioral and cognitive aspects, we found that oppositional behaviors and peer problems were specific predictors for behavioral regulation and cognitive function, respectively. Our findings suggested that treating common predictors in childhood, such as inattention, may potentially improve real-world executive function in autism during the transition into adulthood.

The role of diet in multiple sclerosis onset and course: results from a nationwide retrospective birth-year cohort.

To examine (1) the association between childhood diet and developing MS, age of onset and onset type and (2) the association between diet at age 50 and disability and MRI volumes in people with MS (PwMS). The study enrolled 361 PwMS born in 1966 and 125 age- and sex-matched healthy controls (HCs). Information on individual dietary components (fruit, vegetables, red meat, oily fish, whole-grain bread and candy, snacks and fast food) and MS risk factors at the age of 10 and 50 years were collected using questionnaires. Overall diet quality score was calculated for each participant. Multivariable regression analyses were used to evaluate the association between diet at childhood and developing MS, age of onset and onset type and to evaluate diet at age 50, disability and MRI outcomes. Poorer overall diet quality and individual dietary components during childhood (less whole-grain bread, more candy, snacks and fast food and oily fish) were associated with developing MS and onset type (all p < 0.05), but not with the age of onset. Fruit consumption at age 50 was associated with lower disability (Q3 vs. Q1: -0.51; 95% CI: -0.89 to -0.13). Furthermore, several individual dietary components at age 50 were associated with MRI volumetric measures. Higher-diet quality at age 50 was only associated with lower lesion volumes in PwMS (Q2 vs. Q1: -0.3 mL; 95% CI: -0.5 to -0.02). We demonstrate significant associations between dietary factors in childhood and developing MS, age of onset and onset type and between dietary factors at age 50 and disability and MRI-derived volumes.

Nutritional Status and Its Associated Factors in Children Under 5 Years of Age in the Aseer Region, Southwestern Saudi Arabia

Nutritional Status and Its Associated Factors in Children Under 5 Years of Age in the Aseer Region, Southwestern Saudi Arabia

P18-045-23 Association of Vitamin B12 Status With Body Composition and Metabolic Risk Factors in Children From Southern India

P18-045-23 Association of Vitamin B12 Status With Body Composition and Metabolic Risk Factors in Children From Southern India

Identifying the Blood Lead Reference Value Based on the Advisory Committee on Childhood Lead Poisoning Prevention Guidelines and Factors Associated with Elevated Blood Lead Levels among Preschool Children in Thailand, 2019

The blood lead reference value (BLRV) is used for guiding lead prevention and control measures. It is usually defined as the 97.5th percentile of the population-based blood lead level in each country. This study aims to determine the BLRV and factors associated with elevated (≥5 µg/dL) blood lead levels among children aged 1–5 years in Thailand. A cross-sectional study was conducted using secondary data extracted from a national survey, implemented in 171 hospitals during October 2018–September 2019. Demographic characteristics and potential risk factors including lead-related industries were collected. Multilevel logistic regression was used. Of 3,184 children included in the survey, the BLRV was 6.9 µg/dL. Three significant risk factors were identified: living near a lead factory (adjusted odds ratio (AOR) 2.09, 95% CI 1.27–3.42), exposure to the manufacture of fishing tackle (AOR 4.39, 95% CI 1.54–12.50), and exposure to the manufacture of shot and ammunition (AOR 6.30, 95% CI 1.81–21.93). Despite a calculated BLRV of 6.9 µg/dL, we propose a BLRV of 5 μg/dL in Thailand based on guidelines from the United Kingdom. Surveillance of blood lead levels should be established among children at high risk of lead exposure.

Early Life Disadvantage and the Risk of Depressive Symptoms among Young Black Women.

We examined the association between early-life socioeconomic disadvantage and depressive symptoms in adulthood and assessed whether social factors in adulthood modify the association. The11-item Center for Epidemiologic Studies-Depression Scale (CES-D) assessed adult depressive symptoms among 1612 Black women and other participants with a uterus (hereafter participants) in the Study of Environment, Lifestyle and Fibroids. Baseline self-reported childhood factors (i.e., parents in the household, mother's educational attainment, food insecurity, neighborhood safety, childhood income, and quiet bedroom for sleep) were included in a latent class analysis to derive an early life disadvantage construct. Multivariable log-binomial models estimated the association between early life disadvantage and adult depressive symptoms. Potential effect modifiers included adult educational attainment, social support, and financial difficulty. Participants classified as having high early life disadvantage had 1.34 times (95% CI: 1.20, 1.49) the risk of high depressive symptoms than those in the low early life disadvantage class after adjusting for age, first born status, and childhood health. Adult educational attainment and social support modified the association. Early life disadvantage increased the risk of depressive symptoms in adulthood. Participants with at least some college education and with high social support had greater risk than those with less than college education and low social support, respectively. Thus, the mental health ofBlack women and other participants with a uterusexposed to early life disadvantage do not necessarily benefit from higher education or from social support.

Childhood modifiable risk factors and later life chronic kidney disease: a systematic review

BackgroundRelationships between adulthood modifiable risk factors and chronic kidney disease (CKD) are well-established, but associations with childhood risk factors are unclear. This study systematically assesses the published evidence about childhood modifiable risk factors and adulthood CKD.MethodsWe searched MEDLINE, EMBASE, and Web of Science to 6th May 2022. Articles were included if (1) they were population-based longitudinal studies, (2) exposures were potentially modifiable, for example through pharmacological or lifestyle modifications, including clinical conditions/measures (diabetes, blood pressure, adiposity, and dyslipidaemia); health behaviours (smoking, alcohol consumption, physical activity, fitness, and poor nutrition); and socio-economic factors (socio-economic position), and occurred during childhood (ages 2–19 years), and (3) outcome was CKD or surrogate markers of CKD in adulthood (ages 20 years or older). Three reviewers independently extracted the data.Results15,232 articles were identified after deduplication; 17 articles met the inclusion criteria, reporting childhood blood pressure (n = 8), adiposity (n = 4), type 2 diabetes (n = 1), socio-economic position (n = 1), famine (n = 1), cardiorespiratory fitness (n = 1), and a healthy lifestyle score (n = 1). The results suggested positive associations of childhood adiposity, type 2 diabetes, and low socio-economic position and cardiorespiratory fitness in females with CKD in adulthood. Findings were inconsistent on associations between childhood BP and CKD in adulthood. Childhood healthy lifestyle score and exposure to famine were not associated with risk of CKD in adulthood.ConclusionsThe limited evidence suggests childhood factors may contribute to the CKD risk in adulthood, particularly adiposity, type 2 diabetes, and low socio-economic position and cardiorespiratory fitness in females. Further high-quality community-based studies are needed with long-term follow-up and investigation of a broader range of modifiable risk factors.

Food habits and risk factors for child malnutrition in rural families in the municipality of Soracá, Boyacá, Colombia

ABSTRACT Child malnutrition is a global public health problem which causes irreversible damage to physical and cognitive development in early childhood. In 2015, the National Survey of Nutrition reported that Boyacá, Colombia had a prevalence of chronic malnutrition of 11.6% above the national average, considering that Boyacá is predominantly rural territory. This article analyzes the risk factors that influenced the diets of children between 16 and 38 months among 27 rural families. Through a descriptive cross-sectional study, a survey of the socio-family characterization and knowledge, attitudes, and practices (KAP) were applied with participating families. It was found that among the nutritional risk factors in early childhood are low levels of maternal schooling, low economic income, and barriers to accessing health and education services. The results of this research enable contributions to the contextualization of public policies in health and nutrition with a territorial approach that allow the improvement of the quality of life in early childhood in rural areas.

Quality of Life &amp; Associated Factors in Children Having Polio Related Disabilities; A Cross Sectional Study

Quality of Life &amp; Associated Factors in Children Having Polio Related Disabilities; A Cross Sectional Study

Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study

Introduction: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by deficits in social-emotional reciprocity and associated behavioral symptoms. The goal of this study was to examine perinatal risk factors for ASD and their correlates in a tertiary care hospital in Dubai, United Arab Emirates (UAE). Methods: We conducted a case-control study of 87 children diagnosed with ASD using the DSM-5 criteria, who were born between 1999 and 2014, and diagnosed between 2014 and 2016, and 134 age- and gender-matched control subjects. Data were collected from hospital medical records. Associations between ASD and maternal, birth, and neonatal risk factors were examined using logistic regression analysis. Results: Maternal fever was associated with ASD (p = 0.018), with 0% in the control group and 5% in the cases. Multivariate logistic regression analysis revealed a trend for an association between high birthweight (>4,000 g) and ASD (95% CI: 0.76–59.93, p = 0.086). Conclusion: The data affirmed the established gender difference of approximately four males to one female and supported previous findings associating ASD with prematurity. Larger representative studies are further required to explore risk factors for ASD in the UAE.

The role of somatic factors in early childhood and adolescent psychosomatic disorders

Objective. This study aimed to establish practical evidence of the leading role of somatic factors in psychosomatic health disorders in the early stages of the mental development of children and adolescents.&#x0D; Materials and methods. An interview method was used to obtain complete and reliable historical data for children and youth who applied for primary medical care. In addition, an anonymous questioning method was implemented. It allowed gathering of a reliable database of basic information on the psychosomatic health of children and adolescents in the Western European region. A study enrolled a sample of 1000 children, including 498 girls and 502 boys, aged 13 to 18 years.&#x0D; Results and Discussion. Psychosomatic pathologies were detected in 54% of cases, of which 63% were female. The influence of somatic factors on psychosomatic pathology progression was found to be greater in the early stages of mental development.&#x0D; Conclusion. The study’s findings may serve as a primary basis for understanding the role of somatization factors on psychosomatic disorders in children and adolescents in the early stages of mental development. The study also highlights the need to enhance the methodological basis for preventing psychosomatic disorders in children and adolescents.&#x0D; Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 687-694

Spiritual Well-Being and Related Factors in Children With Cancer.

Introduction: There are specific gaps that call for empirical research in the experiences of spiritual well-being among children 12 years old and younger with cancer. Understanding these relationships can help to develop holistic and family centered care in pediatric oncology wards. This study assessed the spiritual well-being of children with cancer in association with their general well-being, happiness, quality of life, pain intensity, and personal characteristics. Method: The data were collected in Lithuania between June 2020 and November 2021. Children with cancer (N = 81) who were hospitalized at pediatric oncology-hematology centers participated in the study. Inclusion criteria were age (from 5 to 12 years old), diagnosis of oncologic disease for the first time, and absence of other chronic diseases. The instruments used were: Feeling Good, Living Life; Oxford Happiness Questionnaire, Short Form; Well-Being Index; PedsQL™3.0 Cancer Module, and a Wong-Baker FACES® Pain Rating Scale. Results: Communal and personal domains of spiritual well-being had the highest scores among pediatric oncology patients while both dimensions of the transcendental domain scored lowest. Age, level of education, and family composition revealed differences in children's spiritual health, happiness, and well-being, and church attendance was significant for overall spiritual well-being and its transcendental domain on lived experience dimension. Happiness had the strongest effect on all four domains of spiritual well-being. Discussion: Children emphasized the importance of spiritual aspects to feel better to a greater extent than they experienced in their lives. Despite their young age, children were familiar with family traditions, that is, religious practice and church attendance, and followed them in a particular sociocultural context.