We provide evidence that computing the maximum flow value between every pair of nodes in a directed graph on n nodes, m edges, and capacities in the range [1‥ n ], which we call the All-Pairs Max-Flow problem, cannot be solved in time that is significantly faster (i.e., by a polynomial factor) than O ( n 3 ) even for sparse graphs, namely m = O ( n ); thus for general m , it cannot be solved significantly faster than O ( n 2 m ). Since a single maximum st -flow can be solved in time Õ( m √ n ) [Lee and Sidford, FOCS 2014], we conclude that the all-pairs version might require time equivalent to Ω ˜ ( n 3/2 ) computations of maximum st -flow, which strongly separates the directed case from the undirected one. Moreover, if maximum st -flow can be solved in time Õ( m ), then the runtime of Ω ˜ ( n 2 ) computations is needed. This is in contrast to a conjecture of Lacki, Nussbaum, Sankowski, and Wulff-Nilsen [FOCS 2012] that All-Pairs Max-Flow in general graphs can be solved faster than the time of O ( n 2 ) computations of maximum st -flow. Specifically, we show that in sparse graphs G = ( V , E , w ), if one can compute the maximum st -flow from every s in an input set of sources S ⊆ V to every t in an input set of sinks T ⊆ V in time O ((| S || T | m ) 1−ε ), for some | S |, | T | and a constant ε > 0, then MAX-CNF-SAT (maximum satisfiability of conjunctive normal form formulas) with n ′ variables and m ′ clauses can be solved in time m ′ O (1) 2 (1−δ) n ′ for a constant δ(ε) > 0, a problem for which not even 2 n ′ / poly ( n ′) algorithms are known. Such running time for MAX-CNF-SAT would in particular refute the Strong Exponential Time Hypothesis (SETH). Hence, we improve the lower bound of Abboud, Vassilevska-Williams, and Yu [STOC 2015], who showed that for every fixed ε > 0 and | S | = | T | = O (√ n ), if the above problem can be solved in time O ( n 3/2−ε ), then some incomparable (and intuitively weaker) conjecture is false. Furthermore, a larger lower bound than ours implies strictly super-linear time for maximum st -flow problem, which would be an amazing breakthrough. In addition, we show that All-Pairs Max-Flow in uncapacitated networks with every edge-density m = m ( n ) cannot be computed in time significantly faster than O ( mn ), even for acyclic networks. The gap to the fastest known algorithm by Cheung, Lau, and Leung [FOCS 2011] is a factor of O ( m ω−1 / n ), and for acyclic networks it is O ( n ω−1 ), where ω is the matrix multiplication exponent. Finally, we extend our lower bounds to the version that asks only for the maximum-flow values below a given threshold (over all source-sink pairs).