ABSTRACT Ecotherapeutic and nature-based interventions have shown promise in supporting holistic wellness. A pilot study was conducted to measure the effectiveness of Seeds of Wellness, an eight-week horticultural therapy and nature-based expressive arts program designed to support holistic wellness. The Five Factor Wellness Inventory (5F-WEL) and Reese EcoWellness Inventory were used to measure change in wellness throughout the program. A check-in and follow-up assessment was developed and administered at the start and end of each weekly session to measure change throughout the program. The process of development, implementation, study results, and implications are reviewed. Statistical analysis showed that there was a significant improvement in overall EcoWellness Inventory scores from the start to the end of the program. According to the 5F-Wel, there was no significant change in overall wellness behavior scores from the start to the end of the program. However, weekly check-in and follow-up scores illustrated positive changes in participants from the start to the end of each session, suggesting that perceived wellness may have been positively impacted. Future studies could include a focus on the impact of horticultural and nature-based on perceived wellness.