Overload Factor Research Articles

Case of dilated cardiomyopathy after cellular therapy

Dilated cardiomyopathy is an etiologically heterogeneous myocardial disease characterized by left ventricular or biventricular dilation with systolic dysfunction in the absence of hemodynamic overload factors (hypertension, valvular defects, congenital heart anomalies) or coronary pathology (ischemic heart disease) [1].

Indicators of Blood Glucose Imbalance in Children with Beta-thalassemia Major

Children diagnosed with beta-thalassemia major have a significantly increased likelihood of developing an imbalance in their blood glucose levels. It is essential to do screenings for diabetes and prediabetes in children, and to maintain a high degree of suspicion for abnormalities in blood glucose levels, since this is important for their management. Additionally, it is crucial to acknowledge other markers of blood glucose imbalance, including the glycated hemoglobin level, the fructosamine level, and the occurrence of hypoglycemic crises. Implementing preventive measures and closely monitoring one's health can effectively hinder the path towards diabetes. Thalassemia is a prevalent hereditary blood condition. The need for frequent blood transfusions in thalassemia leads to an excess of iron in the body, which has a role in the development of several disorders, including those affecting insulin production and function. This review examines the several markers of blood glucose dysregulation in children diagnosed with beta-thalassemia major. It also explores the impact of iron overload and other factors, such as the effects of desferioxamine and deferasirox. The review also discusses strategies for preventing diabetes and emphasizes the significance of a multidisciplinary team in caring for these youngsters

#2122 Dynamics of peritoneal transport and peritoneal dialysis outcomes

Abstract Background and Aims Volume overload is one of the most important factors associated with cardiovascular disease in peritoneal dialysis (PD) patients. On the other hand, the dynamics of peritoneal transport predicts important changes in the peritoneal membrane associated with local and systemic inflammation, which may be important for the progression of cardiovascular disease. The changes in free water transport (FWT) over time can characterize the development of peritoneal fibrosis. In a prospective study with retrospective historical control, the influence of the initial status and dynamics of peritoneal FWT on the outcomes of peritoneal dialysis, hard and surrogate cardiovascular outcomes was evaluated. Method According ISPD Recommendations (2021) the function of peritoneal membrane solute transfer was evaluated in classical PET in the exchange of 2 liters of 2.5% glucose solution with the calculation of the creatinine D/P4 ratio, which was used in the analysis as a continuous value (peritoneal solute transfer rate - PSTR), as well as categorized into high, medium-high, medium-low and low (H, HA, LA, L, respectively) levels of peritoneal transport. The mass transfer coefficient (MTAC) was also calculated. The ultrafiltration function of the membrane and its dynamics were evaluated by measuring the transport of water through small pores and free water through ultrapores, in double mini-PET (in two one-hour exchanges with solutions of 4.25% and 1.5% glucose). FWT is the calculated value; the primary measured value is the degree of reduction of sodium in the dialysis solution one hour after the start of the exchange (dipNa) formed as a result of electrolyte-free water transport through ultrapores (aquaporins), which dilutes dialysate. Results Table 1 shows the average values of peritoneal transport indicators at the beginning of follow-up and the annual changes calculated over the entire period of prospective follow-up for each patient. Major adverse cardiovascular events (Table 2) were recorded with a relatively low frequency, but significantly differed by incidence between the subgroups with high (H) and high-average (HA) peritoneal transport, on the one hand, and low-average (LA) and low(L), on the other: 0.626 ± 0.049 vs. 0.320 ± 0.042 events per year; p<0.001, (49% fewer events). Similarly, there was a significant difference in the MACE incidence between patients with slow and rapid decrease in free water transport (divided by the median of the rate of in free water transport decrease): 0.414 ± 0.044 vs. 0.510 ± 0.051 events per year; p < 0.001, (19% fewer events). The same calculations for nonfatal cardiovascular events showed a fewer incidence of 47.2% and 17.1%, respectively. Thus, patients with a high transport status (according to the PET test) and patients with a rapid decrease in water transport through aquaporins (indicating an increase in fibrotic changes in the peritoneal mesothelium), accompanied also by an increase in peritoneal permeability to solutes, including glucose, are at greater risk of progression of cardiovascular disease. Conclusion In addition to confirming the link between the initial status of peritoneal transport and the subsequent incidence of cardiovascular events, it would be interesting to confirm the influence of cardiovascular disease (as a proinflammatory condition and as a factor of volume overload, forcing the wider use of concentrated solutions which damage the peritoneum) on the progression of peritoneal fibrosis, but according to available materials it was not possible due to the limited number of patients in the study (especially – patients with repeated assessments of peritoneal transport after the cardiovascular events) and low frequency of peritoneal transport monitoring, on the one hand, and uncertainty in identifying the exact time of development of heart failure and the need for revascularization. Continued prospective observation would clarify these links.

#373 Risk factors for progressive cardiorenal syndrome in patients with chronic kidney disease: the CRIC study

Abstract Background and Aims Cardiorenal syndrome (CRS) is associated with poor outcomes. However, risk factors for progressive CRS are not well studied in patients with chronic kidney disease (CKD). We studied the incidence and risk factors for progressive CRS in a cohort of CKD patients. Method 3 557 participants with CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study were included in this analysis after excluding those with heart failure (HF) at baseline visits. The mean follow-up time was 10.5 years. Progressive CRS was defined as development of both HF and renal failure (RF) (dialysis or transplant) within 12 months of each other. Cox proportional hazards models were used to examine the association of risk factors with progressive CRS. In a sensitivity analysis, risk factors for CRS type 2 (HF preceded RF during entire follow up) and CRS type 4 (RF preceded HF) were analyzed. Results The average baseline age was 59 years for those with progressive CRS and 57 years for those without. The age-adjusted incidence of progressive CRS was 4.5/1000 person-years and was 5.0/1000 person-years in Men and 5.9 in Black. The multivariable-adjusted hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for traditional risk factors are as follow: less than high school education (1.82, 1.2-2.73), history of cardiovascular disease (CVD) (1.48, 1.03-2.12), lower educational attainment (per 1 standard deviation [SD]) in eGFR (1.83, 1.40-2.39), and higher (per 1 SD) albumin-to-creatinine ratio (ACR) (2.26, 1.78-2.86). The multivariable-adjusted HRs with corresponding 95% CIs for a one-standard deviation increase in novel risk factors are as follows: hemoglobin (0.82, 0.68-0.99), hemoglobin A1C (1.31, 1.14-1.52), log alkaline phosphatase (1.18, 1.00-1.38), and log brain natriuretic peptide (1.32, 1.10-1.57), adjusting for age, sex, race, clinic sites, and all significant traditional risk factors (education, CVD, eGFR, and ACR). In sensitivity analysis, the risk factor associated with both CRS type 2 and 4 were kidney dysfunction, albuminuria, and mineral bone disorder (higher alkaline phosphatase and FGF23), inflammation (TNF-α), and fibrotic factor (GDF-15), while diabetes, CVD, systolic blood pressure, waist circumference, anemia, HbA1c, and volume overload were more strongly associated with CRS type 2 compared to CRS type 4. Conclusion This study indicates that education level, history of CVD, kidney dysfunction, albuminuria, mineral bone disorder, diabetes control, anemia, volume overload, inflammation, and fibrotic factors are associated with progressive CRS. Many of these risk factors are modifiable. Further studies are warranted to assess the benefits of specific interventions to improve CRS outcomes.

Exploring the relationship between thalassemia and bone health: A clinicopathological analysis

Objectives: To study the bone mineral density in patients with thalassemia. Thalassemia is a genetic disorder characterized by reduced synthesis of the globin chain, leading to decreased hemoglobin levels. Blood transfusion therapy is the primary treatment, but it can cause iron overload and other factors that increase the risk of low bone mineral density. Despite this, there is limited research on thalassemia patients in India, particularly in the North Eastern region, with a focus on bone mineral density. Material and Methods: We conducted a hospital-based case-control study in the Department of Medicine at Assam Medical College and Hospital, Dibrugarh, from June 1, 2020, to May 31, 2021. We have collected data from 51 cases and 51 healthy controls and analyzed it (SPSS for Windows, version 21.0 Chicago, SPSS Inc.) and Microsoft Excel 2010. Bone mineral density was measured by Dual-Energy X-ray Absorptiometry (DEXA) (Lunar Prodigy Advance DEXA (GE Healthcare, Madison, WI, USA). Results: Our study also showed that thalassemia patients had a 3.775 times higher risk of low bone mineral density at the lumbar vertebra and a 4.0421 times higher risk at the femur neck than the normal healthy population. The mean BMD at the lumbar spine and femur neck were lower for cases than controls, with the difference at the femoral neck being statistically significant. Conclusion: Our study highlights that more than half of thalassemia patients have low bone mineral density, with the femoral neck and lumbar neck being more affected than normal age and sex-matched controls. These findings underscore the importance of monitoring bone health in thalassemia patients and implementing appropriate interventions to prevent or manage low bone mineral density.

LESÃO DE OMBRO NO SURFE: UMA REVISÃO SISTEMÁTICA COM METANÁLISE

ABSTRACT Objective: To establish the epidemiological profile of shoulder injuries suffered by surfers, through the injury proportion rate, type, mechanism and/or severity, caused by surfing. Methods: This systematic review was conducted and written in accordance with the guidelines for systematic reviews– PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The bibliographic research was carried out between January 2020 and January 2022 in journals indexed in the Web of Science, SPORTDiscus, PubMed, Scopus, Cochrane and Embase databases. Data were analyzed in RStudio, and the methodological quality of the studies was assessed. Results: Ten studies were included, all of which were retrospective in cross-sectional design and had an average methodological quality of 75%. The meta-analysis showed an injury incidence rate of 14.88%. Odds ratio analysis showed that injuries of joint origin are 7.26 times significantly higher in individuals with shoulder injuries, and injuries of bone origin and skin injuries had reduced odds of 70% and 89%, respectively. The most common mechanism of injury was the movement of paddling (57,68%), with the average prevalence of acute injuries being 31.53% and chronic injuries being 68.47%. Conclusion: There was a scarcity and/or variation in the categorization of data regarding injuries in the shoulder region resulting from surfing, with injuries of joint and musculotendinous origin being frequent; and rowing, the most overloading factor. Level of evidence II, Systematic Review.

Etiology of gingival recession - a literature review.

Gum recession is a common problem that in most cases does not cause any bothersome symptoms to the patient. They can affect people of any age and are most often diagnosed on the vestibular surfaces of the teeth. They are manifested by the exposure of part of the root through the apical migration of the gingival margin. Its etiology is not fully understood, but it is known that it consists of many factors. The authors discussed such factors as inflammation, gum biotype, patient's age, mechanical and chemical damage, smoking, presence of tartar, cervical defects and their reconstruction, orthodontic treatment, occlusal overload and iatrogenic factors. Additionally, important risk factors also include genetic predispositions and abnormalities in the immune system. In addition, certain hygiene habits, such as improper brushing techniques or lack of regular check-ups at the dentist, may also contribute to the development of gum recession. Understanding the comprehensive nature of these factors is crucial to the effective treatment and prevention of this common condition. It is also worth taking into account the importance of educating patients on proper oral hygiene and regular dental check-ups to prevent gum recession.

ИССЛЕДОВАНИЕ ВЗАИМОСВЯЗИ ПСИХОЛОГИЧЕСКОГО ВЫГОРАНИЯ И ЭМОЦИОНАЛЬНОГО ИНТЕЛЛЕКТА У МЕДИЦИНСКИХ РАБОТНИКОВ

Turbulence in the external environment, information overload, inflated expectations and other factors increase the level of stress experienced by people, including in the workplace. This affects the efficiency of accomplishing organizational tasks, the level of conflict and labor productivity in the company. In this regard, it is of interest to study the relationship between the level of emotional intelligence and emotional burnout syndrome. The object of the study is a team of medical workers of the State Autonomous Healthcare Institution “Interregional Clinical Diagnostic Center” (GAUZ MKDC). Using survey methods and statistical data analysis, it was concluded that there is a connection between emotional intelligence and burnout syndrome in medical workers, which may be useful for the development of prevention and support programs for personnel.

Damage Process Criterion for the Concrete Dam in Geomechanical Model Test

The geomechanical model test (GMT), a means of intuitively exploring the model’s failure modes and revealing failure mechanisms, is considered an effective approach for studying the structural characteristics of dams under complex geological conditions. However, during the overloading process of the model, the catastrophe trends of monitoring data are unclear, and catastrophe points differ at different monitoring sites. These factors have led to large errors in the judgment of researchers regarding the model’s state and misperception of the structural properties during the damage process. In this study, a comprehensive evaluation method for the model’s state intervals in the damage process is proposed. The criterion employed an interval analysis hierarchy process that considered the differences, consistency, and credibility (CDC‐IAHP) among multiple decision‐makers (DMs), effectively reducing the subjectivity of their judgments. Additionally, this process was combined with cusp catastrophe theory (CCT) to determine whether the model underwent an abrupt change at various overload factors comprehensively. This is the first time that CDC‐IAHP and CCT have been combined as criterion for a comprehensive method on the damage process of concrete dams in GMTs, and was applied to the Wudu gravity dam, indicating its applicability is very good. Compared to the researcher’s judgment, this approach is used to analyze and judge the structural state more accurately and scientifically while reducing subjectivity, which can help to better understand the structural characteristics and bearing capacity of actual engineering projects.

Serum albumin levels and fluid overload in patients with hemodialysis: study in a private hospital in Zacatecas

One of the markers to evaluate health in patients with hemodialysis is the level of serum albumin, water overload is a common complication in this type of people that can affect albumin, the objective in this work was to know the levels of serum albumin and its relationship with fluid overload in patients with chronic renal failure on hemodialysis. A descriptive, cross-sectional and analytical study was carried out in a renal therapy unit of a private hospital in the city of Zacatecas, the sample consisted of 50 patients of both sexes. The variables considered were serum albumin, body mass index (BMI), water overload, anthropometry and sociodemographic factors. An intermediate negative correlation (-0.382) was found with a p of 0.003, which suggests a significant association between the two variables. These results are of clinical relevance, since maintaining adequate levels of serum albumin can contribute to the prevention or control of fluid overload in these patients, which in turn can positively impact their health and quality of life.

Comparison of prediction methods for added power and propeller revolution for a 1,800 TEU container ship using resistance tests in regular and irregular waves

This paper predicts the added power and propeller revolution due to irregular head waves for a 1,800 TEU container ship. Resistance tests were conducted with 11 regular waves and irregular waves at SS = 5. Time series (TS) and autocovariance analysis methods were applied to estimate statistical variables and uncertainties. The paper investigated the statistical convergence times of measured data. The wave elevation, heave and pitch motions obtained from the TS agree well with those from spectral analysis in regular and irregular waves. The added resistance from the TS is larger than that from spectral analysis using a regular wave test by 6.1%. The characteristics of response operators and spectra of the added (or reduced) propulsion performances and overload factors are discussed. The power and propeller revolution were evaluated with a variety of methods: SA(LVM-W), LVM-IR, DPM, and RTIM.

Bridge Structural Reliability for Maintenance Prioritization

A significant percentage of assets of the Italian national bridge stock have outlived their nominal design service lives, a situation that has led to an increasing number of structural failures over the years, e.g. the deadly 2018 collapse of Morandi Bridge in Genoa. It would have been impossible to replace all existing infrastructural assets, so the focus was shifted to their upkeep. This is commonly achieved through structural health assessments of bridges and through properly planned and prioritized maintenance interventions. For a proper management of their bridge stock, infrastructure managers need a prioritization tool capable of quickly assessing whether a particular unit is in immediate need of maintenance. Currently, the prioritization of each bridge inside a stock is often based on its structural reliability. Yet, whilst several complex and time-consuming structural reliability assessment methodologies exist, these often fail to be quick in application. The present article provides for this shortcoming by introducing a novel simplified structural reliability model. In particular, it provides a framework for the assessment of overload, degradation, seismic, hydraulic and landslide risk factors and a detailed formalization of the most widespread, i.e. overload and degradation. On the basis of such a swift model, infrastructure managers can quickly detect rapidly deteriorating bridges, guarantee well-timed interventions and improve infrastructure user safety.

Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model

Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography is a commonly used tool for evaluating the risk hierarchy of PH. However, few studies have explored the dynamic changes in the structural and functional changes of the right heart during the process of PH. Previous studies have found that pulmonary circulation coupling right ventricular adaptation depends on the degree of pressure overload and other factors. In this study, we performed a time-dependent evaluation of right heart functional changes using transthoracic echocardiography in a SU5416 plus hypoxia (SuHx)-induced PH rat model. Rats were examined in 1-, 2-, 4-, and 6-week using right-heart catheterization, cardiac echocardiography, and harvested heart tissue. Our study found that echocardiographic measures of the right ventricle (RV) gradually worsened with the increase of right ventricular systolic pressure, and right heart hypofunction occurred at an earlier stage than pulmonary artery thickening during the development of PH. Furthermore, sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), a marker of myocardial damage, was highly expressed in week 2 of SuHx-induced PH and had higher levels of expression of γ-H2AX at all timepoints, as well as higher levels of DDR-related proteins p-ATM and p53/p-p53 and p21 in week 4 and week 6. Our study demonstrates that the structure and function of the RV begin to deteriorate with DNA damage and cellular senescence during the early stages of PH development.

Sparse Neural Network for Detection and Decoding of Non-Binary Polar-Coded SCMA

Sparse code multiple access (SCMA) and polar codes have demonstrated superiority in supporting massive connections and short-packets, which are essential in the uplink transmission of the internet of things. This paper proposes a sparse neural network (SNN) for the detection and decoding of the non-binary polar-coded SCMA. The network consists of the message passing algorithms (MPA) and the sparse belief propagation (SBP) modules, which are immigrated from the MPA and BP algorithms, respectively. The nodes of the bipartite BP factor graph that do not contribute to the belief propagation are pruned to form the SBP module. A structure factor α defined by the ratio of the number of layers in the MPA modules and that of the SBP modules is analyzed to find a balance between the decoding performance and the complexity. The weights are set on the neurons of the layers and trained by the stochastic gradient descent. Finally, the simulation results show substantial improvements in bit error rate with low complexity over the traditional receiver. Specifically, the SNN receiver outperforms the traditional receiver by 2.56 dB in the AWGN channel when the code length is 16, the code rate is 1/2, and the user overloading factor is 150%.

Technical Analysis of Highway Bridge Static Load Test

Highway bridges are an important part of the transportation industry and can promote social economic construction and development. In actual operation, highway bridges are often damaged due to overload and natural factors, which tend to affect the safety and shorten the service life of these bridges. Assessing the overall state and performance of highway bridges is therefore a key element. Static load test, which is a type of sustainable detection experiment, has many advantages, including low cost, high efficiency, and high accuracy. In this paper, the bridge structure is analyzed through the application of theoretical calculations and relevant comparisons, so as to judge the operating state of the bridge.

New sets of non-orthogonal spreading sequences with low correlation and low PAPR using extended Boolean functions

Extended Boolean functions (EBFs) are one of the most important tools in cryptography and spreading sequence design in communication systems. In this paper, we use EBFs to design new sets of spreading sequences for non-orthogonal multiple access (NOMA), which is an emerging technique capable of supporting massive machine-type communications (mMTC) in 5 G and beyond. In this work, first p-ary complementary sequences are constructed using EBFs and then, these sequences are used to design new sets of non-orthogonal spreading sequence sets having very low coherence and peak to average power ratio (PAPR). The proposed spreading sequence sets are capable of supporting a large number of active devices simultaneously. In fact, for a p-ary spreading sequence set, we theoretically achieve an overloading factor of 2p, where p is an odd prime. Specifically, for $$p=3$$ , we achieve an overloading factor of 6, which cannot be achieved through the existing constructions till date.

THE ROLE OF EMPLOYEE STRESS IN WORKPLACE BULLYING AND ITS EFFECT ON ORGANIZATIONAL PERFORMANCE- A STUDY ON BANGLADESHI WORKPLACE

The workplace is an environment that can cause stress and lead to bullying. This study focuses on exploring the relationship between employee stress, workplace bullying, and organizational performance in the Bangladeshi workforce. The study uses qualitative research methods, including open-ended interviews and focus groups, to gather rich data from employees who have experienced or witnessed workplace bullying. The findings reveal that work overload and personal factors, such as age, gender, and education level, are common causes of employee stress in Bangladeshi workplaces. Moreover, employee stress plays a significant role in the occurrence of workplace bullying, making employees more vulnerable to bullies who target those showing signs of weakness, such as anxiety, depression, or disengagement from work. The study also shows that workplace bullying negatively affects employee job satisfaction, motivation, absenteeism, anxiety, stress, and depression, leading to a decline in productivity and employee morale. Additionally, cultural factors, such as a collectivist culture emphasizing loyalty to the group and respect for authority, contribute to workplace bullying in the Bangladeshi workforce.

The temporal dynamics between work stressors and health behaviors.

Applying dynamic equilibrium theory (DET), we examined the temporal dynamics between role overload and three health behaviors (sleep, diet, physical activity). Participants (N = 781) completed five surveys, with 1-month lag between assessments, and the data were analyzed using general cross-lagged panel modeling (GCLM). Results indicated that people had stable health behavior patterns (i.e., there were strong unit effects) that were related to stable role overload patterns (i.e., the chronic role overload and health behavior factors were significantly related). Furthermore, while monthly increases (impulses) in role overload had a negative effect on health behaviors concurrently, health behaviors quickly adapted or regressed back toward previous levels (i.e., there were weak autoregressive and cross-lagged effects after accounting for chronic factors). Impulse response functions were created to show the specific proportion of the initial impulse effect that persisted on each health behavior over time. The results of these response functions indicated that diet and physical activity regressed back to previous levels within 1 month, whereas sleep regressed back to previous levels within 2 months. Collectively, our results suggest that people engage in fairly stable patterns of health behaviors and that these patterns are partly determined by chronic role overload. Our results also suggest that people are generally resilient to temporary changes in role overload, such that the resulting immediate changes in behavior do not persist or become habitual. These results underscore the strength of habits and the resistance to health behavior change, as well as provide support for the use of GCLM for studying DET. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Frequency control of asynchronous motor for an irrigation pump of machine irrigation systems

The working state of freguency-operated asinchronous motor of irrigation pump in the closed system with feedback by velocity are considered. The system issue coefficient, provided a constancy of given value, loading coefficient of motor for voltage control pro rata control freguency are determined. Let us consider the static mode of operation of a frequency-controlled AM in a closed system with speed feedback. A decrease in the rotation speed in irrigation pumps to regulate their productivity is possible up to a certain minimum value, at which the pump head (H) becomes equal to the static head (Hst). The pump output (Q) then drops to zero. The value “k” has been determined, which ensures the constancy of the AM overload factor over the entire range of control frequency change in a closed-loop frequency control system with feedback on the engine speed.

Exploring the Effects of Overload and Stress Factors on WeChat Moments Users’ Discontinuous Usage Intention: an SSO Perspective

This study explores the factors that contribute to social media fatigue and how it affects users’ intentions to stop regularly using their WeChat Moments. The findings demonstrate that information overload, social overload, system feature overload, and upward social comparison (stressors) impact social media fatigue (Strain) and ultimately impact the decision to discontinue using WeChat Moments. Social media fatigue acts as a buffer between the stressors of social interaction and the outcome. Users who bear the pressure of the opinion leader role and have low clustering coefficients in the ego network are more likely to express the desire to discontinue using WeChat Moments.