Purpose The purpose of this study is to investigate potential users’ preferences and expectations for fabric-based wearable e-nose system designs in order to develop painless and non-invasive monitoring systems for diabetes. Design/methodology/approach After developing a fabric-based wearable sensor, this study used an online survey with a mixture of closed- and open-ended questions about people’s desires and preferences for use-contexts, product types, design styles, and other key design factors. Findings This study investigated the preferences and expectations on designs of wearable e-nose systems for diabetes. The results showed that designers and developers need to consider important design components including sizes, shapes, and colors for practical wearable e-nose system designs. There were strong positive and significant correlations between participant characteristics and preferred wearable e-nose system design factors. Research limitations/implications Future research could compare differences between different age groups with different types of diabetes. Practical implications Understanding these differences will help designers and marketers target consumers and create diverse designs with different versions for success in the market. Originality/value There is lack of research for considering designs of wearable monitoring systems for diabetes. This research will be the first research to understand design preferences and expectations for developing wearable e-nose monitoring systems for diabetes.