Factor In Male Patients Research Articles

Gender dimorphism in the DAT1 − 67 T-allele homozygosity and predisposition to bipolar disorder

Linkage and association studies implicate the dopamine transporter gene (DAT1) in the etiopathophysiology of bipolar disorder. We have recently reported the association between the DAT1 core promoter − 67A/T polymorphism and this disorder in a sample of Iranian patients. For the first time, these data support sex dimorphism in the homozygosity for the − 67 T-allele between male and female affected cases. The present study was undertaken with a larger sample size of cases ( N = 240) and controls ( N = 213) to determine whether there is consistent difference between male and female patients and homozygosity for this allele. The results confirm and strengthen our preliminary observation that homozygosity for the T-allele is a predisposing factor in male patients, but not in females ( χ 2 = 8.825, df = 1, p = 0.003). Moreover, Hardy–Weinberg disequilibrium was observed in the female cases studied ( χ 2 = 12.9, df = 1, p = 0.0003), which may reflect the underlying biology. These findings imply gender dimorphism with respect to the DAT1 − 67 alleles and susceptibility to disease.

Assessment of the Relational Factor in Male Patients Consulting for Sexual Dysfunction: The Concept of Couple Sexual Dysfunction

In a consecutive series of 1140 male subjects reporting a stable couple relationship and different degrees of sexual dysfunction, we evaluated the impact of relational factors, as assessed by the Structured Interview on Erectile Dysfunction (SIEDY) Scale 2 (exploring, as reported by the patient, menopausal symptoms, partner's medical illness interfering with sexual activity, and reduced partner desire and climax). We found that the SIEDY Scale 2 is significantly and independently associated with erectile dysfunction (ED), delayed ejaculation, hypoactive sexual desire, and decreased frequency of intercourse. SIEDY Scale 2 scores are associated with an advanced age of the partner and a long couple relationship, independently from patient's age. In addition, an increased relational factor correlates with increased extramarital affairs, conflicts in the couple, alcohol abuse, and presence of depressive symptoms, as assessed by the Middlesex Hospital Questionnaire. Our results should encourage the andrologist to consider the context in which sexual symptoms develop, analyzing the relationship and partner's behaviors and diseases. Resolving, or at least ameliorating, the relational background and the sexual framework might help in treating male sexual dysfunction.

Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia

AbstractCD38 expression of tumor cells has been identified as an important prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Although CD38 is involved in effector functions of T cells, the prognostic value of CD38+ T cells has not yet been addressed in B-CLL. In the present study, CD38-expression levels in B-CLL cells and T cells from 204 patients were analyzed by flow cytometry and correlated with clinical and molecular risk parameters. CD38 expression significantly differed in the neoplastic clone from patients with low versus advanced stage, irrespective of the sex of patients. In contrast, CD38 expression was generally higher in T cells from female compared with male patients but only increased in male patients in a stage-dependent manner. In male patients, combined analysis of CD38 in T cells and B-CLL cells identified 4 subgroups with significantly different treatment-free survival. Multivariate analysis including Rai stage and molecular risk parameters of the neoplastic clone identified CD38-expression levels in T cells as an independent prognostic factor in male patients. Combined analysis of CD38 in B-CLL and T cells is superior in predicting outcome of male B-CLL patients than either parameter alone. Further studies are needed to elucidate the underlying mechanisms of the sex-specific role of CD38+ T cells in B-CLL.

Analysis of the clinical features of recurrent acute pancreatitis in China

Since few systematic studies have focused on recurrent acute pancreatitis in China, we sought to investigate its clinical features, including etiological factors and relative frequency. Patients were selected from a total 1471 patients with acute pancreatitis in ten cities of China. All had been admitted to a hospital with an attack of acute pancreatitis between January 1992 and December 2002. Data for each patient was recorded on a standardized form. Of the 1471 patients with acute pancreatitis, 157 (10.7%) had recurrent acute pancreatitis. The majority (63%) were male, with a mean age of 41 years (range, 13-82 years). Regarding the etiology, alcohol (20.4%) and cholelithiasis (20.4%) were the most frequent causes, followed by diet (13.4%), hypertriglyceridemia (8.3%), biliary tract infection (5.7%), other (5.1%), and idiopathic factors (26.8%). Alcohol was most frequent in male patients (30.3%), whereas cholelithiasis was most frequent (34.5%) in female patients. The majority of patients (79.6%) presented with their second attack of pancreatitis. Complications of recurrent acute pancreatitis in order of frequency were pancreatic pseudocyst, multiple organ failure, diabetes mellitus type 2, and shock. Recurrent acute pancreatitis remains a frequent disease, with cholelithiasis and alcohol being the most usual etiological factors. Alcohol is the primary etiological factor in male patients. In about 26.8% of cases, the etiology remains unknown.

Analysis of depression characteristics and the related factors in male patients with heroin dependence

目的 了解男性海洛因依赖者(MPHD)抑郁情绪特点及影响因素.方法采用一般情况问卷(自拟)、抑郁自评问卷(SDS)、多伦多述情障碍量表(TAS)及渴求问卷(HCQ),对湖南地区218名MPHD(研究组)进行测评,以SDS对82名抑郁症患者(对照组)测评.结果 83.51%的MPHD存在着不同程度的抑郁情绪,9.79%的患者有严重的抑郁情绪.MPHD、SDS总分及忧郁、易哭、睡眠障碍、食欲减退、性兴趣减退、体质量减轻、不安、易激惹、决断困难、无价值感10因子分均低于抑郁症组:SDS总分[(49.75±5.02)分 vs(54.10±9.33)分](P ＜0.01);心悸、思考困难、绝望因子分高于抑郁症组(P ＜0.05或P ＜0.01).以是否抑郁为应变量,对有关变量进行Logistic回归分析,TAS总分、HCQ效果期待因子、戒断前飘的感觉依次进入方程.结论 MPHD抑郁发生率较高,但程度较轻,在某些生物学症状、躯体性障碍、抑郁的心理障碍方面表现得同样严重与突出.述情障碍、渴求、戒断前飘的感觉与MPHD抑郁发生密切相关。

Pathogenetic significance of myxomatous degeneration in fenestration-related massive aortic regurgitation.

Aortic valvular regurgitation has several mechanisms and the present study investigated its clinicopathological correlations with aortic valve fenestration. Six male patients with massive regurgitation and enlarged fenestrations or ruptured fenestrated fibrous cords underwent aortic valve replacement. The clinicopathological features showed many similarities. Four cases had family histories of aortic regurgitation. All six patients showed moderate to severe myxomatous degeneration of the aortic valve and enlargement of aortic annulus. Four patients had 1-2 ruptured fibrous cords, located at the right coronary cusp. Echocardiographic examinations showed an abnormal fibrous cord attached to the prolapsing cusp in 3 cases with ruptured fenestrated valve and detailed examination by transesophageal echocardiography showed an intact fenestrated fibrous cord at the commissure in 1 case. Extensively fenestrated cusps with an enlarged aortic annulus because of myxomatous degeneration can cause chronic regurgitation or sudden deterioration after rupture of the fibrous cord. There is an increasing incidence of fenestration-related aortic regurgitation in the Japanese population. An important pathogenetic factor in male patients is myxomatous degeneration of the aortic cusp and annulus.

Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme

One of the most frequent genetic abnormalities found in patients with glioblastoma multiforme (GBM) is homozygous deletion of the p16 tumor suppressor gene. The authors investigated whether this deletion is associated with prognosis in patients with GBM. In 46 adult patients with supratentorial GBM, homozygous deletion of the p16 gene in tumor DNA was examined using the multiplex polymerase chain reaction assay. The deletion was confirmed in 14 (30.4%) of 46 patients, eight (30.8%) of 26 men and six (30.0%) of 20 women. Cox proportional hazard regression analysis, adjusted for age at surgery, the Karnofsky Performance Scale score, extent of resection, and the MIB-1 labeling index. revealed that homozygous deletion of the p16 gene was significantly associated with overall survival and progression-free survival in men, but not in women. The results of this study suggest that p16 homozygous deletion is a significant unfavorable prognostic factor in male patients with GBM.

Elevation of serum vascular endothelial growth factor in male patients with metastatic nasopharyngeal carcinoma

Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor identified to date. The authors investigated the correlation between the levels of serum VEGF (S-VEGF) in patients with nasopharyngeal carcinoma (NPC) and disease progression. The sera from 65 male patients with nonmetastatic NPC, 22 male patients with metastatic NPC, and 27 healthy male volunteers were obtained. A quantitative enzyme-linked immunosorbent assay was performed to measure the concentrations of S-VEGF in the sera. The mean S-VEGF levels were 371.0 pg/mL(-1) (range, 128.5-691.1 pg/mL(-1)) for healthy controls, 375.6 pg/mL(-1) (range, 72.9-1202.5 pg/mL(-1)) for patients with nonmetastatic NPC, and 958.6 pg/mL(-1) (range, 264.4-3744.9 pg/mL(-1)) for patients with metastatic NPC. The mean S-VEGF level in patients with metastatic NPC was significantly higher than in either patients with nonmetastatic NPC (P < 0.001) or healthy controls (P < 0.001). However, there was no statistical difference between these results for healthy controls and patients with nonmetastatic NPC. At the level of 900 pg/mL(-1), S-VEGF indicated distant dissemination of NPC with a specificity of 95.4%, a sensitivity of 31.8%, a positive predictive value of 70.0%, and a negative predictive value of 80.5%. No significant differences in the levels of S-VEGF were found among various T classifications, N classifications, and clinical stages of nonmetastatic NPC. The levels of S-VEGF were significantly elevated in male patients with metastatic NPC. These levels did not correlate with locoregional progression of NPC. The usefulness of detecting S-VEGF in the early diagnosis of NPC appears to be limited.

Elevation of serum vascular endothelial growth factor in male patients with metastatic nasopharyngeal carcinoma

BACKGROUND Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor identified to date. The authors investigated the correlation between the levels of serum VEGF (S-VEGF) in patients with nasopharyngeal carcinoma (NPC) and disease progression. METHODS The sera from 65 male patients with nonmetastatic NPC, 22 male patients with metastatic NPC, and 27 healthy male volunteers were obtained. A quantitative enzyme-linked immunosorbent assay was performed to measure the concentrations of S-VEGF in the sera. RESULTS The mean S-VEGF levels were 371.0 pg/mL−1 (range, 128.5–691.1 pg/mL−1) for healthy controls, 375.6 pg/mL−1 (range, 72.9–1202.5 pg/mL−1) for patients with nonmetastatic NPC, and 958.6 pg/mL−1 (range, 264.4–3744.9 pg/mL−1) for patients with metastatic NPC. The mean S-VEGF level in patients with metastatic NPC was significantly higher than in either patients with nonmetastatic NPC (P < 0.001) or healthy controls (P < 0.001). However, there was no statistical difference between these results for healthy controls and patients with nonmetastatic NPC. At the level of 900 pg/mL−1, S-VEGF indicated distant dissemination of NPC with a specificity of 95.4%, a sensitivity of 31.8%, a positive predictive value of 70.0%, and a negative predictive value of 80.5%. No significant differences in the levels of S-VEGF were found among various T classifications, N classifications, and clinical stages of nonmetastatic NPC. CONCLUSIONS The levels of S-VEGF were significantly elevated in male patients with metastatic NPC. These levels did not correlate with locoregional progression of NPC. The usefulness of detecting S-VEGF in the early diagnosis of NPC appears to be limited. Cancer 2000;88:255–61. © 2000 American Cancer Society.

Defense styles, hostility, and psychological risk factors in male patients with personality disorders.

The purpose of this study was to compare ratings of defense styles and hostility in male patients with personality disorders, to determine whether either of these is related to a borderline diagnosis, or to specific psychological risk factors. Subjects with personality disorders were divided into borderline personality disorder (BPD) (N = 61) and non-BPD (N = 60) groups were given both the Defense Style Questionnaire (DSQ) and the Buss-Durkee Guilt-Hostility Inventory (BDHI). Risk factors were measured by a developmental interview and the the Parental Bonding Index. The BPD group reported more maladaptive and image distorting defenses on the DSQ, as well as higher ratings on the BDHI. Ratings on both dependent measures were strongly related to diagnosis, and more weakly to measures of psychological risk factors. Thus, in men with personality disorders, immature defense styles and high levels of hostility are strongly associated with a borderline diagnosis.

Dissociation in Female Patients With Borderline and Non-Borderline Personality Disorders

Dissociation in Female Patients With Borderline and Non-Borderline Personality DisordersHallie Zweig-Frank, Joel Paris and Jaswant GuzderHallie Zweig-FrankSearch for more papers by this author, Joel ParisDirect reprint requests to Dr. J. Paris at this address.Search for more papers by this author and Jaswant GuzderInstitute of Community and Family Psychiatry, 4333 Chemin de la Cote Ste, Catherine, Montreal QC H3T 1E4, Canada.Search for more papers by this authorPublished Online:February 2011https://doi.org/10.1521/pedi.1994.8.3.203PDFPDF PLUS ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations About Previous article Next article FiguresReferencesRelatedDetails Cited byCited by1. Child maltreatment-related dissociation and its core mediation schemas in patients with borderline personality disorderOnline publication date: 12 August 2020. Go to citation Crossref Google Scholar2. The So‐Called Borderline Patient: Aetiology, Diagnosis, and TreatmentOnline publication date: 10 September 2020. Go to citation Crossref Google Scholar3. ReferencesOnline publication date: 24 March 2020. Go to citation Crossref Google Scholar4. The extent of dissociation in borderline personality disorder: A meta-analytic reviewOnline publication date: 21 November 2016. Go to citation Crossref Google Scholar5. 32. État limiteOnline publication date: Go to citation Crossref Google Scholar6. Online publication date: Go to citation Crossref 7. The course of dissociation for patients with borderline personality disorder and axis II comparison subjects: a 10-year follow-up studyOnline publication date: Go to citation Crossref Google Scholar8. Fatal Distraction: The Impact of Mortality Salience on Dissociative Responses to 9/11 and Subsequent Anxiety SensitivityOnline publication date: 7 June 2010. Go to citation Crossref Google Scholar9. Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controlsOnline publication date: Go to citation Crossref Google Scholar10. Neurocognitive impairment as a moderator in the development of borderline personality disorderOnline publication date: 12 December 2005. Go to citation Crossref Google Scholar11. The worm at the core: A terror management perspective on the roots of psychological dysfunctionOnline publication date: Go to citation Crossref Google Scholar12. Online publication date: Go to citation Crossref 13. Dissociative disorders in turkish inpatients with conversion disorderOnline publication date: Go to citation Crossref Google Scholar14. The Relationship Between Pathological Dissociation, Self-Injury and Childhood Trauma in Patients with Personality Disorders Using Taxometric AnalysesOnline publication date: Go to citation Crossref Google ScholarGlenn N. Saxe, Neharika Chawla and Bessel Van der Kolk15. Self-Destructive Behavior in Patients with Dissociative DisordersOnline publication date: 2 June 2005. Go to citation Crossref 16. Wie entwickelt sich die kindliche Persönlichkeit? Beiträge zur Diskussion um Vererbung und UmweltOnline publication date: Go to citation Crossref Google Scholar17. The dissociative experiences of borderline patientsOnline publication date: Go to citation Crossref Google Scholar18. NEUROPSYCHOLOGICAL TESTING RESULTSOnline publication date: Go to citation Crossref Google Scholar19. Risk Factors Associated with the Dissociative Experiences of Borderline PatientsOnline publication date: Go to citation Crossref Google Scholar20. The relationship between dissociation and personalityOnline publication date: Go to citation Crossref Google Scholar21. Childhood experiences and personality traits in patients with motor conversion symptomsOnline publication date: Go to citation Crossref Google Scholar22. Twin Study of Dissociative ExperienceOnline publication date: Go to citation Crossref Google Scholar23. Dissociative experiences and dissociative disorders in acute psychiatric inpatientsOnline publication date: Go to citation Crossref Google Scholar24. A Critical Review of Recovered Memories in Psychotherapy: Part I—Trauma and MemoryOnline publication date: 1 May 1996. Go to citation Crossref Google Scholar25. Defense Styles, Hostility, and Psychological Risk Factors in Male Patients with Personality DisordersOnline publication date: Go to citation Crossref Google Scholar26. Online publication date: Go to citation Crossref Volume 8Issue 3Sep 1994 Information© 1994 The Guilford PressPDF download

Crack cocaine and the exchange of sex for money or drugs. Risk factors for gonorrhea among black adolescents in San Francisco.

In contrast to rates for the United States as a whole, the incidence rate of gonorrhea increased 11% in San Francisco between 1986 and 1988, with substantial increases observed among black adolescents. Reports by health department personnel and police suggested that crack cocaine use, specifically the exchange of sex for drugs, contributed to this increase. To test this hypothesis, the authors conducted a case-control study from August 1988 to October 1988 that compared 68 prospectively identified adolescent gonorrhea patients with 136 neighborhood control patients. Thirty-two percent of the female gonorrhea patients had received money or drugs in exchange for sex, while none of the control patients reported having done so (P = 0.0001). Most of the female patients (89%) who had received money or drugs in exchange for sex had used crack. Crack use was less common among female patients who denied receiving money or drugs in exchange for sex (11%) and among control patients (6%). Crack use and providing money or drugs in exchange for sex were not risk factors for gonorrhea among the male patients, but were reported frequently by both gonorrhea patients and control patients. Not living with parents was a risk factor for male patients (odds ratio 4.9, 95% confidence limit 1.4 to 19.5). For all patients, a history of a sexually transmitted disease appeared to be an independent risk factor for gonorrhea. The conclusion is made that crack-related exchange of sex for money or drugs is a risk factor for gonorrhea among black adolescent girls in San Francisco.(ABSTRACT TRUNCATED AT 250 WORDS)