The objective of this work is to evaluate the technical-economic and infrastructure aspects for the Brazilian Pre-salt natural gas use. Factors like technology maturity level, fuel and facilities costs, and electricity market are analyzed; the levelized cost of energy (LCOE) of two possibilities are calculated: (i) offshore Gas-to-Wire (GtW) and (ii) molecular natural gas outflow through the pipeline with onshore thermoelectric generation. This work also discusses the possibility of natural gas (NG) transport via liquefaction, considering the Floating Liquefied NG (FLNG) technology for national and international market. The LCOE of GtW technology is higher (67–87 US$/MWh) than onshore plants (43–69 US$/MWh) for Pre-salt area, higher than the historical energy price of Brazilian NG thermoelectric generation (44 US$/MWh), but, in general, lower than Brazilian NG energy auction price cap (84.5 US$/MWh) and lower than some values found in the literature for onshore plants (42–124 US$/MWh) abroad Brazil. FLNG technology is still new, there is no scale, few players use it, and it does not seem to be a feasible option for Pre-salt NG now. It is concluded that elements such as political uncertainties of the international natural gas market, the high CO2 rate in the Pre-salt's natural gas mixture, and the difficulties in implement deep-sea infrastructure are challenging elements for the three possibilities analyzed. The Brazilian market discussion is relevant since it is a greenfield natural gas area in need of development. Thus, it is of upmost importance to implement a comprehensive energy policy to address offshore-onshore energy integration regulation and technological developments for the offshore transmission systems, and CO2 content separation process.