The relationships between industrialization and urban regions, as well as technological advancements, innovations, and new work patterns and organizations, significantly impact the structuring of cities. Industrial sectors can become key drivers in shaping the form and macrostructure of a city over time. By examining and evaluating the existing system of structures and relations in the settlements in order to “estimate the land use differentiations” that may arise in the future and “to determine the spatial location of industrial facilities or sites,” a model has been developed. This model aims to predict potential “land use differentiations” and determine the “spatial location selection of industrial facilities or sites” in the future based on the analysis and evaluation of existing structures and relational systems in settlements. The model consists of the integration of the LUCAM, which is based on a cellular automata operating system, along with the “GIS-Based Integrated Industrial Area Location Selection Model,” which evaluates all data under the main headings of natural structure characteristics, socio-economic structure characteristics, and built environment characteristics using weighted overlay analysis. In this article, the general structure of the model developed within the scope of the research and İnegöl sampling are explained. The outputs of this model can be used for alternative separation for logistics centers, residential areas, secondary centers, reinforcement areas, and industrial sites in different settlements. In addition, in the research, a detailed model was designed by integrating decision-makers (central administrations, local administrations, registered users, NGOs) into the urban planning process. The proposed model can be used as a tool in designing transportation and other urban systems (distribution order of equipment areas, green area system, grading of centers, etc.).