Impaired Facial Recognition Research Articles

Multimodal Imaging-Monitored Progression of Stroke-Like Episodes in a Case of MELAS Syndrome

We report imaging findings during, between, and after 2 stroke-like episodes in a 45-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome with an A32243G mitochondrial mutation 6 years before. In November 2010, for a first episode, she showed mixed aphasia with logorrhea, disinhibition, agitation, euphoria, and a large left temporoparietal lesion. Symptomatology progressively regressed under L-arginine treatment. She was readmitted in June 2011 for a second episode with great anxiety, disorientation, impaired face recognition, worsening mixed aphasia, and a new right temporal lesion. After additional L-carnitine treatment, she remained without relapse for 14 months.

Understanding face perception by means of prosopagnosia and neuroimaging.

Understanding the human neuro-anatomy of face recognition is a long-standing goal of Cognitive Neuroscience. Studies of patients with face recognition impairment following brain damage (i.e., acquired prosopagnosia) have revealed the specificity of face recognition, the importance and nature of holistic/configural perception of individual faces, and the distribution of this function in the ventral occipito-temporal (VOT) cortex, with a right hemispheric dominance. Yet, neuroimaging studies in this field have essentially focused on a single face-selective area of the VOT and underestimated the right hemisphere superiority. Findings in these studies have also been taken as supporting a hierarchical view of face perception, according to which a face is decomposed into parts in early face-selective areas, these parts being subsequently integrated into a whole representation in higher-order areas. This review takes a historical and current perspective on the study of acquired prosopagnosia and neuroimaging that challenges this latter view. It argues for a combination of these methods, an approach suggesting a coarse-to-fine emergence of the holistic face percept in a non-hierarchical network of cortical face-selective areas.

Cognitive Mechanism and Neural Mechanism of Developmental Prosopagnosia

Developmental prosopagnosia is characterized by severely impaired face recognition, which has no intellectual deterioration, affective disorder, difficulty of object recognition, history of brain damage. The cognitive mechanism involving in developmental prosopagnosia includes the face-specific mechanisms, the disorder of configural processing, the face detection, the face memory deficits and the facial identity recognition. The neural network of developmental prosopagnosia involves the core network and the extended network. The core network associates with facial selective responses and memory representation, while the extended network is responsible for the facial knowledge representation and the facial memory. The future research should develop the extended network and cognitive mechanism, focus on the association of face detection with developmental prosopagnosia, inspect the genetic mechanisms of it, and enhance the developmental study and rehabilitation work of it.

Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia

Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence suggests that intranasal inhalation of the hormone oxytocin can improve face processing in unimpaired participants, and we investigated whether similar findings might be noted in DP. Ten adults with DP and 10 matched controls were tested using a randomized placebo-controlled double-blind within-subject experimental design (AB-BA). Each participant took part in two testing sessions separated by a 14–25 day interval. In each session, participants inhaled 24 IU of oxytocin or placebo spray, followed by a 45 min resting period to allow central oxytocin levels to plateau. Participants then completed two face processing tests: one assessing memory for a set of newly encoded faces, and one measuring the ability to match simultaneously presented faces according to identity. Participants completed the Multidimensional Mood Questionnaire (MMQ) at three points in each testing session to assess the possible mood-altering effects of oxytocin and to control for attention and wakefulness. Statistical comparisons revealed an improvement for DP but not control participants on both tests in the oxytocin condition, and analysis of scores on the MMQ indicated that the effect cannot be attributed to changes in mood, attention or wakefulness. This investigation provides the first evidence that oxytocin can improve face processing in DP, and the potential neural underpinnings of the findings are discussed alongside their implications for the treatment of face processing disorders.

Naming vs knowing faces in primary progressive aphasia

This study examines the anatomical correlates of naming vs recognizing faces using a novel measure that utilizes culturally relevant and age-appropriate items, the Northwestern University Famous Faces (NUFFACE) Test, in primary progressive aphasia (PPA), a syndrome characterized by progressive language deficits and associated with cortical atrophy in areas important for word and object representations. NUFFACE Test performance of 27 controls (mean age 62.3 years) was compared with that of 30 patients with PPA (mean age 62 years). Associations between NUFFACE Test performance and cortical thickness measures were quantified within the PPA group. Patients with PPA displayed significant impairment on the NUFFACE Test, demonstrating that it is a useful measure of famous-face identification for individuals with relatively young-onset dementias. Despite widespread distribution of atrophy in the PPA group, face naming impairments were correlated with atrophy of the left anterior temporal lobe while face recognition impairments were correlated with bitemporal atrophy. In addition to their clinical relevance for highlighting the distinction between face naming and recognition impairments in individuals with young-onset dementia, these findings add new insights into the dissociable clinico-anatomical substrates of lexical retrieval and object knowledge.

Cerebral lateralization of face-sensitive areas in left-handers: Only the FFA does not get it right

Face perception is highly lateralized to the right hemisphere (RH) in humans, as supported originally by observations of face recognition impairment (prosopagnosia) following brain damage. Divided visual field presentations, neuroimaging and event-related potential studies have supported this view. While the latter studies are typically performed in right-handers, the few reported cases of prosopagnosia with unilateral left damage were left-handers, suggesting that handedness may shift or qualify the lateralization of face perception. We tested this hypothesis by recording the whole set of face-sensitive areas in 11 left-handers, using a face-localizer paradigm in functional magnetic resonance imaging (fMRI) (faces, cars, and their phase-scrambled versions). All face-sensitive areas identified (superior temporal sulcus, inferior occipital cortex, anterior infero-temporal cortex, amygdala) were strongly right-lateralized in left-handers, this right lateralization bias being as large as in a population of right-handers (40) tested with the same paradigm (Rossion et al., 2012). The notable exception was the so-called ‘Fusiform face area’ (FFA), an area that was slightly left lateralized in the population of left-handers. Since the left FFA is localized closely to an area sensitive to word form in the human brain (‘Visual Word Form Area’ – VWFA), the enhanced left lateralization of the FFA in left-handers may be due to a decreased competition with the representation of words. The implications for the neural basis of face perception, aetiology of brain lateralization in general, and prosopagnosia are also discussed.

« Mais qui êtes-vous ? » : une prosopagnosie progressive longtemps isolée révélatrice d’une démence sémantique

It has recently been proposed that the face recognition deficits seen in neurodevelopmental disorders may reflect impaired short-term face memory (STFM). For example, introducing a brief delay between the presentation of target and test faces seems to disproportionately impair matching or recognition performance in individuals with Autism Spectrum Disorders. The present study sought to determine whether deficits of STFM contribute to impaired face recognition seen in Developmental Prosopagnosia. To determine whether developmental prosopagnosics exhibit impaired STFM, the present study used a six-alternative-forced-choice match-to-sample procedure. Memory demand was manipulated by employing a short or long delay between the presentation of the target face, and the six test faces. Crucially, the perceptual demands were identical in both conditions, thereby allowing the independent contribution of STFM to be assessed. Prosopagnosics showed clear evidence of a category-specific impairment for face-matching in both conditions; they were both slower and less accurate than matched controls. Crucially, however, the prosopagnosics showed no evidence of disproportionate face recognition impairment in the long-interval condition. While individuals with DP may have problems with the perceptual encoding of faces, it appears that their representations are stable over short durations. These results suggest that the face recognition difficulties seen in DP and autism may be qualitatively different, attributable to deficits of perceptual encoding and perceptual maintenance, respectively.

Neural Correlates of Covert Face Processing: fMRI Evidence from a Prosopagnosic Patient

Brains can perceive or recognize a face even though we are subjectively unaware of the existence of that face. However, the exact neural correlates of such covert face processing remain unknown. Here, we compared the fMRI activities between a prosopagnosic patient and normal controls when they saw famous and unfamiliar faces. When compared with objects, the patient showed greater activation to famous faces in the fusiform face area (FFA) though he could not overtly recognize those faces. In contrast, the controls showed greater activation to both famous and unfamiliar faces in the FFA. Compared with unfamiliar faces, famous faces activated the controls', but not the patient's lateral prefrontal cortex (LPFC) known to be involved in familiar face recognition. In contrast, the patient showed greater activation in the bilateral medial frontal gyrus (MeFG). Functional connectivity analyses revealed that the patient's right middle fusiform gyrus (FG) showed enhanced connectivity to the MeFG, whereas the controls' middle FG showed enhanced connectivity to the LPFC. These findings suggest that the FFA may be involved in both covert and overt face recognition. The patient's impairment in overt face recognition may be due to the absence of the coupling between the right FG and the LPFC.

Bilateral Hemispheric Processing of Words and Faces: Evidence from Word Impairments in Prosopagnosia and Face Impairments in Pure Alexia

Considerable research has supported the view that faces and words are subserved by independent neural mechanisms located in the ventral visual cortex in opposite hemispheres. On this view, right hemisphere ventral lesions that impair face recognition (prosopagnosia) should leave word recognition unaffected, and left hemisphere ventral lesions that impair word recognition (pure alexia) should leave face recognition unaffected. The current study shows that neither of these predictions was upheld. A series of experiments characterizing speed and accuracy of word and face recognition were conducted in 7 patients (4 pure alexic, 3 prosopagnosic) and matched controls. Prosopagnosic patients revealed mild but reliable word recognition deficits, and pure alexic patients demonstrated mild but reliable face recognition deficits. The apparent comingling of face and word mechanisms is unexpected from a domain-specific perspective, but follows naturally as a consequence of an interactive, learning-based account in which neural processes for both faces and words are the result of an optimization procedure embodying specific computational principles and constraints.

Intra-cerebral electrical stimulation of a face-sensitive cortical area causes transient specific impairment in face recognition

Intra-cerebral electrical stimulation of a face-sensitive cortical area causes transient specific impairment in face recognition

Focal electrical intracerebral stimulation of a face-sensitive area causes transient prosopagnosia

Face perception is subtended by a large set of areas in the human ventral occipito-temporal cortex. However, the role of these areas and their importance for face recognition remain largely unclear. Here we report a case of transient selective impairment in face recognition (prosopagnosia) induced by focal electrical intracerebral stimulation of the right inferior occipital gyrus. This area presents with typical face-sensitivity as evidenced by functional neuroimaging right occipital face area (OFA). A face-sensitive intracerebral N170 was also recorded in this area, supporting its contribution as a source of the well-known N170 component typically recorded on the scalp. Altogether, these observations indicate that face recognition can be selectively impaired by local disruption of a single face-sensitive area of the network subtending this function, the right OFA.

Intra-cerebral electrical stimulation of a face-sensitive cortical area causes transient specific impairment in face recognition

Event Abstract Back to Event Intra-cerebral electrical stimulation of a face-sensitive cortical area causes transient specific impairment in face recognition Jacques Jonas1* 1 Université de Lorraine, France We report the first case of transient impairment in face recognition (prosopagnosia) induced by intra-cerebral electrical stimulation. The patient was a 32-year-old right-handed woman (KV) who has medically intractable right occipital epilepsy. She never complained of difficulties in face recognition and present with normal face recognition abilities. Intra-cerebral electrodes were implanted stereotactically to record seizures and to perform focal electrical stimulation in order to define epileptogenic and functional zones. During stimulations of right and left occipito-temporal contacts (biphasic pulse; 50 Hz train of 5 s; from 1 to 1.8 mA), she was asked to name previously correctly recognized famous faces, objects and scenes. Six of seven bipolar stimulations including one common contact (named O7) located within the right inferior occipital gyrus reproducibly induced transient prosopagnosia which completely recovered immediately upon termination of the stimulation. The patient reported a disturbance in perceiving the spatial relationship of facial elements and being unable to perceive the face as a whole. Stimulations at this site never produced visual distortions, deficit in object and scenes recognition or epileptic discharges. Stimulations of all other contacts and electrodes did not elicit prosopagnosia. The brain region of interest was mapped using fMRI and intra-cerebral ERPs by contrasting responses to pictures of faces and objects. The eloquent stimulation site O7 was located exactly within the right occipital face area (rOFA). A N170 face-specific potential was also recorded at the stimulation site reinforcing the functional specificity of this area for face perception. We also found a N170 face-specific potential at an anterior site F6, located at the edge of the right FFA. However, its stimulation did not evoke any prosopagnosia. These findings provide evidences that the right OFA is necessary for normal face perception as part of a bilateral occipito-temporal network of face-sensitive areas. Keywords: face perception, OFA, Electrical Stimulation, Prosopagnosia, N170 Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Higher Brain Functions in health and disease: cognition and memory Citation: Jonas J (2012). Intra-cerebral electrical stimulation of a face-sensitive cortical area causes transient specific impairment in face recognition. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00093 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Aug 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Jacques Jonas, Université de Lorraine, Nancy, France, jac.jonas@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jacques Jonas Google Jacques Jonas Google Scholar Jacques Jonas PubMed Jacques Jonas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Does acquisition of Greeble expertise in prosopagnosia rule out a domain-general deficit?

According to the expertise account of face specialization, a deficit that affects general expertise mechanisms should similarly impair the expert individuation of both faces and other visually homogeneous object classes. To test this possibility, we attempted to train a prosopagnosic patient, LR, to become a Greeble expert using the standard Greeble expertise-training paradigm (Gauthier & Tarr, 2002). Previous research demonstrated that LR's prosopagnosia was related to an inability to simultaneously use multiple features in a speeded face recognition task (Bukach, Bub, Gauthier, & Tarr, 2006). We hypothesized that LR's inability to use multiple face features would manifest in his acquisition of Greeble expertise, even though his basic object recognition is unimpaired according to standard neuropsychological testing. Although LR was eventually able to reach expertise criterion, he took many more training sessions than controls, suggesting use of an abnormal strategy. To further explore LR's Greeble processing strategies, we assessed his ability to use multiple Greeble features both before and after Greeble training. LR's performance in two versions of this task demonstrates that, even after training, he relies heavily on a single feature to identify Greebles. This correspondence between LR's face recognition and post-training Greeble recognition supports the idea that impaired face recognition is simply the most visible symptom of a more general object recognition impairment in acquired prosopagnosia.

Parkinson's disease: Acquired frailty of archaic neural networks?

In Parkinson's disease (PD) many motor and non-motor symptoms are difficult to explain in terms of a purely ascending degeneration process as described by Braak. This essay proposes phylogenetic considerations for consolidating the multidimensional elements of PD. Subtle clinical analysis paired with ethological comparisons as well as patho-anatomical data suggests that disrupted automatic gait control, olfactory deficits, selected visual deficits, impaired emotional face recognition, and REM sleep behavior disorder could be due to dysfunction of phylogenetically ancient networks. Neuroanatomical and behavioral findings lead to a reconsideration of the basal ganglia, to be viewed as the nuclear core of a widely distributed neural network that arborizes throughout the primordial core of the neuraxis, including the brainstem. Fragility of the resulting multiple, closed, ancillary loops that link brainstem and forebrain components of the basal ganglia may be a nodal point, pivotal to the pathogenesis of PD. Other primitive neural networks, such as those located at cardiac or gastro-intestinal levels, may share the same vulnerability. Such a network-based hypothesis overrides the need of a fixed temporal ordering of symptoms based on putative caudal–cephalic propagation patterns of pathological lesions. It also creates testable, secondary hypotheses such as differential gene expression in different neural networks, potential early epigenetic influences, concepts of “overuse” or maladaptation of primitive networks to the constraints of adult life, and system frailty due to irreparable mitochondrial “exhaustion” in highly energy consuming postmitotic cells.

Recognition of Own- and Other-Race Faces in Autism Spectrum Disorders

Empirical data regarding the extent of face recognition abnormalities in autism spectrum disorder (ASD) is inconsistent. Here, 27 ASD and 47 typically developing (TD) children completed an immediate two-alternative forced-choice identity matching task. We contrasted recognition of own- and other-race faces, and, counter to prediction, we found a typical advantage for recognizing own- over other-race faces in both the ASD and TD groups. In addition, ASD and TD groups responded similarly to stimulus manipulations (use of identical or different photographs for identity matching and cropping stimuli to remove hair information). However, age-standardized scores varied widely within the ASD sample, and a subgroup of ASD participants with impaired face recognition did not exhibit a significant own-race recognition advantage. An explanation regarding early experience with faces is considered, and implications for research of individual variation within ASD are discussed.

Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test

Although face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ-matched non-ASD individuals, and age-standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non-ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/- 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non-ASD levels of performance.

The “Reading the Mind in the Eyes” test as a new way to explore complex emotions decoding in alcohol dependence

It has been repeatedly shown that alcohol dependence is associated with emotional impairments, particularly for emotional facial expression decoding. Nevertheless, most earlier studies focused on basic emotions and did not explore more subtle affective states. In order to obtain a more accurate evaluation, and in view of earlier results showing impaired performance for this task among high-risk children of alcohol-dependent participants, the “Reading the Mind in the Eyes” test was used here to explore emotional recognition in alcohol dependence. We showed that the deficit described earlier for basic negative emotions is (1) generalizable to complex and positive emotions; and (2) specific for emotional features. This strengthens the proposition of a general face recognition impairment in alcohol dependence.

The Functional Neuroanatomy of Object Agnosia: A Case Study

Cortical reorganization of visual and object representations following neural injury was examined using fMRI and behavioral investigations. We probed the visual responsivity of the ventral visual cortex of an agnosic patient who was impaired at object recognition following a lesion to the right lateral fusiform gyrus. In both hemispheres, retinotopic mapping revealed typical topographic organization and visual activation of early visual cortex. However, visual responses, object-related, and -selective responses were reduced in regions immediately surrounding the lesion in the right hemisphere, and also, surprisingly, in corresponding locations in the structurally intact left hemisphere. In contrast, hV4 of the right hemisphere showed expanded response properties. These findings indicate that the right lateral fusiform gyrus is critically involved in object recognition and that an impairment to this region has widespread consequences for remote parts of cortex. Finally, functional neural plasticity is possible even when a cortical lesion is sustained in adulthood.

When family looks strange and strangers look normal: A case of impaired face perception and recognition after stroke

We describe a patient (JS) with impaired recognition and distorted visual perception of faces after an ischemic stroke. Strikingly, JS reports that the faces of family members look distorted, while faces of other people look normal. After neurological and neuropsychological examination, we assessed response accuracy, response times, and skin conductance responses on a face recognition task in which photographs of close family members, celebrities and unfamiliar people were presented. JS' performance was compared to the performance of three healthy control participants. Results indicate that three aspects of face perception appear to be impaired in JS. First, she has impaired recognition of basic emotional expressions. Second, JS has poor recognition of familiar faces in general, but recognition of close family members is disproportionally impaired compared to faces of celebrities. Third, JS perceives faces of family members as distorted. In this paper we consider whether these impairments can be interpreted in terms of previously described disorders of face perception and recent models for face perception.

Evidence of differential performance on simultaneous and sequential lineups for individuals with autism-spectrum traits

Given the impaired facial recognition of autistic individuals, we examined whether certain autism-spectrum traits affected eyewitness identification performance in a general adult population. In a sample of 120 individuals, levels of autism-spectrum traits were examined in relation to performance on simultaneous vs. sequential lineups using a signal detection paradigm. For simultaneous lineups, total Autism Spectrum Quotient (AQ) scores and scores on the excessive Attention to detail subscale were related to fewer hits and a more conservative response criterion. Attention to detail interacted with lineup type in that it was significantly related to improved discrimination accuracy and a less conservative response criterion in sequential lineups, but with impaired discrimination accuracy and a more conservative response criterion in simultaneous lineups. Higher AQ scores on the Attention switching subscale resulted in fewer hits, lower discrimination accuracy, and a more conservative response criterion with sequential lineups. Additionally, partial disguises led to more false alarms but not decreased accuracy. More thorough investigations of the effect of lineup type on identifications are needed before policy changes are recommended.