Eyelid Tumors Research Articles

The epidemiology of adults' eyelid malignancies in Germany between 2009 and 2015; An analysis of 42,710 patients' data.

We report the incidence of malignant tumors of the eyelid in Germany between 2009 and 2015. Data pertaining to the period between 2009 and 2015 were extracted from the German Cancer Registry. The International Classification of Diseases for Oncology-3 codes for tumors of the eyelid or canthus were used to identify incidence rates and survival probabilities. Crude and age-standardized incidence rates (ASR) were calculated by age, year, and gender and the individual federated states. Survival was calculated using the Kaplan-Meyer and Life tables methods, and COX-Regression was used to calculate hazard ratios for overall and cancer-specific survival. This study examined data pertaining to 42,710 patients who had been diagnosed with malignant tumors of the eyelid. Basal cell carcinoma was by far the most common tumor of the eyelid (87.1%), followed by squamous cell carcinoma (10.1%) and malignant melanoma (1.1%). ASRs of basal cell carcinoma, squamous cell carcinoma, and melanoma were 65.1, 7.49, and 0.83 per million, respectively. Sebaceous cell carcinoma did not appear to be of high prevalence in Germany. Cancer-specific survival was generally high, exceeding 95%. The overall survival of patients with melanoma was considerably lower than those with other cancers. Both survival rates were inferior to that of basal cell carcinoma (74.9%). Cancer-Specific survival at five years for all groups exceeded 95%. The incidence rates of malignant lid tumors match that of the European countries but shows a different pattern than Asian countries.

Reconstructive blepharoplasty following eyelid melanoma excision using a sliding skin flap in six horses

SummaryMelanomas are common in grey horses, and the eyelid is one of the less common predilection sites. The eyelids play an important role in maintaining ocular health, and damage to the eyelid margin can lead to ocular complications, including ocular pain, conjunctivitis and ulcerative keratitis. Surgical procedures to remove eyelid tumours, therefore, often require reconstruction techniques to re‐establish the eyelid's appearance and function. The sliding skin flap is a simple surgical technique that can be applied to close the defect resulting from surgical excision of eyelid tumours such as melanomas, but there is little published data about the short‐ and long‐term outcomes of this procedure in the horse. This case report reviews six horses where a sliding skin flap was used to reconstruct the eyelid after excision of discrete eyelid melanomas, with short‐ and long‐term follow‐up of the cases. Short‐term complications (including corneal abrasion from a suture) were uncommon (two cases), and there were no reported long‐term complications (follow‐up period 6 months to 13 years), with no melanoma recurrence at the surgical site. However, new melanoma development at other sites of the body occurred in several cases.

Reproducibility of Three-Dimensional Volumetric Measurement of Periocular Tumor Models.

In this study, we measured the volume of customized tumor models in the periocular area using three-dimensional (3D) stereophotogrammetry and evaluated the reproducibility of these measurements. Five tumor models of different colors and sizes were placed in different periocular positions, and 3D facial images were obtained from 68 healthy adult volunteers. Subsequently, the volumes of the tumor models were measured, and the intra- and interrater reproducibility was assessed. The gray 6mm model revealed the highest reliable measurements in both Caucasians (intra- and interrater intraclass correlation coefficients of 0.981 and 0.899, mean absolute difference of 1.446 and 3.327mm3, relative error measurement of 3.497% and 8.120%, technical error of measurement of 1.450 and 3.105mm3, and relative technical error of measurement of 3.506% and 7.580%) and Asians (0.968 and 0.844, 1.974 and 4.067mm3, 4.772% and 9.526%, 2.100 and 4.302mm3, and 5.076% and 10.076%, respectively). The highest reliability of measurements in the lateral upper eyelid (0.88 and 0.95, 4.042 and 3.626mm3, 9.730% and 9.020%, 5.714 and 3.358mm3, and 9.730% and 8.350%, respectively) and medial upper eyelid (0.81 and 0.89, 4.313 and 4.226mm3, 9.730% and 9.020%, 6.098 and 4.069mm3, and 9.730% and 8.350%, respectively) with eyes closed was evident in Caucasians, while the same trend (0.841 and 0.815, 2.828 and 3.757mm3, 9.860% and 9.840%, 4.052 and 4.308mm3, and 9.860% and 9.740%, respectively) was observed in Asians in the medial canthus with eyes closed. This study confirms, for the first time, the high reliability of periocular tumor volume measurements using 3D stereophotogrammetry, suggesting its feasibility for eyelid tumor measurement. Further trials are required to investigate its clinical use for documentation and follow-up of different eyelid tumors.

Trichoblastoma of the Lower Eyelid

Purpose: We report an unusual trichoblastoma of the lower eyelid.Case summary: A 74-year-old male presented with an asymptomatic 0.6 × 0.4-cm left lower eyelid tumor that had developed 3 years prior. On histological examination, a 0.3 × 0.3-cm intradermal tumor that was not connected to the epidermis was observed. The tumor was multilobular, and was surrounded by fibrous stroma and connective tissue. The tumor lobules consisted of basaloid cells, and a few keratinizing cysts were evident. These features are consistent with a trichoblastoma. We observed no recurrence at 1 year after complete resection.Conclusions: Trichoblastoma (a rare, benign skin tumor) is histologically similar to basal cell carcinoma but the prognosis is excellent after complete resection. Trichoblastoma should be considered during the differential diagnosis of basal cell carcinoma of the eyelids.

DEMOGRAPHIC PROFILE AND FREQUENCY OF EYELID AND CONJUNCTIVAL TUMORS; A NORTH INDIAN PERSPECTIVE.

Background: Eyelid and conjunctival tumors are the most common tumors that are encountered by an ophthalmologist. There are innumerable benign and malignant tumors of eyelids and conjunctiva owing to their histological structure. Proper diagnosis both clinically and on histopathological examination helps in appropriate management in cases of both benign and malignant lesions. The purpose of this study was to assess the demographic prole and frequency of eyelid and conjunctival tumors in patients presenting in our OPD. Materials And Methods: A total of 78 patients attending our Eye OPD presenting with eyelid or conjunctival tumors were admitted in hospital and underwent surgical management or excision biopsy and specimens were sent for histopathological examination. The purpose was to study the demographic prole and frequency of benign and malignant eyelid and conjunctival tumors in patients presenting in our hospital. Results: Out of 78 patients, 42(53.84%) were cases of eyelid tumors and 36(46.15%) were of conjunctival growths. Mean age of presentation in cases of eyelid tumors was 54(range 3-75) years and conjunctival tumors was 40(range 8-68) years. Benign lesions were more common than malignant in both eyelids and conjunctiva. Females were affected more than males. Conclusion: In our study, we observed that most frequently observed eyelid and conjunctival growths were benign. Mostly growths were seen in females and study population was largely from rural areas who had cosmetic issues or visual disturbances as main complaints.

One-year Ocular Safety Observation of Workers and Estimations of Microorganism Inactivation Efficacy in the Room Irradiated with 222-nm Far Ultraviolet-C Lamps.

Two krypton-chloride germicidal excimer lamp units (Care222 TRT-104C11-UI-U3, USHIO Inc.) were installed in the examination room of an ophthalmology department. The irradiation dose was set not to exceed the former (i.e., before 2022) threshold limit value (TLV) (22 mJ cm-2 /8 h) recommended by the ACGIH. Section 1: The eyes and lids of the six ophthalmologists (5 wore glasses for myopic correction) who worked in the room for a mean stay of 6.7 h week-1 were prospectively observed for 12 months. Slitlamp examinations revealed neither acute adverse events such as corneal erosion, conjunctival hyperemia, and lid skin erythema nor chronic adverse events such as pterygium, cataract, or lid tumor. The visual acuity, refractive error, and corneal endothelial cell density remained unchanged during the study. Section 2: The irradiation of samples placed on the table or floor using the same fixtures in the room (5-7.5 mJ cm-2 ) was associated with >99% inhibition of φX174 phage and >90% inhibition of Staphylococcus aureus. In conclusion, no acute or chronic health effects in human participants was observed in a clinical setting of full-room ultraviolet germicidal irradiation by 222-nm lamp units, and high efficacy in deactivation of microorganisms was determined in the same setting.

Efficient DNA/RNA extraction from tarsal plates by SK mill, a freeze-crush apparatus.

The tarsal plate is an eyelid tissue that maintains lid structure from inside the upper/lower eyelids, and it surrounds the meibomian glands and supports their unique secretion mechanism. Sebaceous carcinoma, a malignant eyelid tumour, can sometimes develop from the meibomian glands and is usually excised together with the tarsal plate during surgery, so the tarsal plate serves as a control research tissue. However, since the plate is thick, hard and heterogeneous with few cells, obtaining enough genomic DNA and/or total RNA is often difficult. Therefore, we attempted to establish an efficient protocol to obtain DNA and RNA simultaneously by comparing the combinations of homogenization (mortar/pestle, pellet pestle or SK mill) and purification (organic solvent or spin column) methods using rabbit tarsal plates. Based on the yield, quality and hands-on time, the SK mill and spin column was found to be the most efficient combination. We then applied the established protocol to extract DNA/RNA from six human tarsal-plate samples and succeeded in generating high-quality exome and transcriptome datasets via a next-generation sequencer with sufficient coverage and meibomian gland-specific expression of representative genes, respectively. Our new findings will provide ideal reference data for future genetic and gene-expression studies of sebaceous carcinoma.

Modified argon laser therapy for benign tumor of the eyelid

BackgroundTo report about the therapy of benign eyelid tumors with a modified argon laser technique as an alternative to surgery.MethodsNineteen benign tumors of the eyelid were included in this study. After staining the surface of the tumor with a violet marker, low-energy argon laser photoablation was performed. A mean number of 312 spots (spot size ranging from 150 to 500 μm) with a power of 200 to 400 mW, and a duration between 0.1 and 0.2 s were applied.ResultsThe eyelid tumors were located mainly in the lower eyelid (58%). Dermal nevi and papilloma were the most frequently treated lesions. Over a mean follow-up period of 10.5 months (range 6–18 months), all eyelid tumors were successfully treated by a single session of laser therapy. All patients were satisfied with the laser therapy and the cosmetic result. No postoperative complications were observed. No relapses occurred during follow-up.ConclusionsOur modified method of argon laser therapy utilizes the staining of the surface of the eyelid tumor to increase the amount of thermal laser energy absorbed by the target. This novel technique is simple and effective for treating benign eyelid tumors.

Effect of Different Durations of Eye-Covering Pretreatment on Emergence Delirium after Ophthalmic Surgery in Preschool-Aged Children: A Randomized Controlled Study.

Background Preoperative eye-covering training for 3 hours has been reported to effectively reduce the incidence of emergence delirium (ED) in preschool children. However, most children can only maintain the eye being covered for less than 60 min, and shortening eye-covering duration can also achieve similar clinical effects as long duration of eye-covering. This study was designed to compare the effects of 30-min and 60-min eye-covering pretreatment based on cartoon education only on preoperative anxiety, postoperative ED, and pain score after ophthalmic surgery with general anesthesia in preschool-aged children. Methods Preschool-aged children (3–7 years) who were diagnosed with cataract, blepharoptosis, trichiasis, strabismus, eyelid tumor, and underwent ophthalmic surgery with general anesthesia from August 2021 to January 2022 were recruited. A total of 228 patients were randomly assigned at a 1 : 1:1 ratio to receive 30-min eye covering (30-min group), 60-min eye covering (60-min group) pretreatment, or programmed education only (C group). The preoperative anxiety, postoperative emergence delirium, and pain were compared between the groups. Results The preoperative anxiety score, postoperative ED score, and incidence of ED in the 30-min group (n = 76) and 60-min group (n = 72) were significantly lower than those in the C group (n = 76), demonstrating a significant between-group difference (P < 0.001). However, the 30-min group and 60-min group had no significant difference in the abovementioned outcome measures (P > 0.05). Moreover, no significant difference was found in postoperative pain scores among the three groups (H = 0.274, P=0.872). Conclusion Both 30-min and 60-min eye-covering pretreatments significantly reduce preoperative anxiety and postoperative ED after ophthalmic surgery with general anesthesia in preschool-aged children. The effects of the two groups show no intergroup difference, but the 30-min eye-covering pretreatment may be more convenient for practicing. Trial Registration. This study was registered with the No. NCT04973150.

Mohs micrographic surgery versus wide local excision for eyelid melanoma: An analysis of a national database

Although eyelid melanomas represent less than 1% of eyelid neoplasms, they have the worst prognosis. Wide local excision (WLE) and Mohs micrographic surgery (MMS) are mainstay treatment options. We conducted a retrospective analysis to assess all-cause and cause-specific mortality rates in patients undergoing WLE or MMS for eyelid melanoma. A retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) registry was performed for eyelid melanoma treated with WLE or MMS. Cases were limited to American Joint Committee on Cancer (AJCC) stage T1 primary malignancies. A total of 45 cases of WLE were identified along with 48 cases of MMS for eyelid melanoma. There was no significant difference between subgroups in age group, sex, race, ethnicity, marital status at diagnosis, AJCC N stage, AJCC M stage, melanoma histology, chemotherapy use, and radiotherapy use. Among the cohort, all tumors were unilateral. Kaplan-Meier analysis with log-rank demonstrated no significant difference between MMS and WLE subgroups with regard to overall survival (P=0.662) and cancer-specific survival (P=0.494). Cox regression adjusting for variables with α<0.10 and found no significant difference in all-cause mortality (HR, 0.923; 95% CI 0.310-2.747; P=0.885) or cancer-specific mortality (HR, 0.518; 95% CI 0.047-5.711; P=0.591) when patients who underwent MMS were compared to those who underwent WLE. While our study is limited by a small number of patients, our analysis demonstrated no significant difference in all-cause or cause-specific survival for patients with eyelid melanoma treated with MMS compared with WLE. In areas requiring preservation of tissue due to cosmetic or functional purposes, MMS is a reasonable surgical approach.

Palpebral Tumors: A Retrospective, Epidemiological, Clinical And Therapeutic Study: About 16 Cases

The eyelid has the characteristic of containing tissues of very diverse origins in a small volume. All these tissues can degenerate in a malignant or benign way with a benign majority. The orbito-palpebral tumors are characterized by a histological diversity due to the architectural complexity of the orbito-palpebral region. Our study consists in an epidemiological, histological, therapeutic and evolutionary analysis of these carcinomas through a retrospective study extended over a period between April 2021 and March 2022, regrouping 16 patients with eyelid tumors operated in the department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima. The age of our patients varies between 8 and 80 years with an average age of 62.37 years with a clear male predominance. The rural origin represented (68.75%) and the majority was exposed to the sun. All regions of the eyelid were involved with a concentration of lesions in the upper eyelid (75%). Basal cell carcinoma is the most frequent histological type (75%), followed by adenoid cystic carcinoma (18.75%). The macroscopic appearance of the carcinomas was ulcerated in the majority of cases (47.22%). Tumor excision was the therapeutic rule in all our patients, respecting a margin of safety adapted to the histological type and the tumor size. Exenteration has been performed on 13 patients. The repair procedure was adapted to the site and extent of the substance loss. Reconstruction involved locoregional flaps in 63% of cases. Adjuvant radiotherapy was required in 5 patients. The evolution was favorable with a spectacular regression of the clinical signs.

Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors.

Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.

What could this dark lesion on a woman’s eyelid be?

What could this dark lesion on a woman’s eyelid be?

Malignant Melanoma of the Conjunctiva: about A Case and Review of the Literature

Purpose: The aim of this study was to describe the management of a case of malignant melanoma of the conjunctiva at the National Hospital of Zinder in Niger and review of the literature. Observation: This was a young adult, 46 years old, male, from Agadez, with an unfavorable socioeconomic status, with no particular history referred for an upper left eyelid tumour. On examination, his general condition was preserved. On inspection, a mass hanging from the free edge of the left upper eyelid was noted; resulting in total mechanical ptosis preventing examination of the condition was preserved. On inspection, a mass hanging from the free edge of the left upper eyelid was noted, resulting in total mechanical ptosis preventing examination of the anterior segment. Palpation of the orbital rim did not note anything in particular, the lymph node areas were free. On the ophthalmological examination, on the right the visual acuity from afar without correction was 10/10 with a normal biomicroscopic examination, on the left the visual acuity was counting the fingers at one meter and a biomicroscopy hampered by the ptosis The assessment laboratory was normal, the orbitocerebral computed tomography showed the conjunctival origin of the tumor without notion of extension in the vicinity. Macroscopically complete excision was performed. Histopathological examination of the approximately 5 cm surgical specimen noted a malignant melanoma of the conjunctiva with impregnation of the margins (R1 resection). Adjuvant treatment with mitomycin C was instituted. The postoperative course was simple. After 6 months of postoperative follow-up, the ophthalmological examination was normal and the search for metastases was negative. Conclusion: Malignant melanoma of the conjunctiva is a rare neoplasia that can mimic a palpebral tumor. Histopathological examination remains important for treatment and monitoring.

Holding back the tears: is there a role for marsupialisation?

ObjectiveMedial eyelid tumours may result in the loss of the proximal lacrimal system during staged excision and delayed reconstruction, to achieve tumour margin clearance. The remnant canaliculus was marsupialised during...

Spectrum of ophthalmic diseases in children hospitalized in a tertiary ophthalmology hospital in China from 2010 to 2019

BackgroundDescribing the pattern of pediatric eye diseases is necessary for appropriate eye care in children. This study explored the spectrum and characteristics of pediatric ophthalmic diseases in a typical tertiary ophthalmology hospital in China.MethodsA retrospective study was conducted at a tertiary ophthalmology hospital between 2010 and 2019 in Guangzhou, China. This study included 44,552 inpatients who were younger than 18 years old. Demographic and diagnostic data were collected from the electronic medical record system. Multiphase regression analysis was used to estimate trends in the annual percentages of ten common ophthalmic diseases.ResultsFrom 2010 to 2019, 44,552 inpatients met the inclusion criteria. The majority were male (61.9%), aged 7 to 12 years (30.3%) and self-paying (56.6%). The top ten conditions were refractive error (41.2%), strabismus (36.1%), cataract (13.6%), trauma (11.8%), congenital ptosis (8.8%), tumor (8.1%), amblyopia (7.1%), glaucoma (7.0%), entropion and trichiasis of eyelid (7.0%), and retinal detachment (6.5%). The annual percentage changes (APCs) for refractive error, strabismus, and retinal detachment were 9.3% (95% CI, 8.1–10.5%), 4.7% (95% CI, 3.8–5.6%) and − 2.8% (95% CI, − 5.1% to − 0.4%) respectively. For trauma, the average APC (AAPC = -9.2%, (95% CI, − 12.1% to − 6.2%) decreased gradually from 2010 to 2015 (APC = -4.2% (95% CI, − 8.8-0.7%)) and decreased rapidly from 2015 to 2019 (APC = -15.1% (95% CI, − 21.0% to − 8.7%)).ConclusionsPediatric ophthalmic diseases are common in China. Preventive strategies and health education aimed at the prevention of refractive error, strabismus, and entropion and trichiasis of eyelid will be crucial in reducing the burden of pediatric ophthalmic diseases on health care systems and human development.

Efficacy and Safety of Cryotherapy for Residual Tarsus and Free Tarsal Graft Implantation After Excision of Malignant Eyelid Tumor

To examine the usefulness and safety of cryotherapy for residual tarsus and free tarsal graft implantation for eyelid reconstruction after excision of malignant eyelid tumor. Fifteen patients with 17 eyelid malignancies (10 sebaceous gland carcinomas and 7 basal cell carcinomas) who underwent eyelid reconstruction between June 2017 and February 2021 were included in the study. In these patients, the tumors were resected in the entire eyelid layer including the safety margin. Only sebaceous gland carcinomas patients underwent cryotherapy at the residual tarsus margin. Then, a free tarsal graft taken from the ipsilateral or contralateral upper eyelid was transplanted into the eyelid plate defect, and anterior lamella reconstruction was performed with an orbicularis oculi myocutaneous advance flap. In both the non-cryotherapy and cryotherapy groups, there were no serious complications such as dropout or necrosis of the free tarsal graft. There were no differences in the occurrence of complications such as eyelid retraction or trichiasis between the 2 groups, but 1 patient who underwent cryotherapy required revision surgery to correct eyelid retraction. In addition, there were no complications on the donor side associated with free tarsal graft collection. The use of a free tarsal graft in the reconstruction of eyelid malignancies is relatively effective and safe, and if vascular support of the anterior lamella is obtained, cryotherapy is less likely to affect the viability of the free tarsal graft and may contribute to a decrease in local recurrence.

Noninvasive identification of Benign and malignant eyelid tumors using clinical images via deep learning system

Eyelid tumors accounts for 5–10% of skin tumors. It is important but difficult to identify malignant eyelid tumors from benign lesions in a cost-effective way. Traditional screening methods for malignancy in eyelid tumors require laborious and time-consuming histopathological process. Therefore, we aimed to develop a deep learning (DL)-based image analysis system for automatic identification of benign and malignant eyelid tumors. Using a common digital camera, we collected clinical images from patients who were histopathologically diagnosed with eyelid tumors. We trained 8 convolutional neural network (CNN) models to identify benign and malignant eyelid tumors, including ResNet-50, ResNet-101, InceptionV3, and InceptionResNetV2. Another group of patients with eyelid tumors were also collected as the prospective validation dataset. Performance of DL models and human clinicians in prospective validation dataset were evaluated and compared. A total of 309 images from 209 patients were used for training DL system, all eight models reached an average accuracy greater than 0.958 in the internal cross-validation. 36 images from 36 patients were included for the prospective validation, the models reached the best performance in accuracy, sensitivity, specificity, and area under curve (AUC) of 0.889 (95% CI 0.747–0.956), 0.933 (95% CI 0.702–0.988), 0.857 (95% CI 0.654–0.950), and 0.966 (95% CI 0.850–0.993), respectively. DL system had a similar performance as the senior ophthalmologists, and outreached the performance of junior ophthalmologists and medical students. DL system can identify benign and malignant tumors through common clinical images, with a better performance than most ophthalmologists. Combining DL system with smartphone may enable patients’ self-monitoring for eyelid tumors and assist in doctors’ clinical decision making.

Abstract 1717: Single-cell RNA sequencing reveals insights into the intra-tumoral heterogeneity and tumor microenvironment of ocular adnexal sebaceous carcinoma

Abstract Sebaceous carcinoma (SC) is a malignant neoplasm that predominantly arises from the sebaceous glands of the ocular adnexa. It is the second most common malignant eyelid neoplasm in the United States. No standardized treatment exists, but surgical excision is the mainstay of therapy. Therapeutic advances have been stagnant largely due to a limited understanding of SC tumor biology. We performed single-cell RNA sequencing to profile primary ocular adnexal SC and gain insights into its tumor microenvironment. Ocular adnexal SC has extensive intra-tumoral heterogeneity at the transcriptional level. Dimensionality reduction via principal component analysis was performed to identify major cell types. 8 clusters were detected, including clusters for cancer epithelial cells and various immune cells. Transcriptional programs were related to pathways in cancer, immune response, and antigen processing and processing, among others. We identified unique subpopulations of tumor-infiltrating immune cells, including plasma B cells, GNLY+ natural killer cells, CD8+ T cells, memory T cells, and CD20+ B cells. This complex ecosystem of tumor and immune cells provides new insights into SC biology. Additional patient samples we be analyzed in the immediate future. Follow-up mechanistic studies are needed to clarify the roles of the identified immune cells and how they can be exploited for immunotherapeutic approaches. Citation Format: Ryan Alexander Gallo, Michelle G. Zhang, David T. Tse, Daniel Pelaez, Andrew J. Rong. Single-cell RNA sequencing reveals insights into the intra-tumoral heterogeneity and tumor microenvironment of ocular adnexal sebaceous carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1717.

Epidemiological characteristics of malignant eyelid tumors at a referral hospital in Japan.

To clarify the incidence and demographic characteristics of malignant eyelid tumors diagnosed in a single institute in Japan. Retrospective, observational case series METHODS: Patients with malignant eyelid tumors diagnosed histopathologically at Tokyo Medical University Hospital between 1995 and 2019 were reviewed retrospectively. The incidence and demographic profile of malignant eyelid tumors were analyzed. The number of benign eyelid tumors diagnosed histopathologically during the same period was also counted. A total of 412 patients with histopathologically proven malignant eyelid tumors were included. The most common malignant eyelid tumor was sebaceous carcinoma (n = 180, 44%), followed by basal cell carcinoma (n = 148, 36%), squamous cell carcinoma (n = 35, 9%), lymphoma (n = 28, 7%), Merkel cell carcinoma (n = 11, 3%) and others (n = 10, 2%). Mean age of all patients with malignant eyelid tumor at the time of diagnosis was 71.0 ± 13.0 years. For sebaceous carcinoma, the proportion of female patients was significantly higher than that of male patients (P = 0.0283) and the proportion of involvement of upper eyelid was significantly higher than that of lower eyelid (P = 0.0001). On the other hand, there was no sex predominance in basal cell carcinoma and squamous cell carcinoma. The proportion of involvement of lower eyelid was significantly higher than of upper eyelid in basal cell carcinoma (P = 0.001) and squamous cell carcinoma (P = 0.0012). There were 1433 patients with benign eyelid tumors accounting for 78% of all eyelid tumors during the study period. Sebaceous carcinoma is the major malignant eyelid tumor in Japan and is more frequent in women than in men. Epidemiology of malignant eyelid tumors may be affected by the trend of population age structure associated with the recent population aging.