Purpose. To study the morphofunctional state of the rabbit eye after intravitreal injection of epidermal growth factor. Material and methods. In an experiment on rabbits, intravitreal course administration of Eberprot-P containing recombinant epidermal growth factor (EGF) at a dose of 100 ng was carried out. 7 and 30 days after each injection, biomicroscopy and ophthalmoscopy of the eye, optical coherence tomography (OCT) of the fundus in vivo were performed. Morphological studies were performed according to the generally accepted method with staining of histological preparations with hematoxylin and eosin. The cell density of the ganglionic layer, the inner and outer nuclear layers of the retina was assessed. SPSS software for Windows was used for statistical analysis. Results. Biomicroscopic and ophthalmoscopic studies of the intraocular structures of the experimental eyes did not reveal signs of edema or intraocular inflammation, toxic or irritant effects of intravitreal injection. There were no pathological changes in the form of cataracts, Tyndall's phenomenon in the anterior chamber moisture, vitreous opacities, retinal infiltrates. According to OCT data, the retinal thickness remained unchanged: 158 ± 5µm versus the control 158 ± 3µm (p = 1.0), no retinal wrinkling effects were detected. The morphological picture of the intraocular tissues of the eye after intravitreal injection was characterized by the absence of any pathological changes in the architectonics of the layers and cellular structures of the retina. Histomorphometric analysis showed no difference in the cell density of the ganglion layer, inner and outer nuclear layers of the retina of the experimental and control eyes of animals. Conclusion. Intravitreal application of EGF in rabbits does not cause intraocular specific inflammation or any destructive effects in the retina, which indicates the potential for its clinical use in the treatment of dystrophic retinal diseases. Keywords: epidermal growth factor, retina, intravitreal injection, morphology, histomorphometry