Smartphones are very convenient and accessible communication devices. Smartphone usage over long durations with poor posture can lead to musculoskeletal pain in adult users. To compare pain in the neck, shoulder, upper back, lower back, arm, hand, and eye regions. Thirty-five asymptomatic adults aged 18-25 years were divided into two groups: 1. use of an innovative smartphone app for the promotion of ergonomic behaviour (app use) and 2. no use of the innovative smartphone app (no app use). Participants sat upright, holding a smartphone with two hands, eyes 30-40 cm away from the screen, with frequent breaks consisting of stretching the neck and hand muscles while resting the eyes. The task involved taking part in online social networking for a duration of 45 minutes. A body pain chart and the visual analog scale (VAS) were used to evaluate the location and severity of pain. Pain in the neck, shoulder, upper back, arm, and hand regions in the "app use" condition were significantly lower than in the "no app use" condition at 15, 30, and 45 min (p-value<0.05). However, there were negligible differences between the two groups for eye pain, and lower back pain. Pain in the neck, shoulder, upper back, and arm regions in adult users in the "app use" condition was less than in the "no app use" condition. We would recommend that adults use the innovative smartphone app to prevent the risk of musculoskeletal pain potentially caused by smartphone usage.