Eye Infections Research Articles

378 Hydroxypropyl beta cyclodextrin barrier prevents respiratory and eye viral infections

OBJECTIVES/GOALS: Susceptible mucocutaneous membranes of the eye and nasal cavity are easily infected by viruses leading to pink eye or respiratory infections whose direct cost has been estimated as $16 billion annually in the United States. We have developed a novel and effective barrier that will be agnostic to variants enveloped viruses like coronaviruses. METHODS/STUDY POPULATION: We evaluated the efficacy of hydroxypropyl cyclodextrin barrier in preventing respiratory coronavirus infections using 25 humanized angiotensin converting enzyme-2 receptor (hACE-2) mice under a BSL3 laboratory setting. We have shown the barrier is safe and efficacious in preventing coronavirus infections in in vitro respiratory cell lines. We instilled 10 uL aliquot of the barrier into the nostril of the mouse 30 minutes before exposing them to a 10uL titer containing 10,000 plaque forming units of the SARS-CoV-2 delta variant. The control mice received the SARS-CoV-2 infection but not the barrier. The mice were observed for 5 days after which they were sacrificed. We analyzed the lungs and nasal palates for viral load using reverse transcription-polymerase chain reaction. RESULTS/ANTICIPATED RESULTS: We observed our barrier to be effective in preventing SARS-CoV-2 delta variant infection in hACE2 mice models. The lungs and nasal secretions of treated mice were less infectious with lower viral load than the control mice. The lungs of treated mice showed decrease in IFN gene expression and many cytokines and chemokines that regulate virally induced inflammatory responses such as IL-1b, IL-8, CXCL9, CXCL10, and the CCLs. We observed the plasma Angiotensin I and Angiotensin II decreased with barrier treatment, correlating with the viral load observed in the lungs. These peptides may be useful biomarkers for monitoring viral load within the lungs of virally infected individuals. DISCUSSION/SIGNIFICANCE: This supports the barrier’s efficacy to reduce transmission and prevent infections of SARS-CoV-2. This easy to use barrier can augment the mucocutaneous layers of the eye and nasal cavity. Our agnostic barrier will reduce the economic and public health burden of seasonal respiratory and eye viral infections and their related deaths amongst the public.

A case series of patients with ophthalmic manifestations of monkeypox in Spain

Monkeypox virus (MPXV) is a zoonotic orthopox DNA virus presently causing a global outbreak. The mucosae are affected in 41% of the cases; the nasal and eye regions are the least affected (1%). The most frequent eye infection is conjunctivitis with severe cases of corneal affection leading to permanent visual sequelae. We describe two cases of patients presenting facial edema, erythema, and vesiculo-pustular lesions with confirmed positive MPXV DNA polymerase chain reaction (PCR). Preseptal cellulitis and MPXV infection were diagnosed and treated with antibiotics and tecovirimat. A third patient was admitted to the hospital with pain and redness of the right eye and vesiculo-pustular skin lesions. On ophthalmological examination, he was diagnosed with a corneal ulcer and a creamy white infiltrate and was treated with systemic tecovirimat and ciprofloxacin eye drops. Healthcare professionals should be familiar with ocular manifestations of MPXV infection and consult ophthalmologists to reduce the risk of potentially vision-threatening complications.

Biophilic Positive Carbon Dot Exerts Antifungal Activity and Augments Corneal Permeation for Fungal Keratitis.

Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness of conventional antifungal drugs is limited due to the intrinsic ocular barrier that impedes drug absorption. There is an urgent need to develop new therapeutic strategies to effectively combat FK. Herein, we synthesized an ultrasmall positively charged carbon dot using a simple stage-melting method. The carbon dot can penetrate the corneal barrier by opening the tight junctions, allowing them to reach the lesion site and effectively kill the fungi. The results both in vitro and in vivo demonstrated that it exhibited good biocompatibility and antifungal activity, significantly improving the therapeutic effect in a mouse model of FK. Therefore, this biophilic ultrasmall size and positive carbon dot, characterized by its ability to penetrate the corneal barrier and its antifungal properties, may offer valuable insights into the design of effective ocular nanomedicines.

Small Interfering RNA Drug Delivery System in Cancer

siRNAs(Small interfering RNA) have emerged as new nucleic acid drugs to treat life-threatening diseases such as malignant tumors as our understanding of the molecular mechanisms of endogenous RNA interference has increased. Synthetic small interfering RNAs (siRNA) or short hairpin RNAs (shRNA) have been shown to have clinical potential in dental illnesses, eye infections, cancer, metabolic syndromes, neurological disorders, and other illnesses in subsequent RNAi investigations. Although various siRNA are used as a medication for respiratory and ophthalmic illnesses in clinical trials, there are problems in developing siRNA for malignancy treatments because systemic delivery would be required in the treatment of the majority of patients. Aside from nonspecific off-target effects and immunological stimulation issues, proper administration remains a significant challenge. The technologies that have been created for the formulation of siRNA therapeutics, including antisense oligonucleotides and plasmid DNA, have prepared the path for rapid advancement in in-vivo siRNA delivery. This review focuses on the Potential uses of siRNA in different diseases and its challenges in usage.

Aeromonas veronii-associated endogenous endophthalmitis: a case report

BackgroundAeromonas veronii is a very rare and highly pathogenic microorganism. We investigate the clinical characteristics and significance of endogenous endophthalmitis caused by Aeromonas veronii in our patient.Case presentationA 30-year-old Asian women with systemic lupus erythematosus, uremia, and hypertension developed acute infectious endophthalmitis caused by Aeromonas veronii. After emergency vitrectomy and antibiotic therapy, the clinical condition worsened requiring enucleation.ConclusionsAeromonas veronii can cause infection in the human eye, which can manifest as acute endophthalmitis. Early diagnosis and targeted therapy are important for successful treatment.

Risks, Identification, and Antibiotic Susceptibility Against High Prevalence of Bacterial Infection in Contact Lens Solutions

Background: Contact lens wear has become increasingly common for vision correction and cosmetic purposes. However, it also causes risks of microbial contamination leading to ocular infections. The aim of our study was to investigate the bacterial contamination in commercial contact lens solutions. Method: A total of 33 samples were collected and analyzed for bacterial presence using both phenotypic and molecular methods. Phenotypic diagnosis involved culturing samples on specific media and utilizing the Vitik system. Results: Our results showed the presence of various bacterial groups in contact lens preservation solutions, with Pseudomonas aeruginosa and Staphylococcus epidermidis being the most prevalent at 27.2% and 21.2%, respectively. The highest percentage of infections occurred in the age range of 12-20 years (41%), followed by 21-30 years (22%), 31-40 years (19%), 41-50 years (13%), and 51-60 years (5%). Regarding education level, individuals with primary education showed a higher percentage of eye infections (63%) compared to those with secondary education (27%) or higher education (10%). A higher percentage of infections was observed among individuals wearing lenses for 24 hours (57%) compared to those wearing them for 12, 6, or 1 hour, at 22%, 14%, and 7% respectively. Conclusion: In conclusion, the study demonstrated the importance of adherence to proper lens care practices to improve lens safety and reduce microbial contamination. Effective measures are essential to mitigate the risks associated with contact lens wear and maintain optimal eye health.

Can Topical Magistral Antibiotics Drops be Applied When Resistant Agents Grow in Eye and Ear Infections?

Can Topical Magistral Antibiotics Drops be Applied When Resistant Agents Grow in Eye and Ear Infections?

Eye infection risks from Pseudomonas aeruginosa via hand soap and eye drops.

Eye infections from bacterial contamination of bulk-refillable liquid soap dispensers and artificial tear eye drops continue to occur, resulting in adverse health outcomes that include impaired vision or eye enucleation. Pseudomonas aeruginosa (P. aeruginosa), a common cause of eye infections, can grow in eye drop containers and refillable soap dispensers to high numbers. To assess the risk of eye infection, a quantitative microbial risk assessment for P. aeruginosa was conducted to predict the probability of an eye infection for two potential exposure scenarios: (i) individuals using bacteria-contaminated eye drops and (ii) contact lens wearers washing their hands with bacteria-contaminated liquid soap prior to placing the lens. The median risk of an eye infection using contaminated eye drops and hand soap for both single and multiple exposure events (per day) ranged from 10-1 to 10-4, with contaminated eye drops having the greater risk. The concentration of P. aeruginosa was identified as the parameter contributing the greatest variance on eye infection risk; therefore, the prevalence and level of bacterial contamination of the product would have the greatest influence on health risk. Using eye drops in a single-use container or with preservatives can mitigate bacterial growth, and using non-refillable soap dispensers is recommended to reduce contamination of hand soap. Given the opportunistic nature of P. aeruginosa and its ability to thrive in unique environments, additional safeguards to mitigate bacterial growth and exposure are warranted.IMPORTANCEPseudomonas aeruginosa (P. aeruginosa) is a pathogen that can persist in a variety of unusual environments and continues to pose a significant risk for public health. This quantitative microbial risk assessment (QMRA) estimates the potential human health risks, specifically for eye infections, associated with exposure to P. aeruginosa in bacteria-contaminated artificial tear eye drops and hand soap. This study applies the risk assessment framework of QMRA to evaluate eye infection risks through both consumer products. The study examines the prevalence of this pathogen in eye drops and soap, as well as the critical need to implement measures that will mitigate bacterial exposure (e.g., single-use soap dispensers and eye drops with preservatives). Additionally, limitations and challenges are discussed, including the need to incorporate data regarding consumer practices, which may improve exposure assessments and health risk estimates.

The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study

BackgroundIn this study, the risk of dementia in patients with a history of herpes simplex virus (HSV) or varicella zoster virus (VZV) infection was evaluated.MethodsThis nationwide cohort study used data from the Korean National Health Insurance Service collected between 2006 and 2017. A total of 752,205 subjects ≥ 45 years of age not diagnosed with dementia until 2006 were included. A multivariate Cox regression model, adjusted for age, sex, and other comorbidities, was used to assess the hazard ratio (HR) for dementia based on VZV or HSV infection. The interaction effects of both viral infections were analysed. Viral infections are classified into four categories: eye, central nervous system (CNS), simple, and complicated. The hazard ratio (HR) of viral infection was analysed based on the type of dementia.ResultsIn multivariable analysis, both HSV and VZV infection were associated with an increased risk of dementia (HR = 1.38, 95% confidence interval, CI:1.33–1.43) and (HR = 1.41, 95% CI:1.37–1.46), respectively. Patients who experienced both HSV and VZV infections were also at an increased risk of dementia (HR = 1.57, 95% CI:1.50–1.63). The co-infection group showed the shortest time from viral infection to dementia diagnosis (4.09 ± 3.02 years). In the subgroup analysis, all types of HSV and VZV infections were associated with an increased risk of dementia compared to the non-infection group. The eye, CNS, and complicated VZV infections were associated with a significantly higher risk than simple VZV infections. There were no significant differences between the subtypes of HSV infection. Furthermore, HSV, VSV, and co-infection were associated with an increased risk of all dementia types, including Alzheimer’s disease (AD) and vascular dementia (VD).ConclusionsIndividual HSV and VZV infections were associated with an increased risk of all types of dementia, including AD and VD. Patients co-infected with HSV and VZV, VZV infection in the eye, CNS, or complicated type were more vulnerable to the development of dementia.

Exploring Heparanase Levels in Tears: Insights From Herpes Simplex Virus-1 Keratitis Patients and Animal Studies.

Heparanase (HPSE) cleaves heparan sulfate proteoglycans during herpes simplex virus-1 (HSV-1) infection, aiding in viral egress and disease progression. Its action has been well established in in vitro and in vivo models, but its relevance in human patients remains unclear. This study aimed to specifically evaluate tear HPSE levels of patients with herpes simplex keratitis (HSK) and to correlate these findings with a commonly used murine model. Tear samples from patient and mice samples were collected at LV Prasad Eye Institute, Hyderabad, India, and at the University of Illinois, Chicago, IL, respectively. Tears were collected from HSV-1 patients, bacterial/fungal keratitis cases, and healthy individuals. For in vivo study, C57BL/6 mice were infected with HSV-1 (McKrae strain) followed by tear fluid collection at various time points (0-10 days). The HSV-1, bacterial keratitis, fungal keratitis, and healthy control groups each had 30 patients. There was a significant difference in HPSE expression in the HSV-1 infected eyes (1.55 ± 0.19 units/mL) compared to HSV-1 contralateral eyes (1.23 ± 0.13 units/mL; P = 0.82), bacterial keratitis eyes (0.87 ± 0.15 units/mL; P = 0.0078), fungal keratitis eyes (0.64 ± 0.09 units/mL; P < 0.00001), and normal controls (0.53 ± 0.06 units/mL; P < 0.00001). C57BL/6 mice tear HPSE expression in infected eyes was 0.66 to 5.57 ng heparan sulfate (HS) removed per minute when compared to non-infected eye (range, 0.70-3.67 ng HS removed per minute). To the best of our knowledge, this study is the first to report elevated HPSE levels in the tears of patients with different forms of HSV-1 keratitis, and it confirms similar findings in a murine model, providing a valuable basis for future in vivo and clinical research on HSV-1 ocular infection.

Detection of infectious SARS-CoV-2 in ocular samples is linked to viral load in the nasopharynx.

SARS-CoV-2 is known to infect respiratory tissue cells. However, less is known about infection of ocular tissue and potential infectivity of lacrimal fluid. With this study, we want to compare viral loads in eye and nasopharyngeal swabs and analyze these for infectious virus. Between May 2020 and April 2021 ocular and nasopharyngeal swabs were collected from 28 SARS-CoV-2 infected patients treated on the corona virus disease 2019 (COVID-19)-ward of the University Hospital of Innsbruck, Austria. Samples with PCR detectable SARS-CoV-2 were analyzed via whole genome sequencing and an attempt was made to isolate infectious virus. At the time point of sample collection, 22 individuals were still PCR positive in nasopharyngeal samples and in 6 of these patients one or both ocular samples were additionally positive. CT-values in eyes were generally higher compared to corresponding nasopharyngeal samples and we observed a tendency for lower CT-values, i.e. increased viral load, in nasopharyngeal swabs of individuals with at least one infected eye, compared to those where ocular samples were PCR negative. Ocular and nasopharyngeal sequences from the same patient were assigned to the same variant, either the D614G or the Alpha variant. Infectious virus was successfully isolated from 9 nasopharyngeal swabs, however only from one of the seven PCR positive ocular samples. We could detect SARS-CoV-2 in eyes of some of the infected patients albeit at lower levels compared to nasopharyngeal swabs. However, our results also indicate that lacrimal fluid might be infectious in patients with high viral load.

A Review on the Detection and Classification of Glaucoma Disease Based on Transfer Learning

An eye infection is a condition affecting the eyes that can be caused by a bacterium, virus, or fungus. Numerous eye infections exist, such as glaucoma, cellulitis, keratitis, and conjunctivitis. A few of the symptoms may be itching, discharge, altered eyesight and others. Antibiotics are not effective in treating viral infections. Antibiotics treat infections caused by bacteria exclusively. A class of eye infection known as glaucoma can result in blindness and visual loss by harming the optic nerve, a nerve located at the back of the eye. You might not notice the symptoms at first because they can appear so slowly. A thorough dilated eye exam is the only way to determine if you have glaucoma . Efforts have been done to automate the procedures for the recognition and classification of glaucoma. In this paper, we have proposed a transfer learning model by reviewing pre-trained models and the model is able to provide a better accuracy. Our model is classifying the datasets into positive and negative cases during testing and validation. We utilize different prêt rained models, that are ResNet50 (90%), EffiecintNet (78%) and CNN(79%) evaluate how well they perform when trained using various optimizers. Our results show differences in accuracy and provide important information about the possibility of these models for the detection of glaucoma. An important first step towards improving the precision and dependability of glaucoma detection models in clinical settings is represented by this work.

Perceived occupational health risks, noise and dust exposure levels among street sweepers in Mwanza City in Northern Tanzania.

Solid waste has been a major problem particularly in Sub-Saharan Africa countries as it has been increasing in several years. One of the methods employed in solid waste management is street sweeping which is done by street sweepers. Street sweepers are being predisposed to respiratory and non-respiratory infection like eye infection, skin infection and musculoskeletal disorders. This analytical cross-sectional study enrolled a total of 233 street sweepers to assess perceived occupational health risks, particulate matters (i.e., PM2.5, PM5 and PM10 measured in (mg/m3)) dust and noise exposure levels in decibel units-dB(A), and utilization of protective personnel equipment among street sweepers in Mwanza city, Northern Tanzania. Modified poison regression was used to determine the association between exposures variables (i.e., sociodemographic, and socioeconomic factors) and outcomes ((i.e., noise dose level and particulate matters))). More than half (50.2%) of the participants were aged between 46-80 years. Their Median age was 46(IQR: 28-59) years. Large percent (63.1%) of the participants reported that their working environment have high health risks. The Median concentrations of the noise dose and particulates matters were 85.4 (IQR = 76.4-92.3) for noise dose, 13426 (IQR = 9637-17632) for PM2.5, 5522 (IQR = 2453-7679) for PM5, and 2310(IQR = 1263-3201). The Median concentrations of the noise dose and particulates matters were 85.4 (IQR = 76.4-92.3) for noise dose in decibel units dB(A); 13426 (IQR = 9637-17632) for PM2.5; 5522 (IQR = 2453-7679) for PM5; and 2310(IQR = 1263-3201) for PM10. Individual Street sweepers in Mwanza city are highly exposed to noise dose and fine particulate matters at levels above the reference values for human of 85dB(A) and 5mg/m3 respectively, making it a public health issue that requires holistic public health measures.

High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer

BackgroundLeucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (BC), high intratumoral LRG-1 protein expression levels are associated with reduced survival. In this study, we assessed serum levels of LRG-1 in patients with early BC and investigated its correlation with the presence of disseminated tumor cells (DTCs) in the bone marrow and survival outcomes.MethodsSerum LRG-1 levels of 509 BC patients were determined using ELISA and DTCs were assessed by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3. We stratified LRG-1 levels according to selected clinical parameters. Using the log-rank (Mantel–Cox) test and multivariate Cox regression analysis, Kaplan–Meier survival curves and prognostic relevance were assessed.ResultsMean serum levels of LRG-1 were 29.70 ± 8.67 µg/ml. Age was positively correlated with LRG-1 expression (r = 0.19; p < 0.0001) and significantly higher LRG-1 levels were found in patients over 60 years compared to younger ones (30.49 ± 8.63 µg/ml vs. 28.85 ± 8.63 µg/ml; p = 0.011) and in postmenopausal patients compared to premenopausal patients (30.15 ± 8.34 µg/ml vs. 26.936.94 µg/ml; p = 0.002). Patients with no DTCs showed significantly elevated LRG-1 levels compared to the DTC-positive group (30.51 ± 8.69 µg/ml vs. 28.51 ± 8.54 µg/ml; p = 0.004). Overall and BC-specific survival was significantly lower in patients with high serum LRG-1 levels (above a cut-off of 33.63 µg/ml) compared to patients with lower LRG-1 levels during a mean follow-up of 8.5 years (24.8% vs. 11.1% BC-specific death; p = 0.0003; odds ratio 2.63, 95%CI: 1.56—4.36). Multivariate analyses revealed that LRG-1 is an independent prognostic marker for BC-specific survival (p = 0.001; hazard ratio 2.61).ConclusionsThis study highlights the potential of LRG-1 as an independent prognostic biomarker in patients with early BC.

Awareness and Hygiene Practices Among Contact Lens Wearers: A Population-Based Cross-Sectional Survey.

Background More than 150 million individuals worldwide wear contact lenses (CL) for therapeutic as well as cosmetic purposes. Researchers have linked failure to adhere to CL care instructions with outbreaks of serious eye infections. In the current study, we assess the consequences of inadequate cleanliness as well as awareness of and adherence to appropriate CL hygiene. Methods This is a cross-sectional descriptive study conducted in the Jazan region, southwest Saudi Arabia, during the period between October 2022 and April 2023. Results Out of a total of 718 participants, 391 (54.4%) were wearing CL. Of these, 318 (81.33%) CL wearers were female, while 73 (18.67%) were male. Among the CL wearers, 196 (50%) were aged 24 and younger. The overall knowledge was higher in females, with 320 (74.6%) having a high level of knowledge, compared to 195 (67.5%) males (p-value = 0.044). The level of knowledge was higher in those who had had an eye examination before using CL. Regarding practice, 202 (63.5%) females demonstrated better practices, while only 32 (43.8%) males did (p-value = 0.002). Variations in the adequacy of practice regarding CLs were identified according to the duration of CL use and the risk of suffering from eye dryness (p-values <0.05). Conclusions The participants' overall knowledge and practices were good. This should be encouraged by performing an eye examination before wearing CL and demonstrating good wearing habits in terms of hygiene behavior.

Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.

Herpes simplex virus-1 (HSV-1) infections are among the most frequent serious viral eye infections in the U.S. and are a major cause of viral-induced blindness. HSV-1 infection is known to induce T cell activation, proliferation, and differentiation that play crucial roles in the development of virus-induced inflammatory lesions, leading to eye disease and causing chronic corneal damage. CD80 is a co-stimulatory molecule and plays a leading role in T cell differentiation. Previous efforts to limit lesion severity by controlling inflammation at the cellular level led us to ask whether mice knocked out for CD80 would show attenuated virus replication following reactivation. By evaluating the effects of CD80 activity on primary and latent infection, we found that in the absence of CD80, virus replication in the eyes and virus reactivation in latent trigeminal ganglia were both significantly reduced. However, latency in latently infected CD80-/- mice did not differ significantly from that in wild-type (WT) control mice. Reduced virus replication in the eyes of CD80-/- mice correlated with significantly expanded CD11c gene expression as compared to WT mice. Taken together, our results indicate that suppression of CD80 could offer significant beneficial therapeutic effects in the treatment of Herpes Stromal Keratitis (HSK).IMPORTANCEOf the many problems associated with recurrent ocular infection, reducing virus reactivation should be a major goal of controlling ocular herpes simplex virus-1 (HSV-1) infection. In this study, we have shown that the absence of CD80 reduces HSV-1 reactivation, which marks the establishment of a previously undescribed mechanism underlying viral immune evasion that could be exploited to better manage HSV infection.

Exploring the Antibacterial Potential of Platymiscium pinnatum

Antibiotic resistance is a growing concern worldwide, necessitating the exploration of alternative antimicrobial agents. Platymiscium pinnatum (Jacq), a tree belonging to the Fabaceae family, has traditionally held medicinal value, especially in the form of leaf infusions for treating skin and eye infections. This study delves into the antibacterial potential of the ethanolic extract obtained from the bark of P. pinnatum. Using the established Kirby-Bauer agar disk diffusion method, the antibacterial activity of the extract was assessed against both Gram-positive and Gram-negative bacteria. Results indicated a pronounced inhibitory effect on several Gram-positive strains, with Staphylococcus aureus demonstrating the highest susceptibility. This signifies the potential of the extract as a therapeutic agent against infections caused by Gram-positive bacteria. On the contrary, the bioactivity of the extract was comparatively limited against prominent Gram-negative strains, such as E. coli and Pseudomonas aeruginosa. The differential activity between Gram-positive and Gram-negative bacteria could provide insights into the mode of action or specific compounds within the extract. The distinctive antibacterial properties of the P. pinnatum bark extract highlight its potential as a source for developing novel antimicrobial agents. These findings pave the way for further phytochemical analyses and studies to understand the specific bioactive components responsible for the observed effects.

Efficacy and Safety of Iris-Claw and Scleral Fixated Intraocular Lens in Pediatric Ectopia Lentis : A Systematic Review

Abstract&#x0D; Introduction &amp; Objectives : Ectopia lentis is a condition that involves displacement of the crystalline lens because of weakened or damaged zonules. Surgical intervention is indicated in cases of poor best corrected visual acuity (BCVA) and progressive severity of subluxation. This systematic review aims to elucidate current evidence regarding the efficacy and safety of iris-claw and scleral-fixated intraocular lenses (IOLs) to treat children with ectopia lentis.&#x0D; Methods : A comprehensive search from multiple electronic databases such as PubMed, Cochrane Library, ProQuest, Scopus, EBSCO, Wiley, and Embase within the last ten years of publication. All seventeen studies matched with studies’ criteria were included in this review and assessed with eligibility assessment tools. The outcomes extracted and compared were BCVA, endothelial cell density, postoperative complications, IOL stability, and intraocular pressure (IOP).&#x0D; Results : Seventeen studies were included in this review; three observational studies, nine retrospective studies and five interventional studies in which majority have a low risk of bias. Significant improvement of post-operative BCVA on both IOLs. The most frequent complications found on ICIOL was pupillary ovalization, while SCIOL was eye infection. Endothelial cell loss was higher in SCIOL, and both IOL showed no significant difference (p &gt; 0,05) in terms of the post-operative IOP. Dislocation of IOL more frequently found on ICIOL. However, ICIOL much more preferred due to less manipulation and duration of surgery.&#x0D; Conclusion : ICIOL and SFIOL were both effective and safe for treating pediatric ectopia lentis. There was no superiority in which technique is better, technique varied according to each surgeon's preference.

Efficacy and Safety of Iris-Claw and Scleral Fixated Intraocular Lens in Pediatric Ectopia Lentis : A Systematic Review

Introduction &amp; Objectives : Ectopia lentis is a condition that involves displacement of the crystalline lens because of weakened or damaged zonules. Surgical intervention is indicated in cases of poor best corrected visual acuity (BCVA) and progressive severity of subluxation. This systematic review aims to elucidate current evidence regarding the efficacy and safety of iris-claw and scleral-fixated intraocular lenses (IOLs) to treat children with ectopia lentis.&#x0D; Methods : A comprehensive search from multiple electronic databases such as PubMed, Cochrane Library, ProQuest, Scopus, EBSCO, Wiley, and Embase within the last ten years of publication. All seventeen studies matched with studies’ criteria were included in this review and assessed with eligibility assessment tools. The outcomes extracted and compared were BCVA, endothelial cell density, postoperative complications, IOL stability, and intraocular pressure (IOP).&#x0D; Results : Seventeen studies were included in this review; three observational studies, nine retrospective studies and five interventional studies in which majority have a low risk of bias. Significant improvement of post-operative BCVA on both IOLs. The most frequent complications found on ICIOL was pupillary ovalization, while SCIOL was eye infection. Endothelial cell loss was higher in SCIOL, and both IOL showed no significant difference (p &gt; 0,05) in terms of the post-operative IOP. Dislocation of IOL more frequently found on ICIOL. However, ICIOL much more preferred due to less manipulation and duration of surgery.&#x0D; Conclusion : ICIOL and SFIOL were both effective and safe for treating pediatric ectopia lentis. There was no superiority in which technique is better, technique varied according to each surgeon's preference.

Ocular Penetration Trauma due to Bamboo Resulting in Evisceration: A Case Report

Introduction : Penetrating ocular trauma includes open-eye trauma, which leads to the time and a precision of eye- penetrating trauma’s management determine the advanced vision prognosis. In this case a male experience penetration trauma of the right eye due to exposure to the bamboo, delaying and inadequate management resulted in evisceration of the right eye. A 42-year-old male came to ER RSUD Prof. Soekandar mojokerto with bloody right eye and pain from getting a piece of bamboo from two days before entering the hospital. The patient also complained that the right eye is swollen so that it is unable to open the eyes. vision examination revealed LP (-) in the right eye, visual acuity in the left eye was 6/6, soft palpation in the right eye, normal palpation in the left eye, examination of the right anterior segment of the eye revealed that part of the eyeball content had prolapsed and for the left eye within the normal range. During laboratory tests, 15.280 white blood cells were found, which confirmed the infection of the right eye.&#x0D; Case Illustration : Descriptive Study&#x0D; Discussion : The observations on these patients include covered the right eye, antibiotic, steroids, and analgesic by intravenous injection. Based on the condition of the patient's right eye, it is advisable to do evisceration of the right eyeball under general anesthesia.&#x0D; Conclusion : Penetrating ocular trauma resulting in extensive intra ocular tissue damage and poor vision prognosis, considered for evisceration, in order to prevent the development of the sympatetic ophthalmia.